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Biomimic strategies for modulating the interaction between particle adjuvants and antigen-presenting cells

Biomater. Sci., 2020, 8,2366-2375
DOI: 10.1039/C9BM02098E, Review Article
Jie Wu, Guanghui Ma
The design strategies of particle adjuvants by mimicking natural pathogens to strengthen their interaction with antigen-presenting cells.
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Super-assembled core/shell fibrous frameworks with dual growth factors for in situ cementum–ligament–bone complex regeneration

Biomater. Sci., 2020, 8,2459-2471
DOI: 10.1039/D0BM00102C, Paper
Tian Ding, Jianhua Li, Xingshuang Zhang, Lingqian Du, Yang Li, Dengwang Li, Biao Kong, Shaohua Ge
In this work, a super-assembled framework (SAF) was fabricated to achieve sequential delivery of bFGF and BMP-2 for in situ cementum–ligament–bone complex regeneration.
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Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper–tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer

Biomater. Sci., 2020, 8,2420-2433
DOI: 10.1039/C9BM01905G, Paper
Vera L. Silva, Abdessamad Kaassis, Ashkan Dehsorkhi, Cédrik-Roland Koffi, Maja Severic, Moustafa Abdelhamid, Duuamene Nyimanu, Christopher J. Morris, Wafa’ T. Al-Jamal
Cu(TPZ)2 complex as a promising hypoxia selective cytotoxin in prostate cancer.
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Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

Biomater. Sci., 2020, 8,2627-2637
DOI: 10.1039/D0BM00041H, Paper
Hwan D. Kim, Jungha Park, Sivashanmugam Amirthalingam, R. Jayakumar, Nathaniel S. Hwang
VEGF-overexpressing human tonsil-derived stem cells (VEGF-hTMSCs) and a whitlockite microenvironment induce vascularized bone tissue formation in biodegradable polymeric scaffolds.
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A medical adhesive used in a wet environment by blending tannic acid and silk fibroin

Biomater. Sci., 2020, 8,2694-2701
DOI: 10.1039/D0BM00322K, Paper
Xijie Gao, Qiyuan Dai, Longtao Yao, Hua Dong, Qingtao Li, Xiaodong Cao
A medical adhesive called TASK based on polyphenol-gel systems was developed and showed wet-adhesive, stretchable, self-healing and restorable properties.
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Spatial immobilization of endogenous growth factors to control vascularization in bone tissue engineering

Biomater. Sci., 2020, 8,2577-2589
DOI: 10.1039/D0BM00087F, Paper
Marta R. Casanova, Catarina Oliveira, Emanuel M. Fernandes, Rui L. Reis, Tiago H. Silva, Albino Martins, Nuno M. Neves
An engineered biofunctional system comprises endogenous BMP-2 and VEGF bound in a parallel pattern. It successfully enabled obtaining the spatial osteogenic and angiogenic differentiation of human hBM-MSCs under basal culture conditions.
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A thermo-responsive, self-assembling biointerface for on demand release of surface-immobilised proteins

Biomater. Sci., 2020, 8,2673-2681
DOI: 10.1039/C9BM01957J, Paper
Angela Saccardo, Mikhail Soloviev, Enrico Ferrari
Engineering of the neuronal SNARE proteins yields chimeric bio-materials that reversibly assemble and disassemble at set temperatures.
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The electrospinning of a thermo-responsive polymer with peptide conjugates for phenotype support and extracellular matrix production of therapeutically relevant mammalian cells

Biomater. Sci., 2020, 8,2611-2626
DOI: 10.1039/C9BM01965K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
F. A. A. Ruiter, L. E. Sidney, K. L. Kiick, J. I. Segal, C. Alexander, F. R. A. J. Rose
The fabrication and application of a biocompatible peptide conjugated thermo-responsive fibrous scaffolds for cellular phenotype support and enzymatic-free passaging of mammalian cells.
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Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

Biomater. Sci., 2020, 8,2394-2397
DOI: 10.1039/C9BM02019E, Communication
Peng-Hao Hsu, Carina Arboleda, Alexandra Stubelius, Ling-Wei Li, Jason Olejniczak, Adah Almutairi
Nanoparticles formulated from fast-degrading oxidation-responsive polycaprolactone are responsive to 50 μM of H2O2.
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Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications

Biomater. Sci., 2020, 8,2434-2446
DOI: 10.1039/D0BM00182A, Paper
Jann Harberts, Undine Haferkamp, Stefanie Haugg, Cornelius Fendler, Dennis Lam, Robert Zierold, Ole Pless, Robert H. Blick
Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
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A multifunctional metal-biopolymer coordinated double network hydrogel combined with multi-stimulus responsiveness, self-healing, shape memory and antibacterial properties

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00425A, Paper
Kun Yan, Feiyang Xu, Chunyu Wang, Yingying Li, Yuanli Chen, Xiufang Li, Zhentan Lu, Dong Wang
A universal, straightforward macroscale assembly technology has been presented for fabrication of polysaccharide-based multifunctional DN gels based on metal coordination chemistry.
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Modulating neutrophil extracellular traps for wound healing

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00355G, Paper
Tejinder Kaur, Shweta Dumoga, Veena Koul, Neetu Singh
An alginate-GelMa scaffold for modulating neutrophil extracellular traps using a PAD4 inhibitor could be a novel therapeutic approach for wound healing.
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A transport system based on a quantum dot-modified nanotracer is genetically and developmentally stable in pregnant mice

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00311E, Paper
Open Access
Hye Jin Kim, Ji Sun Park, Se Won Yi, Minyeon Go, Hye-Ryun Kim, Su Jin Lee, Jong Min Park, Dong Hyun Cha, Sung Han Shim, Keun-Hong Park
The use of nanoscale materials (NMs) could cause problems such as cytotoxicity, genomic aberration, but the impacts of NM exposure during pregnancy remain uncharacterized in the context of clinical applications.
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Surface engineering of titanium alloy using metal-polyphenol network coating with magnesium ions for improved osseointegration

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00566E, Paper
Sangmin Lee, Yun-Young Chang, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Yang-Hun Jung, Jeong-Ho Yun, Heungsoo Shin
Although titanium-based implants are widely used in orthopedic and dental clinics, improved osseointegration at the bone–implant interface is still required.
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Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00556H, Paper
Ana Baião, Flávia Sousa, Ana Oliveira, Carla Oliveira, Bruno Sarmento
Colorectal cancer (CRC) is one of the most incident and mortal cancers in the world, mainly due to its metastatic and metabolic ability. CD44 receptor isoform containing exon 6 (CD44v6)...
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Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide

Toxicol. Res., 2019, 8,850-861
DOI: 10.1039/C9TX00067D, Paper
Wei Huang, Chuanxin Liu, Lijuan Xie, Yuming Wang, Yanyan Xu, Yubo Li
Integrated network pharmacology and targeted metabolomics to reveal the nephrotoxicity mechanism of triptolide.
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miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway

Toxicol. Res., 2019, 8,875-884
DOI: 10.1039/C9TX00100J, Paper
Xuan-Ying Chen, Wei-Lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-He Li, Jian-Ping Xiong
Bevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.
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Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489

Toxicol. Res., 2019, 8,1057-1058
DOI: 10.1039/C9TX00158A, Comment
Michael E. Mullins, Mark C. Yarema, Marco L. A. Sivilotti, Margaret Thompson, D. Adam Algren, Michael C. Beuhler, Christopher P. Holstege
We point out an acetylcysteine protocol that a previous article (D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489–498) overlooked.
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Characteristic synergistic cytotoxic effects toward cells in graphene oxide dressing with cadmium and copper ions

Toxicol. Res., 2019, 8,908-917
DOI: 10.1039/C9TX00146H, Paper
Yiyang Dong, Yulin Chang, Haidi Gao, Victoria Arantza León Anchustegui, Qiang Yu, Haifang Wang, Jia-Hui Liu, Shihui Wang
Cadmium ions exerted synergistic toxic effects with graphene oxide on Hela cells.
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Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress

Toxicol. Res., 2019, 8,918-927
DOI: 10.1039/C9TX00186G, Paper
Li Pang, Ping Deng, Yi-dan Liang, Jing-yu Qian, Li-Chuan Wu, Ling-ling Yang, Zheng-ping Yu, Zhou Zhou
α-Lipoic acid antagonizes paraquat toxicity.
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Environmental distribution of the neurotoxin L-BMAA in Paenibacillus species

Toxicol. Res., 2019, 8,781-783
DOI: 10.1039/C9TX00203K, Viewpoint
Peter B. Nunn, Geoffrey A. Codd
The neurotoxic amino acid, 3-N-methyl-2,3-diaminopropanoic acid (BMAA), known in plants of the genus Cycas and in aquatic cyanobacteria and other organisms, is a component of antibiotic peptides in two species of Paenibacillus.
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Reply to the ‘Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use”’ by M. E. Mullins, M. C. Yarema, M. L. A. Sivilotti, M. Thompson, D. A. Algren, M. C. Beuhler and C. P. Holstege, Toxicol. Res., 2019, 8, DOI: 10.1039/C9T

Toxicol. Res., 2019, 8,1059-1059
DOI: 10.1039/C9TX00216B, Comment
Open Access
D. Nicholas Bateman, James W. Dear
Mullins et al. made a comment on our article (DOI: 10.1039/C9TX00002J) stating they noticed the omission of the one-bag, standard concentration protocol which is shared by several centers in North America when we discussed IV acetylcysteine protocols.
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Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats

Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
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Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials

Toxicol. Res., 2019, 8,979-987
DOI: 10.1039/C9TX00227H, Paper
Saavia Alice Naame, Decheng Li, Ruixue Huang
Diabetes mellitus is of major public health concerns; its incidence is continuously increasing.
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Methanol extract of Iphiona aucheri ameliorates CCl4 induced hepatic injuries by regulation of genes in rats

Toxicol. Res., 2019, 8,815-832
DOI: 10.1039/C9TX00157C, Paper
Jawaid Ahmed Zai, Muhammad Rashid Khan, Zaib un Nisa Mughal, Riffat Batool, Irum Naz, Sonia Maryam, Zartash Zahra
Alteration in expression of ER stress associated genes, inflammatory genes and antioxidant biochemical induced with CCl4 in liver of rats were restored towards the control rats by co-administration of methanol extract of Iphiona aucheri to rats.
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Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae

Toxicol. Res., 2019, 8,1009-1015
DOI: 10.1039/C9TX00215D, Paper
S. J. Sudharshan, Raghavendra Tirupathi, Madhu Dyavaiah
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
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Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines

Toxicol. Res., 2019, 8,1016-1027
DOI: 10.1039/C9TX00179D, Paper
Open Access
Lars Leibrock, Sandra Wagener, Ajay Vikram Singh, Peter Laux, Andreas Luch
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
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Application of the direct peptide reactivity assay (DPRA) to inorganic compounds: a case study of platinum species

Toxicol. Res., 2019, 8,802-814
DOI: 10.1039/C9TX00242A, Paper
Jocelyn D. C. Hemming, Mark Hosford, Martin M. Shafer
The in chemico Direct Peptide Reactivity Assay (DPRA) was developed as a non-animal, relatively high throughput, screening tool for skin sensitization potential.
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Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae

Toxicol. Res., 2019, 8,1035-1041
DOI: 10.1039/C9TX00139E, Paper
Abhishek Raj, Vasanthi Nachiappan
BQ exposure inhibited cell growth, increased the ROS-mediated apoptosis, and altered the phospholipids that resulted in membrane proliferation.
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India's credit profile to face further pressure due to Covid-19: Moody's

Moody's rating on the government of India is Baa2 with negative outlook




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Nomura predicts Indian GDP to contract by 5.2% in FY21, more rate cuts

Analysts at Goldman Sachs expect the Indian economy to contract 0.4 per cent in FY21 versus consensus median 2.7 per cent




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Export contraction in April could surpass March's steep 25-year decline

Major forex earning sectors cite lack of labour, funds and key supplies




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Ministry of Defence inks Rs 1,200 cr contract to boost electronics sector

The deal, Modernisation of Air Field Infrastructure Phase 2 (MAFI-2), follows from an earlier contract, called MAFI-1, which TPSED won in 2011 to upgrade 30 IAF airfields.




