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Near infrared fluorogen and fluorescent activating proteins for in vivo imaging and live-cell biosensing

Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags. An “optical window,” farther red than most autofluorescence sources and in a region of low hemoglobin and water absorbance, lies between 650 and 900 nm. This valley of relative optical clarity is an attractive target for fluorescence-based studies within tissues, intact organs, and living organisms. Novel fluorescent tags were developed herein, based upon a genetically targeted fluorogen activating protein and cognate fluorogenic dye that yields emission with a peak at 733 nm exclusively when complexed as a “fluoromodule”. This tool improves substantially over previously described far-red/NIR fluorescent proteins in terms of brightness, wavelength, and flexibility by leveraging the flexibility of synthetic chemistry to produce novel chromophores.




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Pharmaceutical composition

The invention relates to a solid pharmaceutical composition comprising solid amorphous fulvestrant, said composition being formulated in combination with a solubilizing composition. The invention also relates to a method for preparing said composition and a kit including the composition.




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Agrochemical formulations of microcapsules for compounds containing carboxamide groups

The present invention is directed towards microcapsules, uses and methods of microencapsulation with improved properties regarding agglomeration, bleeding and control of the reaction. The invention is especially suitable for chemical compounds with at least one carboxamide group, preferably for microencapsulation of those compounds wherein the carbonyl group is attached to a nitrogen atom or nitrogenated heterocycle and wherein the microencapsulation reaction may be too vigorous. The microcapsules are characterized by a mixed glycoluril-polyurea polymer wall, wherein the polyurea groups come from a urea-formaldehyde resin and not from isocyanate monomers or prepolymers. The process of making such microcapsules a dispersant in the oil phase of the type of block copolymer of vinylpyrrolidone/vinylalkene and/or vinylpyrrolidone/vinyl acetate and the microencapsulation reaction may be carried out without the presence of any polyamine/polyol acting as a catalyst.




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Plant growth regulator compositions, methods of preparation and use thereof

Suspension concentrate compositions are disclosed for delivering S-(+)-Abscisic acid either alone or in combination with a second plant growth regulator to crop seed prior to planting as well as for foliar, soil drench, in-furrow and sprench (foliar spray and soil drench) applications are disclosed. The compositions, when properly combined in an aqueous carrier and processed through wet milling to achieve the desired particle size, will result in stable compositions that are desirable for treating crop seeds.




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Tobacco axillary bud inhibitor and tobacco axillary bud-inhibiting method

An inhibitor for tobacco axillary bud growth, the inhibitor containing one or more cell division inhibitors selected from pyridine-based compounds and benzamide-based compounds. This inhibitor may further include an aliphatic alcohol having 6 to 20 carbon atoms in combination with the one or more cell division inhibitors.




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Penoxsulam as a turfgrass, vineyard and orchard floor herbicide

Penoxsulam, 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]-triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide, is useful in controlling broadleaf weeds and sedges in turfgrass and in vine and orchard floors.




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Pyridazinone compound and herbicide and noxious arthropod controlling agent comprising it

The present invention relates to a pyridazinone compound of the formula (I): wherein R1 represents hydrogen, a C1-6 alkyl group, and the like, R2 represents halogen, a cyano group, a nitro group, a C1-6 alkoxy group, and the like, G represents hydrogen, and the like, Z represents halogen, a cyano group, a nitro group, a C1-6 alkyl group, and the like, and n represents an integer of 1-5 useful as an active ingredient in a herbicide and a noxious arthropod controlling agent.




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Safening composition of 6-(trisubstituded phenyl)-4-amino-2-pyridinecarboxylate herbicides and cloquintocet-mexyl for cereal crops

Herbicidal injury caused by 6-trisubstituted phenyl)-4-amino-2-pyridinecarboxylates in wheat and barley is reduced with the use of low rates of cloquintocet.




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Synergistic combination to improve grape color and to alter sensory characteristics of wine

This invention describes the use of S-abscisic acid (S-ABA) and ethylene producing-agents such as ethephon to synergistically improve red color in grapes and to alter the sensory characteristics of wine.




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Methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models

Methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models can be used for determining mechanical property parameters of a sample. An exemplary method includes applying acoustic energy to a sample to apply a mechanical force to the sample, measuring a response by the sample during the application of the acoustic energy, measuring a recovery response of the sample following cessation of the application of the acoustic energy, and determining a value for at least one additional mechanical property parameter of the sample based on the response measured during application of the acoustic energy and the recovery response measured following cessation of the application of acoustic energy.




