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Hunting for new epilepsy drugs, and capturing lightning from space

About one-third of people with epilepsy are treatment resistant. Up until now, epilepsy treatments have focused on taming seizures rather than the source of the disease and for good reason—so many roads lead to epilepsy: traumatic brain injury, extreme fever and infection, and genetic disorders, to name a few. Staff Writer Jennifer Couzin-Frankel talks with host Sarah Crespi about researchers that are turning back the pages on epilepsy, trying to get to the beginning of the story where new treatments might work. And Sarah also talks with Torsten Neurbert at the Technical University of Denmark’s National Space Institute in Kongens Lyngby about capturing high-altitude “transient luminous events” from the International Space Station (ISS). These lightning-induced bursts of light, color, and occasionally gamma rays were first reported in the 1990s but had only been recorded from the ground or aircraft. With new measurements from the ISS come new insights into the anatomy of lightning. This week’s episode was edited by Podigy. Ads on this week’s show: Bayer; Lightstream; KiwiCo Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Gemini Observatory; Music: Jeffrey Cook]




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Dog noses detect heat, the world faces coronavirus, and scientists search for extraterrestrial life

On this week’s show, Online News Editor David Grimm joins host Sarah Crespi to discuss how dogs’ cold noses may be able to sense warm bodies. Read the research. International News Editor Martin Enserink shares the latest from our reporters covering coronavirus. And finally, from a recording made at this year’s AAAS annual meeting, host Meagan Cantwell talks with Jill Tarter, chair emeritus at the SETI Institute, about the newest technologies being used to search for alien life, what a positive signal would look like, and how to inform the public if extraterrestrial life ever were detected. This week’s episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF).




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Blood test for multiple cancers studied in 10,000 women, and is our Sun boring?

Staff Writer Jocelyn Kaiser joins Sarah to talk about a recent Science paper describing the results of a large study on a blood test for multiple types of cancer. The trial’s results suggest such a blood test combined with follow-up scans may help detect cancers early, but there is a danger of too many false positives. And postdoctoral researcher Timo Reinhold of the Max Planck Institute for Solar System Research joins Sarah to talk about his paper on how the Sun is a lot less variable in its magnetic activity compared with similar stars—what does it mean that our Sun is a little bit boring? This week’s episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF).




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Materials for Carbon Capture


 

Covers a wide range of advanced materials and technologies for CO2 capture

As a frontier research area, carbon capture has been a major driving force behind many materials technologies. This book highlights the current state-of-the-art in materials for carbon capture, providing a comprehensive understanding of separations ranging from solid sorbents to liquid sorbents and membranes. Filled with diverse and unconventional topics throughout, it seeks



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Biobased Polyols for Industrial Polymers


 
The replacement of polyols synthesized from petrochemical by polyols originating from natural products, notably from vegetable oils and animal fats, has been the subject of research projects for a number of decades.

Very recently, however, the polymers industry has intensified its efforts to include the “green products”, such as biobased polyols, in applications already available in the market. Examples of such applications include polyurethane foams


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Flexible and Wearable Electronics for Smart Clothing


 
Provides the state-of-the-art on wearable technology for smart clothing

The book gives a coherent overview of recent development on flexible electronics for smart clothing with emphasis on wearability and durability of the materials and devices. It offers detailed information on the basic functional components of the flexible and wearable electronics including sensing, systems-on-a-chip, interacting, and energy, as well as the integrating and connecting

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Ferroic Materials for Smart Systems: From Fundamentals to Device Applications


 
Presents state-of-the-art knowledge?from basic insights to applications?on ferroic materials-based devices

This book covers the fundamental physics, fabrication methods, and applications of ferroic materials and covers bulk, thin films, and nanomaterials. It provides a thorough overview of smart materials and systems involving the interplays among the mechanical strain, electrical polarization, magnetization, as well as heat and light. Materials presented

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Nanotechnology for Microfluidics


 
The book focuses on microfluidics with applications in nanotechnology. The first part summarizes the recent advances and achievements in the field of microfluidic technology, with emphasize on the the influence of nanotechnology. The second part introduces various applications of microfluidics in nanotechnology, such as drug delivery, tissue engineering and biomedical diagnosis.

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Former Delhi Police Commissioner recalls the day terror struck Parliament

Nearly 20 years ago, when a suicide squad stormed the complex, the author was among the first to appear on the scene.




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Product :: Swift for Beginners: Develop and Design, 2nd Edition




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'My only grudge is Irrfan spoiled me for life'

'It's difficult to explain what a wondrous, beautiful, overwhelming, painful and exciting this journey has been.'