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Covid-19: Chhattisgarh CM asks Rs 30,000 cr package for state from PM

CM Baghel has urged the prime minister to release Rs 10, 000 crore immediately, out of the total amount.




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Lockdown: Closure of commercial activity has hit Bihar, UP villages

But most respondents to a survey conducted by Smart Power India said they saw a positive change in social hygiene behaviour during lockdown




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UP steps up efforts to reach out to 74 global firms looking to exit China

European Business Group hails covid-19-induced labour reforms in UP; state goes online to connect with five nations and companies like Microsoft, Dow and IBM and showcase investment opportunities




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Release of graphene-related materials from epoxy-based composites: characterization, quantification and hazard assessment in vitro

Nanoscale, 2020, Advance Article
DOI: 10.1039/C9NR10245K, Paper
Open Access
Woranan Netkueakul, Daria Korejwo, Tobias Hammer, Savvina Chortarea, Patrick Rupper, Oliver Braun, Michel Calame, Barbara Rothen-Rutishauser, Tina Buerki-Thurnherr, Peter Wick, Jing Wang
We measured the cytotoxicity of pristine GRMs and the abraded particles from epoxy/GRM composites, which indicated low risks to consumers of such composites.
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Conductive-bridging random-access memories for emerging neuromorphic computing

Nanoscale, 2020, Advance Article
DOI: 10.1039/D0NR01671C, Review Article
Jun-Hwe Cha, Sang Yoon Yang, Jungyeop Oh, Shinhyun Choi, Sangsu Park, Byung Chul Jang, Wonbae Ahn, Sung-Yool Choi
This review covers CBRAM-based artificial synapses and neurons towards emerging computing applications from the operation principles of CBRAMs to state-of-the-art experimental demonstrations.
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Hybrid Phase 1T/2H-MoS2 with Controllable 1T Concentration and Its Promoted Hydrogen Evolution Reaction

Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR02525A, Paper
Yuxiao Zhang, Yasutaka Kuwahara, Kohsuke Mori, Catherine Louis, Hiromi Yamashita
MoS2 has been investigated as a low-cost alternative to Pt in electrochemical hydrogen evolution reaction. One of the promising method to further activate MoS2 is phase engineering. MoS2 generally exhibit...
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Facile fabrication of sponge-like porous micropillar arrays via an electrochemical process

Nanoscale, 2020, Advance Article
DOI: 10.1039/D0NR01518K, Paper
Deyin Zheng, Chang-Hwan Choi, Xin Zhao, Guangyi Sun
Highly ordered and aligned pore structures perpendicular to the exposed surfaces are achieved on the surfaces of 3D Si microstructures.
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Proton exchange membrane with plasmon-active surface for enhancement of fuel cell effectivity

Nanoscale, 2020, Accepted Manuscript
DOI: 10.1039/D0NR00295J, Paper
Roman Elashnikov, Kristina Zahorjanova, Elena Miliutina, Zdenka Kolska, Miroslav Cieslar, Václav Švorčík, Oleksiy Lyutakov
The action of fuel cells with proton-exchanged membrane (PEM) requires the implementation of hydrogen oxidation reaction (HOR) and oxygen reduction reaction (ORR) on the opposite sides of PEM. Recently, based...
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Correction: Anomalous polarization dependence of Raman scattering and crystallographic orientation of black phosphorus

Nanoscale, 2020, Advance Article
DOI: 10.1039/D0NR90098B, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jungcheol Kim, Jae-Ung Lee, Jinhwan Lee, Hyo Ju Park, Zonghoon Lee, Changgu Lee, Hyeonsik Cheong
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Self-responsive co-delivery system for remodeling tumor intracellular microenvironment to promote PTEN-mediated anti-tumor therapy

Nanoscale, 2020, 12,9392-9403
DOI: 10.1039/D0NR00563K, Paper
Yifei Wang, Ruiting Wang, Sixuan Wu, Jingyi An, Yan Liang, Lin Hou, Zhenzhong Zhang
Delivering the pten gene into tumor cells to reacquire PTEN functionality is considered to be an attractive method for cancer treatment.
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Interfacial synergy between dispersed Ru sub-nanoclusters and porous NiFe layered double hydroxide on accelerated overall water splitting by intermediate modulation