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Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through metabolic pathways of interest.




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Abnormality determination apparatus for angle detection device

The abnormality determination apparatus, which is for determining presence of an abnormality in an angle detection device configured to output an output signal having a value equivalent to a rotational angle of a rotating body, includes a smoothing device configured to receive the output signal of the angle detection device to smooth a dependent variable of a function whose independent variable is the rotational angle equivalent value, and a parameter calculation device for calculating an abnormality determination parameter based on the dependent variable smoothed by the smoothing device. The function is such that an integrated value of the rotational angle equivalent value over a predetermined time section is always positive or negative, and is configured to vary the dependent variable continuously in accordance with continuous variation of the independent variable in at least a part of the predetermined time section.




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Subject information acquisition apparatus and subject information acquisition method

A subject information acquisition apparatus includes a first holding member that holds a subject, a probe that receives an elastic wave from the subject through the first holding member, a first holding member deformation amount measuring unit that measures an amount of deformation of the first holding member, and a processing unit that creates an area for generating subject information by using the amount of deformation of the first holding member and position information of the first holding member deformation amount measuring unit and generates an information value of subject information corresponding to the area for generating subject information by using a signal outputted by the probe.




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Systems and methods for providing component characteristics

Systems and methods are disclosed for providing a signal indicative of one or more types of individual measurable device characteristic/s that are unique to a given electronic device by providing a signal indicative of the measurable and unique device characteristic/s in a passive manner from the electronic device. The signal indicative of one or more types of individual measurable device characteristic/s may be so provided without requiring operational power to be applied to any active electronic circuitry of the device, and without requiring any power to be generated by the device.




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Estimating loss rates of links in smart grids

A method for estimating loss rates of links in a smart grid includes identifying end-to-end passage rates from a source to each of multiple receiver and/or load meters in a smart grid, and estimating a loss in at least one link of the grid by identifying the sparsest solution of link loss rates that matches the end-to-end passage rates. Also, a system includes a memory, a processor coupled thereto, and software modules executing on the processor, including a monitoring module for monitoring power flow of receiver and/or load meters in a smart grid, a measurement collector module for collecting measurements to compute end-to-end passage rates from a source to each receiver and/or load meter, and a processing module for estimating a loss in a link of the grid by identifying the sparsest solution of link loss rates matching the end-to-end passage rates.




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Electronic apparatus

When discharge power calculated based on a current value detected by a current detector is smaller than expected maximum power, which is the maximum power expected in an actual operation, a discharge efficiency at the expected maximum power is set as a discharge efficiency used for remaining capacity calculation. This ensures that a remaining capacity based on power required for a photographing operation can be detected.




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Voltage-driven intelligent characterization bench for semiconductor

A system for testing a plurality of transistors on a wafer having a storage device or personal computer connected via a bus to a plurality of drivers. Each of the voltage drivers having a microcontroller adapted to receive test parameters and provide test data from a plurality of voltage drivers. By utilizing a bus structure, the personal computer can look on one bus for flags indicating test data is available from a driver and receive the data. In addition a bus may be used to provide test parameters to the drivers. In this manner, multiple drivers may be run at the same time incorporating multiple tests. When data is available it is transferred to the personal computer, for providing test parameters to a plurality of drivers, and connected via a second bus for receiving test results from the plurality of drivers.




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Absolute position measurement apparatus and method

An absolute position measurement apparatus measures an absolute position of an object to be measured using a first light source and a second light source which has coherency lower than that of the first light source. The absolute position measurement apparatus includes a measurement part which measures a point where phases of interference signals from the first and the second light sources coincide with each other or a point where an intensity of the interference signal from the second light source is maximized, an origin defining part which defines the point measured by the measurement part as an origin position, a phase storing part which stores the phase of the interference signal from the first light source at the origin position, an origin redefining part which redefines the origin position, and a position calculating part which calculates the absolute position of the object to be measured.




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Promotion of performance parameters in distributed data processing environment

A method of performance monitoring in a data processing environment is provided. The data processing environment includes multiple systems, each of which has resources. Each resource relates to a resource type, wherein at least one performance parameter is defined for each resource type. The method includes determining a value of the at least one performance parameter for at least one resource, aggregating performance parameter values and related resources of a resource type, creating for at least a part of the resources a next predefined aggregation level which includes all resources relating to the resource type and associating all performance parameter values to this aggregation level, and repeating the creating for at least a part of the resources a next predefined aggregation level until a predefined target aggregation level of the data processing environment has been reached.




