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Chiral Ru(II) complexes act as a potential non-viral gene carrier for directional transportation to the nucleus and cytoplasm

Metallomics, 2020, 12,504-513
DOI: 10.1039/C9MT00192A, Paper
Qiong Wu, Shuang-Yan Zhang, Si-Yan Liao, Jie-Qiong Cao, Wen-Jie Zheng, Li Li, Wen-Jie Mei
A novel approach has been proposed to develop a potent gene carrier system for enantioselectivity on the self-assembly of G-quadruplex DNA promoted by chiral Ru(II) complexes, and the different assembled nanostructures of cellular uptake to the nucleus and cytoplasm.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lanthanum chloride impairs spatial learning and memory by inducing [Ca2+]m overload, mitochondrial fission–fusion disorder and excessive mitophagy in hippocampal nerve cells of rats

Metallomics, 2020, 12,592-606
DOI: 10.1039/C9MT00291J, Paper
Miao Yu, Jinghua Yang, Xiang Gao, Wenchang Sun, Shiyu Liu, Yarao Han, Xiaobo Lu, Cuihong Jin, Shengwen Wu, Yuan Cai
Lanthanum chloride damages hippocampal nerve cells of rats through inducing [Ca2+]m overload, mitochondrial fission–fusion disorder, and excessive mitophagy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selenium deficiency exacerbates LPS-induced necroptosis by regulating miR-16-5p targeting PI3K in chicken tracheal tissue

Metallomics, 2020, 12,562-571
DOI: 10.1039/C9MT00302A, Paper
Lanqiao Wang, Xu Shi, Shufang Zheng, Shiwen Xu
Se deficiency can induce necroptosis in tracheal tissue. LPS-induced necroptosis can be exacerbated by Se deficiency. The miR-16-5p-PI3K/AKT pathway participates in the occurrence of necroptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hierarchical binding of copperII to N-truncated Aβ4–16 peptide

Metallomics, 2020, 12,470-473
DOI: 10.1039/C9MT00299E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xiangyu Teng, Ewelina Stefaniak, Paul Girvan, Radosław Kotuniak, Dawid Płonka, Wojciech Bal, Liming Ying
Multiple intermediates were found in Cu(II) binding to Aβ4–16 before the formation of a tight complex.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ruthenium(III) complexes containing thiazole-based ligands that modulate amyloid-β aggregation

Metallomics, 2020, 12,491-503
DOI: 10.1039/D0MT00054J, Paper
Samantha E. Huffman, Gideon K. Yawson, Samuel S. Fisher, Paige J. Bothwell, David C. Platt, Marjorie A. Jones, Christopher G. Hamaker, Michael I. Webb
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder where one of the commonly observed pathological hallmarks is extracellular deposits of the peptide amyloid-β (Aβ).
The content of this RSS Feed (c) The Royal Society of Chemistry




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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00076K, Paper
Xinyang Li, Chao Zuo, Mei Wu, Zunzhen Zhang
Linc-ROR modulates the cell proliferation in arsenite-transformed keratinocytes via inhibiting P53 activity through the PI3K/AKT pathway.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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History and Imperialism: Writings, 1963-1986


 
Writings on History brings together a selection of texts by Louis Althusser dating from 1963 to 1986, including essays, a lecture, notes to his collaborators, and the transcript of an informal 1963 discussion of literary history. The centrepiece of this collection is Althusser’s previously unpublished Book on Imperialism, a theorization of globalized capitalism that remained unfinished.  All these writings are concerned with the place of history in

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History and Imperialism: Writings, 1963-1986


 
Writings on History brings together a selection of texts by Louis Althusser dating from 1963 to 1986, including essays, a lecture, notes to his collaborators, and the transcript of an informal 1963 discussion of literary history. The centrepiece of this collection is Althusser’s previously unpublished Book on Imperialism, a theorization of globalized capitalism that remained unfinished.  All these writings are concerned with the place of history in

Read More...




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Reacher Said Nothing: Lee Child and the Making of Make Me


 
It had never been attempted before, and might never be done again. One man watching another man write a novel from beginning to end.
 
On September 1, 2014, in an 11th floor apartment in New York, Lee Child embarked on the twentieth book in his globally successful Jack Reacher series. Andy Martin was there to see him do it, sitting a couple of yards behind him, peering over his shoulder as the writer took another drag of a Camel cigarette and tapped

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Reacher Said Nothing: Lee Child and the Making of Make Me


 
It had never been attempted before, and might never be done again. One man watching another man write a novel from beginning to end.
 
On September 1, 2014, in an 11th floor apartment in New York, Lee Child embarked on the twentieth book in his globally successful Jack Reacher series. Andy Martin was there to see him do it, sitting a couple of yards behind him, peering over his shoulder as the writer took another drag of a Camel cigarette and tapped

Read More...




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Kangpokpi asks passenger vehicles not to stop midway

Kangpokpi asks passenger vehicles not to stop midway




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[ASAP] Development of Mischmetal–Fe–Co–B Permanent Magnet Alloys via High-Throughput Methods

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00190




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[ASAP] Optimized Multimetal Sensitized Phosphor for Enhanced Red Up-Conversion Luminescence by Machine Learning

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00035




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[ASAP] Experimental and Theoretical Investigation on Phase Formation and Mechanical Properties in Cr–Co–Ni Alloys Processed Using a Novel Thin-Film Quenching Technique

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00170




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Annual Report to the Nation: Overall cancer mortality continues to decline; Special section on adults ages 20 to 49 shows higher cancer incidence and mortality for women than men

The 2019 Annual Report to the Nation on the Status of Cancer finds overall cancer death rates continue to decline and cancer incidence dropped in men and remained stable in women. A special section reports on recent cancer trends in younger adults.




