mi

An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

Lab Chip, 2020, 20,1390-1397
DOI: 10.1039/D0LC00021C, Communication
Bo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. Maidment
PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.
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Scalable microfluidic droplet on-demand generator for non-steady operation of droplet-based assays

Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper
Open Access
Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
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mi

Rapid lipolytic oscillations in ex vivo adipose tissue explants revealed through microfluidic droplet sampling at high temporal resolution

Lab Chip, 2020, 20,1503-1512
DOI: 10.1039/D0LC00103A, Paper
Juan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. Easley
High temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.
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mi

Applications of the microphysiology systems database for experimental ADME-Tox and disease models

Lab Chip, 2020, 20,1472-1492
DOI: 10.1039/C9LC01047E, Paper
Open Access
Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough
The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.
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mi

Mathematical modeling and computational analysis of centrifugal microfluidic platforms: a review

Lab Chip, 2020, 20,1318-1357
DOI: 10.1039/C9LC00775J, Critical Review
Open Access
Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. Madou
This paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.
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mi

Nanoplasmon-enhanced drop-screen for high throughput single-cell nucleocytoplasmic miRNA profiling

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01226E, Paper
Jia Liu, Guoyun Sun, Shih-Chung Wei, Song Guo, Weikang Nicholas Lin, Chia-Hung Chen
Nanoplasmon-enhanced drop screen is developed to measure single-cell multiple miRNAs with high sensitivity of 0.1 nM, addressing cell nucleocytoplasmic profile in a throughput ∼100 cells per minute.
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mi

Stretching DNA to twice the normal length with single-molecule hydrodynamic trapping

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01028A, Paper
Open Access
Yan Jiang, Theodore Feldman, Julia A. M. Bakx, Darren Yang, Wesley P. Wong
High-speed hydrodynamic trapping enables combined surface-free force spectroscopy and fluorescence imaging of single DNA molecules at extreme forces.
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mi

ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00254B, Paper
Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
A perfusable and stretchable gelatin-based microfluidic system that can apply both simultaneous fluidic shear stress and stretch stress to in vitro endothelial 3D tissues is presented.
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mi

A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00263A, Paper
Jaime L. Korner, Elanna B. Stephenson, Katherine S. Elvira
A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.
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mi

Seeded droplet microfluidic system for small molecule crystallization

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00122H, Paper
N. Garg, R. Tona, P. Martin, P. M. Martin-Soladana, G. Ward, N. Douillet, D. Lai
A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.
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mi

A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00059K, Paper
Open Access
Christian G. M. van Dijk, Maarten M. Brandt, Nikolaos Poulis, Jonas Anten, Matthijs van der Moolen, Liana Kramer, Erik F. G. A. Homburg, Laura Louzao-Martinez, Jiayi Pei, Merle M. Krebber, Bas W. M. van Balkom, Petra de Graaf, Dirk J. Duncker, Marianne C. Verhaar, Regina Luttge, Caroline Cheng
We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.
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mi

Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00144A, Critical Review
Jia Li, Chang-Jin “CJ” Kim
Electrowetting on EWOD surface: a droplet beading or spreading (left) or translating (right) by electric signals. The EWOD technology made the once-obscure electrowetting phenomenon practical, leading to the host of commercial products today.
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mi

Microfluidic device for high-throughput affinity-based isolation of extracellular vesicles

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01190K, Paper
Ting-Wen Lo, Ziwen Zhu, Emma Purcell, Daniel Watza, Joyful Wang, Yoon-Tae Kang, Shruti Jolly, Deepak Nagrath, Sunitha Nagrath
Immunoaffinity based EV isolation technologies use antibodies targeting surface markers on EVs to provide higher isolation specificity and purity compared to existing approaches.
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mi

Direct loading of blood for plasma separation and diagnostic assays on a digital microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00302F, Paper
Christopher Dixon, Julian Lamanna, Aaron R. Wheeler
The integration of 3D porous membranes in a digital microfluidic device enables the generation of cell-free plasma from finger-stick volumes of blood with in-line, on-chip analysis.
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mi

Correction: Deformability-induced lift force in spiral microchannels for cell separation

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC90036B, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ewa Guzniczak, Oliver Otto, Graeme Whyte, Nicholas Willoughby, Melanie Jimenez, Helen Bridle
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mi

A new polymer lab-on-a-chip (LOC) based on a microfluidic capillary flow assay (MCFA) for detecting unbound cortisol in saliva

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00071J, Paper
Vinitha T. U., Sthitodhi Ghosh, Alexander Milleman, Thinh Nguyen, Chong H. Ahn
A new polymer lab-on-a-chip with on-chip dried reagents for microfluidic capillary flow assay (MCFA) detection of unbound cortisol in saliva.
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mi