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Method and apparatus for adaptive display calibration

A calibration system may be provided for calibrating displays in electronic devices during manufacturing. The calibration system may include calibration computing equipment and a test chamber having a light sensor. The calibration computing equipment may be configured to operate the light sensor and the display to gather display performance data. The calibration computing equipment may extract display performance statistics from the display performance data and adaptively select and perform display calibration sequences using the display performance statistics. The calibration computing equipment may be configured to determine whether or not to perform display calibration and whether or not to gather additional display performance data based on display performance statistics extracted during a preceding display calibration sequence. The calibration computing equipment may be configured to iteratively and adaptively perform display calibration sequences until a display is successfully calibrated.




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Methods and processes for non-invasive assessment of genetic variations

Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.




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Hardcoat composition

A hard coating composition including at least the following components (A) to (E): Component (A): A poly(methyl)glycidyl ether compound derived from a chain aliphatic polyol or a chain aliphatic polyether polyol, which may or may not contain a hydroxyl group, Component (B): A silsesquioxane compound containing a cationic polymerizable group, Component (C): A silicate compound, Component (D): A silane compound containing a cationic polymerizable group, or a partial condensed compound thereof, or a mixture thereof, and Component (E): A cationic photopolymerization initiator, wherein the composition includes 5 to 40 parts by weight of the component (A), 60 to 95 parts by weight of the total of the components (B), (C) and (D), and 0.1 to 10 parts by weight of the component (E), each based on 100 parts by weight of the total of the components (A) to (D).




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Hard coat film, polarizer and image display device

Provided is a hard coat film having high hardness and excellent restorability in view of the above circumstances. A hard coat film comprising: a light-transmitting substrate; and a hard coat layer, the hard coat layer comprising a cured product of a composition for a hard coat layer, the composition including an isocyanuric skeleton-containing urethane(meth)acrylate.




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Pressure-sensitive adhesive for polarizing plates, pressure-sensitive adhesive sheet, polarizing plate with pressure-sensitive adhesive and production process for the same and optical film and production process for the same

Provided is a pressure-sensitive adhesive for polarizing plates which can adhere a polarizing plate on a liquid crystal cell with good adhesion durability and has the characteristic that a liquid crystal display device obtained therefrom is less liable to cause light leakage even under the environment of high temperature and high humidity and which makes it possible remove the polarizing plate. The pressure-sensitive adhesive for polarizing plates is prepared by irradiating a pressure-sensitive adhesive material comprising (A) an acrylic base polymer having a weight average molecular weight of 1,000,000 or more comprising a monomer having a hydroxyl group in a monomer composition ratio of 10 mass % or less, (B) an acrylic base polymer having a weight average molecular weight of 1,000,000 or more comprising a monomer having a carboxyl group in a monomer composition ratio of 10 mass % or less and (C) an active energy beam-curable compound with an active energy beam, wherein a mass ratio of the component (A) to the component (B) is 100:1 to 100:50, and a storage elastic modulus (G') at 23° C. is 0.3 MPa or more.




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Polarizing plate, method for producing same and image display device comprising same

The present invention relates to a polarizing plate, a method for producing the same, and an image display device comprising the same, and more specifically to a polarizing plate which is characterized by comprising: a) a polarizer, b) a hardening resin layer which is provided on at least one side of the polarizer and formed from a photocurable composition comprising: 4 to 95 parts by weight of (A) a photocurable acrylic polymer, 4 to 95 parts by weight of (B) a poly-functional acrylic monomer, and 1 to 20 parts by weight of (C) a photo-polymerization initiator, based on 100 parts by weight of the photocurable composition, a method for manufacturing the same, and an image display device using the same. According to the present invention, a polarizing plate, which exhibits excellent polarizing properties and durability, has high surface hardness, and may be formed as a thin plate, may be provided.




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Flame retardant polymer compositions

In one aspect, the invention relates to crosslinkable, flame retardant polymer compositions are provided comprising a polyamide or polyester; a flame retardant system; a crosslinking agent; and a flame retardant system coagent. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.




