Biomater. Sci., 2024, 12,1716-1725
DOI: 10.1039/D3BM01981K, Paper

Zhongming Huang, Tongren Yang, Jie Yu, Yijian Gao, Yuhua Weng, Yuanyu Huang, Shengliang Li
Through molecular screening, ionic liquid-conjugated polymers (IL-CPs) are developed for highly efficient delivery of CRISPR/Cas9 system, which demonstrated high-performance genome editing-based tumor therapy.
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Biomater. Sci., 2024, 12,1707-1715
DOI: 10.1039/D3BM01765F, Paper

Andrew C. Murphy, Heidi F. Oldenkamp, Nicholas A. Peppas
This article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.
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Biomater. Sci., 2024, 12,1630-1642
DOI: 10.1039/D3BM02026F, Review Article

Beilei Sun, Limin Zhang, Mengzhen Li, Xin Wang, Weizhi Wang
To meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.
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Biomater. Sci., 2024, 12,1726-1737
DOI: 10.1039/D3BM01767B, Paper

Zichun Gao, Yixuan Liu, Wenjiao Lin, He Lian, Zhaoxu Meng
Hyaluronic acid microneedles loaded with polydopamine nanoparticles induce fat browning, offering innovative localized obesity treatment.
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Biomater. Sci., 2024, 12,1883-1897
DOI: 10.1039/D3BM01793A, Paper

Yunji Sun, Chang Su, Jinfeng Liu, Zheng He, Shengting Che, Qinglan Wan, Jingyu Cai, Hao Zhan, Chao Feng, Xiaojie Cheng, Feng Lin, Junqiang Wei, Xiguang Chen
Diatom hemostatic particles prepared by one-pot reaction have streamlined process and mass production potential, can significantly stop bleeding and reduce accidental deaths.
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Biomater. Sci., 2024, 12,1750-1760
DOI: 10.1039/D3BM01904G, Paper

Xinyi Long, Qian Yuan, Rui Tian, Wanting Zhang, Lang Liu, Minghui Yang, Xin Yuan, Zhujie Deng, Quanjiang Li, Ronghui Sun, Yuyi Kang, Yingying Peng, Xiubin Kuang, Lingfang Zeng, Zhengqiang Yuan
An alginate hydrogel loaded with mesenchymal stem-cell-derived extracellular vesicles (EVs) and a 7-amino-acid peptide (7A) constitutes a novel dressing for efficient healing of diabetic wounds with anti-inflammation and pro-angiogenesis mechanisms.
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Biomater. Sci., 2024, 12,1847-1863
DOI: 10.1039/D3BM02072J, Paper

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Beom-Seok Kim, Jeong-Uk Kim, Jae Woo Lee, Kyung Min Ryu, Rachel H. Koh, Kyoung-Ha So, Nathaniel S. Hwang
The supercritical (SC) fluid-based method were utilized for nerve tissue decellualrization. In vitro, vivo assessments underscore its potential for advanced tissue engineering and regenerative applications.
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Biomater. Sci., 2024, 12,1662-1692
DOI: 10.1039/D3BM01451G, Review Article

Qiao Li, Yuan Lianghao, Gao Shijie, Wang Zhiyi, Tang Yuanting, Chen Cong, Zhao Chun-Qin, Fu Xianjun
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.
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Biomater. Sci., 2024, 12,1738-1749
DOI: 10.1039/D3BM01849K, Paper

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Gauthier Menassol, Boudewijn van der Sanden, Laetitia Gredy, Capucine Arnol, Thibaut Divoux, Donald K. Martin, Olivier Stephan
Immediate care of skin wounds and burns is essential to repair this mechanical and chemical barrier to infections.
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Biomater. Sci., 2024, 12,1788-1800
DOI: 10.1039/D4BM00034J, Paper

