Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

Kyle Scott (UK) joined OM Europe’s Transit Challenge Team at Transform 2010 and spent the next 6 months travelling from Italy through Southern Europe to the Balkans. After returning home for Christmas, he flew to Germany for the GO conference in January 2011, from where he joined the OM team in France. We were curious to know more…

Six OMers spent two weeks in the south of France sharing God's love with children as part of a large music festival.

God prompts a worker to take along a Farsi Bible during his day manning the literature stand so that a Farsi-speaking man can find the Truth.

A 20-member church and a volunteer pastor seek long-term help for sharing the gospel with the 24,000 people in their town.

Martin and Petro De Lange start ministry to Turks in France.

An OM France couple works among trafficked women and fights for justice before government officials.

OM worker Lynn, along with teammates, ministers to immigrant women in France.

A French man met in the street prefered to live without God, thinking He would take away his freedom.

During her three months mission trip to Paris, Madeline realised how precious it is to be a living testimony for the homeless.

A group of 12 came to France through the Transform conference, to partner with a church and establish connections in the local refugee camp.

In the 1980s, OM organised large summer campaigns with the huge task of covering every town and village in France with Christian literature.

OM France marks OM’s 60th anniversary, inviting International Director, Lawrence Tong, to grace this special occasion.

David’s role on the Riverboat is to act as a homeless man. In reality, he is acting out a familiar life he used to lead.

“It was a long, green boat, sailing gently along the river,” recalled Ana Barros (Portugal), as she described her dream to her mum. This happened before she had even seen a picture of OM's Riverboat.

OMer Martin sees Muslims coming to Christ as he ministers to Turkish speakers in France.

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.

Although Harris clashed with Biden over his record on school desegregation, some of her education proposals might dovetail well with his.

Six in 10 programs worry they will have to shut down permanently, a survey finds—and that was before so many districts announced fall remote-learning plans.

Second grade teacher Kitten Vaa shares how her students develop argumentation skills with the use of scientific modeling.

In Queens, N.Y., Maria Katsanos' 3rd grade class conducts scientific explanations through the "KLEWS" strategy—identifying what students already know, what they're going to learn, the evidence, their wonderings, and scientific words and concepts.

Elizabeth Iwaszewicz, a kindergarten teacher at Lafayette Elementary School in San Francisco, uses music to help students focus their attention as they line up. She uses Jeopardy!'s theme song to make the routine like a quick and timed game.

Kaia Tomokiyo, a kindergarten teacher from Southern Heights Elementary in Seattle and Fallon King, a 1st and 2nd grade teacher from Cedarhurst Elementary in Burien, Wash., share how they engage younger students in scientific modeling through observation and discussion.

Thinking logs incorporate both literacy and math skills by asking students to write complete sentences explaining how they solved an equation and arrived at a solution.

Ryan Reilly, a 1st grade teacher at White Center Heights Elementary School in Seattle, shares how he uses related equations so students can identify similarities and differences in numbers and symbols. By noticing patterns, they learn to justify their reasons and can then solve similar problems.

Jeanne Wright creatively introduces her 1st grade students to a variety of strategies for solving addition problems.

A 5th grade teacher uses fractions to promote both language and math skills in her dual-language classroom.

A simple letter home to parents explaining a Texas 2nd grade teacher's no-homework policy has gone viral and is leading to more discussion about what's appropriate for elementary school students.

Teacher Antoinette Pippin engages her 5th grade students in a "Claims, Evidence, Reasoning" protocol. Using what she calls "the trifecta of argument," she helps her students make claims and support their claims with evidence and reasoning.

This elementary routine encourages students to make sense of a math problem by listing what they both notice and wonder about the given information.

Elementary math specialist Kristin Gray helps her 2nd graders understand different subtraction strategies by talking through their thought processes.

Second grade teacher Tita Ugalde explains how giving 'brain breaks' lets her students shake out their extra energy and refuel in between lessons.

A former dancer uses her choreography skills to plan her students' movement through the classroom.

See how one preschool teacher helps her students learn how to count collections of objects.

A math specialist shares how she uses dots to allow students to see the connections between mathematical operations, like addition and multiplication.

What you say about the coronavirus depends on the child's developmental stage. Here are examples of the best age-appropriate language for discussing the pandemic.

Students in cities around the country are organizing petition drives that are generating thousands of signatures to demand that their schools offer anti-racist curricula and instruction.

In this week's episode of SA Money Report we examine how racial discrimination impacts the property market and interrupts economic growth.

In this week's episode of SA Money Report, we delve into Eskom's latest plunge into darkness.

In this week's episode of SA Money Report, we explore government's plans to allow private operators to use Transnet’s rail network, which is expected to instantly move some 58 million tons of cargo off South Africa’s battered roads.

In this week's episode of SA Money Report, Fin24s sustainability expert Lameez Omarjee provides a seismic blast of information, helping us to understand what's Shell's plans are for waters off the Eastern Cape, and why people are so furious about it.

In this week's episode of SA Money Report, Fin24 investigative reporter Jan Cronje delves into Public Protector Busisiwe Mkhwebane's curious investigation of the country's push for more renewable energy.

This week, SA Money Report drills down into the 'game changing' oil find off the coast of Namibia, and how this factors into the recent court battles over seismic blasting on the SA West Coast.

This week, SA Money Report unpacks how a series of emails by former Steinhoff CEO Markus Jooste is an integral part of proving a case against one of his allies in the UK

This week, SA Money Report journeys in the heart of war, and comes back with a tale about Naspers' exposure in Russia, and its ties to VKontakte, whose 38-year-old CEO Vladimir Kiriyenko was sanctioned by the US.

This week, SA Money Report focuses on the controversy around the appointment of Arrie Rautenbach as Absa CEO.

This week Carin Smith explains why Kulula.com operator Comair grounded its planes, and what it will take to get them back in the air.