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Property-based optimisation of PROTACs

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
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Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00724G, Research Article
Zhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei Mao
A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00654B, Review Article
Madison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. Leung
The emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.
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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 12:48:36 +0530


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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 17:44:09 +0530

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago


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50 new primary health centres to be opened in State soon: Minister

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 19:37:18 +0530


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Data crucial for building climate resilience, says ISRO scientist

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 19:40:51 +0530


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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 21:04:51 +0530


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Tiruchi Today (November 7, 2024)

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:16:44 +0530


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Ensure time-bound implementation of development schemes, says Thirumavalavan

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:29:00 +0530


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Agro-tourism push needs industry-specific policies, say farmers

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:37:41 +0530


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Paddy crop loss compensation pegged at ₹36,500

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:53:01 +0530


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TNSTC Kumbakonam Division mops up ₹17.13 crore in four days

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:59:26 +0530


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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 19:30:58 +0530


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Case filed against actor Kasthuri over remarks on Telugu community

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 19:46:03 +0530


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Urban Primary Health Centre stuck in cramped, temporary facility

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 20:31:50 +0530


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Property owners block the entrance to Balasubramanya temple in Karur

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 17:35:45 +0530


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Govt. urged to extend last date to pay crop insurance premium by farmers

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 17:45:02 +0530


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Deputy CM releases commemorative flag of Bharat Scouts and Guides

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 17:48:40 +0530


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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 18:48:04 +0530

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects


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Railways using treated water from its STP for maintaining green spaces

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 20:46:00 +0530

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction


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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 07:51:25 +0530

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base


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Consultant to be appointed soon to design Kalaignar grand library in Tiruchi

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 18:41:18 +0530

The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events


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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 18:56:40 +0530

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa


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NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 19:03:53 +0530


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Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 19:20:03 +0530

Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand


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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 19:25:49 +0530


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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 20:25:59 +0530


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Two doctors posted at Uppiliyapuram UPHC

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 20:29:46 +0530


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Library to hold Group II-A Mains, Group IV TNPSC model test

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 17:59:22 +0530


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Advanced baggage handling system introduced in Tiruchi airport

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:01:36 +0530


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Art and literary contests lined up for District Central Library’s National Library Week

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:07:57 +0530


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Tiruchi Corporation office expansion plan witnesses more delay

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:22:07 +0530


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‘State should retain primary agricultural cooperative societies under its purview’

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:23:59 +0530


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IECD holds graduation ceremony of SUITS

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 19:08:19 +0530

As many as 93,435 students from Grade V to Grade IX in 358 schools across the State appeared for 2023-2024 BDU examinations


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Students and agriculture officials grapple with logistical, technical issues during digital crop survey

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 20:32:48 +0530


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Nagapattinam MP presses for new express trains, railway line extensions

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 20:34:19 +0530


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Association holds protest against delay in Anna University’s staff absorption, promotions

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 22:02:50 +0530


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AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami

By www.thehindu.com
Published On :: Mon, 11 Nov 2024 00:39:42 +0530


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Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu

By www.thehindu.com
Published On ::


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543: Zach Leatherman on Eleventy, Mastodon, Twitter, and is-land

By shoptalkshow.com
Published On :: Tue, 29 Nov 2022 16:30:32 +0000

Zach Leatherman talks with us about what's new with Eleventy, setting up on Mastodon, what's happened with Twitter, and is-land.


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546: Ryan Dahl and Deno

By shoptalkshow.com
Published On :: Mon, 19 Dec 2022 09:11:01 +0000

Ryan Dahl stops by to talk about Node, Deno, JavaScript, testing, V8, and thoughts around getting started with Deno.


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550: Sanity with Simen Svale Skogsrud and Espen Hovlandsdal

By shoptalkshow.com
Published On :: Mon, 30 Jan 2023 10:11:40 +0000

Simen and Espen from Sanity stop by to talk about the origins of Sanity, how Sanity Studio works, good use cases for Sanity, how Sanity does real time updates, what Groq is, and where to start with Sanity.


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551: PlanetScale with Iheanyi Ekechukwu and Mike Coutermarsh

By shoptalkshow.com
Published On :: Mon, 06 Feb 2023 19:44:27 +0000

Iheanyi Ekechukwu and Mike Coutermarsh talk about PlanetScale, what Vitess is, if PlanetScale is for both side and big projects, what read only regions are, what schema changes are, and how PlanetScale compares to other projects.


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552: Do You Want to Build a JS Framework? ☃️ CSS Wishlist for 2023

By shoptalkshow.com
Published On :: Mon, 13 Feb 2023 10:07:40 +0000

Austin power updates, what do you need if you want to build a new JavaScript framework, and what do we hope CSS brings in 2023?


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553: TypeScript, DX, GripeScript, and Astro v2 with Fred Schott

By shoptalkshow.com
Published On :: Mon, 20 Feb 2023 10:37:22 +0000

Fred Schott stops by to talk about TypeScript, what DX means in 2023, a bit of GripeScript, and being transparent about what Astro is good at, and what it's not.


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555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices

By shoptalkshow.com
Published On :: Mon, 06 Mar 2023 09:39:37 +0000

Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation.


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