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[ASAP] Discovery of an Isothiazolinone-Containing Antitubercular Natural Product Levesquamide

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00339




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[ASAP] Deactivation of Secondary Amine Catalysts via Aldol Reaction–Amine Catalysis under Solvent-Free Conditions

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00665




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[ASAP] The Synthesis of Functionalized 3-Aryl- and 3-Heteroaryloxazolidin-2-ones and Tetrahydro-3-aryl-1,3-oxazin-2-ones via the Iodocyclocarbamation Reaction: Access to Privileged Chemical Structures and Scope and Limitations of the Method

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.9b03400




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[ASAP] Acylphloroglucinol Derivatives with a Tricyclo-[4.4.1.1<sup>1,4</sup>] Dodecane Skeleton from <italic toggle="yes">Garcinia bracteata</italic> Fruits

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00637




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[ASAP] Synthesis of <italic toggle="yes">ent</italic>-Cleistanthane Diterpenoid Spruceanol: Construction of an Aromatic C Ring <italic toggle="yes">via</italic> Lewis Acid-Controlled Regioselective Diels–Alder C

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00713




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[ASAP] Oxaazabicyclooctene Oxides, Another Type of Bridgehead Nitrones: Diastereoselective Assembly from Acetylene Gas, Ketones, and Hydroxyl Amine

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00742




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[ASAP] Accessing Dihydro-1,2-oxazine via Cloke–Wilson-Type Annulation of Cyclopropyl Carbonyls: Application toward the Diastereoselective Synthesis of Pyrrolo[1,2-<italic toggle="yes">b</italic>][1,2]oxazine

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00531




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[ASAP] Application of Pyridinium 1,4-Zwitterionic Thiolates: Synthesis of Benzopyridothiazepines and Benzothiophenes

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00374




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[ASAP] Synthesis of Branched Monodisperse Oligoethylene Glycols and <sup>19</sup>F MRI-Traceable Biomaterials through Reductive Dimerization of Azides

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00331




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[ASAP] Palladium-Catalyzed Cascade Cyclization/Dearomatization/Arylation of Alkyne-Containing Phenol-Based Biaryls with Aryl Halides: An Entry to Diversely Functionalized Spirocyclohexadienones

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00710




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[ASAP] Palladium-Catalyzed Synthesis of <italic toggle="yes">N</italic>,<italic toggle="yes">N-</italic>Dimethylanilines via Buchwald–Hartwig Amination of (Hetero)aryl Triflates

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.0c00491




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Lipidomic profiling of virus infection identifies mediators that resolve herpes simplex virus-induced corneal inflammatory lesions

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00263A, Paper
Cuiping Zhang, Zuojian Hu, Ke Wang, Lujie Yang, Yue Li, Hartmut Schlüter, Pengyuan Yang, Jiaxu Hong, Hongxiu Yu
11(12)-EET derived from arachidonic acid (AA) inhibits Herpes Simplex Virus (HSV) replication.
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Rapid and sensitive detection of NGAL for the prediction of acute kidney injury via a polydopamine nanosphere/aptamer nanocomplex coupled with DNase I-assisted recycling amplification

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00474J, Paper
Yiting Hu, Xie-an Yu, Ying Zhang, Ran Zhang, Xuefei Bai, Mi Lu, Jiwei Li, Lifei Gu, Ji-Hua Liu, Bo-Yang Yu, Jiangwei Tian
A rapid and sensitive method for NGAL detection has been developed to predict acute kidney injury and evaluate the protective effect of drug on renal disease.
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Isothermal cross-boosting extension–nicking reaction mediated exponential signal amplification for ultrasensitive detection of polynucleotide kinase

Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02569C, Paper
Xiao-Yu Li, Yun-Xi Cui, Yi-Chen Du, An-Na Tang, De-Ming Kong
A novel nucleic acid-based isothermal signal amplification strategy, named cross-boosting extension–nicking reaction (CBENR) is developed and successfully used for rapid and ultrasensitive detection of polynucleotide kinase (PNK) activity.
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Nanodiagnostics to monitor biofilm oxygen metabolism for antibiotic susceptibility testing

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00479K, Paper
Megan P. Jewell, Samuel C. Saccomano, Alexa A. David, J. Kirk Harris, Edith T. Zemanick, Kevin J. Cash
A method utilizing oxygen-sensitive nanosensor technology to monitor the oxygen consumption dynamics of living biofilms as they are exposed to antibiotics. This method provides information on the MBIC as well as kinetic response.
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A signal cascade amplification strategy based on RT-PCR triggering of G-quadruplex DNAzyme for a novel electrochemical detection of viable Cronobacter sakazakii