Nanoscale, 2020, 12,9669-9679
DOI: 10.1039/D0NR01491E, Paper
Yao Wang, Peng Zheng, Mingxuan Li, Yunrui Li, Xin Zhang, Juan Chen, Xu Fang, Yujie Liu, Xiaolin Yuan, Xiaoping Dai, Hai Wang
Benefitting from the desired potential-induced interfacial synergy, the Ru–NiFe LDH interfaces will convert to RuO2–NiFe(OOH)x interfaces to meet the requirements of an anode and cathode reaction, respectively.
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Facile synthesis of core–shell structured Si@graphene balls as a high-performance anode for lithium-ion batteries

Nanoscale, 2020, 12,9616-9627
DOI: 10.1039/D0NR01346C, Paper
Anif Jamaluddin, Bharath Umesh, Fuming Chen, Jeng-Kuei Chang, Ching-Yuan Su
Encapsulating silicon (Si) nanoparticles with graphene nanosheets in a microspherical structure is proposed to increase electrical conductivity and solve stability issues when using Si as an anode material in lithium-ion batteries (LIBs).
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The CpG molecular structure controls the mineralization of calcium phosphate nanoparticles and their immunostimulation efficacy as vaccine adjuvants

Nanoscale, 2020, 12,9603-9615
DOI: 10.1039/C9NR09782A, Paper
Razieh Khalifehzadeh, Hamed Arami
Effects of the CpG molecular structure on the mineralization and immunostimulation efficacy of calcium phosphate nanoparticles are explored for vaccine delivery applications.
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Oxygen vacancy-rich amorphous porous NiFe(OH)x derived from Ni(OH)x/Prussian blue as highly efficient oxygen evolution electrocatalysts

Nanoscale, 2020, 12,9557-9568
DOI: 10.1039/D0NR00607F, Paper
Shuang Wang, Xingbo Ge, Chao Lv, Cun Hu, Hongtai Guan, Jing Wu, Zhengnan Wang, Xianhui Yang, Yan Shi, Jiangfeng Song, Zhi Zhang, Akira Watanabe, Jinguang Cai
Oxygen vacancy-rich amorphous porous NiFe(OH)x on carbon paper is prepared through a two-step electrochemical depostion of Prussian blue nanocrystal layer and Ni(OH)x layer followed by an alkaline etching process for efficient OER catalysis.
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Enhanced motility in a binary mixture of active nano/microswimmers

Nanoscale, 2020, 12,9717-9726
DOI: 10.1039/D0NR01765E, Paper
Debajyoti Debnath, Pulak Kumar Ghosh, Vyacheslav R. Misko, Yunyun Li, Fabio Marchesoni, Franco Nori
The proposed mechanism of motility transfer from more active to less active species allows enhancing the motility of active nano-/microswimmers, e.g., Janus particles, as agents of chemical reactions, or weak sperm cells, for better fertilization.
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Enhanced type I photoreaction of indocyanine green via electrostatic-force-driven aggregation

Nanoscale, 2020, 12,9517-9523
DOI: 10.1039/D0NR01208D, Paper
Huizhen Fan, Yu Fan, Wenna Du, Rui Cai, Xinshuang Gao, Xinfeng Liu, Hao Wang, Lei Wang, Xiaochun Wu
ICG forms aggregates in positively charged mesoporous silica, which show an enhanced type I photoreaction pathway.
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Binding patterns and dynamics of double-stranded DNA on the phosphorene surface

Nanoscale, 2020, 12,9430-9439
DOI: 10.1039/D0NR01403F, Paper
Baoyu Li, Xuejie Xie, Guangxin Duan, Serena H. Chen, Xuan-Yu Meng, Ruhong Zhou
Molecular dynamics simulations and electrophoresis experiments show that dsDNA can form a stable binding on the phosphorene surface through the terminal base pairs and adopt an upright orientation regardless of its initial configurations.
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