Jingjing Cheng, Haixin Zhang, Kunyan Lu, Yi Zou, Dongxu Jia, Hong Yang, Hong Chen, Yanxia Zhang, Qian Yu
A bi-functional antibiofilm nanoplatform was developed based on a complex of quercetin and copper integrating bactericidal and anti-quorum sensing properties.
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Biomater. Sci., 2024, 12,1871-1882
DOI: 10.1039/D3BM01922E, Paper

Meng Zhang, Hongjin Xue, Jiaxin Yang, Xin Zhao, Mei Xue, Wei Sun, Jianfeng Qiu, Zhihong Zhu
A Cu/ZIF-8/Vc-Ca/HA nanosystem synchronously releases Fenton catalytic Cu²⁺ and Vc-Ca to achieve improved chemodynamic therapy via H₂O₂ self-supply and GSH depletion.
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Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper

Open Access

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Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
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Biomater. Sci., 2024, 12,1617-1629
DOI: 10.1039/D3BM01894F, Review Article

Mengjun Huang, Qiliang Teng, Fei Cao, Jinsheng Huang, Jun Pang
Existing treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.
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Biomater. Sci., 2024, 12,1841-1846
DOI: 10.1039/D4BM00145A, Paper

Jingtao Zheng, Lei Rong, Yao Lu, Jing Chen, Kai Hua, Yongzhong Du, Qiang Zhang, Weishuo Li
A neutrophil-extracellular-trap mimic nanoparticle effectively eliminates bacteria in a trap & kill manner.
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Biomater. Sci., 2024, 12,1864-1870
DOI: 10.1039/D3BM01994B, Paper

Yongzhi Chen, Qiuxia Tan, Yuanyu Tang, E. Pang, Rui Peng, Minhuan Lan, Dousheng Bai
Hepatocellular carcinoma (HCC) is characterized by a high degree of malignancy and mortality.
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Biomater. Sci., 2024, 12,1761-1770
DOI: 10.1039/D3BM02035E, Paper

Hao Deng, Yuheng Jiang, Junhao Deng, Feifan Chang, Junyu Chen, Xinyu Sun, Dongliang Cheng, Zhongqi Wang, Ran Li, Jiang Liu, Yi Li, Licheng Zhang, Pengbin Yin
Extracellular vesicles (EVs) produced by 3D-cultured MSCs can modulate macrophage activation through ANXA1, thereby promoting wound healing.
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Biomater. Sci., 2024, 12,1643-1661
DOI: 10.1039/D3BM02038J, Review Article

Yanting Zhu, Chenwei Zhang, Ying Liang, Jianyuan Shi, Qiuhao Yu, Shen Liu, Dengguang Yu, Hui Liu
Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.
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Biomater. Sci., 2024, 12,1924-1931
DOI: 10.1039/D3BM01926H, Paper

Xiaoke Zhang, Qianwen Yang, Sensen Zhou, Cheng Li, Xiqun Jiang
A H₂O₂-sensitive macromolecular optical probe which can effectively bind to collagen was developed for real time noninvasive visualization of fibrotic tissues.
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Biomater. Sci., 2024, 12,1771-1787
DOI: 10.1039/D3BM01150J, Paper

Jin Teng Chung, Mehrnoosh Rafiei, Ying Chau
Antigens are delivered in self-adjuvanted arginine-modified dextran-based nanogels to the dendritic cells in promoting antigen specific cellular immunity.
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Biomater. Sci., 2024, 12,1898-1913
DOI: 10.1039/D3BM01665J, Paper

Kai Wang, Ming Zhou, Yuanshu Zhang, Yesheng Jin, Yuan Xue, Dong Mao, Yongjun Rui
Schematic illustration of the mechanism by which an IM promotes bone formation. FMOD secreted by the IM promotes osteogenesis of BMSCs and angiogenesis of HUVECs by inhibiting the TGF-β/SMAD signaling pathway, thus facilitating bone formation.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01875J, Review Article

Yingxue Jiang, Chenhui Zhu, Xiaoxuan Ma, Daidi Fan
In recent years, the design and synthesis of Janus hydrogels have advanced significantly, overcoming single-performance material limitations and broadening applications in tissue engineering and regenerative medicine.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01338C, Review Article

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Adam Shearer, Matthew Molinaro, Maziar Montazerian, Jessica J. Sly, Marta Miola, Francesco Baino, John C. Mauro
Alkali and alkaline earth elements play a crucial role in the structure, processing, and properties of bioactive glasses, widely used in medical applications since their inception in 1969.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM02111D, Paper

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Hohyeon Han, Minji Kim, Uijung Yong, Yeonggwon Jo, Yoo-mi Choi, Hye Jin Kim, Dong Gyu Hwang, Dayoon Kang, Jinah Jang
This study introduces gelatinized dECM, a tissue-specific rheological modifier, enabling high-resolution printing of flexible tissue constructs with enhanced resilience.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00083H, Paper

Jing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao, Xintao Shuai
An ROS-labile nanodrug co-encapsulating Ce6 and a Bcl-2 inhibitor enabled PDT and reversed apoptotic resistance, demonstrating a potent inhibitory effect on tumor growth.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00061G, Paper

Hang Ren, Peng Wang, Hanwen Huang, Junshen Huang, Yuheng Lu, Yanfeng Wu, Zhongyu Xie, Youchen Tang, Zhaopeng Cai, Huiyong Shen
Modified Ti with a porous N-halaminated spermidine-containing polymeric coating is constructed, and it has both excellent antibacterial and osteogenic abilities to enhance osseointegration, making it potentially applicable in orthopedics.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00155A, Review Article

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Yungang Hu, Lu Yu, Qiang Dai, Xiaohua Hu, Yuming Shen
Due to their distinctive physical and chemical properties as well as their biological functionalities, multifunctional antibacterial hydrogels possess significant advantages in the treatment of chronic wounds.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00003J, Paper

Jing Liu, Jie Zhang, Yongteng Zhang, Wei Wei, Meixiao Zhan, Zhiren Zhang, Bing Liu, Xianglong Hu, Weiling He
Facile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00159A, Paper

Shulei Zhang, Bo Zheng, Yiqi Wei, Yuhao Liu, Lan Yang, Yujiao Qiu, Jing Su, Mingfeng Qiu
Breast cancer, a pervasive malignancy affecting women, demands a diverse treatment approach including chemotherapy, radiotherapy, and surgical interventions.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00024B, Minireview

Pramit Kumar Ghosh, Maddila Jagapathi Rao, Chandra Lekha Putta, Sandipan Ray, Aravind Kumar Rengan
The use of nanoparticles for identifying and suppressing telomerase presents promising opportunities for anticancer strategies, particularly in relation to circadian regulation.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01900D, Paper

Veronika Sarnatskaya, Yuliia Shlapa, Denis Kolesnik, Olexandra Lykhova, Dmytro Klymchuk, Serhii Solopan, Svitlana Lyubchyk, Iuliia Golovynska, Junle Qu, Yurii Stepanov, Anatolii Belous
Nano-dispersed cerium dioxide is promising for use in medicine due to its unique physicochemical properties, low toxicity, the safety of in vivo usage, active participation in different redox processes occurring in living cells, and its regenerative potential.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90027H, Correction

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Safieh Boroumand, Faraz Sigaroodi, Seyed Mohsen Ahmadi Tafti, Keyvan Khoshmaram, Masoud Soleimani, Mohammad-Mehdi Khani
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90029D, Correction

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Ee Taek Hwang, Yeahwa Yoon, Ka Ram Kim, Chan Hee Lee, Kyung Chan Jeon, Ji Ho Min, Jae Won Lee, Jangyong Kim
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90028F, Correction

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Keqin Ji, Mingrui Fan, Dong Huang, Lingna Sun, Bingqin Li, Ruoting Xu, Jiajing Zhang, Xuan Shao, Yanzuo Chen
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00357H, Paper