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00270D, Paper
Yuanyuan Yuan, Xianyong Wu, Zhanmin Liu, QIqi Ning, Liqiang Fu, Sujuan Wu
Cronobacter sakazakii is an important opportunistic food-borne pathogen, and it can cause severe diseases with main symptoms including neonatal meningitis, necrotizing enterocolitis, and sepsis. For the achievement of practical and...
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iso-μmGene: Isothermal amplification-based portable microfluidic system for simple, reliable and flexibly multiplexed Genetic identification and quantification

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00560F, Paper
Runtao Zhong, Shilin Liu, Guohao Zhang, Mengyu Wang, Yeqing Sun
Simple, reliable and flexibly multiplexed genetic identification and quantification of microbial pathogens is in urgent need for early disease diagnosis and timely treatment. This study presented an isothermal amplification-based portable...
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In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance

Analyst, 2020, 145,3236-3244
DOI: 10.1039/D0AN00168F, Paper
Akihiro Taguchi, Stephen DeVience, Benoit Driesschaert, Valery V. Khramtsov, Hiroshi Hirata
A simultaneous mapping method was established for the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance.
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Trace manganese detection via differential pulse cathodic stripping voltammetry using disposable electrodes: additively manufactured nanographite electrochemical sensing platforms

Analyst, 2020, 145,3424-3430
DOI: 10.1039/D0AN00018C, Paper
Open Access
Diego P. Rocha, Christopher W. Foster, Rodrigo A. A. Munoz, Gary A. Buller, Edmund M. Keefe, Craig E. Banks
Additive manufacturing is a promising technology for the rapid and economical fabrication of portable electroanalytical devices.
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In situ multiplex detection of serum exosomal microRNAs using an all-in-one biosensor for breast cancer diagnosis

Analyst, 2020, 145,3289-3296
DOI: 10.1039/D0AN00393J, Paper
Huizhen Wang, Dinggeng He, Kejing Wan, Xiaowu Sheng, Hong Cheng, Jin Huang, Xiao Zhou, Xiaoxiao He, Kemin Wang
Herein, a simple all-in-one biosensor based on a DNA three-way junction has been constructed for in situ simultaneous detection of multiple miRNAs by competitive strand displacement.
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Using the interfacial barrier effects of p–n junction on electrochemistry for detection of phosphate

Analyst, 2020, 145,3217-3221
DOI: 10.1039/C9AN02579K, Communication
Yu Ding, Minggang Zhao, Jiatuo Yu, Xiaomin Zhang, Zhengming Li, Hui Li
The electrochemical response to phosphate was produced by the induced change of the interfacial barrier of the NiO/ZnO p–n junction foam.
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Colorimetric identification of lanthanide ions based on two carboxylic acids as an artificial tongue

Analyst, 2020, 145,3359-3363
DOI: 10.1039/D0AN00357C, Paper
Chi Zhang, Juan Huang, Wei Wei, Zhengbo Chen
We report a colorimetric array, which consists of two carboxylic acids (quinolinic acid (QA), tannic acid (TCA)) as the sensor element and Eriochrome Black T (EBT) as the colorimetric signal readout.
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The fingerprint of essential bio-oils by Fourier transform ion cyclotron resonance mass spectrometry

Analyst, 2020, 145,3414-3423
DOI: 10.1039/C9AN02492A, Paper
Claudia X. Ramírez, Diana Catalina Palacio Lozano, Hugh E. Jones, Rafael Cabanzo Hernández, Mark P. Barrow, Enrique Mejia-Ospino
Six essential oils were analyzed by Fourier transform ion cyclotron resonance mass spectrometry coupled to negative electrospray ionization (ESI(–)/FT-ICR MS).
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Recent advances in nanomaterial-enhanced enzyme-linked immunosorbent assays

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00597E, Critical Review
Lu Gao, Qianfan Yang, Peng Wu, Feng Li
Despite serving as a gold standard for protein analysis, the classic enzyme-linked immunosorbent assay (ELISA) is currently challenged by the ever-increasing needs of sensitivity and simplicity. Towards the ongoing needs,...
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Quantitative toxicological study of dose-dependent arsenic-induced cells via synchrotron-based STXM and FTIR measurement

