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y Ultra-efficient delivery of CRISPR/Cas9 using ionic liquid conjugated polymers for genome editing-based tumor therapy By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1716-1725DOI: 10.1039/D3BM01981K, PaperZhongming Huang, Tongren Yang, Jie Yu, Yijian Gao, Yuhua Weng, Yuanyu Huang, Shengliang LiThrough molecular screening, ionic liquid-conjugated polymers (IL-CPs) are developed for highly efficient delivery of CRISPR/Cas9 system, which demonstrated high-performance genome editing-based tumor therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y A highly tuneable inverse emulsion polymerization for the synthesis of stimuli-responsive nanoparticles for biomedical applications By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1707-1715DOI: 10.1039/D3BM01765F, PaperAndrew C. Murphy, Heidi F. Oldenkamp, Nicholas A. PeppasThis article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Applications of peptide-based nanomaterials in targeting cancer therapy By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1630-1642DOI: 10.1039/D3BM02026F, Review ArticleBeilei Sun, Limin Zhang, Mengzhen Li, Xin Wang, Weizhi WangTo meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Efficient healing of diabetic wounds by MSC-EV-7A composite hydrogel via suppression of inflammation and enhancement of angiogenesis By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1750-1760DOI: 10.1039/D3BM01904G, PaperXinyi Long, Qian Yuan, Rui Tian, Wanting Zhang, Lang Liu, Minghui Yang, Xin Yuan, Zhujie Deng, Quanjiang Li, Ronghui Sun, Yuyi Kang, Yingying Peng, Xiubin Kuang, Lingfang Zeng, Zhengqiang YuanAn alginate hydrogel loaded with mesenchymal stem-cell-derived extracellular vesicles (EVs) and a 7-amino-acid peptide (7A) constitutes a novel dressing for efficient healing of diabetic wounds with anti-inflammation and pro-angiogenesis mechanisms.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Comparative analysis of supercritical fluid-based and chemical-based decellularization techniques for nerve tissue regeneration By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1847-1863DOI: 10.1039/D3BM02072J, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Beom-Seok Kim, Jeong-Uk Kim, Jae Woo Lee, Kyung Min Ryu, Rachel H. Koh, Kyoung-Ha So, Nathaniel S. HwangThe supercritical (SC) fluid-based method were utilized for nerve tissue decellualrization. In vitro, vivo assessments underscore its potential for advanced tissue engineering and regenerative applications.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1662-1692DOI: 10.1039/D3BM01451G, Review ArticleQiao Li, Yuan Lianghao, Gao Shijie, Wang Zhiyi, Tang Yuanting, Chen Cong, Zhao Chun-Qin, Fu XianjunIn this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Copper(II)-based metal–organic framework delivery of calcium ascorbate for enhanced chemodynamic therapy via H2O2 self-supply and glutathione depletion By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1871-1882DOI: 10.1039/D3BM01922E, PaperMeng Zhang, Hongjin Xue, Jiaxin Yang, Xin Zhao, Mei Xue, Wei Sun, Jianfeng Qiu, Zhihong ZhuA Cu/ZIF-8/Vc-Ca/HA nanosystem synchronously releases Fenton catalytic Cu2+ and Vc-Ca to achieve improved chemodynamic therapy via H2O2 self-supply and GSH depletion.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Free drug and ROS-responsive nanoparticle delivery of synergistic doxorubicin and olaparib combinations to triple negative breast cancer models By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1822-1840DOI: 10.1039/D3BM01931D, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron AlexanderCombinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1617-1629DOI: 10.1039/D3BM01894F, Review ArticleMengjun Huang, Qiliang Teng, Fei Cao, Jinsheng Huang, Jun PangExisting treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Trap & kill: a neutrophil-extracellular-trap mimic nanoparticle for anti-bacterial therapy By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1841-1846DOI: 10.1039/D4BM00145A, PaperJingtao Zheng, Lei Rong, Yao Lu, Jing Chen, Kai Hua, Yongzhong Du, Qiang Zhang, Weishuo LiA neutrophil-extracellular-trap mimic nanoparticle effectively eliminates bacteria in a trap & kill manner.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Sorafenib and tetrakis (4-carboxyphenyl) porphyrin assembled nanoparticles for synergistic targeted chemotherapy and sonodynamic therapy of hepatocellular carcinoma By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1864-1870DOI: 10.1039/D3BM01994B, PaperYongzhi Chen, Qiuxia Tan, Yuanyu Tang, E. Pang, Rui Peng, Minhuan Lan, Dousheng BaiHepatocellular carcinoma (HCC) is characterized by a high degree of malignancy and mortality.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Extracellular vesicles produced by 3D cultured MSCs promote wound healing by regulating macrophage activation through ANXA1 By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1761-1770DOI: 10.1039/D3BM02035E, PaperHao Deng, Yuheng Jiang, Junhao Deng, Feifan Chang, Junyu Chen, Xinyu Sun, Dongliang Cheng, Zhongqi Wang, Ran Li, Jiang Liu, Yi Li, Licheng Zhang, Pengbin YinExtracellular vesicles (EVs) produced by 3D-cultured MSCs can modulate macrophage activation through ANXA1, thereby promoting wound healing.