y A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D3AY02200E, PaperQiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan GaoTuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y How to Disable JavaScript in Almost Any Browser By www.impressivewebs.com Published On :: Mon, 04 Apr 2022 10:00:00 +0000 In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile. I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit. The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs. Full Article Browsers JavaScript Web Design Articles Web Design Tutorials
y Don’t Let ChatGPT Write Your Code By www.impressivewebs.com Published On :: Wed, 20 Dec 2023 11:00:00 +0000 We can all agree it's ridiculous to suggest that we should ignore a modern tool that makes it exponentially easier to finish our work. But as I've learned in 20+ years of writing code, there's always going to be a drawback to using any tool that "makes life easier". In this case, AI-based tools that use ChatGPT or some other AI-based foundation are similar to the frameworks we've been using for years. The post Don’t Let ChatGPT Write Your Code appeared first on Impressive Webs. Full Article Web Design Articles
y YouTube’s Time-Based UX Problem for Live Sports By www.impressivewebs.com Published On :: Mon, 30 Sep 2024 10:00:00 +0000 I like to play beach volleyball here in the Toronto area. I also watch beach volleyball on YouTube, which includes a lot of live streams from the AVP league in the US. It's a fun sport that I recommend to anyone looking for a new athletic competition to follow. In most leagues and tournaments, beach volleyball games have a 3-set format, with each set finishing when a team reaches 21 points (or higher if they're not yet ahead by 2). The third set (played if needed) will go up to 15 points (again, win by 2). Some leagues/tournaments will play all three sets up to 15. It depends on the venue, tournament, etc. The post YouTube’s Time-Based UX Problem for Live Sports appeared first on Impressive Webs. Full Article UX Web Design Articles
y Losing a friend, virtually By www.thehindubusinessline.com Published On :: Mon, 03 Jun 2013 13:04:35 +0530 Full Article R Dinakaran
y Location tracking - do you need it? By www.thehindubusinessline.com Published On :: Sat, 17 Aug 2013 16:31:13 +0530 Full Article R Dinakaran
y QR codes for security in vehicles By www.thehindubusinessline.com Published On :: Tue, 03 Sep 2013 16:32:33 +0530 Full Article R Dinakaran
y It's a snapchatty world By www.thehindubusinessline.com Published On :: Wed, 25 Dec 2013 15:27:46 +0530 Full Article R Dinakaran
y Good, but not enough: On the extended coverage of the Ayushman Bharat scheme By www.thehindu.com Published On :: Fri, 13 Sep 2024 00:20:00 +0530 Extension of free health coverage to all over 70 years is good, but more needs to be done Full Article Editorial
y Clarity of vision: On eye drops for presbyopia and ‘claims’ By www.thehindu.com Published On :: Tue, 17 Sep 2024 00:15:00 +0530 A useful drug is undone by fantastic claims about its efficacy Full Article Editorial
y A way out: On the government and doctor-led protests in West Bengal By www.thehindu.com Published On :: Wed, 18 Sep 2024 00:20:00 +0530 The West Bengal government must enable the changes doctors want to see Full Article Editorial
y Party on the move: On the Aam Aadmi Party, its leader By www.thehindu.com Published On :: Thu, 19 Sep 2024 00:20:00 +0530 AAP’s Arvind Kejriwal continues to surprise, also outlining his political ambitions Full Article Editorial
y Staunch the breach: On India, Pakistan and the Indus Waters Treaty By www.thehindu.com Published On :: Sat, 21 Sep 2024 00:20:00 +0530 India and Pakistan need to drop their hard line stances on the Indus Waters Treaty Full Article Editorial
y Staying the course: On the fight against air pollution in the Indo-Gangetic plains By www.thehindu.com Published On :: Sat, 28 Sep 2024 00:10:00 +0530 The Centre and the States need to fight air pollution together Full Article Editorial
y Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case By www.thehindu.com Published On :: Sat, 28 Sep 2024 00:20:00 +0530 Senthilbalaji’s release on bail was overdue, but he should not be made a Minister Full Article Editorial
y Demand flux: On growth dynamics By www.thehindu.com Published On :: Mon, 30 Sep 2024 00:20:00 +0530 Growth dynamics may falter with waning urban consumption Full Article Editorial
y Steady but slow: On the VIPER mission, lessons for India By www.thehindu.com Published On :: Tue, 01 Oct 2024 00:30:00 +0530 India’s space programme needs more resources to realise its full potential Full Article Editorial
y Heartland murmurs: On the Haryana Assembly elections By www.thehindu.com Published On :: Wed, 02 Oct 2024 00:20:00 +0530 Haryana may throw up surprises after the realignments Full Article Editorial
y Healthy sign: On the voting in the 2024 J&K Assembly elections By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:10:00 +0530 Turnout numbers in the Assembly elections show distinct patterns in south Kashmir Full Article Editorial
y Inflection point: On the escalation in the multi-party West Asia conflict By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:20:00 +0530 West Asia needs the intervention of major world powers for peace Full Article Editorial
y Split decision: On the rivalry between the two NCP factions By www.thehindu.com Published On :: Fri, 04 Oct 2024 00:25:00 +0530 The ECI and the office of the Speaker have not played fair in cases of defection Full Article Editorial
