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​First responder: On Maldives-India ties

India and Maldives let subtle diplomacy surpass muscular posturing 




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Take the gauntlet: On safety and the Indian Railways

‘Kavach’ implementation is a priority but will not be a silver bullet




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Abject failure: On India’s Global Hunger Index ranking

India’s ranks 105 out of 127 countries in the Global Hunger Index, 2024




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Canadian frostbite: On the India-Canada diplomatic war

India must consider the impact of its next steps on its diplomacy and image




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Israel versus the UN: On Tel Aviv’s move and India’s response

India’s stand must keep in mind the UN’s importance in the global order




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​Complicit: On India and the U.S and Canada cases

India must come clean on its stance on transnational killings 




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​West versus the rest: On western conduct and India

The West must not tolerate terror threats in the name of free speech 




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​Over the borderline: On the India-China deal 

The agreement between India and China opens new opportunities  




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​Celebration and vigil: On India, kala-azar and trachoma

India must not let its guard down on kala-azar




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​Fair trade: On the 29th COP and India’s carbon market

India must develop a transparent carbon trade policy 




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At a loss: On the New Zealand-India three-match series

India batters frittered away the home advantage against New Zealand 




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Towards Europe: On the India visits by the leaders of Germany, Spain

India used visits by leaders of Germany and Spain to balance ties in Europe 




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
The content of this RSS Feed (c) The Royal Society of Chemistry




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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Agro-tourism push needs industry-specific policies, say farmers




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AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami




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Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers

Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time




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Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu




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599: Fighting the Algorithm With RSS, Blogging, and the IndieWeb

Dave and Chris discuss indie web culture, the role of social media in today's society, and the challenges and strategies of freelancing. Additionally, they discuss a range of topics from content moderation, coding and refining tech skills, to emerging startups and the future of web technology.




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604: VS Code Plugins, Git as a Radical Statement, Tailwind & Arc Drama

A follow up on jQuery conversation, Microsoft owning all the things, what VS Code plugins are your ride or die, the ability to Git from wherever you want, Tailwind drama, global design system follow up, Arc Search gets roasted, and Frontend Design Conference is back!




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615: Dave Goes Windows For Real

Dave's got job news to share, as well as insight into the process of what applying for a job in tech is like in 2024. We also talk about styling, scoping, positioning, and floating UI.




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Improve quality of indoor air

Outdoor air pollutants are impacting the indoor environment and builders have to take remedial measures, says M.A. Siraj




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Power from wind and sun

Human activities are rapidly depleting non-renewable energy sources; therefore hybrid energy has emerged as a viable alternative




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Could Maini be India's next F1 driver?

India could finally have a driver on the F1 grid after 13 long years.




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A sporty knock from India Inc

A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too




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Unlocking renewable energy from industrial waste: Biogas production from spent wash

It is a sustainable solution for industrial waste management and renewable energy generation




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From agri waste to industrial raw material

altM is developing alternatives to mined materials and petrochemicals 




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As India’s installed solar capacity crosses 90GW, a look at the journey 

Sun-sational growth: In September, India’s installed solar power capacity reached 90,762 MW. Given the current rate of monthly capacity additions, there is little doubt that installed capacity will exceed 100 GW in 2024-25.




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Investing in companies with ‘indicorn’ potential

Titan Capital backs seed-stage companies with potential to reach ₹100 crore revenue within five years




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The secret sauce behind ITC’s enduring restaurant brands

The promise of an unchanged, consistent menu and supreme culinary artistry has drawn food lovers to ITC’s tables for decades




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Catalysing Indian IP creation 

How policy support and monetisation can rev up India’s innovation ecosystem



  • Science and Technology

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‘Our goal is beauty for each,’ says L’Oréal India chief

Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey




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Indo National plans battery of home-care launches

The maker of Nippo batteries plans to innovate in its core business and get into LED bulbs




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India seeks $70 million from Climate Investment Funds

India looks to accelerate proposed ‘renewable energy integration programme’




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Why power from Sri Lanka is a better option than offshore wind

Wind industry sources estimate island nation has 65 GW onshore potential




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Toxic air chokes urban India 

Residents grapple with respiratory, cardiac, and other ailments as the air thickens




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Why more NRIs are buying health insurance in India

The number of NRIs buying health insurance from India has increased steadily over the past three years




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Corporates look to tread the India Way  

Business leaders are realising that longevity may be a better marker for growth than shareholder value maximisation




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Make Hindi universally acceptable: Amit Shah says at Kendriya Hindi Samiti meet

Speaking at the 32nd meeting of the Kendriya Hindi Samiti, Union Home Minister Amit Shah said it was necessary to translate all education curricula into Hindi and other Indian languages




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India's climate policies expected to reduce CO2 emissions by around 4 billion tonnes by 2030: Report

The study by Delhi-based independent think tank Council on Energy, Environment and Water (CEEW) said policies for India's power, residential and transport sectors have already saved 440 million tonnes of carbon dioxide (MtCO2) between 2015 and 2020.




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Can India arrest income inequality?

Thomas Piketty’s prescriptions are too radical. Dattopant Thengadi’s vision is more useful for us




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A theory of fiscal dominance in India

Former RBI Deputy Governor Viral Acharya offers solutions on how the central bank can ensure financial stability in the country




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Thirukkural and Indian diplomacy

India’s unique ethos will help it navigate the choppy waters of global diplomacy, writes Jaishankar




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The speculator and the industrialist

A book outlines how speculation can be constructive and lead to the creation of an industrial empire




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Towards a fossil-free India

The data-rich book chalks out the challenges and opportunities in India’s renewables push




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Millennial money mindset

Helping young adults make sense of the world of finance