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Dynamic monitoring of the fibrosis disease by a collagen targeting near infrared probe By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1924-1931DOI: 10.1039/D3BM01926H, PaperXiaoke Zhang, Qianwen Yang, Sensen Zhou, Cheng Li, Xiqun JiangA H2O2-sensitive macromolecular optical probe which can effectively bind to collagen was developed for real time noninvasive visualization of fibrotic tissues.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Self-adjuvanted L-arginine-modified dextran-based nanogels for sustained local antigenic protein delivery to antigen-presenting cells and enhanced cellular and humoral immune responses By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1771-1787DOI: 10.1039/D3BM01150J, PaperJin Teng Chung, Mehrnoosh Rafiei, Ying ChauAntigens are delivered in self-adjuvanted arginine-modified dextran-based nanogels to the dendritic cells in promoting antigen specific cellular immunity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1801-1821DOI: 10.1039/D3BM01688A, PaperManju Sharma, Samraggi Choudhury, Anand Babu, Varun Gupta, Dipanjan Sengupta, Syed Afroz Ali, Mrunali D. Dhokne, Ashok Kumar Datusalia, Dipankar Mandal, Jiban Jyoti PandaThe graphical abstract portraying the utility of peizoactive polydopamine-coated PVDF nanospheres as potential therapeutic modalities for Alzheimer's disease. The nanospheres induced fibril disaggregation and neuroprotection upon acoustic activation in neural cells and animal model.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1898-1913DOI: 10.1039/D3BM01665J, PaperKai Wang, Ming Zhou, Yuanshu Zhang, Yesheng Jin, Yuan Xue, Dong Mao, Yongjun RuiSchematic illustration of the mechanism by which an IM promotes bone formation. FMOD secreted by the IM promotes osteogenesis of BMSCs and angiogenesis of HUVECs by inhibiting the TGF-β/SMAD signaling pathway, thus facilitating bone formation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Application of a meshed artificial dermal scaffold and negative-pressure wound therapy in the treatment of full-thickness skin defects: a prospective in vivo study By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1914-1923DOI: 10.1039/D3BM01675G, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Pei Wei, Lijiao Wu, Hongteng Xie, Zhaohong Chen, Rongwei Tan, Zhaorong XuA novel meshed ADS combined with NPWT can reduce the risk of scaffold-related complications, which helps to improve the quality of wound repair and promotes a broader range of applications.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Janus hydrogels: merging boundaries in tissue engineering for enhanced biomaterials and regenerative therapies By pubs.rsc.org Published On :: Biomater. Sci., 2024, Advance ArticleDOI: 10.1039/D3BM01875J, Review ArticleYingxue Jiang, Chenhui Zhu, Xiaoxuan Ma, Daidi FanIn recent years, the design and synthesis of Janus hydrogels have advanced significantly, overcoming single-performance material limitations and broadening applications in tissue engineering and regenerative medicine.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Tissue-specific gelatin bioink as a rheology modifier for high printability and adjustable tissue properties By pubs.rsc.org Published On :: Biomater. Sci., 2024, Advance ArticleDOI: 10.1039/D3BM02111D, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Hohyeon Han, Minji Kim, Uijung Yong, Yeonggwon Jo, Yoo-mi Choi, Hye Jin Kim, Dong Gyu Hwang, Dayoon Kang, Jinah JangThis study introduces gelatinized dECM, a tissue-specific rheological modifier, enabling high-resolution printing of flexible tissue constructs with enhanced resilience.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Light-inducible nanodrug-mediated photodynamic and anti-apoptotic synergy for enhanced immunotherapy in triple-negative breast cancer By pubs.rsc.org Published On :: Biomater. Sci., 2024, Advance ArticleDOI: 10.1039/D4BM00083H, PaperJing Huang, Xingliang Liu, Minzhao Lin, Zecong Xiao, Xintao ShuaiAn ROS-labile nanodrug co-encapsulating Ce6 and a Bcl-2 inhibitor enabled PDT and reversed apoptotic resistance, demonstrating a potent inhibitory effect on tumor growth.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y N-Halaminated spermidine-containing polymeric coating enables titanium to achieve dual functions of antibacterial and osseointegration By pubs.rsc.org Published On :: Biomater. Sci., 2024, Advance ArticleDOI: 10.1039/D4BM00061G, PaperHang Ren, Peng Wang, Hanwen Huang, Junshen Huang, Yuheng Lu, Yanfeng Wu, Zhongyu Xie, Youchen Tang, Zhaopeng Cai, Huiyong ShenModified Ti with a porous N-halaminated spermidine-containing polymeric coating is constructed, and it has both excellent antibacterial and osteogenic abilities to enhance osseointegration, making it potentially applicable in orthopedics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Multifunctional antibacterial hydrogels for chronic wound management By pubs.rsc.org Published On :: Biomater. Sci., 2024, Advance ArticleDOI: 10.1039/D4BM00155A, Review Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yungang Hu, Lu Yu, Qiang Dai, Xiaohua Hu, Yuming ShenDue to their distinctive physical and chemical properties as well as their biological functionalities, multifunctional antibacterial hydrogels possess significant advantages in the treatment of chronic wounds.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy By pubs.rsc.org Published On :: Biomater. Sci., 2024, Advance ArticleDOI: 10.1039/D4BM00003J, PaperJing Liu, Jie Zhang, Yongteng Zhang, Wei Wei, Meixiao Zhan, Zhiren Zhang, Bing Liu, Xianglong Hu, Weiling HeFacile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
