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Property-based optimisation of PROTACs

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
The content of this RSS Feed (c) The Royal Society of Chemistry




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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Four schools and a college in Tiruchi receive hoax bomb threats

Three schools declared a holiday on Tuesday as a precautionary measure




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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50 new primary health centres to be opened in State soon: Minister




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Data crucial for building climate resilience, says ISRO scientist




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Tiruchi Today (November 7, 2024)




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Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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TNSTC Kumbakonam Division mops up ₹17.13 crore in four days




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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation




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Plea to include ‘panneer karumbu’ in Pongal gift hamper




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Urban Primary Health Centre stuck in cramped, temporary facility




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Property owners block the entrance to Balasubramanya temple in Karur




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Govt. urged to extend last date to pay crop insurance premium by farmers




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Deputy CM releases commemorative flag of Bharat Scouts and Guides




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Bids invited for setting up International Dugong Conservation Centre at Manora

The proposed centre, to be set up at an estimate of ₹41 crore, is being established to conserve endangered Dugong species and its habitat in the Palk Bay




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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive




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HR&CE plans to bring properties around the Vennaimalai Temple under tenants list

The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders




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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base




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Power shutdown in parts of Tiruchi on November 9




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Consultant to be appointed soon to design Kalaignar grand library in Tiruchi

The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events




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NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi




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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy




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Library to hold Group II-A Mains, Group IV TNPSC model test




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Advanced baggage handling system introduced in Tiruchi airport




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Art and literary contests lined up for District Central Library’s National Library Week




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Association holds protest against delay in Anna University’s staff absorption, promotions




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Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers

Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time




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542: Breaking Up with CSS-in-JS, Mastodon, and Stories on the Web

We're talking CSS-in-JS, Token CSS, Matuzo being suspended from Twitter, trying out Mastodon, testing out stable diffusion, stories on the web, and Jake Albaugh's new social network.




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544: Feedback, RSS Talk, Arc Brower, and Product Talk

Getting feedback for what you're building or writing, RSS feed reminiscing, Arc browser thoughts, products that didn't make that should have.




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545: Arc Browser with Nate Parrott

Nate Parrott from The Browser Company of New York stops by to talk about Arc - including the history of Arc, how boosts work, building out dev features, how they deciding on what features to build, and feedback from Dave and Chris on Arc.




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547: WordPress and GraphQL with Jason Bahl

Jason Bahl joins the show to talk about the GraphQL and WordPress connection, his work on WP GraphQL plugin, Faust and Atlas from WP Engine, Jamstack and Wordpress, and more.




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549: Ben Ubois of Feedbin

Ben Ubois is the founder of Feedbin, the RSS reader of choice for Dave and Chris. What influenced the creation of Feedbin, the state of RSS in 2023, curating your RSS feed, and subscribing to newsletters in Feedbin.




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552: Do You Want to Build a JS Framework? ☃️ CSS Wishlist for 2023

Austin power updates, what do you need if you want to build a new JavaScript framework, and what do we hope CSS brings in 2023?




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554: Jamstack Thoughts with Brian Rinaldi

Brian Rinaldi joins us to talk about the state of Jamstack in 2023, acronym confusion, SPA confusion, developing common tools of understanding, why Netlify bought Gatsby, and the state of developer conferences.




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555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices

Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation.




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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life

When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.




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558: Esoteric Weird Content Editable Problems with Kristin Valentine

Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??"




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560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS!

After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS.




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561: Web Perf News, Web Sommelier, Data Analytics, and Passkeys

Topics for this one include how do you learn about web performance news? Do you need a web components sommelier? Our thoughts on Syntax going to Sentry, and being able to focus on the things you want to focus on. Passkeys, Arc split screen, and vibe driven development.




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563: Getting Pulled by the Algorithm, AI Training Data, and SVG Drawing

There's a special guest on the show who takes aim at the billionaires in web dev, do we know better than the algorithm for news, why is AI training data such a secret, Chris and Dave discover JetBrains, monorepo struggles, and SVG drawing tools.




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564: Render ATL, New Colors Available, Gradients, HDR, and More

Chris previews a bit of his Render ATL 2023 talk, and then we mouth blog some color ideas, thoughts, and shame you for your non-HD websites.




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565: The Hurdy-Gurdy, OKLCH, Edge Dev Tools, and Ad Blocking

Dave doesn't hate the hurdy-gurdy, but it's creation is an interesting parallel to software development. OKLCH follow up, @media, Edge drops new dev tools, CSS and Astro theming, JavaScript devs discover PHP, how many people block ads, and accessibility and grids.




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567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious

What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery?