New research has shown that our response to infection changes over the course of each day, and - even more importantly - that sleep disruption can leave our immune system compromised (file photo).

A walk in the park could cause hayfever sufferers to sneeze, even if the pollen count is low, a US-German study has found. Research on 25 men found even a simple smell could trigger hayfever symptoms.

History shows how lethal disease pandemics have a habit of seeming to shrink away - but then returning suddenly in subsequent waves. Chillingly, these latter waves can prove far deadlier.

One sample collected from an Arizona coronavirus patient showed a deletion of 81 genetic 'letters' that suppresses the virus's ability to fight the human immune system, also seen as SARS began to fade.

Scientific evidence suggests that people who are overweight - which two thirds of adults in the UK are - have a 39 per cent higher risk of dying if they catch the coronavirus.

Sir Patrick Vallance told MPs on the Health and Social Care Select Committee that masks could have a 'marginal but positive' impact on curbing transmission of the life-threatening infection.

Doctors say they're being inundated with calls about COVID toes, mysterious bruises, rashes and lesions on their feet, who don't have other traditional symptoms such as fever and coughing.

In the new survey, from PR firm Bospar, researchers found those between ages 18 and 24 were the least likely to get vaccinated against the coronavirus with only 57.8% saying they'd get the jab.

Researchers at Los Alamos National Laboratory have discovered a mutation to the coronavirus's spike protein that may make it more infectious - and it has spread around the globe.

A new study, led by Tsinghua University. found that recovered coronavirus patients had varying antibodies such as immune cells that stop the virus from attaching to our cells.

Researchers from the University of Sheffield and Los Alamos National Laboratory in New Mexico found that a newer, faster-spreading version of the virus seems to edge out the older type.

Just yesterday University of Sheffield researchers claimed that a new, more infectious type of COVID-19 had been racing through Europe. But the finding was today dismissed as 'unfounded'.

Professor Lucy Yardley, from the University of Bristol, sounded the alarm today, saying evidence shows 'viral load' plays a big role in how sick someone will become.

A new survey from The Ohio State University Wexner Medical Center found that 80% said they would be concerned to go to a scheduled prenatal appointment amid the coronavirus pandemic.

Experts say the vulnerability of health systems in Eastern Europe spurred leaders into decisive action while governments in the west felt a 'greater sense of complacency'.

The Rugby World Cup is just round the corner and Sportsmail has everything you need to know. SIR CLIVE WOODWARD has the lowdown on every team in the tournament in Japan.

SIR CLIVE WOODWARD: It is not often you get a full nineday lay-off in tournament rugby these days and using this period to optimum effect is important for Eddie Jones and England.

SIR CLIVE WOODWARD: Everything is coming to the boil nicely and sometime soon this England side is going to produce a performance for the ages. This Saturday would be the perfect time.

SIR CLIVE WOODWARD: There should be no recriminations over England's defeat and performance - only learnings and a heartfelt acknowledgement of South Africa's superiority.

SIR CLIVE WOODWARD: It is very seldom I tip against England, if ever, as I just never see them losing at rugby. But I must confess I make France the favourites in Paris.

SIR CLIVE WOODWARD WEEKLY COLUMN: The highlights reel from that game will be brief but as a former England coach who has lost in filthy conditions at Murrayfield I can assure you victory will feel sweet.

About a year ago, my friend and Radio 2 colleague Vassos Alexander told me he’d placed a deposit on a car that didn’t exist. The name of that car was the Jaguar I-Pace

Back in the late 1960s and early 1970s, the A110 was a doyenne of its genre, taking the constructor’s title in the 1973 World Rally Championship. Original cars remain much-loved classics

Like the Royal Wedding a few weeks ago, Royal Ascot a few days ago, or William Shakespeare and Windsor Castle a few centuries ago, we Brits are unbeatable when we play to our strengths

Compared to last week’s all-our Christmases-have-come-at-once-Bentley, I thought the A 200 was going to be a run-of-the-mill, practical and prosaic affair. Well, not so

The A7 is a good-looking, sophisticated, old-school German motorway-muncher, with one eye on tomorrow as opposed to one foot in the past

The new 911 GT2 RS is a vision to look at, a dream to drive, heaven to smell and irresistible to the touch – in short, it’s the best version of everything it could possibly be

Spurs have lost both Harry Kane (hamstring) and Son Heung-min (broken arm) to serious injury in recent months, leaving them without a senior centre forward for most of the final weeks of the season.

Jose Mourinho's extraordinary managerial career has contained many memorable moments on and off the pitch, with the highly-decorated Portuguese not afraid to speak his mind.

DANIEL MATTHEWS: It's easy, amid the meandering monologues of Jose Mourinho, to forget there was another team in town on Wednesday night. But over 90 minutes, RB Leipzig outplayed Spurs.

JAMIE REDKNAPP: If Mourinho needs a striker, then he could do worse than look at Troy Parrott. He's been training with the first team, learning from the master Kane and has been capped by Ireland.

Jose Mourinho ramped up the mind games for Tottenham's clash at Chelsea by suggesting he knows Frank Lampard's tactics for Saturday's Premier League match.

Dele Alli reacted angrily to his 64th minute substitution during a 1-0 Champions League defeat to RB Leipzig on Wednesday. The England international has now been dropped to the bench.

MATT BARLOW AT STAMFORD BRIDGE: Mourinho summoned Ndombele and was hoping to get a 'good hour' out of him. It was impossible to describe his hour as a good one.

Who'd have thought Jose Mourinho would have left a legacy at Old Trafford after all? Mourinho signings Nemanja Matic and Fred have been very important in their recent success.

There was a glint in Pep Guardiola's eye as he talked about Real Madrid, as European football's most influential coach gets ready to tackle its ultimate winning machine.

JAMIE REDKNAPP: We look at VAR as if it's the oracle but in reality it's one man, sat behind a bank of screens at Stockley Park, offering his opinion. It's not matter of fact - it's subjective.

PETE JENSON IN SPAIN: Manchester City left empty handed on the dramatic night in 2012 after a sensational late 3-2 win for Real Madrid brought manager Jose Mourinho to his knees.

Spurs manager Jose Mourinho was full of praise for the RB Leipzig man after his side lost 1-0 against them in the Champions League last week. His agent is not surprised.

THE NUMBERS GAME - JORDAN SEWARD: Dele Alli is statistically Tottenham's biggest goal threat right now with Kane and Son injured. Mourinho needs him firing ahead of important run of games.

MATT BARLOW AT THE TOTTENHAM HOTSPUR STADIUM: Just eight days after Frank Lampard showed the temerity to outsmart Jose Mourinho for a third time in his short managerial career.

SAMI MOKBEL AT TOTTENHAM HOTSPUR STADIUM: Having led twice, Spurs slumped to defeat against Wolves - their second consecutive loss in the Premier League.

Toby Alderweireld has described the 'strange' time around the sacking of Mauricio Pochettino at Tottenham and Jose Mourinho's ensuing arrival as manager. 

Eric Dier believes his Tottenham future is at centre-half after Jose Mourinho started him in the position for the first time in his side's defeat to Wolves on Sunday.

A clip has gone viral on social media of Tottenham midfielder Tanguy Ndombele sluggishly tracking back against Wolves' Pedro Neto, who nearly set up a goal for the visitors.

Jose Mourinho has ruled out 'massive changes' to his Tottenham squad this summer even if they end the season without any silverware. Mourinho has only made minor adjustments so far.

MATT BARLOW AT THE TOTTENHAM HOTSPUR STADIUM: Norwich have booked their place in the quarter-finals of the FA Cup after beating Jose Mourinho's Tottenham on penalties.

Jose Mourinho's Tottenham have lost their last four games in all competitions and have struggled without talisman Harry Kane and forward Son Heung-min.

Eric Dier's decision to cross the ancient boundary and storm the West Stand at White Hart Lane was not the first error of judgment by a Spurs player on the night they crashed out of the FA Cup.

It all went wrong off the pitch for Spurs on Wednesday but it's not going well on it either. Eric Dier made headlines, although the display was not much to write home about.