y A defeat foretold: On the Maoist insurgency By www.thehindu.com Published On :: Mon, 07 Oct 2024 00:30:00 +0530 Maoists must abandon armed struggle and enter the democratic process Full Article Editorial
y Marina mayhem: On the IAF’s Chennai air show By www.thehindu.com Published On :: Tue, 08 Oct 2024 00:23:00 +0530 The deaths at the air show in Chennai could have been prevented with better arrangements Full Article Editorial
y Deep roots: On the 2024 Physics Nobel Prize By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:10:00 +0530 Physics Nobel Prize acknowledges the diverse foundations of AI Full Article Editorial
y Flipping scripts: On the Haryana and J&K election results By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:20:00 +0530 BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir Full Article Editorial
y Against the odds: On the 2024 Haryana Assembly elections By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:20:00 +0530 The Congress could not counter the caste polarisation in Haryana Full Article Editorial
y Biology transformed: On the Nobel Prize in chemistry By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:28:00 +0530 Nobel for determining protein structure recognises a big advance Full Article Editorial
y Take the gauntlet: On safety and the Indian Railways By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:38:00 +0530 ‘Kavach’ implementation is a priority but will not be a silver bullet Full Article Editorial
y Culture and society: On upholding Section 6A of the Citizenship Act By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:30:00 +0530 Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems Full Article Editorial
y Beyond intoxication: On alcohol regulation, judicial verdict By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:20:00 +0530 Batting for States, the Supreme Court of India holds federal balance on regulating alcohol Full Article Editorial
y Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:10:00 +0530 Actor Vijay seems to be targeting both the BJP and the DMK Full Article Editorial
y Tough task: On the battle lines in the Jharkhand Assembly election By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:20:00 +0530 Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand Full Article Editorial
y Sun signs: On extreme heat and Tamil Nadu’s policy decision By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:10:00 +0530 States should prepare to assist the vulnerable during extreme heat events Full Article Editorial
y Towards Europe: On the India visits by the leaders of Germany, Spain By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:20:00 +0530 India used visits by leaders of Germany and Spain to balance ties in Europe Full Article Editorial
y Watch: When Jimmy Sheirgill Got Violent By www.rediff.com Published On :: 'As a storyteller, one always looks to create something for the audience which is thrilling, engaging and entertaining and that is exactly what we have endeavoured with Sikandar Ka Muqaddar.' Full Article
y What Makes <I>Andaz Apna Apna</I> Such Fun Even Today By www.rediff.com Published On :: Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie. Full Article
y Why Kriti Is So Grateful By www.rediff.com Published On :: Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release. Full Article
y The Raj & DK Line-Up You Cannot Miss By www.rediff.com Published On :: Sukanya Verma looks at their eclectic career of over two decades as their latest offering Citadel: Honey Bunny, the Indian leg of the Russo Brothers globetrotting spy universe series, drops on Amazon Prime Video on November 7. Full Article
y Why Abhishek Missed Aishwarya's Birthday By www.rediff.com Published On :: When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher. Full Article
y The Woman Who Lost Everything By www.rediff.com Published On :: When the landslide hit, Sruthi's house was washed away, along with its inhabitants. Full Article
y 'He Doesn't Have The Air He Is Raj Thackeray's Son' By www.rediff.com Published On :: 'I love to meet people.' Full Article
y Ananya-Suhana Party Together By www.rediff.com Published On :: Ananya Panday celebrated her birthday with family and the media, but she really wasn't done yet. Full Article
y Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y The role of silicon in drug discovery: a review By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3286-3344DOI: 10.1039/D4MD00169A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van OtterloThis review aims to highlight the role of silicon in drug discovery.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3507-3528DOI: 10.1039/D4MD00417E, Research ArticleYuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan PanIn continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3576-3596DOI: 10.1039/D4MD00438H, Research ArticleRuolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang ChenRho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3469-3476DOI: 10.1039/D4MD00422A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim NenckaSARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3418-3432DOI: 10.1039/D4MD00170B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van TranMadecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3345-3370DOI: 10.1039/D4MD00317A, Review ArticleMeghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep KumarSemisynthetic phytochemicals in cancer treatment.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article