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China reaffirms boundaries of sea near flashpoint reef

Philippine President Ferdinand Marcos on Friday (November 8, 2024) signed two laws defining the country's sea waters and imposing fixed lanes for foreign ships, sparking a sharp riposte by China which summoned Manila's envoy




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Canadian Foreign Ministry denies blocking Indian-diaspora media outlet Australia Today

The news site and video of media comments by both India’s Foreign Minister Jaishankar and Australia’s Foreign Minister Wong can be easily and freely viewed in Canada, the Ministry said




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Egyptians exhume the dead as city development takes over cemeteries in Cairo

Since 2020, thousands of graves have been demolished at the UNESCO-listed World Heritage Site




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Kremlin denies Putin and Trump spoke on phone

Kremlin spokesman Dmitry Peskov told journalists that the Washington Post report was "simply false information", denying any phone call took place




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After storm over allegations, Australia Today clarifies ban was by Meta platforms, not Canadian government 

The Ministry of External Affairs, which had slammed Canada over the allegations last week, has been silent over clarification




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North Korea ratifies mutual defence treaty with Russia

The report came amid international criticism over increasing military cooperation between the two countries, with North Korea having sent tens of thousands of troops to Russia to support its war against Ukraine




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Left parties to protest against power tariff on November 19

State government burdening the people by steeply increasing electricity charges in the name of true-up charges, adjustments and others, say leaders




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Tirupati universities form cluster to work towards conserving biodiversity

IIT-T, IISER Tirupati, SPMVV and Dravidian University comes together to create campus biodiversity registers as part of APSCHE-IIC research programme




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A.P. universities undertake novel initiative to introduce students to natural farming

Sri Venkateswara University and Sri Padmavati Mahila Viswa Vidyalayam establish organic vegetable gardens at their respective premises, where vegetables like brinjal, chilli, tomato and lady’s finger, roots like carrot, beetroot, and radish are planted




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Journal of the Ottoman and Turkish Studies Association [electronic resource]

Binghamton, NY : Ottoman and Turkish Studies Association, [2014]-




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Response strategies and biological applications of organic fluorescent thermometry: cell- and mitochondrion-level detection

Anal. Methods, 2024, 16,1968-1984
DOI: 10.1039/D4AY00117F, Minireview
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Shuai Li, Yaoxuan Li, Shiji Zhang, Haixiao Fang, Ze Huang, Duoteng Zhang, Aixiang Ding, Kajsa Uvdal, Zhangjun Hu, Kai Huang, Lin Li
In this review, we primarily summarized four temperature-response strategies. Then, we further analyzed the chemical modifications and biological applications of the probes. Finally, we have provided a prospective on the future development of probes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A simple, fast and inexpensive approach to quantify low concentrations of iron in biodiesel by voltammetry after extraction induced by microemulsion breaking

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00342J, Paper
Cristian Henrique Krause, Alexandre Batista Schneider, Leandro Kolling, Lauren Thauani Teixeira Oliveira, Márcia M. Silva
An alternative approach to assay iron (Fe) in biodiesel by differential pulse adsorptive cathodic stripping voltammetry (DPAdCSV) is presented herein. The sample treatment involved a simple, rapid, but effective extraction...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A simple and rapid colorimetric detection of Staphylococcus Aureus relied on the distance-dependent optical properties of silver nanoparticles

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02189K, Paper
Ngoc Anh Thu Phan, Hoang Men Nguyen, Cam Duyen Thi Vo, Toi Vo Van, Phuoc Long Truong
The quick and accurate diagnosis of pathogens has appeared as a pressing issue in clinical diagnostics, environmental monitoring, and food safety. The current assays are suffering from limited capacities in...
The content of this RSS Feed (c) The Royal Society of Chemistry




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​First responder: On Maldives-India ties

India and Maldives let subtle diplomacy surpass muscular posturing 




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​Governor vs Government: On the hostilities in Tamil Nadu

Mr. Ravi must be withdrawn for needlessly wading into controversies




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At a loss: On the New Zealand-India three-match series

India batters frittered away the home advantage against New Zealand 




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Western front: On the parties and their prospects in the Maharashtra polls

Granular factors can determine the outcome in Maharashtra 




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Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00654B, Review Article
Madison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. Leung
The emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Agro-tourism push needs industry-specific policies, say farmers




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HC directs authorities to maintain park and ensure no encroachment




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HR&CE plans to bring properties around the Vennaimalai Temple under tenants list

The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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Fishermen seek healthcare and cold storage facilities




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‘State should retain primary agricultural cooperative societies under its purview’




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AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami




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542: Breaking Up with CSS-in-JS, Mastodon, and Stories on the Web

We're talking CSS-in-JS, Token CSS, Matuzo being suspended from Twitter, trying out Mastodon, testing out stable diffusion, stories on the web, and Jake Albaugh's new social network.




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Sunshine cities

Kochi and Thiruvananthapuram are among the 60 cities that have received in principle approval from the Union Ministry of New and Renewable Energy to be developed as Solar Cities, writes K.A. Martin




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Design water-smart cities

We need an army of people who will ensure the protection of water bodies, and who will strive to create a water-literate community.




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Cold plunges, hot saunas, smoothies, and fasting

Fitness regimen on the go




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Investing in companies with ‘indicorn’ potential

Titan Capital backs seed-stage companies with potential to reach ₹100 crore revenue within five years




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Cargo companies upsize for new business

Booming demand for ecommerce delivery spurs freight handlers to open more centres, digitise for efficiency




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How radio waves can power smart cities 

Practically omnipresent, thanks to human activity, radio frequency is the new area of focus for energy harvesting technology



  • Science and Technology

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Govt., BJP spar over Chhath planning as festivities begin today




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HC tells jail authority to decide plea on lack of facilities for visiting lawyers




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India's climate policies expected to reduce CO2 emissions by around 4 billion tonnes by 2030: Report

The study by Delhi-based independent think tank Council on Energy, Environment and Water (CEEW) said policies for India's power, residential and transport sectors have already saved 440 million tonnes of carbon dioxide (MtCO2) between 2015 and 2020.




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‘Threat culture’ in Centre for West Asian Studies of JNU: former seminar coordinator

Sima Baidya also says she has lodged a complaint against the chairperson of the centre and has sought security from the university authorities as she has been intimidated




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Devotees throng Delhi ghats, mark Chhath Puja festivity with prayers, songs, selfies

Lakhs of devotees offer ‘Sandhya Arghya’ to the setting sun on the third day of the four-day festival; political leaders make a beeline for ghats with an eye on Purvanchali voters ahead of Assembly poll




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A deep look into China’s realities

Ananth Krishnan shines a light on the different sides of China that largely remain hidden from Indian citizens




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Strategies for an enduring legacy

How firms can thrive in an era of social tension, economic nationalism and tech revolution




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16 leaders, as many economic verities

Vince Cable profiles 16 personalities who rung in deep rooted economic change in their societies