ot In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3704-3710DOI: 10.1039/D4MD00552J, Research ArticleJaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul PyunFv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3795-3799DOI: 10.1039/D4MD00458B, Research ArticleKazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki TamaokiA photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cis–trans photoisomerization with blue-green light and fast thermal relaxation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Amaran is a film about a soldier’s life, nothing more: Seeman By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:55:42 +0530 Full Article Tamil Nadu
ot AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:30:55 +0530 “During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said Full Article Tamil Nadu
ot Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:48 +0530 Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme Full Article Tamil Nadu
ot IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
ot Greaves Cotton Q2 net loss narrows to ₹14 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:59:39 +0530 Full Article Business
ot Devotees offer special prayers at Sri Kalyana Venkateswara Swamy temple in Srikakulam By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:39 +0530 Full Article Andhra Pradesh
ot Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:31 +0530 Full Article Andhra Pradesh
ot Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:18:36 +0530 Full Article Hyderabad
ot Prasar Bharati OTT launch, private FM stations for small towns on cards By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:29:11 +0530 Full Article Hyderabad
ot COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article World
ot Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36352-36369DOI: 10.1039/D4RA07074G, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. CoveyPhotoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ot Karnataka bypolls: A few residents of Savanur boycott polling in Shiggaon Assembly constituency By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:31:09 +0530 Some families at Dandinpet in Savanur boycotted the bypolls over not being given record of occupancy rights to them. Full Article Karnataka
ot Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:21:10 +0530 Full Article Karnataka
ot Kalaburagi city police arrests 30 vehicle lifters, recovers 105 motorbikes By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:13 +0530 Full Article Karnataka
ot 80.48% voter turnout recorded in Shiggaon By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:51:07 +0530 The polling for the byelection to Shiggaon Legislative Assembly Constituency in concluded peacefully with large number of voters turning up at 241 polling stations in the assembly segment to exercise their franchise on Wednesday Full Article Karnataka
ot Comeback man Shami hogs the spotlight as MP takes honours on opening day against Bengal By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:38:38 +0530 Full Article Sport
ot Devotees, martial arts, chants fill Hyderabad streets for Guru Nanak’s birth anniversary By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:30:14 +0530 Full Article Telangana
ot KSRTC invites EoI to ready commercial complex at Ernakulam depot By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:00:29 +0530 Full Article Kerala
ot Yet another incident of doctor being attacked By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:22:03 +0530 Full Article Chennai
ot CCI starts buying cotton at minimum support price By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:21:21 +0530 Full Article Business
ot Sindhu movers to pre-quarters, Lakshya bows out of Kumamoto Masters Japan By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:10:19 +0530 Full Article Sport
ot Unorganised workers federation protests New Labour Codes with demonstration By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:04:19 +0530 Full Article Tiruchirapalli
ot Migrants return to Channapatna in droves to cast their vote By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:05:41 +0530 Many voters across the constituency spoke freely about ‘high amounts’ paid by two parties both sides, besides transport charges, in this intensely fought electoral battle Full Article Karnataka
ot Donald Trump meets Joe Biden in White House; both pledge smooth transition By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:05:43 +0530 In a brief meeting, the two leaders assured the nation of a peaceful transition of power on January 20, 2025. Full Article U.S. Elections
ot Bottle booths to check littering in Kochi By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:06:49 +0530 Full Article Kochi
ot Rajasthan Assembly bypolls: 65% voter turnout recorded; largely peaceful By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:23:07 +0530 Highest voter turnout of 75.27% was recorded in Ramgarh; independent candidate slaps government officer Full Article Rajasthan
ot UPPSC aspirants protest continues for third day over exam format By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:35:28 +0530 The job aspirants protest multiple shifts and score normalisation in exams, demanding a fair and unified testing process Full Article Uttar Pradesh
ot Photographer from Gaza Strip among winners at top photography award in UAE By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:19:09 +0530 The Hamdan bin Mohammed bin Rashid Al Maktoum International Photography Award (HIPA) is the richest photography competition in the world. Full Article World
ot 64.98% cast votes in Malappuram in Wayanad bypoll By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:39:14 +0530 While Eranad and Wandoor registered 69.42% and 64.43% polling respectively, voting percentage in Nilambur stood at 61.91% Full Article Kerala
ot African swine fever: culling of pigs complete at Kottiyur in Kannur By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:42:15 +0530 A 48-member rapid response team led by District Animal Husbandry Officer Dr. V. Prasanth and Chief Veterinary Officer Dr. P. Biju oversaw the culling of 193 pigs across three farms Full Article Kerala
ot In Beed, Independent candidates on strong footing against party nominees By www.thehindu.com Published On :: Thu, 14 Nov 2024 05:43:54 +0530 Candidates who rebelled against party diktat stand out with strong support at the ground level and also have high chances of winning the seat Full Article Maharashtra Assembly
ot Minister discusses solutions to traffic bottleneck on Bengaluru’s airport road By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:05:00 +0530 One of the proposals involves widening the stretch near the military land Full Article Bengaluru
ot Social media for children: To ban or not to ban By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:36:00 +0530 Experts call for model behaviour from parents, supervision and restrictions on usage rather than a blanket ban Full Article Bengaluru
ot Mother, sister arrested for suicide of 32-year-old Pakshikere resident seek bail By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:00:00 +0530 Full Article Mangaluru
ot First phase of polling ends in Jharkhand with 64.86% turnout of voters By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:30:02 +0530 Polling was held in 15 districts of Jharkhand and the Kharsawan Assembly seat received the maximum polling of 77.32%, Ranchi, the State capital of Jharkhand witnessed the lowest polling with just 51.5% Full Article Jharkhand
ot This week's sponsor: Hotjar By synd.co Published On :: 2017-02-20T05:01:00+00:00 Hotjar, see how your visitors are really using your site. Try it free. Full Article
ot Centre approves widening of Rajahmundry-Anakapalli and Rayachoti-Kadapa national highways to six lanes, says MP By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:40:27 +0530 Full Article Visakhapatnam
ot Jana Sena Party corporator alleges neglect of crematorium facelift, stages protest By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:10:51 +0530 Full Article Visakhapatnam