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Solid state deformation processing of crosslinked high molecular weight polymeric materials

Solid-state deformation processing of crosslinked high molecular weight polymers such as UHMWPE, for example by extrusion below the melt transition, produces materials with a combination of high tensile strength and high oxidative stability. The materials are especially suitable for use as bearing components in artificial hip and other implants. Treated bulk materials are anisotropic, with enhanced strength oriented along the axial direction. The material is oxidatively stable even after four weeks of accelerated aging in a pressure vessel containing five atmospheres of oxygen (ASTM F2003). Because of its oxidative stability, the deformation processed material is a suitable candidate for air-permeable packaging and gas sterilization, which has thus far been reserved for remelted crosslinked UHMWPE.




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Photo-curable transparent resin composition

Provided is a photo-curable transparent resin in which an oxetane monomer for promotion of photo-curing, control of viscosity, and improvement of physical properties is mixed with a photo-cationically polymerizable cyclo-aliphatic epoxy group-containing oligosiloxane resin prepared by a sol-gel reaction. The photo-cationically polymerizable photo-curable transparent resin added with the oxetane monomer provides a cured product having high curing density and retaining excellent mechanical properties, thermal-mechanical properties, and electrical properties.




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Frame sealant, process for preparing same and use thereof

Embodiments of the invention provide a frame sealant and a process for preparing the same, as well as use thereof. The frame sealant comprises, by weight, 25%-30% acrylic resins, 25%-30% oligomers as shown in Structure Formula I, 10%-15% organic powders, 10%-15% inorganic powders, 0%-10% epoxy resins, 10%-15% heat curing agents, 0.1%-1% photoinitiators, and 0.1%-1% coupling agents, wherein, in Structure Formula I, n indicates an integer of 10-20.




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Acrylic resin composition, method of manufacturing the same, and architectural material, fashion accessory, and optical material formed using the same

The present invention provides an acrylic resin composition containing a polycrystal of colloidal particles of silicon oxide in an acrylic resin that is formed by curing an acrylic monomer liquid at room temperature and/or an acrylic oligomer liquid at room temperature, wherein a mean distance between the colloidal particles in the polycrystal is 140 to 330 nm. The size of the single crystal that constitutes the polycrystal can be controlled by adjusting the content of silicon oxide and/or the additive amount of impurities. An architectural material, a fashion accessory, and an optical material are provided that are formed by using the acrylic resin composition.




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Crosslinked compositions, method of making them, and articles comprising them

The present invention relates to a composition comprising at least one propylene-based polymer comprising less than 0.1 wt. % diene-derived units based on the weight of the propylene-based polymer, an antioxidant, and a co-agent. The composition can be at least partially crosslinked by electron beam irradiation in a dose of less than 200 kGy, and may be further formed into articles including fibers, yarns, films, and nonwovens, among others. The propylene-based polymer of the present invention may be a polymer blend formed by forming a reactor blend from of two or more polymers produced in two or more reactors.




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Apparatus and method for separating and concentrating fluids containing multiple components

An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.




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Apparatus and method for filtering a material from a liquid medium

An apparatus for filtering a material from a medium includes a first housing having a wall with a plurality of openings formed therein, a conveyor disposed in the housing for moving the material therealong, and a conduit line communicating with the interior of the housing for supplying the medium to the apparatus. At least one of the first housing and the conveyor rotate relative to a central axis to direct the medium toward the wall so as to separate the material from the medium. A method for filtering a material from a medium includes supplying the medium to a first housing, spinning the medium within the housing, passing the medium through a wall of the housing to separate the material from the medium, moving the material along the housing, introducing a fluid into the material within the housing, and washing the material using the fluid.




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Centrifugal separator and swing rotor for centrifugal separator

A centrifugal separator comprising: a driving portion; and a swing rotor including, a rotor body, a through-hole passing through the rotor body, pin insert grooves which are provided parallel to the through-hole so as to oppose each other and only partially penetrate the rotor body, and a bucket including, a bucket body that has a contact surface which is configured to contact the rotor body during centrifugal separation, and a cap assembly that seals the bucket body and has a swing shaft extending in a direction perpendicular to an longitudinal direction of the bucket, wherein the swing rotor is rotated when the bucket is inserted into the through-hole, to swing the bucket, and the swing shaft can be moved in the longitudinal direction of the bucket relative to the bucket body and rotated about a longitudinal central axis of the bucket.