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00346H, Paper
Huiqiang Liu, Junshan Xiu, Yunyan Liu, Bengyi Wang, Yanling Xue, Min Chen, Te Ji
Inorganic arsenic (iAs) is a well-known naturally occurring metalloid with abundant hazards in our environment, especially being a human carcinogen through arsenic contaminated drinking water. The iAs-related contamination is usually...
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In situ amplified photothermal immunoassay for neuron-specific enolase with enhanced sensitivity using Prussian blue nanoparticle-loaded liposomes

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00417K, Paper
Li-Juan Zhi, Ai-Li Sun, Dianping Tang
Methods based on prussian blue nanoparticles (PBNPs) have been reported for photothermal immunoassays in analytical nanoscience fields but most suffer from low sensitivity and are not beneficial for routine use.
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An electrochemical biosensor based on methylene blue-loaded nanocomposites as signal-amplifying tags to detect pathogenic bacteria

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00470G, Paper
Shengjun Bu, Kuiyu Wang, Zhongyi Li, Chengyu Wang, Zhuo Hao, Wensen Liu, Jiayu Wan
Synthesis of new methylene blue–magainin I organic–inorganic nanocomposites as electrochemical signal labels for the detection of bacteria.
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Liquid-crystal-based immunosensor for detection of cardiac troponin I

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00425A, Paper
Chunli Xia, dong Zhou, yueming Su, guangkai Zhou, Lishuang Yao, Weimin sun, yongjun Liu
Cardiac troponin I (cTnI) is one of the most sensitive and specific markers of myocardial cell injury, which can detect even minor myocardia damage. It is recognized as the main...
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A homogeneous photoelectrochemical hydrogen sulfide sensor based on the electronic transfer mediated by tetrasulfophthalocyanine

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00302F, Paper
Xinyang Wang, Huanan Zhao, Zhonghui Chen, Fang Luo, Longhua Guo, Bin Qiu, Zhenyu Lin, Jian Wang
A homogeneous photoelectrochemical sensor for H2S detection based on the electronic transfer mediated by [Fe(III)PcS4]+ was developed with an un-modified photoelectrode.
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A novel turn-on fluorescent sensor for sensitive detection of glutathione via gold nanoclusters preparation based on controllable ligand-induced etching

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00807A, Paper
Yun Chen, Xiawei Dong, Youkun Zheng, Yi-Han Wang, Zengchao Guo, Hui Jiang, Xuemei Wang
In this study, we report a facile one-pot chemical etching approach to simply and rapidly prepare gold nanoclusters capped with luminol (Lum-AuNCs) in alkaline aqueous solution at room temperature. A...
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An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00721H, Paper
Open Access
Xiaoxiao Guo, Jodie R Malcolm, Marrwa M Ali, Goreti Ribeiro Morais, Steve Shnyder, Paul Loadman, L H Patterson, Robert Andrew Falconer
The polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology...
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[ASAP] <italic toggle="yes">In Vivo</italic> Production of Five Crocins in the Engineered <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00039




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[ASAP] Blue-Light-Switchable Bacterial Cell–Cell Adhesions Enable the Control of Multicellular Bacterial Communities

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00054




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[ASAP] A Novel Biosynthetic Pathway for the Production of Acrylic Acid through ß-Alanine Route in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00019




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[ASAP] SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00059




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[ASAP] Determinants for Efficient Editing with Cas9-Mediated Recombineering in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00440




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[ASAP] A Synthetic Genetic Circuit Enables Precise Quantification of Direct Repeat Deletion in Bacteria

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00256




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[ASAP] Transcript Barcoding Illuminates the Expression Level of Synthetic Constructs in <italic toggle="yes">E. coli</italic> Nissle Residing in the Mammalian Gut

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00040




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[ASAP] Truncating the Structure of Lipopolysaccharide in <italic toggle="yes">Escherichia coli</italic> Can Effectively Improve Poly-3-hydroxybutyrate Production

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00071




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[ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic>

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00028




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[ASAP] Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids

ACS Synthetic Biology
DOI: 10.1021/acssynbio.0c00038





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Christians and the Coronavirus

Do not be anxious and seek first the kingdom of God.




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[ASAP] Pyridine-Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00280




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[ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00227




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[ASAP] Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02097




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[ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00599




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[ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01936




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[ASAP] Design of Radiolabeled Analogs of Minigastrin by Multiple Amide-to-Triazole Substitutions

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01937




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[ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00215