Spatially isolated reactions in a complex array: using magnetic beads to purify and quantify nucleic acids with digital and quantitative real-time PCR in thousands of parallel microwells

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00069H, Paper
W. Hampton Henley, Nathan A. Siegfried, J. Michael Ramsey
Encoded beads carrying primer pairs for nucleic acid targets are used for sample preparation and multiplexed-in-space digital PCR quantification.
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mi

Clip-to-release on amplification (CRoA): a novel DNA amplification enhancer on and off microfluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00318B, Paper
Ren Shen, Yanwei Jia, Pui-In Mak, Rui P. Martins
A proposed DNA amplification enhancer with a “clip-to-release on amplification” mechanism reduces dye-mediated inhibition to amplification, increases fluorescence signal up to 10-fold, and eliminates false-negative results for on-chip PCR.
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mi

Nanocrystal synthesis, μfluidic sample dilution and direct extraction of single emission linewidths in continuous flow

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00213E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ioannis Lignos, Hendrik Utzat, Moungi G. Bawendi, Klavs F. Jensen
We present a flow-based system coupled with an optical interferometry setup for the extraction of single nanocrystal properties.
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mi

Bioinspired reconfiguration of 3D printed microfluidic hydrogels via automated manipulation of magnetic inks

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00280A, Communication
Amin Mansoorifar, Anthony Tahayeri, Luiz E. Bertassoni
We proposed a novel concept for reconfiguration of hydrogel microfluidic devices, where multiple fluidic pathways could be generated via reversible manipulation of magnetic inks.
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mi

Catalytic exchange of hydrogen isotopes intensified by two-phase stratified flow in wettability designable microchannels

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00250J, Paper
Yuexiao Song, Feng Xin, Yongsheng Xu
This work develops a reliable method to achieve stratified flow in squared cross-section microchannels by endowing the four channel walls with very different wettabilities. The gas–liquid flows are studied experimentally...
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mi

PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology

Lab Chip, 2020, 20,1628-1638
DOI: 10.1039/C9LC01165J, Paper
Jose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum Han
Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.
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mi

Multiscale brain research on a microfluidic chip

Lab Chip, 2020, 20,1531-1543
DOI: 10.1039/C9LC01010F, Critical Review
Yanan Zhao, Utkan Demirci, Yun Chen, Pu Chen
We report recent progress in applying innovative microfluidic chip-based neurotechnologies to promote multiscale brain research across the hierarchical organizations from the molecular, cellular, and tissue levels up to the whole organism level.
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mi

Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method

Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper
Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
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mi

Microfluidic device to study flow-free chemotaxis of swimming cells

Lab Chip, 2020, 20,1639-1647
DOI: 10.1039/D0LC00045K, Paper
Nicolas Garcia-Seyda, Laurene Aoun, Victoria Tishkova, Valentine Seveau, Martine Biarnes-Pelicot, Marc Bajénoff, Marie-Pierre Valignat, Olivier Theodoly
Permeable agarose barriers allow flow-free gradient generation, applicable to adherent and non-adherent (swimming) cells, as well as co-culture experiments.
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mi

Quantitatively controllable fluid flows with ballpoint-pen-printed patterns for programmable photo-paper-based microfluidic devices

Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper
Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
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mi

Monitoring the two-dimensional concentration profile of toluene vapors by using polymer-stabilized nematic liquid crystals in microchannels

Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper
Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
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mi

Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels

Lab Chip, 2020, 20,1648-1657
DOI: 10.1039/D0LC00276C, Paper
Charuksha Walgama, Michael P. Nguyen, Lisa M. Boatner, Ian Richards, Richard M. Crooks
A hybrid paper/plastic microfluidic device for detection of Ag nanoparticle labels at concentrations as low as 12 pM.
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mi

A microfluidic platform for functional testing of cancer drugs on intact tumor slices

Lab Chip, 2020, 20,1658-1675
DOI: 10.1039/C9LC00811J, Paper
A. D. Rodriguez, L. F. Horowitz, K. Castro, H. Kenerson, N. Bhattacharjee, G. Gandhe, A. Raman, R. J. Monnat, R. Yeung, R. C. Rostomily, A. Folch
We have developed a digitally-manufacturable microfluidic platform that allows for multiplexed drug testing of intact tumor slices.
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mi

Selective cell propagation via micropatterning of a thermally-activated hydrogel

Lab Chip, 2020, 20,1544-1553
DOI: 10.1039/C9LC01230C, Communication
Jeffrey C. Y. Chiu, Joyce A. Teodoro, Jeong Hyun Lee, Kerryn Matthews, Simon P. Duffy, Hongshen Ma
Inverse gelation of methylcellulose enables hydrogel micropatterning to selectively propagate cells identified by microscopy.
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mi

In-flow measurement of cell–cell adhesion using oscillatory inertial microfluidics

Lab Chip, 2020, 20,1612-1620
DOI: 10.1039/D0LC00089B, Paper
Baris R. Mutlu, Taronish Dubash, Claudius Dietsche, Avanish Mishra, Arzu Ozbey, Kevin Keim, Jon F. Edd, Daniel A. Haber, Shyamala Maheswaran, Mehmet Toner
Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.
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mi

Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment

Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper
Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
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mi

High-sensitivity microliter blood pressure sensors based on patterned micro-nanostructure arrays

Lab Chip, 2020, 20,1554-1561
DOI: 10.1039/D0LC00063A, Communication
Nianzuo Yu, Yongshun Liu, Bai Ji, Shuli Wang, Yunyun Chen, Tianmeng Sun, Junhu Zhang, Bai Yang
Blood pressure sensors are proposed to measure the value of central venous pressure, and diagnose the severity of hypertension, hypotension and arterial thrombosis.
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mi

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Lab Chip, 2020, 20,1621-1627
DOI: 10.1039/D0LC00304B, Paper
Fu Sun, Anurup Ganguli, Judy Nguyen, Ryan Brisbin, Krithika Shanmugam, David L. Hirschberg, Matthew B. Wheeler, Rashid Bashir, David M. Nash, Brian T. Cunningham
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
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mi

Microfluidic assessment of red blood cell mediated microvascular occlusion

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00112K, Paper
Yuncheng Man, Erdem Kucukal, Ran An, Quentin Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A Little, Umut A. Gurkan
Abnormal red blood cells (RBC) deformability contributes to hemolysis, thrombophilia, inflammation, and microvascular occlusion in various circulatory diseases. A quantitative and objective assessment of microvascular occlusion mediated by RBCs with...
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mi

Particle/cell separation using sheath-free deterministic lateral displacement arrays with inertially focused single straight input

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00354A, Paper
Naotomo Tottori, Takasi Nisisako
We propose sheath-free microfluidic deterministic lateral displacement devices with inertially focused single straight input.
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mi

A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredient

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper
Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
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mi

Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00142B, Paper
Sharif M. Rahman, Joshua M. Campbell, Rachael N. Coates, Katie M. Render, C. Ethan Byrne, Elizabeth C. Martin, Adam T. Melvin
Breast cancer cells co-cultured with adipose-derived stem cells (ASCs) in a microfluidic device exhibited enhanced growth, a more aggressive morphology and polarization towards the ASCs, and increased drug resistance.
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mi

Liquid-liquid-liquid three-phase microsystem: hybrid slug flow-laminar flow

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00292E, Communication
Tao Wang, Cong Xu
Liquid-liquid-liquid three-phase microfluidics provides abundant flow patterns and attractive characteristics that substantially extend the applications of liquid-liquid two-phase microfluidics. Although the manipulation of stable interfaces between adjacent liquid phases is...
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mi

Picoliter Agar Droplet Breakup in Microfluidics Meets Microbiology Application: Numerical and Experimental Approaches

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00300J, Paper
Asmaa Khater, Osama Abdelrehim, Mehdi Mohammadi, Milad Azarmanesh, Mohsen Jonmaleki, Razieh Salahandish, AbdulMajeed Mohamad, Amir Sanati Nezhad
Droplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environment, and live monitoring of growth and proliferation. The droplets are mainly generated from...
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mi

Here are the 33 writers who returned their Sahitya Akademi awards




mi

7th Pay Commission recommendations: All you need to know




mi

[ASAP] Comparing Cryo-EM Reconstructions and Validating Atomic Model Fit Using Difference Maps

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01103




mi

[ASAP] Computational Protocol for Assessing the Optimal Pixel Size to Improve the Accuracy of Single-particle Cryo-electron Microscopy Maps

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01107




mi

[ASAP] SPREAD: A Fully Automated Toolkit for Single-Particle Cryogenic Electron Microscopy Data 3D Reconstruction with Image-Network-Aided Orientation Assignment

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01099




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[ASAP] What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00123




mi

[ASAP] What Could Go Wrong? A Practical Guide to Single-Particle Cryo-EM: From Biochemistry to Atomic Models

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01178




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[ASAP] Structural Biology in the Multi-Omics Era

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01164




mi

[ASAP] Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction?

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00177




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[ASAP] Correction of Missing-Wedge Artifacts in Filamentous Tomograms by Template-Based Constrained Deconvolution

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01111