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A portable electrochemiluminescence bipolar electrode array for the visualized sensing of Cas9 activity

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00678E, Paper
Rui Guo, Shanwen Hu, Zonghua Wang
A new type of closed BPE-ECL system based on an Au electric circuit at a portable substrate is designed for the visualized sensing of Cas9 Activity in the CRISPR/Cas9 system.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Portable surface-enhanced Raman scattering analysis performed with microelectrode-templated silver nanodendrites

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00484G, Paper
Joshua Raveendran, Aristides Docoslis
Using a handheld Raman spectrometer, we demonstrate how silver nanodendritic substrates formed on microelectrode platforms can be used for ultrasensitive detection of target analytes, such as cocaine and melamine. The...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A signal cascade amplification strategy based on RT-PCR triggering of G-quadruplex DNAzyme for a novel electrochemical detection of viable Cronobacter sakazakii

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00270D, Paper
Yuanyuan Yuan, Xianyong Wu, Zhanmin Liu, QIqi Ning, Liqiang Fu, Sujuan Wu
Cronobacter sakazakii is an important opportunistic food-borne pathogen, and it can cause severe diseases with main symptoms including neonatal meningitis, necrotizing enterocolitis, and sepsis. For the achievement of practical and...
The content of this RSS Feed (c) The Royal Society of Chemistry




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iso-μmGene: Isothermal amplification-based portable microfluidic system for simple, reliable and flexibly multiplexed Genetic identification and quantification

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00560F, Paper
Runtao Zhong, Shilin Liu, Guohao Zhang, Mengyu Wang, Yeqing Sun
Simple, reliable and flexibly multiplexed genetic identification and quantification of microbial pathogens is in urgent need for early disease diagnosis and timely treatment. This study presented an isothermal amplification-based portable...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Accelerated non-crosslinking assembly of DNA-functionalized nanoparticles in alcoholic solvents: for application in the identification of clear liquors

Analyst, 2020, 145,3229-3235
DOI: 10.1039/D0AN00029A, Paper
Luyang Wang, Guoqing Wang, Yali Shi, Lan Zhang, Ran An, Tohru Takarada, Mizuo Maeda, Xingguo Liang
Accelerated aggregation of DNA-functionalized gold nanoparticles is discovered in alcoholic solvents upon adding full-match DNA and is potentially useful for the identification of Baijiu.
The content of this RSS Feed (c) The Royal Society of Chemistry




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In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance

Analyst, 2020, 145,3236-3244
DOI: 10.1039/D0AN00168F, Paper
Akihiro Taguchi, Stephen DeVience, Benoit Driesschaert, Valery V. Khramtsov, Hiroshi Hirata
A simultaneous mapping method was established for the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Why ammonium detection is particularly challenging but insightful with ionophore-based potentiometric sensors – an overview of the progress in the last 20 years

Analyst, 2020, 145,3188-3210
DOI: 10.1039/D0AN00327A, Critical Review
Open Access
María Cuartero, Noemi Colozza, Bibiana M. Fernández-Pérez, Gastón A. Crespo
An overview of ionophore-based electrodes for ammonium sensing critically analyzing contributions in the last 20 years and with focus in analytical applications.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Model independent peak fitting and uncertainty assignment for high-precision time-of-flight mass spectrometry

Analyst, 2020, 145,3401-3406
DOI: 10.1039/D0AN00325E, Paper
Aleksey Vladimirovich Chudinov, Marco Rosenbusch, Vyacheslav Ivanovich Kozlovskiy, Valeriy Vladislavovich Raznikov, Peter Schury, Michiharu Wada, Hermann Wollnik
Logarithmic scale splines for smooth extraction of a native peak shape, and uncertainty estimation using direct trials.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Colorimetric identification of lanthanide ions based on two carboxylic acids as an artificial tongue

Analyst, 2020, 145,3359-3363
DOI: 10.1039/D0AN00357C, Paper
Chi Zhang, Juan Huang, Wei Wei, Zhengbo Chen
We report a colorimetric array, which consists of two carboxylic acids (quinolinic acid (QA), tannic acid (TCA)) as the sensor element and Eriochrome Black T (EBT) as the colorimetric signal readout.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Nano-crystalline cellulose-coated magnetic nanoparticles for affinity adsorption of glycoproteins