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A fluorescence-positioned hybridization chain reaction system for sensitive detection of Salmonella in milk

Anal. Methods, 2020, 12,1958-1965
DOI: 10.1039/D0AY00184H, Paper
Guotai Yang, Shuang Yu, Yang Liu, Jin Huang, Qianying Li, Zoraida P. Aguilar, Hengyi Xu
In this study, a fluorescence-positioned hybridization chain reaction (HCR) system for the detection of single-stranded DNA (ssDNA) specific to Salmonella was developed.
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A membraneless gas-trapping device for cyanide detection and quantification

Anal. Methods, 2020, 12,2009-2015
DOI: 10.1039/D0AY00245C, Paper
Chatipat Lorpaiboon, Wanutcha Lorpaiboon, Manchuta Dangkulwanich
A novel device for trapping gaseous compounds was invented and employed to create a user-friendly cyanide test kit for aqueous solutions.
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A deep learning approach to identify association of disease–gene using information of disease symptoms and protein sequences

Anal. Methods, 2020, 12,2016-2026
DOI: 10.1039/C9AY02333J, Paper
Xingyu Chen, Qixing Huang, Yang Wang, Jinlong Li, Haiyan Liu, Yun Xie, Zong Dai, Xiaoyong Zou, Zhanchao Li
Prediction of disease–gene association based on a deep convolutional neural network.
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The development and validation of a GC-MS method for the quantification of glycolaldehyde formed from carbohydrate fragmentation processes

Anal. Methods, 2020, 12,1975-1987
DOI: 10.1039/C9AY02639H, Paper
Samin Fathalinejad, Esben Taarning, Peter Christensen, Jan H. Christensen
Glycolaldehyde is a small sugar-like molecule that is readily formed by the thermochemical fragmentation of carbohydrates and it has similar physico-chemical properties to sugars.
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A bimetallic PtPd hybrid nanostructure-amplified enzyme-free conductometric immunoassay for lipocalin-2 in renal cell carcinoma on an interdigitated micro-comb electrode

Anal. Methods, 2020, 12,1988-1994
DOI: 10.1039/C9AY02525A, Paper
Chaoqun Huang, Fengling Zhang, Qingshui Wang, Yao Lin, Jiyi Huang
A new enzyme-free conductometric immunoassay based on bimetallic PtPd hybrid nanostructures was developed for the sensitive determination of lipocalin-2 in renal cell carcinoma.
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Evaluation of segmented non-target data acquisition (SWATH/vDIA) in a QToF and QOrbitrap for pesticide residue analysis

Anal. Methods, 2020, 12,2027-2038
DOI: 10.1039/D0AY00290A, Paper
Łukasz Rajski, Iciar Beraza, María José Gómez Ramos, Carmen Ferrer, Amadeo R. Fernández-Alba
Two high-resolution instruments (a QToF and a QOrbitrap) were used to evaluate a segmented non-target MS2 (SWATH/vDIA) acquisition for pesticide residue analysis.
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Liquid–liquid microextraction of glyphosate, glufosinate and aminomethylphosphonic acid for the analysis of agricultural samples by liquid chromatography

Anal. Methods, 2020, 12,2039-2045
DOI: 10.1039/D0AY00120A, Paper
Javier Marín, Natalia Campillo, Manuel Hernández-Córdoba, Isabel Garrido, José Fenoll, Pilar Viñas
An ion-pair liquid–liquid microextraction procedure followed by LC tandem mass spectrometry allows a reliable and sensitive determination glyphosate, glufosinate y aminomethylphosphonic acid in agricultural samples.
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Methodology for elemental analysis of mineral fertilizer, some of its raw materials and limestone using microwave-induced plasma optical emission spectrometry (MIP OES)

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00459F, Paper
Dirce Pozebon, Alexandre Müller, Anderson Schwingel Ribeiro
Elemental analysis of complex matrices such as superphosphate-fertilizer and agricultural inputs by means of microwave induced plasma optical emission has been evaluated in the present study. A commercial single superphosphate-fertilizer...
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Recent advance in the analysis methodologies for microplastics in aquatic organisms: Current knowledge and research challenges

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00143K, Minireview
Jingkun Zhu, Can Wang
The widespread occurrence and high bioavailability of microplastics have increasingly attracted wide attention to society. Because of the presence of microplastics in aquatic organisms, it is necessary to investigate their...
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Detection of prostate-specific antigen in semen using DNA aptamers: an application of nucleic acid aptamers in forensic body fluid identification

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00371A, Paper
Tetsuya Satoh, Seiya Kouroki, Yusuke Kitamura, Toshihiro Ihara, Kazutoshi Matsumura, Susumu Iwase
In forensics, body fluid identification plays an important role because it aids in reconstructing the crime scene. Therefore, it is essential to develop simple and reliable techniques for body fluid...
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A dual-functional PDMS-assisted paper-based SERS platform for reliable detection of thiram residue both on fruit surface and in juice

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00483A, Paper
Shuang Lin, Wuliji Hasi, Siqingaowa Han, Xiang Lin, Li Wang
In this work, a dual-functional SERS platform was developed via a paper-based SERS substrate with the aid of hydrophobic Polydimethylsiloxane (PDMS) for effective and reliable measurements of thiram on fruit...
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A novel microfluidic paper-based analytical device based on chemiluminescence for the determination of β-agonists in swine hair

Anal. Methods, 2020, Advance Article
DOI: 10.1039/C9AY02754H, Paper
Wei Li, Yong Luo, Xiqing Yue, Junrui Wu, Rina Wu, Yu Qiao, Qing Peng, Bo Shi, Bingcheng Lin, Xu Chen
β-Agonists are illegal feed additives in the feed industries of many countries, especially China.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A simple and rapid method for blood plasma separation driven by capillary force with an application on protein detection

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00240B, Paper
Qingxue Gao, Yongjia Chang, Qingmei Deng, Hui You
Blood plasma separation is a vital sample pre-treatment procedure for microfluidic devices of blood diagnostic, which requires reliability and speediness. In this work, we propose a novel and simple method...
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Effective methods for the determination of triphenyltin residues in surface water and soil samples by high-performance liquid chromatography with tandem mass spectrometry

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00329H, Paper
Gabriel C. dos Santos, Állisson A. da S. Avellar, Rômulo de O. Schwaickhardt, Nelson M. G. Bandeira, Filipe F. Donato, Osmar D. Prestes, Renato Zanella
Monitoring of triphenyltin (TPhT) in the environment, particularly to control its misuse in agriculture, is of great importance because of its high toxicity.
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Direct measurement of Cu and Pb isotopic ratios without column chemistry for bronzes using MC-ICP-MS

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00561D, Paper
Zhian Bao, Chunlei Zong, Peng Liang, Yan Zhang, Kaiyun Chen, Honglin Yuan
This study presents a practical method for high-precision Cu and Pb isotope determination without column chemistry for bronzes using MC-ICP-MS. The standard-sample bracketing method combined with Ga internal normalization (SSBIN)...
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Development of a magnetic dispersive micro-solid-phase extraction method based on a deep eutectic solvent as a carrier for the rapid determination of meloxicam in biological samples

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00095G, Paper
Samira Rastbood, Mohammad Reza Hadjmohammadi, Seyedeh Maedeh Majidi
An environmentally friendly magnetic dispersive micro solid phase extraction based on a deep eutectic solvent as a carrier and disperser of adsorbents.
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Dopamine-modified magnetic graphene oxide as a recoverable sorbent for the preconcentration of metal ions by an effervescence-assisted dispersive micro solid-phase extraction procedure

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00522C, Paper
Basira Karbalaie, Maryam Rajabi, Bahareh Fahimirad
Nanomagnetic graphene oxide modified with dopamine (GO–Fe3O4–DA) was synthesized via a very simple procedure.
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A novel hybrid micro extraction for sensitive determination of 17β-Estradiol in water samples

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00581A, Paper
Shivender Singh Saini
A novel and green hybrid of pipette tip micro solid phase extraction (PT-µSPE) and supported liquid extraction (SLE) has been tailored and established for efficient and sensitive determination of 17β-Estradiol...
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Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00305K, Paper
Xiao-fan Wang, You-xi Zhang, Hai-ying Ma
Targeted profiling of amino acid metabolome in serum by LC-MS: application to identify potential markers for diet-induced hyperlipidemia.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Fast magnetic solid-phase extraction using Fe3O4-NH2@MOF material for monohydroxy polycyclic aromatic hydrocarbons in urine of coke-oven workers

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00449A, Paper
Yahui Wang, Meng Yan, Qianqian Ji, Manman Wang, Qian Wang, Xue-Sheng Wang, Yulan Hao
In this work, magnetic material (Fe3O4-NH2@MIL-101) was successfully prepared, and the material was used as a sorbent for the magnetic solid-phase extraction (MSPE) of trace level monohydroxy polycyclic aromatic hydrocarbons...
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Multivariate optimization of an analytical method for the analysis of Abruzzo white wines by ICP OES

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00478B, Paper
Fabrizio Ruggieri, Angelo Antonio D'Archivio, Martina Foschi, Maria Anna Maggi
An inductively coupled plasma-optical emission spectrometry (ICP OES) method was optimized and applied for determining the concentration of 14 elements (Ba, Ca, Co, Cu, Fe, K, Li, Mg, Mn, Na,...
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Elemental chemical composition and As speciation in rice varieties selected for biofortification

Anal. Methods, 2020, 12,2102-2113
DOI: 10.1039/D0AY00294A, Paper
Bruna Moreira Freire, Vivian da Silva Santos, Pericles de Carvalho Ferreira Neves, Juliana Maria Oliveira Souza Reis, Samuel Simião de Souza, Fernando Barbosa, Bruno Lemos Batista
Toxic elements, essential elements and other elements were determined in Brazilian rice by inductively coupled plasma-mass spectrometry (ICP-MS). A method for As speciation using hydride generation was developed and applied in rice samples.
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Ultrasensitive immunochromatographic strips for fast screening of the nicarbazin marker in chicken breast and liver samples based on monoclonal antibodies

Anal. Methods, 2020, 12,2143-2151
DOI: 10.1039/D0AY00414F, Paper
Xiaoxin Xu, Liqiang Liu, Xiaoling Wu, Hua Kuang, Chuanlai Xu
Nicarbazin is an anticoccidial drug with a residue limit in animal husbandry.
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Versatile additively manufactured (3D printed) wall-jet flow cell for high performance liquid chromatography-amperometric analysis: application to the detection and quantification of new psychoactive substances (NBOMes)

Anal. Methods, 2020, 12,2152-2165
DOI: 10.1039/D0AY00500B, Paper
Open Access
Hadil M. Elbardisy, Eduardo M. Richter, Robert D. Crapnell, Michael P. Down, Peter G. Gough, Tarek S. Belal, Wael Talaat, Hoda G. Daabees, Craig E. Banks
Additive manufacturing is an emerging technology of vast applicability, receiving significant interest in a plethora of industrial and research domains as it allows the translation of designs produced via computer software, into 3D printed objects.
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Quality by Design (QbD) approach for the development of a rapid UHPLC method for simultaneous determination of aglycone and glycoside forms of isoflavones in dietary supplements

Anal. Methods, 2020, 12,2082-2092
DOI: 10.1039/C9AY02778E, Paper
Kornelija Lasić, Ana Mornar, Biljana Nigović
Systematic development of a UHPLC method by QbD approach as performed for simultaneous determination of aglycone (genistein, daidzein, biochanin A and formononetin) and glycoside (genistin, daidzin, sissotrin, ononin) forms of isoflavones.
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Multi-residue determination of micropollutants in Nigerian fish from Lagos lagoon using ultrasound assisted extraction, solid phase extraction and ultra-high-performance liquid chromatography tandem mass spectrometry

Anal. Methods, 2020, 12,2114-2122
DOI: 10.1039/D0AY00411A, Paper
Idera Fabunmi, Natalie Sims, Kathryn Proctor, Aderonke Oyeyiola, Temilola Oluseyi, Kehinde Olayinka, Barbara Kasprzyk-Hordern
This reports for the first time a simple and robust approach in determining pharmaceuticals in different fish species in Nigeria.
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Development of a paper-immobilized yeast biosensor for the detection of physiological concentrations of doxycycline in technology-limited settings

Anal. Methods, 2020, 12,2123-2132
DOI: 10.1039/D0AY00001A, Paper
Rachel A. Miller, Galen Brown, Elsa Barron, Jamie L. Luther, Marya Lieberman, Holly V. Goodson
To combat pharmaceutical counterfeiting in low- and middle-income countries (LMIC), there is a need for improved low-cost, portable methods that monitor pharmaceutical concentrations relevant to dosage forms and physiological fluids.
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Correction: Towards simultaneous quantification of protease inhibitors and inflammatory biomarkers in serum for people living with HIV

Anal. Methods, 2020, 12,2196-2196
DOI: 10.1039/D0AY90050H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Pengyi Wang, Charles S. Venuto, Raymond Cha, Benjamin L. Miller
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Au nanoparticle preconcentration coupled with CE-electrochemiluminescence detection for sensitive analysis of fluoroquinolones in European eel (Anguilla anguilla)

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00264J, Paper
Longhua Guo, Meihua Liu, Yuechun Yin, Lifen Chen, Zhitao Chen, Jing-Jing Liu, Bin Qiu
In this work, a novel method based on gold nanoparticle preconcentration coupled with CE for electrochemiluminescent detection of ciprofloxacin, enrofloxacin, ofloxacin, and norfloxacin in European eels was developed. The addition...
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Confirmation of brand identification in infant formulas by using near-infrared spectroscopy fingerprints

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00375A, Paper
Shuyi Chang, Chengcheng Yin, Sha Liang, Mei Lu, Ping Wang, Zhicheng Li
The NIR spectra of 12 batches of each stage of Brand A infant formulas.
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Portable and benchtop Raman spectrometers coupled to cluster analysis to identify quinine sulfate polymorphs in solid dosage forms and antimalarial drug quantification in solution by AuNPs-SERS with MCR-ALS

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00693A, Paper
Sarmento J. Mazivila, Helena I. S. Nogueira, Ricardo N. M. J. Páscoa, David S. M. Ribeiro, João L. M. Santos, João M. M. Leitão, Joaquim C. G. Esteves da Silva
Raman spectrometers coupled to cluster analysis were able to identify two polymorphs of quinine sulfate in solid dosage forms. Gold nanoparticles-surface-enhanced Raman scattering with MCR-ALS was used to antimalarial drug quantification in solution.
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The design and synthesis of two imidazole fluorescent probes for the special recognition of HClO/NaHSO3 and their applications

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00334D, Paper
Hong-Lin Ding, Yan-Qing Pu, Da-Ying Ye, Zi-Yue Dong, Man Yang, Cheng-Wei Lü, Yue An
The design and synthesis of two imidazole fluorescent probes for the special recognition of HClO/NaHSO3 and their applications are shown.
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Comparison of surfactant-mediated liquid chromatographic modes with sodium dodecyl sulphate for the analysis of basic drugs

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00526F, Paper
N. Pankajkumar-Patel, E. Peris-García, M. J. Ruiz-Angel, M. C. García-Alvarez-Coque
A comprehensive overview of the performance of MLC, HSLC and MELC for the analysis of basic compounds.
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Solid-phase microextraction using a β-ketoenamine-linked covalent organic framework coating for efficient enrichment of synthetic musks in water samples

Anal. Methods, 2020, Advance Article
DOI: 10.1039/C9AY02755F, Paper
Lian Wen, Peng Wu, Lei-Lei Wang, Li-Zong Chen, Ming-Lin Wang, Xia Wang, Jin-Ming Lin, Ru-Song Zhao
This study indicated the promising applicability of the TpPa-1 as a solid-phase microextraction fiber coating for reliably detecting synthetic musks at trace levels from environmental samples.
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Sample treatment based on molecularly imprinted polymers for the analysis of veterinary drugs in food samples: a review

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00533A, Critical Review
Israel Samuel Ibarra, J. M. Miranda, Irma Perez, Aldo C Jardinez, Gabriela Islas
The use of veterinary drugs in medical treatments and in the livestock industry is a recurrent practice. In subtherapeutic doses during prolonged times act to growth promoters. Residues of these...
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Multivariate optimization of an ultrasound-assisted extraction procedure for the determination of Cu, Fe, Mn, and Zn in plant samples by flame atomic absorption spectrometry

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00554A, Paper
Floriatan Santos Costa, Raquel Viana Pinto Leal, Clissiane Soares Viana Pacheco, Fábio Alan Carqueija Amorim, Raildo Mota de Jesus, Luana Novaes Santos, Erik Galvão Paranhos da Silva
A new ultrasound-assisted extraction method simple and fast was developed employing multivariate optimization.
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Colorimetric indicators for volatile amines based on succinic anhydride (SAh)-grafted poly (lactic acid) (PLA)

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00550A, Paper
Adrian Lopera-Valle, Anastasia Elias
Smart materials that can undergo changes in color upon the detection of amines have the potential to provide information on the freshness of fish and meat.
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Facile dispersive solid-phase extraction based on humic acid for the determination of aflatoxins in various edible oils

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00534G, Paper
Ping Liu, Yan-Hua Liao, Hao-Bo Zheng, Yang Tang
Aflatoxins (AFs), as the secondary metabolites produced by some toxigenic fungi of Aspergillus species, are well known to be extremely harmful to humans and animals because of their high toxicity, mutagenicity, carcinogenicity, and teratogenicity.
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Miniaturized QuEChERS method for determination of 97 pesticide residues in wine by ultra-high performance liquid chromatography coupled to tandem mass spectrometry

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00744G, Paper
Gabrieli Bernardi, Magali Kemmerich, Martha B Adaime, Osmar Damian Prestes, Renato Zanella
A miniaturized sample preparation method was developed and validated for the multiresidue determination of 97 pesticide residues in wine samples. The proposed extraction procedure is based on QuEChERS acetate method...
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