In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.

Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine.

Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships.

Moving discoveries from academia to industry requires a delicate balance of risk, reward, skill sets and personalities, according to a translational panel held at BIO-Europe's partnering conference.

The 19th century Italian writer Emilio Salgari once remarked that ‘reading is travelling without the bother of baggage’. That is great advice, particularly in the time of COVID-19. Now that one is forcibly home-bound, works of literature and of scholarship can help transport one to different countries, different times. They can stimulate the mind, and [...]

Mar 24, 2020

The 2018 National Defense Strategy (NDS) is predicated on a single organizing principle: America’s military pre-eminence is rapidly eroding. This is not a new concept. For years, experts have warned that the economic and technological advancements of U.S. adversaries, coupled with the 2008 financial crisis and America’s focus on peripheral conflicts, have caused a decline in America’s military dominance. 

In this context, the advances of near-peer competitors such as China and Russia have created plausible “theories of victory” in potential conflicts across Eastern Europe and East Asia. Competitors’ unaddressed improvements in strategic innovation, economic investment, and dual-use technology increases the risk of conflict and strains the U.S. alliance system. It is urgent that the United States reestablish and maintain credible deterrents against these near-peer competitors. After decades of focusing on post-Cold War ‘shaping’ operations, the American military needs to reinvigorate for full spectrum great power competition.

This report is intended as a blueprint on how to begin that process from graduate students at the Belfer Center for Science and International Affairs at Harvard University. Contained inside are 12 memorandums. Each provides a high-level overview and specific recommendations on a key issue of American defense policy. 

Apr 29, 2020

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  

May 7, 2020

History is replete with irony, but rarely more poignantly than in the summer of 2016 when, on 23 June, the UK voted to leave the European Union and the next day, 24 June, the EU published its Global Strategy document asserting its ambition of “strategic autonomy.” Whither Franco-British defense cooperation in such chaotic circumstances? This paper attempts to provide the outline of an answer to that question.

Apr 29, 2020

Americans are not going to wait for sufficient testing. So what happens then? Juliette Kayyem describes "opening up" as a high-stakes version of a coloring book. States can use more and more crayons, but the goal is to avoid going over the edges.

Feb 14, 2020

Emily Whalen reviews Anatomies of Revolution by George Lawson (Cambridge: Cambridge University Press, 2019).

Apr 27, 2020

Argentina’s latest effort to restructure its overseas debt probably won’t be its last, according to Harvard University economist Carmen Reinhart, who has sounded alarms over coming emerging markets crises in Venezuela and Turkey.

Apr 29, 2020

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  

Apr 29, 2020

Americans are not going to wait for sufficient testing. So what happens then? Juliette Kayyem describes "opening up" as a high-stakes version of a coloring book. States can use more and more crayons, but the goal is to avoid going over the edges.