Analyst, 2020, 145,3407-3413
DOI: 10.1039/D0AN00442A, Paper
Jiaying Zhang, Xiangyu Feng, Jing Wang, Guozhen Fang, Jifeng Liu, Shuo Wang
A new core–shell structured nanomaterial based on Fe3O4 nanoparticles and 2,3-dialdehyde nanocrystalline cellulose (DAC) coatings and its high efficiency in the preconcentration of glycoproteins were described in this work.
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In situ amplified photothermal immunoassay for neuron-specific enolase with enhanced sensitivity using Prussian blue nanoparticle-loaded liposomes

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00417K, Paper
Li-Juan Zhi, Ai-Li Sun, Dianping Tang
Methods based on prussian blue nanoparticles (PBNPs) have been reported for photothermal immunoassays in analytical nanoscience fields but most suffer from low sensitivity and are not beneficial for routine use.
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Driving Force to Detect Alzheimer's Disease Biomarkers: The Application Of A Thioflavine T@Er-MOF Ratiometric Fluorescent Sensor for Smart Detection of Presenilin 1, amyloid β-protein and Acetyl Choline

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00440E, Paper
Xing Ze Wang, jing du, Nannan Xiao, Yan Zhang, Ling Fei, Jed D. LaCoste, Zhuo Huang, Qian wang, Xin Rui Wang, Bin Ding
Currently, the highly sensitive detection of Alzheimer's Disease (AD) biomarkers, namely presenilin 1, amyloid β-protein (Aβ), and acetylcholine (ACh), are vital to helping us prevent and diagnose AD. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Portable and field-deployed surface plasmon resonance and plasmonic sensors

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00316F, Critical Review
Jean-Francois Masson
Plasmonic sensors are portable devices that can be employed in situ for the detection of analytes in environmental sciences, clinical diagnostics, infectious diseases, food, and industrial applications.
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A paper-supported sandwich immunosensor based on upconversion luminescence resonance energy transfer for the visual and quantitative determination of a cancer biomarker in human serum

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/C9AN02307K, Paper
Mengyuan He, Ning Shang, Lin Shen, Zhi-hong Liu
In this paper, a paper-supported analytical device based on a sandwich immunoreaction and luminescence resonance energy transfer (LRET) was reported for the visual and quantitative determination of a cancer biomarker,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Facilitating Protein Expression with Portable 5'-UTR Secondary Structures in <italic toggle="yes">Bacillus licheniformis</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00355




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Relief for the Uncertain

Our covenant-making, covenant-keeping Lord goes before us and he is with us.




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[ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02075




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[ASAP] Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00117




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[ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02161




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[ASAP] Computational Chemistry on a Budget: Supporting Drug Discovery with Limited Resources<subtitle>Miniperspective</subtitle>

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02126




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[ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00215




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[ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00441




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[ASAP] Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00075




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[ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00669




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[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00639




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[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00131




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[ASAP] Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00066




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Construction has started on the largest solar project in Nepal

The reports say that the constructions of a 25MW largest solar PV project in Nepal has begun. The foundation stone was laid last week at Devighat in Nuwakot by Minister for Energy, Water Resources and Irrigation, Barsha Man Pun. The government plans to finish the construction of the project in a year. As stated by …

The post Construction has started on the largest solar project in Nepal appeared first on LatestSolarNews.




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Contextual styling with custom properties

Something I’ve been wanting for a long time, define different regions like a footer section, or side bar and not have to deal with all the contextual styling hassle. A.k.a. “Now that this button is used on a dark background, the button needs to change its colors too. Where should the styles live?”. Here an old post about struggling with contextual styling.

So then the other day I was doing some experiments with using custom properties for Atom’s UI. Turns out, using custom properties might make contextual styling a bit easier. For the rest of the post, let’s switch to a more simple example. A page where the main area is light, but then has a dark hero and footer section. Like this:

In the past, I probably would’ve created variations like Button--dark or overwrote it with header .Button {…}. Depends a bit on the project. Here another approach: Create themes with a set of variables, then apply the theme to the different areas.

1. Default theme

First let’s define our default theme with a bunch of variables.

[data-theme="default"] {
  --fg:         hsl(0,0%,25%);
  --border:     hsl(0,0%,75%);
  
  --bg:         hsl(0,0%,95%);
  --button-bg:  hsl(0,0%,99%);
  --input-bg:   hsl(0,0%,90%);
}

Then we create some components where we use the variables defined above.

[data-theme] {
  color: var(--fg);
  background-color: var(--bg);
}

.Button {
  color: var(--fg);
  border: 1px solid var(--border);
  background-color: var(--button-bg);
}

.Input {
  color: var(--fg);
  border: 1px solid var(--border);
  background-color: var(--input-bg);
}

And lastly we add the [data-theme="default"] attribute on the body so that our components will pick up the variables.

<body data-theme="default">

If you wonder why use data-theme attributes over classes? Well, no specific reason. Maybe with attributes, it’s a hint that only one theme should be used per element and is more separated from your other classes.

At this point we get this:

See the Pen Contextual styling with custom properties (1/3) by simurai (@simurai) on CodePen.

2. Dark theme

But our designer wants the hero and footer to be dark. Alright, let’s define another theme region.

[data-theme="dark"] {
  --fg:         hsl(0,10%,70%);
  --border:     hsl(0,10%,10%);
  
  --bg:         hsl(0,0%,20%);
  --button-bg:  hsl(0,0%,25%);
  --input-bg:   hsl(0,0%,15%);
}

And add the theme attribute to the header and footer.

<header data-theme="dark">
<footer data-theme="dark">

Which gives us this:

See the Pen Contextual styling with custom properties (2/3) by simurai (@simurai) on CodePen.

The reason why this works is that custom properties cascade and can be overridden on nested elements, just like normal properties.

3. Hero theme

A few months pass and our designer comes back with a redesigned hero section. “To make it look fresh” with a splash of color.

No problem! Just like with the dark theme, we define a new “hero” theme.

[data-theme="hero"] {
  --fg:         hsl(240,50%,90%);
  --border:     hsl(240,50%,10%);
  
  --bg:         hsl(240,33%,30%);
  --button-bg:  hsl(240,33%,40%);
  --input-bg:   hsl(240,33%,20%);
}
<header data-theme="hero">

And here is that fresh hero:

See the Pen Contextual styling with custom properties (3/3) by simurai (@simurai) on CodePen.

It’s also not limited to colors only, could be used for sizes, fonts or anything that makes sense to define as variables.

Benefits

Using these theme “regions” lets your components stay context un-aware and you can use them in multiple themes. Even on the same page.

  • Developers can add components, move components around, without having to know about in what context (theme) they live. The markup for the components stays the same.
  • Design systems authors can create new components without worrying about where they get used, the variables used in components stay the same.
  • Designers can define new theme regions, or change existing ones, without having to make changes to a component’s HTML or CSS, it stays the same.

Less time to talk about who, how and where, more time to talk about the weather. ☔️????

Concerns

Yeah, right. The big question: But does it scale? Can this be used for all use cases.

Ok, I’m pretty sure it doesn’t fit all situations. There are just too many to find a single solution for them all. And I’m actually not sure how well it scales. I guess it works great in these simple demos, but I have yet to find a larger project to test it on. So if you have used (or plan to use) this approach, I’m curious to know how it went.

A concern I can imagine is that the list of variables might grow quickly if themes have totally different characteristics. Like not just a bit darker or lighter backgrounds. Then you might need to have foreground and border colors for each component (or group of components) and can’t just use the general --fg and --border variables. Naming these variables is probably the hardest part.

Update I

@giuseppegurgone made an interesting comment:

in suitcss projects I used to define component level custom props, theme variables and then create themes by mapping the former to the latter suitcss-toolkit

So if I understood it correctly, by mapping theme variables to component variables, you could avoid your theme variables from growing too much and you can decide for each component how to use these theme variables.

Update II

If it’s too early to use custom properties in your project, @szalonna posted an example how to do something similar in SCSS.




