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A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper
Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
The content of this RSS Feed (c) The Royal Society of Chemistry




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How to Disable JavaScript in Almost Any Browser

In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile.

I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit.

The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs.




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Don’t Let ChatGPT Write Your Code

We can all agree it's ridiculous to suggest that we should ignore a modern tool that makes it exponentially easier to finish our work.

But as I've learned in 20+ years of writing code, there's always going to be a drawback to using any tool that "makes life easier". In this case, AI-based tools that use ChatGPT or some other AI-based foundation are similar to the frameworks we've been using for years.

The post Don’t Let ChatGPT Write Your Code appeared first on Impressive Webs.



  • Web Design Articles

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YouTube’s Time-Based UX Problem for Live Sports

I like to play beach volleyball here in the Toronto area. I also watch beach volleyball on YouTube, which includes a lot of live streams from the AVP league in the US. It's a fun sport that I recommend to anyone looking for a new athletic competition to follow.

In most leagues and tournaments, beach volleyball games have a 3-set format, with each set finishing when a team reaches 21 points (or higher if they're not yet ahead by 2). The third set (played if needed) will go up to 15 points (again, win by 2). Some leagues/tournaments will play all three sets up to 15. It depends on the venue, tournament, etc.

The post YouTube’s Time-Based UX Problem for Live Sports appeared first on Impressive Webs.



  • UX
  • Web Design Articles

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Losing a friend, virtually




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Location tracking - do you need it?




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QR codes for security in vehicles




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It's a snapchatty world




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Good, but not enough: On the extended coverage of the Ayushman Bharat scheme

Extension of free health coverage to all over 70 years is good, but more needs to be done  




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Clarity of vision: On eye drops for presbyopia and ‘claims’

A useful drug is undone by fantastic claims about its efficacy




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A way out: On the government and doctor-led protests in West Bengal

The West Bengal government must enable the changes doctors want to see




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Party on the move: On the Aam Aadmi Party, its leader

AAP’s Arvind Kejriwal continues to surprise, also outlining his political ambitions




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Staunch the breach: On India, Pakistan and the Indus Waters Treaty

India and Pakistan need to drop their hard line stances on the Indus Waters Treaty




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Staying the course: On the fight against air pollution in the Indo-Gangetic plains

The Centre and the States need to fight air pollution together 




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​Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case

Senthilbalaji’s release on bail was overdue, but he should not be made a Minister




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​Demand flux: On growth dynamics

Growth dynamics may falter with waning urban consumption




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​Steady but slow: On the VIPER mission, lessons for India

India’s space programme needs more resources to realise its full potential




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​Heartland murmurs: On the Haryana Assembly elections

Haryana may throw up surprises after the realignments




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​Healthy sign: On the voting in the 2024 J&K Assembly elections

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir




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​Inflection point: On the escalation in the multi-party West Asia conflict

West Asia needs the intervention of major world powers for peace 




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Split decision: On the rivalry between the two NCP factions

The ECI and the office of the Speaker have not played fair in cases of defection




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A defeat foretold: On the Maoist insurgency

Maoists must abandon armed struggle and enter the democratic process




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​Marina mayhem: On the IAF’s Chennai air show

The deaths at the air show in Chennai could have been prevented with better arrangements 




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Deep roots: On the 2024 Physics Nobel Prize 

Physics Nobel Prize acknowledges the diverse foundations of AI




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​Flipping scripts: On the Haryana and J&K election results  

BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir




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​Against the odds: On the 2024 Haryana Assembly elections

The Congress could not counter the caste polarisation in Haryana 




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Biology transformed: On the Nobel Prize in chemistry

Nobel for determining protein structure recognises a big advance




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Take the gauntlet: On safety and the Indian Railways

‘Kavach’ implementation is a priority but will not be a silver bullet




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Culture and society: On upholding Section 6A of the Citizenship Act

Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems




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​Beyond intoxication: On alcohol regulation, judicial verdict

Batting for States, the Supreme Court of India holds federal balance on regulating alcohol




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​Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference  

Actor Vijay seems to be targeting both the BJP and the DMK 




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​Tough task: On the battle lines in the Jharkhand Assembly election

Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand




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Sun signs: On extreme heat and Tamil Nadu’s policy decision

States should prepare to assist the vulnerable during extreme heat events




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Towards Europe: On the India visits by the leaders of Germany, Spain

India used visits by leaders of Germany and Spain to balance ties in Europe 




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Watch: When Jimmy Sheirgill Got Violent

'As a storyteller, one always looks to create something for the audience which is thrilling, engaging and entertaining and that is exactly what we have endeavoured with Sikandar Ka Muqaddar.'




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What Makes <I>Andaz Apna Apna</I> Such Fun Even Today

Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie.




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Why Kriti Is So Grateful

Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release.




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The Raj & DK Line-Up You Cannot Miss

Sukanya Verma looks at their eclectic career of over two decades as their latest offering Citadel: Honey Bunny, the Indian leg of the Russo Brothers globetrotting spy universe series, drops on Amazon Prime Video on November 7.




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Why Abhishek Missed Aishwarya's Birthday

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.




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The Woman Who Lost Everything

When the landslide hit, Sruthi's house was washed away, along with its inhabitants.




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'He Doesn't Have The Air He Is Raj Thackeray's Son'

'I love to meet people.'




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Ananya-Suhana Party Together

Ananya Panday celebrated her birthday with family and the media, but she really wasn't done yet.




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The role of silicon in drug discovery: a review

RSC Med. Chem., 2024, 15,3286-3344
DOI: 10.1039/D4MD00169A, Review Article
Open Access
Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van Otterlo
This review aims to highlight the role of silicon in drug discovery.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells

RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective

RSC Med. Chem., 2024, 15,3345-3370
DOI: 10.1039/D4MD00317A, Review Article
Meghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep Kumar
Semisynthetic phytochemicals in cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry