A continuous centrifuge includes: a cylindrical rotor configured to separate a specimen; a centrifuging chamber accommodating the rotor; a driving unit configured to rotate the rotor; a specimen line configured to continuously supply and discharge the specimen to and from the rotor during rotation of the rotor; and a controller configured to control the driving unit. The control unit has a cleansing mode which flows a liquid chemical through the specimen line so as to conduct sterilization and/or cleansing while rotating the rotor.

An apparatus and method to identify at least one component from a plurality of components in a fluid mixture, includes a first input channel containing the fluid mixture of components; at least one buffer input channel, into which at least one additional flow of buffer solution is introduced; a plurality of regions disposed at the other end of the apparatus, which are adapted to receive outputs of at least one selected component of the plurality of components, the selected component which is selectively removed from the first flow to one of the regions; a waste channel through which unselected components are removed from the first flow; a plurality of pumps connected to at least one reservoir, to control flow rates of the first flow and the additional flow(s); and a computer which controls a selection of one of the plurality of components from the fluid mixture.

A vertical centrifugal separator includes a casing, a bowl that is rotatably housed in the casing and provided to separate a solution to be processed which is supplied to an interior of the bowl into a liquid and a solid by an action of centrifugal force and discharge the liquid and the solid, and a discharge assembly that is rotatably housed in the bowl and provided to discharge the solid in the bowl. The bowl and the discharge assembly each have an engagement portion that is engaged or disengaged when the bowl and the discharge assembly are moved relative to each other in an axial direction and a position adjustment mechanism for adjusting a phase between the discharge assembly and the bowl relative to a rotation axis, for example, at a single relative position.

Embodiments of the present invention generally relate to methods and apparatus for centrifugal separation. In one embodiment, a separator includes an outer tubular having ends sealed from the environment and an inner tubular. The inner tubular is disposed within the outer tubular, has ends in fluid communication with a bore of the outer tubular, and is attached to the outer tubular. The separator further includes an inlet. The inlet is disposed through a wall of the outer tubular, in fluid communication with a bore of the inner tubular, and tangentially attached to the inner tubular so that fluid flow from the inlet to the inner tubular is centrifugally accelerated. The separator further includes a gas outlet in fluid communication with the outer tubular bore; and a liquid outlet in fluid communication with the outer tubular bore.

In a decanter centrifuge a bowl is provided and rotates in use around a horizontal axis of rotation, a base plate provided at one longitudinal end of said bowl, the base plate having an internal side and an external side, an outlet opening provided in said base plate, the outlet opening extending through a first angular interval relative to the axis of rotation, and a wall projecting from the external side of said base plate, wherein the wall extends from the vicinity of the outlet opening towards a rim of the base plate, the wall extending through a second angular interval, the second angular interval being at least 30°, and the wall having in a radial plane perpendicular to the axis of rotation an inclination relative to the radial direction of at least 60°.

A separation cone (30) is mounted into the interior chamber of a centrifugal separator rotor (10), which comprises a cover (14) releasably connected to a base (16), in order to provide a frusto-conical wall subdividing the chamber into upper and lower regions. This slows the passage of fluid from the upper to the lower region, which takes place via openings (24) and/or via a gap between the inner rim (32) of the cone (30) and the axial inlet tube (12). The separation cone (30) is connected to the cover (14) by a releasable snap fit arrangement, such as by deflectable tabs (38) around the periphery of the separation cone (30) engaging into a groove (15) around the interior surface adjacent a lower edge of the cover (14). This allows there to be a predetermined sequence of servicing operations and ensures that the separation cone (30) will reliably stay with the cover (14) when the cover is removed.

An apparatus for use with a centrifugal cellular separation device that comprises a rotor rotatable about an axis of rotation is provided that comprises a fluid separation chamber having a first port, a second port spaced apart from the first port, and a third port located intermediate the first port and the second port. The fluid separation chamber has a cross sectional area generally transverse to a radius extending from the axis of rotation that varies between the first port and the second port. The fluid separation chamber is adapted to be mounted to the rotor so as to be rotatable therewith, with the first port located at a greater radial distance from the axis than the second port, and the third port located radially intermediate the first port and the second port.

A color-changing marking system, including a color-changing marking medium and a substrate. The color-changing marking medium has a nominal color and includes a color developer activator and/or color former leuco dye. The substrate includes a treated portion on which a color former leuco dye and/or color developer activator has been applied. Application of the color-changing marking medium to an untreated portion of the substrate causes the color-changing marking medium to create marks of the nominal color. Application of the color-changing marking medium to the treated portion of the substrate causes the color-changing marking medium to create marks of a changed color in response to a chemical or mechanical reaction between the leuco dye and the activator. The marking medium may a crayon, colored pencil, marker ink or paint.

Methods to produce pH-sensitive microparticles that have an active agent dispersed in a polymer matrix have certain advantages over microcapsules with an active agent encapsulated in an interior compartment/core inside of a polymer wall. The current invention relates to pH-sensitive microparticles that have a corrosion-detecting or corrosion-inhibiting active agent or active agents dispersed within a polymer matrix of the microparticles. The pH-sensitive microparticles can be used in various coating compositions on metal objects for corrosion detecting and/or inhibiting.

A heat-sensitive recording material includes at least a paper substrate, a heat-sensitive recording layer arranged on the front side of the substrate and which has at least one dye precursor and at least one color acceptor, wherein dye precursor and color acceptor react with one another under the action of heat to form color, and an authenticating security feature. The authenticating security feature is a mark which is applied to the back side of the paper substrate and which is made of a tincture having at least one organic solvent. A barrier coating is arranged between the substrate and heat-sensitive recording layer and is suitable to protect the heat-sensitive recording layer against penetration of the tincture into the heat-sensitive recording layer from the back side.

A decoration piece has: a design piece made of thermoplastic synthetic resin formed with a design and having an outer profile line; a lower layer; and a dye migration preventing layer arranged between the design piece and the lower layer, said dye migration preventing layer having an outer profile same as that of said design piece, said dye migration preventing layer capable of being adhered to both said design piece and the lower layer, said dye migration preventing layer capable of preventing any migrating of dye. The dye migration preventing layer includes a dye migration preventing film made of ethylene-vinyl alcohol copolymer or polyamide MXD6, or a dye migration preventing film made of polyvinylidene chloride.

The present invention provides heat-sensitive coating compositions, which comprise a color developer of formula (1) or mixtures thereof wherein R1 can be hydrogen, C1-20-alkyl, C3-8-cycloalkyl, C2-10-alkenyl, aryl or SO3H, and R2 and R3 can be the same or different and can be hydrogen, halogen, C1-20-alkyl, C3-8-cyclo-alkyl, C2-10-alkenyl, aryl, OR6, NR7R8, SR9, SO3H or COOR10 and R4 and R5 can be the same or different, and can be hydrogen, halogen, C1-20-alkyl, C3-8-cyclo-alkyl, C2-10-alkenyl, aryl, OR6, NR7R8 or SR9, R6, R7, R8, R9 and R10 can be the same or different and can be hydrogen, C1-30-alkyl, C3-8-cycloalkyl, C2-10-alkenyl or aryl, wherein C1-20-alkyl can be unsubstituted or substituted with one or more C3-8-cycloalkyl, C2-10-alkenyl, phenyl, halogen, OR11, NR12R13, SR14, SO3H or COOR15, and aryl can be unsubstituted or substituted with one or more halogen, C1-10-alkyl, halogenated C1-10-alkyl, C3-8-cycloalkyl C2-10-alkenyl, phenyl, OR11, NR12R13, SR14, SO3H or COOR15, wherein R11, R12, R13, R14 and R15 can be the same or different and can be hydrogen, C1-10-alkyl, C3-8-cycloalkyl or C2-10-alkenyl, a process for the preparation of these compositions, a process of coating substrates with these compositions, substrates coated with these compositions, a process for preparing marked substrates using these compositions, marked substrates obtainable by the latter process, and certain color developers.

A thermosensitive recording medium having excellent image quality and surface strength is provided. The thermosensitive recording medium having excellent image quality and surface strength is obtained by containing a saturated fatty acid amide in the substrate to lower the density of the substrate. The thermosensitive recording medium of the present invention has an adequate general printability and problems such as print through are avoided. Furthermore, the thermosensitive recording medium of the present invention can assure adequate image quality and general printability even when an undercoat layer is not installed.

This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemotherapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomicin C, imatinib, iressa and velcade (vortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics.

Provided is a direct thermal media containing a regular repeating pattern of color-forming thermally-imageable stripes printed parallel to the print head element line and a system for using such direct thermal media in color direct thermal printers including an optical registration system optimized for use with this media and an image processing unit that monitors the position of the stripe pattern relative to the print head and synchronizes the start of the printing process. This direct thermal media together with the optical registration system and image processing unit comprise an operative system in that the design of the thermal media, the optical registration system and image processing unit used to control printing are optimized for use with each other. This system may be utilized, for example, in color thermal printers for documents, receipts, tags, tickets or labels.

A reversible thermosensitive recording medium including a support, a reversible thermosensitive recording layer provided on the support and an antistatic layer, wherein the antistatic layer is provided on at least one of the reversible thermosensitive recording layer and a surface of the support opposite to the surface thereof on which the reversible thermosensitive recording layer is provided, wherein the antistatic layer contains spherical fillers and a curable conductive polymer, and wherein the spherical fillers satisfy the following Expression (1): 4≦average particle diameter of the spherical fillers/thickness of the antistatic layer≦6 Expression (1).

A heat-sensitive color-developing composition containing a hydroxyquinoline compound having a methyl group and an acid anhydride compound represented by general formula (1): wherein ring A represents a substituted or unsubstituted aromatic hydrocarbon ring, and n represents an integer of 1 to 3, and a heat-sensitive recording material containing the composition in a recording layer.

A thermal image receiver element dry image receiving layer has a Tg of at least 25° C. as the outermost layer. The dry image receiving layer has a dry thickness of at least 0.5 μm and up to and including 5 μm. It comprises a polymer binder matrix that consists essentially of: (1) a water-dispersible acrylic polymer comprising chemically reacted or chemically non-reacted hydroxyl, phospho, phosphonate, sulfo, sulfonate, carboxy, or carboxylate groups, and (2) a water-dispersible polyester that has a Tg of 30° C. or less. The water-dispersible acrylic polymer is present in an amount of at least 55 weight % of the total dry image receiving layer weight and at a dry ratio to the water-dispersible polyester of at least 1:1 to and including 20:1. The thermal image receiver element can be used to prepare thermal dye images after thermal transfer from a thermal donor element.

A method of color laser marking an article having a polymeric foil with at least one colorless layer containing an infrared absorber, a polymeric binder and a color forming compound; including the steps of:—laser marking the colorless layer with an infrared laser using a first laser operation mode to generate a blue or cyan color; and—laser marking the same colorless layer with an infrared laser using a second laser operation mode to generate a black color, wherein the first laser operation mode applies less energy to the colorless layer than the second laser operation mode. Also disclosed is an article, such as a security document, including a polymeric foil and a colorless layer containing laser marked graphical data having a blue or cyan color and laser marked information having a black color.

A thermal image receiver element dry image receiving layer has a Tg of at least 25° C. and is the outermost layer. The dry image receiving layer has a dry thickness of at least 0.5 μm and up to and including 5 μm. It comprises a water-dispersible release agent and a polymer binder matrix that consists essentially of: (1) a water-dispersible acrylic polymer comprising chemically reacted or chemically non-reacted hydroxyl, phospho, phosphonate, sulfo, sulfonate, carboxy, or carboxylate groups, and (2) a water-dispersible polyester that has a Tg of 30° C. or less. The water-dispersible acrylic polymer is present in an amount of at least 55 weight % and at a dry ratio to the water-dispersible polyester of at least 1:1. The thermal image receiver element can be used to prepare thermal dye images after thermal transfer from a thermal donor element.

A security document precursor including, in order: a) at least one transparent biaxially stretched polyester foil; b) one colorless color forming layer containing at least an infrared absorber, a colorless dye-precursor and a polymeric binder; and c) a polymeric support; wherein the polymeric binder is copolymer including at least 90 wt % of a chlorinated ethylene and 1 wt % to 10 wt % of vinyl acetate both based on the total weight of the binder. Methods for making the security document precursor are also disclosed.

A method for preparing a color laser marked article comprising the steps of: a) infrared laser marking a security element including a polymeric support and a color forming layer comprising a color forming compound, an infrared dye and a polymeric binder comprising vinyl acetate and at least 85 wt % of vinyl chloride based on the total weight of the binder; and b) exposing the laser marked security element with light having a wavelength higher than 440 nm. The light exposure of step b) hinders the falsification of an issued security document without significant increase of background density.

Disclosed are a polysiloxane-modified polyhydroxy polyurethane resin characterized by being derived from a reaction between a 5-membered cyclic carbonate polysiloxane compound represented by the below-described formula (1) and an amine compound, and its production process; and a resin composition, thermal recording medium, imitation leather, thermoplastic polyolefin resin skin material, weather strip material, and weather strip, all of which make use of the resin. wherein A means

The present invention relates to a thermochromic color-memory composition containing: (I) an electron donating coloring organic compound, (II) an electron accepting compound, and (III) an ester compound represented by the following formula (1) as a reaction medium which controls color reaction of the components (I) and (II): (in the formula, X represents any of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, and a halogen atom, m represents an integer of from 1 to 3, and n represents an integer of from 1 to 20).

A thermal dye image receiver element has a substrate comprising a voided compliant layer and metalized layer. Disposed on the metalized layer is an opacifying layer that includes an opacifying agent and a dye receiving layer. This thermal dye image receiver element can be a duplex element with image receiving layers on both sides of the substrate, and it can be used in association with a thermal donor element to provide a thermal image on either or opposing sides of the receiver element. The metalized layer provides increased specular reflectance under resulting thermal dye images.

A security document precursor including, in order, at least: a) a transparent biaxially stretched polyethylene terephthalate foil; b) a colorless color forming layer containing at least an infrared absorber, a color forming component and a polymeric binder; and c) a polymeric support; wherein the colorless color forming layer contains at least one component forming a compound having a melting temperature of less than 20° C. upon laser marking the colorless color forming layer with an infrared laser. Methods for securing a security document using the security document precursor are also disclosed.

The invention provides a phenolsulfonic acid aryl ester represented by formula (1) wherein each symbol is as defined in the description. The phenolsulfonic acid aryl ester is useful as a developer to provide a thermal recording material with good color-developing sensitivity, image density when printed at a low application energy (i.e., high start-up sensitivity), and heat and plasticizer resistance. The invention also provides a thermal recording material using the developer.

The present invention provides a thermosensitive multiple recording sheet characterized in that a second base material having light transmission properties is attached to the side of a first thermosensitive recording layer of a first thermosensitive recording sheet comprising a first base material and the first thermosensitive recording layer formed on one surface of the first base material, through a temporary adhesive layer, the second base material is composed of an information disclosing portion and an information non-disclosing portion, a shielding layer is formed at the position corresponding to the information non-disclosing portion on the second base material, and an ultraviolet curable resin layer are formed as an outermost layer of the sheet.

To provide a thermosensitive recording material, which contains: a support; a thermosensitive recording layer provided on one surface of the support; and a back layer provided on the other surface of the support, wherein the support has a surface formed of a resin, and wherein the back layer contains a combination of a core-shell acrylic resin and an oxazoline resin, or a reaction product thereof, or both thereof.

A method of increasing the solubility and/or dispersibility of a perylene dye in a liquid medium. The method comprises binding the perylene dye to a polymer which is soluble in the liquid medium. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

The invention discloses an improved multistage fischer tropsch process scheme for the production of hydrocarbon fuels comprising feeding gaseous phase syngas and liquid stream hydrocarbons in a counter current manner such as herein described into the reaction vessel at a number of stages containing reaction catalysts; wherein fresh syngas enters into the stage where the product liquid stream leaves and the fresh liquid stream enters into the stage where the unreacted syngas leaves; wherein further the temperature of each stage can be controlled independently. More particularly the invention relates to improving the heat release in different reactors, product selectivity and reactor productivity of FT reactors.

A system and method for reducing the CO2 in a gaseous stream between 33% up to and even in excess of 90%, by reducing CO2. A gaseous stream that includes substantial amounts of CO2 is provided to a reaction chamber along with H2O (steam) and a carbon source such as charcoal, coke or other carbonaceous material. Carbon is provided to the chamber at a ratio (C/CO2) of between about 0.100 to 0.850, and between about 0.200 to 0.900 of H2O to the provided CO2. The CO2, H2O and carbon are heated to between about 1500° F. and about 3000° F. at about one atmosphere to produce syngas (i.e. carbon monoxide (CO) and hydrogen (H2)) and reduces the amount of CO2. The Syngas may then be cleaned and provided to a Fischer-Tropsch synthesis reactor or a Bio-catalytic synthesis reactor to produce a fuel, such as Methanol, Ethanol, Diesel and Jet Fuel.

The invention relates to a process for increasing the carbon monoxide content of a feed gas mixture comprising carbon dioxide, hydrogen and carbon monoxide via a catalytic reversed water gas shift reaction, comprising the steps of (1) heating the feed gas mixture having an initial feed temperature of at most 350° C. in a first zone to a temperature within a reaction temperature range in the presence of a first catalyst; and (2) contacting the heated feed gas in a second zone within the reaction temperature range with a second catalyst. This process shows relatively high conversion of carbon dioxide, and virtually no methane or coke is being formed, allowing stable operation.

A gasification-liquefaction disposal method, system and equipment for MSW are disclosed. The method involves the MSW pretreatment of dehydrating and separating, thus reducing water and inorganic substance content of the waste. Then, the MSW is introduced into a plasma gasifier (23) by a carbon dioxide air-sealed feeding device (13) and gasified therein to obtain hydrogen-rich syngas. The hydrogen-rich syngas is then cooled, deacidified, dedusted and separated to obtain carbon dioxide. Then, the hydrogen-rich syngas is catalyzed to produce methanol product in a methanol synthesis reactor (52). The separated carbon dioxide is sent back to a carbonation reaction chamber (2007) of a gasification system to perform carbonation reaction with calcium oxide, thereby releasing heat to provide assistant heat energy for gasification and avoiding greenhouse gas from being discharged into environment. Exhaust gas is returned to the plasma gasifier (23) for remelting treatment, thus forming a closed-loop circulation production system and realizing the disposal of the MSW with zero discharge and no pollution, thereby avoiding dioxin pollution and converting the MSW to chemical raw materials and fuel needed by mankind. The method, system and equipment are suitable for harmless and recycling disposal of MSW, industrial high polymer waste, composting waste and waste in waste sorting sites.

A process for improving the hydrogen content of a synthesis gas stream to a synthesis loop, comprising the steps of: (a) removing a purge stream comprising hydrogen and hydrocarbons from a synthesis loop; (b) separating hydrogen from the purge stream; (c) passing the purge stream to a reformer and reacting with steam and oxygen to produce a stream comprising hydrogen and carbon monoxide; (d) subjecting the reformed reaction product stream to a shift reaction to produce a stream comprising carbon dioxide and hydrogen; (e) subjecting the product stream from the shift reaction to separation to separate hydrogen from carbon dioxide; (f) supplying the separated hydrogen to the synthesis loop; and (g) removing the carbon dioxide.

A system for intelligent monitoring and management of an electrical system is disclosed. The system includes a data acquisition component, a power analytics server and a client terminal. The data acquisition component acquires real-time data output from the electrical system. The power analytics server is comprised of a real-time energy pricing engine, virtual system modeling engine, an analytics engine, a machine learning engine and a schematic user interface creator engine. The real-time energy pricing engine generates real-time utility power pricing data. The virtual system modeling engine generates predicted data output for the electrical system. The analytics engine monitors real-time data output and predicted data output of the electrical system. The machine learning engine stores acid processes patterns observed from the real-time data output and the predicted data output to forecast an aspect of the electrical system.

The present disclosure includes methods, systems, and devices for prioritization of three dimensional dental elements. One method for prioritizing three dimensional dental elements includes receiving a virtual initial dental data set (IDDS) of teeth having spatial information regarding the positions of a number of teeth in the virtual IDDS with respect to each other for presentation of the teeth in a virtual three dimensional space to be viewed on a user interface, setting prioritization values of a number of elements of one or more of the number of teeth, and prioritizing the number of elements to be selected by a user based upon their prioritization values.

A design system for generating a power equipment proposal for a particular location, comprises an insolation database, a load database, and a processing system. The insolation database comprises insolation values associated with a plurality of geographic data points. The load database associates appropriate power equipment with load requirements. The processing system generates at least one power equipment proposal based on load requirements generated from the insolation database based on the insolation values associated with a geographic data point closest to the particular location and solar power equipment appropriately selected from the load database based on the load requirements generated from the insolation database.

Methods, systems, and apparatus, including computer program products, for determining energy indicator values for a plurality of thermoplastic materials. An energy indicator value represents expected energy requirements for performing an injection of the material in a mold cavity. An injection of each of a plurality of thermoplastic materials in a first modeled mold cavity is simulated. A respective value of a first expected energy parameter is determined for each of the plurality of thermoplastic materials based on the simulated injections. A respective energy indicator is determined, for each of the plurality of thermoplastic materials, based at least on the corresponding value of the first expected energy parameter. The respective energy indicator value of one or more of the plurality of thermoplastic materials is presented.

The systems and methods of the present disclosure calibrate impedance loss model parameters associated with an electrosurgical system having no external cabling or having external cabling with a fixed or known reactance, and obtain accurate electrical measurements of a tissue site by compensating for impedance losses associated with the transmission line of an electrosurgical device using the calibrated impedance loss model parameters. A computer system stores voltage and current sensor data for a range of different test loads and calculates sensed impedance values for each test load. The computer system then predicts a phase value for each load using each respective load impedance value. The computer system back calculates impedance loss model parameters including a source impedance parameter and a leakage impedance parameter based upon the voltage and current sensor data, the predicted phase values, and the impedance values of the test loads.

Methods and apparatuses for circuit design are described. In one embodiment, the method comprises determining a distribution of nets of a circuit, the distribution of the nets comprising numbers of blocks that each of the nets has in each of a plurality of partitions of the circuit in a partitioning solution, moving a first block of the circuit from a source partition to a destination partition to modify the partitioning solution, and updating the distribution of the nets after the moving.

A computer method of material modeling for crash test dummy finite element models includes the steps of making a material card for the material, applying the material card to validate a finite element model of a crash test dummy component, determining whether the finite element model is acceptable, ending the method if the finite element model is acceptable, and adjusting a relative volume (J) range for the material to make the material soft or stiff if the finite element model is not acceptable.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising acquiring an anatomical model of at least part of the patient's vascular system; performing, using a processor, one or more of geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical model; and identifying, using the processor, a personalized cardiovascular device for the patient, based on results of one or more of the geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of anatomical model.

Embodiments include methods of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining pathology characteristics from cardiovascular geometry of the patient specific model; defining an objective function for a device based on design considerations and one or more estimates of hemodynamic and mechanical characteristics; optimizing the objective function, by simulating at least one change in devices and evaluating the objective function using fluid dynamic or structural mechanic analysis; and using the optimized objective function to either (i) select a device from a set of available devices or (ii) manufacture a desired device.

A method (and system) of emulation in a multiprocessor system, includes performing an emulation in which a host multiprocessing system of the multiprocessor system supports a weak consistency model, and the target multiprocessing system of the multiprocessor system supports a strong consistency model.

A method for computer-aided closed and/or open-loop control of a technical system is provided. A first value of an output quantity is predicted on a data-based model at a current point in time. A second value of the output quantity is determined from an analytical model. The state of the technical system at the current point is assigned a confidence score in the correctness of prediction of the data-based model. A third value of the output quantity is determined from the first and second value as a function of the confidence score for controlling the technical system. A suitable value for the output quantity can be derived from the analytical model even for regions of the technical system in which the quality of prediction of the data-based model is low because of a small set of training data. The technical systems can be turbines, such as gas turbines.

Systems and methods are provided for evaluating performance of forecasting models. A plurality of forecasting models may be generated using a set of in-sample data. Two or more forecasting models from the plurality of forecasting models may be selected for use in generating a combined forecast. An ex-ante combined forecast may be generated for an out-of-sample period using the selected two or more forecasting models. The ex-ante combined forecast may then be compared with a set of actual out-of-sample data to evaluate performance of the combined forecast.

Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Methods, systems, and computer readable media for simulating realistic movement of user equipment in an LTE network are disclosed. According to one method, a logical topology of a long term evolution (LTE) access network is defined that includes defining connections between one or more eNodeBs (eNBs). A physical topology of the LTE access network is defined that includes defining locations of the eNBs and sectors, where the physical network topology is mapped to the logical network topology. One or more problem areas are defined within the physical network topology, where the one or more problem areas include locations where signal quality is degraded. One or more paths are defined through the physical network topology. A traffic profile for a user equipment (UE) device is defined. A plurality of messages is generated for simulating the movement of a UE device along a path through the physical network topology.

The present disclosure relates to a method of melt processing an active agent. The method may include encapsulating an active agent in a first polymer material exhibiting a first processing temperature T1 and forming capsules including the active agent. The method may also include melt processing the capsules with a second polymer material exhibiting a second processing temperature T2, wherein T1>T2.