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Multiple modular in-line rotary separator bundle

An apparatus and method for separating a mixed flow into a higher-density component and a lower-density component is provided. The apparatus may include a casing having a fluid entrance assembly, a fluid outlet assembly, and a drain. The apparatus may also include a plurality of rotary separators disposed in the casing. Each of the plurality of rotary separators may include an inlet in fluid communication with the fluid entrance assembly, a discharge in fluid communication with the fluid outlet assembly, and an outlet passage in communication with the drain. At least one of the plurality of rotary separators may include a stationary housing and a rotatable drum disposed at least partially in the stationary housing. The stationary housing may define a slot at least partially providing the outlet passage, and the rotatable drum may be configured to centrifuge the mixed flow.




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Separator comprising a direct drive with an elastically supported motor

A separator includes a centrifugal drum having a vertical axis of rotation and a feed line for material to be centrifuged. A drive spindle for the centrifugal drum is rotatably mounted on a housing via a bearing, the housing being supported elastically on a machine frame. A drive device includes a motor housing and an electric motor having a stator and an armature which is aligned with the drive spindle. The drive device and the motor housing move with the drive spindle as co-vibrating units during an operation of the separator. The drive device is connected to the machine frame below the bearing at a lower axial end of the bearing via one or more joint elements.




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Centrifuge with vacuum pump configured of auxiliary vacuum pump and oil diffusion pump

A centrifuge includes a vacuum pump machine configured of an auxiliary vacuum pump and an oil diffusion pump for exhausting gas inside a rotary chamber to outside, in which a rotor rotates at high speed. In the centrifuge, a thermistor for detecting a temperature of oil and an oil surface inside a boiler of the oil diffusion pump is provided inside the boiler, and power of a heater is adjusted with the temperature detected by the thermistor, so that a degree of vacuum inside the rotary chamber is stably reduced from atmospheric pressure to a high vacuum state. Besides, when the heater does not heat, a current is carried through the thermistor for self-heating, and it is determined from variation in a resistance value whether the oil exists or not at a position at which the thermistor 8 is placed.




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Cartridge and centrifuge having a cartridge

The invention relates to a cartridge (1) for accommodating blood bags (35), which is provided for the separation of blood components for the application in a centrifuge. The cartridge (1) has a partition wall (3) which separates a blood bag section (5) positioned radially inside from a product section (7) positioned radially outside, and a cover (9) disposed in a mounting position above the blood bag section (5). The cover (9) is connected to the partition wall (3) pivotally in a first point (11) and detachably in a second point (13), so that the blood bag section (5) is freely accessible by means of laterally pivoting the cover (9) out of the way. The cartridge is applicable in the rotor of a centrifuge.




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Automated system and method for blood components separation and processing

A blood processing centrifuge comprising: a rotor having an axis of rotation and being controllably spun around the axis, a mechanism for processing whole blood within the rotor while spinning, a computer controlling blood processing operations, the computer being mounted to the rotor and spinning therewith.




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Method for simply separating carbon nanotube

Disclosed are a method and an apparatus for separating metallic CNT and semiconducting CNT, comprising treating with a physical separation means of centrifugation, freezing-thawing-squeezing, diffusion, permeation or the like using a gel containing CNT as a dispersed and isolated state (CNT-containing gel), to thereby make semiconducting CNT exist in gel and make metallic CNT exist in solution.




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Method for optimizing spin time in a centrifuge apparatus for biologic fluid

A method for controlling a centrifuge blood component separation system for separating components of a blood product, the separation system comprising a centrifuge and a separation bag and at least one transfer bag. The method comprises selecting a nominal hematocrit value such that an actual hematocrit value is expected to be less than said nominal hematocrit; centrifuging a separation bag containing a volume of composite liquid so as to cause the sedimentation of at least a first component and a second component; transferring some of the first component to a first transfer bag; detecting time of passage of a red blood cell interface at a pre-selected location in the separation bag; and adjusting a predicted processing time based on the time of passage of the red blood cell interface.




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Method of separating free oil from fat

A syringe piston used in fat transplantation is structured such that free oil is easily separated from suctioned fat by a syringe piston having a filter and naturally discharged through the rear side thereof. The syringe piston without a shaft, used in fat transplantation, disposed in a syringe-shaped cylindrical vessel, includes a piston body without the shaft, a packing coupled with an outer surface of the piston body to seal between the piston body and the syringe-shaped cylindrical vessel, a free oil discharging hole communicated with the front side and the rear side of the piston body, an opening and closing device for opening and closing the free oil discharging hole, and a filtering device disposed in a passage through which free oil is discharged to filter fat and pass the free oil.