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Immunotherapy drug improves outcomes for some children with relapsed leukemia

For children and young adults with certain relapsed B-cell acute lymphoblastic leukemia (B-ALL), the immunotherapy drug blinatumomab is superior to standard chemotherapy, an NCI-sponsored Children’s Oncology Group trial shows.




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In NIH trial, selumetinib shrinks tumors, provides clinical benefit for children with NF1

An NCI clinical trial finds the drug selumetinib improves outcomes for children with neurofibromatosis type 1 (NF1), shrinking inoperable tumors called plexiform neurofibromas, reducing pain, and improving function and overall quality of life.




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NCI study provides genetic insights into osteosarcoma in children

A new study offers insight into genetic alterations associated with osteosarcoma, the most common bone tumor of children and adolescents, and the findings have implications for genetic testing of children with osteosarcoma and their families.




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Higher daily step count linked with lower all-cause mortality

In a new study, higher daily step counts were associated with lower mortality risk from all causes. Researchers found that the number of steps taken each day, but not the intensity of the stepping, had a strong association with mortality.




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The colonial fantasy : why white Australia can't solve black problems / Sarah Maddison

Maddison, Sarah, author




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Manyjilyjarra - English pictorial dictionary of landscape terms / [prepared for Kanyirninpa Jukurrpa by Clair Hill and Andrew Turk with assistance from Martu language speakers: Gladys Bidu; Jakayu Biljabu; Nancy Chapman; Mulyatingki Marney; Minyawu Miller




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Moondang-ak Kaaradjiny : the carers of everything / Noel Nannup Karda

Karda, Noel Nannup, author




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Young dark emu : a truer history / Bruce Pascoe

Pascoe, Bruce, 1947- author




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Xian dai ru xue de hui gu yu zhan wang / Yu Yingshi zhu

Yu, Yingshi




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Zhongguo dang dai zheng zhi yu Zhongguo zhi shi fen zi / Liu Xiaobo

Liu, Xiaobo, 1955-




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Xian dai wei ji yu si xiang ren wu / Yu Yingshi zhu

Yu, Yingshi




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Wu ji qi yu xian Qin wen hua zhi guan xi / Li Tianrui zhu

Li, Tianrui




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Er shi shi ji Zhongguo ren wu zhuan ji zi liao suo yin / Fu dan da xue li shi xi zi liao shi bian




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Zhong yan yuan li shi yu yan yan jiu suo ji kan lun wen lei bian. Kao gu bian / [Zhonghua shu ju bian ji bu bian]




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Min sheng qi shi er hang / Ying Huanqi zhu

Ying, Huanqi




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Li Shizhen da zhuan / Wang Jian bian zhu

Wang, Jian




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Zhongguo qi pao wen hua shi = The history of Chinese qipao culture / Liu Yu zhu

Liu, Yu




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Li shi de mian kong / Shi Feixiang zhu

Shi, Feixiang




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Zhi shi fen zi, li shi yu wei lai : Xu Zhuoyun jiang yan lu

Xu, Zhuoyun, 1930-




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Qing gan yu zhi du : Wei Jin shi dai de mu zi guan xi / Zheng Yaru zhu

Zheng, Yaru




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Xi Zhou li zhi wen hua tan lun / Wang Ruijie zhu

Wang, Ruijie




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Fan Qin ji tuan mie Qin yu fen lie zhan zheng cheng bai zhi yan jiu / Zhan Shimo zhu

Zhan, Shimo, 1953-




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Da Tang shi jie yu "huang di, tian ke han" zhi yan jiu / Zhu Zhenhong zhu

Zhu, Zhenhong, 1974-




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An Shi zhi luan yu Su Dai er chao xin zheng quan jie gou de kai zhan / Lin Weizhou zhu

Lin, Weizhou




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Xi Jin mo nian zhi dong Jin shi qi de "fen xia" zheng zhi : fen quan hua xian xiang xia de chao ting yu zhou zhen / Zhao Lixin zhu

Zhao, Lixin




hi

Dong Jin nan bei chao shi zu jia ting jiao yu yan jiu / Fang Biyu zhu

Fang, Biyu




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Tang Wu dai liang Zhe di qu jing ji fa zhan zhi yan jiu / Zhu Zude zhu

Zhu, Zude




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Kai jian wu deng: Xi Jin wu deng jue zhi cheng li de li shi kao cha / Wang Antai zhu

Wang, Antai, 1978-




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Nan Tang xian zhu Li Bian yan jiu / Zeng Yanshi zhu

Zeng, Yanshi, 1975-




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Song dai jian dang guan ti xi zhi yan jiu / Lei Jiasheng zhu

Lei, Jiasheng, 1970-




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Ming dai de yu zheng guan li : guo jia zhi du de si fa quan li yun zuo / Lian Qiyuan zhu

Lian, Qiyuan




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Ming dai ye shi de fa zhan te se / Liao Ruiming zhu

Liao, Ruiming




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Quan Zuwang zhi shi xue / Zhang Lizhu zhu

Zhang, Lizhu