Bin Zhang, Rui Yang, Hongwei Yu, Yamin Peng, Haoyu Huang, Meera Moydeen Abdul Hameed, Han Wang, Guixiang Zhang, Mohamed EL-Newehy, Mingwu Shen, Xiangyang Shi, Shaojun Peng
Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles can be developed to cross the blood–brain barrier for magnetic resonance imaging and chemo/chemodynamic therapy.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00158C, Paper

Yiduo Chen, Yirong Guo, Xinyi Li, Yanchen Chen, Jiarong Wang, Honglin Qian, Jing Wang, Youxiang Wang, Xinyang Hu, Jian'an Wang, Jian Ji
Three surface-initiated hydrogel coatings (pMPC, pAMPS, pHEMA) are constructed on polymeric heart valves. The zwitterionic pMPC coating displays optimal performances, including durable anti-coagulation, anti-inflammation, and anti-calcification.
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Biomater. Sci., 2024, 12,1950-1964
DOI: 10.1039/D3BM01733H, Review Article

Mingjun Xie, Ji Wang, Sufan Wu, Sheng Yan, Yong He
This review introduces different methods used to generate microgels and the microgel-based bioink for bioprinting. Besides, the further tendency of microgel development in future is predicted.
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Biomater. Sci., 2024, 12,2041-2056
DOI: 10.1039/D3BM01674A, Paper

David A. McBride, James S. Wang, Wade T. Johnson, Nunzio Bottini, Nisarg J. Shah
The study develops a computational framework to model factors that lead to the evolution of autoreactive T cells in inflammatory arthritis. The results provide a tool for planning immunomodulatory strategies focused on new disease-modifying agents.
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Biomater. Sci., 2024, 12,2086-2095
DOI: 10.1039/D3BM01575K, Paper

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Pinghui Li, Zhidie Huang, Xiaoyan Duan, Tao Wang, Shaowen Yang, Dawei Jiang, Jianbo Li
We constructed ⁶⁸Ga-BDF and employed PET imaging to establish its pharmacokinetic model. BDF was eliminated from the body via the urinary system. We observed distinct imaging indicators in UUO and AKI mouse models. Furthermore, we observed the therapeutic effect of BDF on AKI.
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Biomater. Sci., 2024, 12,2121-2135
DOI: 10.1039/D3BM01901B, Paper

Ruideng Wang, Xi He, Zhengyang Chen, Shilong Su, Jinwu Bai, Haifeng Liu, Fang Zhou
A photo-crosslinked nanocomposite hydrogel was prepared by incorporating an osteo-inductive inorganic nanoparticle for endogenous bone regeneration.
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Biomater. Sci., 2024, 12,1981-2006
DOI: 10.1039/D3BM01841E, Review Article

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Ali Zareein, Mina Mahmoudi, Shruti Sunil Jadhav, Joel Wilmore, Yaoying Wu
Biomaterials enhance B cell immunity by modulating the delivery approach, crosslinking B cell receptors, and promoting T cell help, while inhibitory co-receptor engagement via biomaterial design suppresses B cell function.
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Biomater. Sci., 2024, 12,2096-2107
DOI: 10.1039/D4BM00125G, Paper

Yimeng Zhao, Xuefei Lv, Yu Chen, Chen Zhang, Di Zhou, Yulin Deng
Neuroinflammatory response on a novel combinatorial cell–cell interaction chip.
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Biomater. Sci., 2024, 12,2019-2032
DOI: 10.1039/D3BM02070C, Review Article

Zheng Wang, Zilong Chen, Zhenhao Zhang, Hongzhen Wang, Haichang Zhang
Organic fluorescent materials (OFMs) play a crucial role in the development of biosensors, enabling the extraction of biochemical information within cells and organisms, extending to the human body.
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Biomater. Sci., 2024, 12,1965-1980
DOI: 10.1039/D3BM01952G, Review Article

Fuping Zhang, Shuyu Wang, Shuo Yang, Feihe Ma, Hui Gao
Recent progress in nanomaterials for bacteria-related tumor therapy in terms of chemotherapy, immunotherapy and synergistic therapy is summarized in this review in order to provide some insights into this emerging and rapidly growing research area.
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