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Thanks to Covid-19, Website Accessibility Has Never Been More Important

The first global pandemic of the digital era is upon us. We’re living in unprecedented and uncomfortable times. For our senior citizens, these past several weeks have been particularly discomforting. According to the CDC, men and women over the age of 65 are significantly more likely to develop complications from COVID-19. As we seek to […]




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The matter of photography in the Americas / Natalia Brizuela and Jodi Roberts ; with contributions by Lisa Blackmore, Amy Sara Carroll, Marianela D'Aprile, María Fernanda Domínguez, Heloisa Espada, Rachel Price, Diana Ruiz, Tatiane Santa Ro

Rotch Library - TR184.B75 2018




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How art can be thought: a handbook for change / Allan deSouza

Rotch Library - N7425.D459 2018




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Library of light: encounters with artists and designers / Jo Joelson

Rotch Library - N8219.L5 J64 2019




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Mathias Goeritz: modernist art and architecture in Cold War Mexico / Jennifer Josten

Rotch Library - N6559.G64 J67 2018




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Djordje Ozbolt: regaining memory loss / exhibition curator, Nicoletta Lambertucci

Rotch Library - N6488.I8 V433 2019 Y8




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New design, neoplasticism: Nieuwe beelding / Piet Mondrian ; English translation by Harry Holtzman and Martin S. James

Rotch Library - N6948.5.D42 M6613 2019




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Art for people's sake: artists and community in Black Chicago, 1965-1975 / Rebecca Zorach

Rotch Library - NX512.3.A35 Z67 2019




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It's about time: Pavilion of Applied Arts / curator, Ralph Rugoff ; artist, Marysia Lewandowska

Rotch Library - N6488.I8 V433 2019 A67




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Altered states: Substanzen in der zeitgenössischen Kunst = substances in contemporary art / herausgegeben von = edited by Milena Mercer ; Texte = texts, Max Daly ... [and thirteen others]

Rotch Library - N8251.S555 A48 2018




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Women, art and money in late Victorian and Edwardian England: the hustle and the scramble / Maria Quirk

Rotch Library - N8354.Q57 2019




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Neuer Norden Zürich: ein Kunstprojekt im öffentlichen Raum, 9. Juni-2. September 2018 = New north Zurich: a public art project, 9th of June-2nd of September 2018 / herausgegeben von Christoph Doswald ; fotografiert von Pierluigi Macor ; Übe

Rotch Library - N6496.3.S9 Z876 2018




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Fogo Island arts: what do we know? What do we have? What do we miss? What do we love? / Brigitte Oetker, Nicolaus Schafhausen (eds.)

Rotch Library - N6546.N6 F64 2019




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Raoul de Keyser: oeuvre / editors, Martin Germann and Bernhart Schwenk

Rotch Library - ND673.K396 A4 2019




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April in Paris: theatricality, modernism, and politics at the 1925 Art Deco Expo / Irena R. Makaryk

Hayden Library - N6493 1925.M35 2018




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New life quarterly / Wolfman

Hayden Library - NX60.N49 2018




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Biennale Arte 2019: may you live in interesting times: 11.05-24.11 Venezia Giardini/Arsenale

Rotch Library - N6488.I8 V433 2019 A1




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Saules: Suns / artist = māksliniece, Daiga Grantin̦a ; curators = kuratori, Valentinas Klimašauskas, Inga Lāce

Rotch Library - N6488.I8 V433 2019 L35




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Padiglione Indonesiano all Biennale di Venezia 2019 / team artistico, Syagini Ratna Wulan, Handiwirman Saputra, artisti ; Asmudjo J. Irianto, Yacobus Ari Respati, curatore

Rotch Library - N6488.I8 V433 2019 I5




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Socially engaged art and the neoliberal city / Cecilie Sachs Olsen

Rotch Library - N72.A76 O47 2019




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Conversation pieces: the world of Bruegel / Abdelkader Benali, Alexandra van Dongen, Katrien Lichtert, Sabine Pénot, Lucinda Timmermans ; translation, Patrick Lennon, Michael Lomax

Rotch Library - ND673.B73 B46 2018