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Apparatus for processing biological material

A gripper unit for handling a vessel for receiving biological material is proposed, inter alia. The vessel has a lid which can assume an open position and a closed position. The gripper unit comprises a gripper for gripping and releasing the vessel, and a lid holder, for holding a lid in a defined position in relation to the vessel. The defined position is an open position of the lid.




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Multiple laminar flow-based particle and cellular identification

The present invention provides a method and apparatus to identify at least one component from a plurality of components in a fluid mixture, the apparatus including a first input channel into which a first flow containing a plurality of components is introduced; a plurality of buffer input channels, into which additional flows of buffer solution are introduced, disposed on either side of the first input channel; wherein the first flow and the additional flows have a flow direction along a length of the apparatus; a detector apparatus which detects and identifies selected components of the plurality of components; a laser which emits a laser beam which damages or kills selected components of the plurality of components; and at least one channel disposed at the another end of the apparatus which is adapted to receive the first flow and the additional flows after operation of the laser on the selected components.




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Methods and apparatus for isolating platelets from blood

A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.




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Centrifuge for separating of whole blood into blood components as well as fluidically communicating containers for insertion into the centrifuge, as well as a method for obtaining a highly enriched thrombocyte concentrate out of whole blood

The invention refers to a centrifuge for separating whole blood into its blood components and a method for extracting a highly enriched thrombocyte concentrate out of whole blood. For this purpose, the centrifuge comprises a closed loop and/or open-loop control unit as well as a drive unit coupled to the closed loop and/or open-loop control unit, a rotor (12) having at least two container receptacles (14a, 14b; 16a, 16) for removably holding containers (18, 20, 22, 24) being in fluid communication with each other, at least one sensor arranged between the container receptacles (14a, 14b; 16a, 16b) and coupled with the closed loop and/or open-loop control unit for detecting a separation layer. Herein, a motor/gear unit (30a, 30b, 32a, 32b) coupled to the closed loop and/or open-loop control unit is associated with each of the container receptacles (14a, 14b; 16a, 16b). Each of the motor/gear units is in operational contact through means (34) with each of the containers (18, 20, 22, 24) supported in the respective container receptacle (14a, 14b; 16a, 16b) such that a transfer and back-transfer of blood components between the containers (18, 20, 22, 24) is initiated.




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Method for removing particulates from a fluid

A method for removing particulates from a fluid, the method including the steps of: producing a laminar flow of the fluid through a single-flow passageway defined by an interior surface of an outer rotor of a centrifuge; and imparting centrifugal force on the fluid in a direction orthogonal to a direction of the flow of the fluid to capture the particulates from the fluid. The method may further comprise rotation of the centrifuge at a speed of 5,000 to 15,000 revolutions per minute. The method may also or alternatively comprise locating the interior surface between 3 and 5 inches from an axis of rotation of the centrifuge.




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Method and apparatus for removal of tars or resins from a scrubber liquid using a centrifuge with a discharge chamber scraper

The invention is a method of processing tarry or resinous liquids. Tarry liquids include wet scrubber liquids containing tars and chars derived from gasification, pyrolysis or drying of biomass. Resinous liquids include those derived from processing coniferous biomass. Tarry or resinous liquid is processed by a horizontal axis centrifuge having a discharge chamber containing a scraper to prevent centrifuge clogging or fouling. The removed tar and char can be used as solid fuel or recycled to the gasification or pyrolysis process. Polymers, for instance cationic polymers, can be added to the tarry or resin containing liquid prior to centrifugation to assist in solids/liquids separation. Removed resin can be recycled for further use. Tar, char or resin depleted wet scrubber liquid can be recycled for further use or more easily treated prior to disposal.




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Bladed drum for rotary separator system and method

A separator method and apparatus that includes a rotatable drum defining an annular passageway therein, a plurality of blades coupled to the rotatable drum and located in the annular passageway, each of the plurality of blades including a leading section, a trailing section, a concave surface, and a convex surface, the concave and convex surfaces extending from the leading section to the trailing section, each of the plurality of blades disposed circumferentially adjacent to at least another one of the plurality of blades so as to define blade flowpaths therebetween, and a housing at least partially surrounding the rotatable drum and defining a fluid collection chamber fluidly communicating with the annular passageway.




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System for blood separation with side-tapped separation chamber

A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, and outlet and a side tap outlet adjacent the inlet. The inlet may protrude into the cell separation chamber forming a circumferential well surrounding the protruding inlet. The side tap outlet may connect to the well. The set and system comprise means for selectively drawing fluid from either the outlet or the side tap outlet.