Opposition spokesman on tourism, Dr Wykeham McNeill, is calling for an investigation into allegations that some employers of tourism workers have not been turning over income tax deductions to government.  The situation has resulted in...

There was an issue with the tracker where old torrents with an old announce URL were not working properly. This has been fixed now.

A review by Medio DeCritici (165). A 2020 Review - Aliens Versus Predator (PC, 1999)

A review by Medio DeCritici (165). A 2020 Review - Aliens vs. Predator (PC, 2010)

A review by Medio DeCritici (165). A 2020 Review - Alpha Protocol (PC, 2010)

Компания Meizu вчера, кроме флагманских смартфонов, представила ещё свои обновлённые накладные Bluetooth-наушники Meizu HD60.

Компания обещает бесплатный ремонт устройств и возмещение расходов, если ноутбук уже отремонтировали.

Tattoo pistols are definitely the devices that are used to create and use tattoos. These pistols are also known as tattoo models. They have been utilized for several years to create stylish and delightful bits of system craft. Right now,… Continue Reading →

Every cricket follower fervently needs to watch real-time cricket suit. Nothing can change the excitement, delights and excitement of real-time cricket suit. Live cricket suit is of much worry for a fan during any recurring series or competitions. Every cricket… Continue Reading →

“Even after weeks of staying home, my kids are just not interested in all the stuff we have. Let’s be honest. If a toy isn’t getting any action amid this distraction-free, stuck-at-home living, chances are it’s never getting touched again.” Liz Russell figures out what really engages and changes kids during the quarantine, and will […]

I realize that sounds kinda nuts — why are we asking PARENTS to show us their KIDS being independent? Who, after all, is better at making videos? Mom or little Ava (who’s 5)? But legally we can’t ask anyone under 13 to do anything. So go document your children doing something new on their own, […]

What expression does — did — your mom use all the time? What skill did you learn from her?  What does (or did) she encourage you to do? These are great questions for any mom and child, whether the kid is 5 or 50. And if you click here, you can print out a very […]

Parents, kids: Fear not the silica gel pack. Sure it says DO NOT EAT and THROW AWAY. But you should only follow one of those rules.    Instead, save the packs and use them a whole lot of ways: Place them on the car dashboard by the windshield to keep it from fogging up.   […]

These “cards” are really an excuse for kids to interview their moms and shower them with the ultimate gifts: attention to mom’s quirky uniqueness, gratitude, and offers of help! Here you go — click here! (Mother’s Day is SUNDAY!)

1.8 million people in the United States drive heavy trucks for a living and are at risk of losing their jobs when trucks become autonomous. That number is from the BLS category heavy and tractor-trailer trucking with 1.8 million employees. A separate category Delivery Truck Drivers and Driver/Sales Workers has 1.3 million workers. The heavy duty truckers are more at risk than the local delivery drivers because it is easier to automate long haul driving on interstates than to automate driving on more complex (cross traffic, pedestrians, parked cars, etc) local roads. Plus, delivery drivers have to run up to houses and businesses to make most deliveries. Building robots to do that work will take longer. Railroad operation is easier...

The incentive to automate will be enormous for $15 per hour minimum wage. Of America’s nearly 16 million retail workers, the biggest group — 4.6 million — are salespeople. Their average wage is $10.47 an hour. After that, the country has another 3.4 million cashiers, and their average wage is $9.28 an hour. Only a quarter of salespeople earn more than $14 — and only 10 percent earn more than $19. The figures are worse for cashiers. But in the race to automate there will be a clear winner: Amazon. Why: Amazon can automate more easily than can physical stores. It is analogous to why long haul trucking can be automated before taxis: Just as highways are simpler places than...

Uber also made a deal with Volvo to cooperate on self-driving cars. Self-driving cars are an existential threat to Uber if Uber doesn't develop them first. Suppose Ford makes self-driving cars viable a few years before does and rolls them out in many cities. Uber gets wiped out by Ford's ability to charge less for a ride. Uber's big competitive advantage from a large set of recruited drivers could vanish as fast as sufficiently safe autonomous vehicles can get manufactured. Sufficiently safe: that's the challenge. But autonomous vehicle makers who limit themselves to some urban markets can lower the bar for their initial roll-out by just excluding any streets and corners that are too tricky to handle. They'll lose some...

The Miami Beach danger zone for mosquitoes carrying Zika virus is expanding. This isn't just about microcephaly in developing fetuses. Since Zika attacks neural progenitor cells it might cause lasting damage in adults too. A case of acute sensory polyneuropathy in an adult caused symptoms that lasted for months. It is suspected that Zika causes inflammation of sensory nerves and possibly an auto-immune response. So Zika is bad. What should we do about it? Wipe out the mosquitoes that carry it. Totally drive them to extinction. These mosquitoes are invasive in the Western Hemisphere. If a mosquito causes major health problems for the human species we should just wipe it out. Wiping out a mosquito species could be done with...

I've previously argued that going to Mars and trying to live there is a dumb idea for the foreseeable future. Notwithstanding assorted recent comments by Elon Musk this is still true. The best treatment of Musk's proposal for a big trip to Mars comes from The Martian science fiction author Andy Weir in his comments to Ars Technica. I think Weir went too easy the obviously ridiculous low cost estimates made by Musk and didn't address many of the problems with a Mars colony. But he makes excellent points. Read the article if you are interested. I like Weir's point that solar panels weigh too much to cart all the way to Mars. Better to take a nuclear reactor. I've...

In a nutshell: editing offspring DNA at the embryo stage will eventually offer so many advantages that lots of people will cave in on some advantage. Don't want to make your kid smarter? Make him or her better looking? Don't want that? How about a throwing arm competitive in major league baseball? Opposed to that? How about avoiding passing along your terrible allergies, need for braces, terrible eyesight, tendency to get depressed or perhaps anxiety attacks or eating disorders? Lots of ways to be persuaded to step over the line once the tech becomes safe. If asked whether one would genetically engineer one's offspring today many people would answer "No" to the hypothetical question. But today choosing genes for your...

Elon Musk thinks a universal basic income is inevitable. Musk doesn't see plausible alternatives. I hope not. So here's the optimistic scenario: On the one hand, manual and low skilled work will mostly get automated out of existence. So one could imagine why demand for people at lower skill levels and lower levels of cognitive ability could just evaporate. On the other hand, automation will cut costs and boost the wealth of those still employed. Even if the pay of manual laborers is low the goods a manual laborer will need to survive should become very cheap. So any upper class people who can find a use for them might pay them enough to survive. But I see a stronger...

Already we've hit the $1000 genome and faster and cheaper DNA sequencing is on the way. DNA sequencing is going through a speed-up and cost-cutting rate that is similar to that which computer processors have been going through for decades. While the doubling rate of computer power has slowed quite a bit the rate of decrease in DNA sequencing costs has kept up the pace and, in fact, the rate of decline in DNA sequencing costs suddenly accelerated at the end of 2007 has been going down pretty sharply ever since. The cost decline seemed to halt during 2014 only to plunge in 2015. So why should you care? Really cheap massive amounts of DNA sequencing of cancerous cells will...

The National Highway Traffic Safety Administration (NHTSA) finds Tesla's Autopilot cuts crashes by 40%. How cool is that? Autonomous vehicles are going to cause a huge decline in accidents and deaths. Even short of autonomous vehicles, when you get your next car try to get one that supports automatic braking on imminent collision detection. You could get a large fraction of the collision avoidance benefit at a much lower cost today. Check out Insurance Institute for Highway Safety ratings of collision avoidance systems in current cars. Watch a Tesla react to a crash in front of it: Watch a Tesla avoid hitting a reckless driver: A recent analysis finds that autonomous vehicles will allow 2 million disabled people to get...

Check out this qz article: The robot that takes your job should pay taxes, says Bill Gates. About 35-40 years ago secretary was the biggest job in most states. Those days are long past. As you can see by advancing the time bar for the USA states map on that page, by 2000 truck driver was the biggest job. So I have a question for Bill Gates: Do you want to tax word processors too? Also, autonomous vehicle technology will surely wipe out most truck driving jobs in the next 20 years. Do you want to tax autonomous truck technology to slow the rate of that transition? Keep in mind that thousands of lives will be saved each year once...

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The bartender says “You can’t have that thing in here! Get out!” The guy says “It’s okay, this Alligator is highly trained. Just give me a few seconds and I’ll show you.” The bartender, intrigued, gives him the go-ahead. The man gingerly lifts the alligator up onto a table. By this point, everybody in the […]

The post A Man Walks Into A Bar With An Alligator On A Leash appeared first on Funny & Jokes.

Do you have a fear of standing alone at your company party with nobody to talk to and no way to break the ice? Have no fear, F&J is here! Here’s a quick and dirty arsenal of one-liner jokes that are sure to make you the life of the party. Rest assured that nobody will […]

The post 11 Crappy One-Liners Sure To Leave You A Loser appeared first on Funny & Jokes.

A wealthy Catholic man travels to the Vatican City to see the Bishop of Rome in person, and hopes to meet this leader of the worldwide Catholic Church. Wearing his finest suit, he prays to God that he might be able to meet the Holy Father. During the morning’s Papal procession, he manages to work […]

The post From Riches to Rags appeared first on Funny & Jokes.

It’s not everyday we regurgitate a few old (and new!) chemistry jokes. How often do we tell them? Periodically. We told one the other day, but there was no reaction. Hahaha! Wait? How come nobody else is laughing? Ehem… well, anyways, here are a few more: When I first heard oxygen and magnesium got together […]

The post Top 20 Chemistry Jokes of Some Time appeared first on Funny & Jokes.

The post Team Spotlight: Getting to Know Ocean Blue’s James Stamatis appeared first on Ocean Blue Fishing Adventures.

The post New Arrivals: Top Fishing Sunglasses You Can Try this 2020 appeared first on Ocean Blue Fishing Adventures.

The post The Great Pause: A Second Chance to a Better World appeared first on Ocean Blue Fishing Adventures.

Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycoside antibiotics or platinum-containing chemotherapy agents. In animal models, induction of heat shock confers substantial otoprotection against aminoglycoside- and cisplatin-induced hair cell death. In this issue of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock protein 70 (HSP70) in response to heat stress. HSP70 acted by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death. Exosomes and the HSP70/TLR4 pathway could thus provide treatment targets for the protection of hair cells from chemically induced death or from other insults, such as noise.

The renaissance of complement diagnostics and therapeutics has introduced precision medicine into a widened field of complement-mediated diseases. In particular, complement-mediated diseases (or complementopathies) with ongoing or published clinical trials of complement inhibitors include paroxysmal nocturnal hemoglobinuria, cold agglutinin disease, hemolytic uremic syndrome, nephropathies, HELLP syndrome, transplant-associated thrombotic microangiopathy, antiphospholipid antibody syndrome, myasthenia gravis, and neuromyelitis optica. Recognizing that this field is rapidly expanding, we aim to provide a state-of-the-art review of (a) current understanding of complement biology for the clinician, (b) novel insights into complement with potential applicability to clinical practice, (c) complement in disease across various disciplines (hematology, nephrology, obstetrics, transplantation, rheumatology, and neurology), and (d) the potential future of precision medicine. Better understanding of complement diagnostics and therapeutics will not only facilitate physicians treating patients in clinical practice but also provide the basis for future research toward precision medicine in this field.

Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the largest pool of cell surface–expressed cancer-specific epitopes, making them attractive targets for cancer therapies. Soluble bispecific molecules that incorporate an anti-CD3 effector function are being developed to redirect T cells against these targets using 2 different approaches. The first achieves pHLA recognition via affinity-enhanced versions of natural TCRs (e.g., immune-mobilizing monoclonal T cell receptors against cancer [ImmTAC] molecules), whereas the second harnesses an antibody-based format (TCR-mimic antibodies). For both classes of reagent, target specificity is vital, considering the vast universe of potential pHLA molecules that can be presented on healthy cells. Here, we made use of structural, biochemical, and computational approaches to investigate the molecular rules underpinning the reactivity patterns of pHLA-targeting bispecifics. We demonstrate that affinity-enhanced TCRs engage pHLA using a comparatively broad and balanced energetic footprint, with interactions distributed over several HLA and peptide side chains. As ImmTAC molecules, these TCRs also retained a greater degree of pHLA selectivity, with less off-target activity in cellular assays. Conversely, TCR-mimic antibodies tended to exhibit binding modes focused more toward hot spots on the HLA surface and exhibited a greater degree of crossreactivity. Our findings extend our understanding of the basic principles that underpin pHLA selectivity and exemplify a number of molecular approaches that can be used to probe the specificity of pHLA-targeting molecules, aiding the development of future reagents.

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.

Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly understood. Neuropeptide Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in diverse cancer-related hallmarks including aging and metabolic alterations, but its impact on liver cancer had been unclear. Here, we observed increased expression of NPY5 receptor (Y5R) in HCC, which correlated with tumor growth and survival. Furthermore, we found that its ligand NPY was secreted by peritumorous hepatocytes. Hepatocyte-derived NPY promoted HCC progression by Y5R activation. TGF-β1 was identified as a regulator of NPY in hepatocytes and induced Y5R in invasive cancer cells. Moreover, NPY conversion by dipeptidylpeptidase 4 (DPP4) augmented Y5R activation and function in liver cancer. The TGF-β/NPY/Y5R axis and DPP4 represent attractive therapeutic targets for controlling liver cancer progression.

Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD.