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Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00617C, Communication
Wei Liu, Vinay Gopal Jannu, Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang, Yiguang Zhu
N-Methyltransferase TsnB8 was demonstrated to catalyze successive methyltransfer reactions in the biosynthesis of trichostatin.
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Catalyst- and Solvent-Free Efficient Access to N-Alkylated Amines via Reductive Amination using HBPin

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00740D, Communication
ARNAB RIT, Vipin Kumar Pandey, Somnath Bauri
A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and...
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Discrimination of cellular developmental states focusing on glycan transformation and membrane dynamics by using BODIPY-tagged lactosyl ceramides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00547A, Paper
Kenta Arai, Atsuko Ohtake, Shusaku Daikoku, Katsuhiko Suzuki, Yukishige Ito, Kazuya Kabayama, Koichi Fukase, Yoshimi Kanie, Osamu Kanie
Different cellular states were discriminated by analysing either the glycan transformation of exogenously introduced fluorescently tagged probe molecules or fluorescence recovery after photobleaching before conversion.
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Copper(I)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00546K, Paper
Hao Cui, Ke Li, Yue Wang, Manman Song, Congcong Wang, Donghui Wei, Er-Qing Li, Zheng Duan, François Mathey
A copper/Ganphos-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described, producing the spiro[pyrrolidin-3,3'-oxindole]s in good yields with high ee.
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Synthesis of methylene cyclopropane-fused chromenes and dihydroquinolines by sequential [4 + 2]- and [1 + 2]-annulation

Org. Biomol. Chem., 2020, 18,3303-3311
DOI: 10.1039/D0OB00389A, Paper
Tianyu Lu, Xuange Zhang, Zhiwei Miao
A base promoted sequential [4 + 2]- and [1 + 2]-annulation of 2-hydroxychalcones or 2-tosylaminochalcones with prop-2-ynylsulfonium salts was developed.
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Modular continuous flow synthesis of orthogonally protected 6-deoxy glucose glycals

Org. Biomol. Chem., 2020, 18,3254-3257
DOI: 10.1039/D0OB00522C, Communication
Subbarao Yalamanchili, Tu-Anh V. Nguyen, Nicola L. B. Pohl, Clay S. Bennett
The use of a continuous flow platform for the rapid and highly efficient construction of differentially protected glycals from commercial sources is described.
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Dipyrazolodioxadiazocines as shelf-stable “ready-to-use” precursors for an in situ generation of enolate-iminium 1,4-dipoles: a straightforward atom-economical approach to pyrazolo[5,1-d][1,3,5]dioxazines

Org. Biomol. Chem., 2020, 18,3382-3391
DOI: 10.1039/D0OB00451K, Paper
Vladimir E. Zhulanov, Valeria A. Vigovskaya, Maksim V. Dmitriev, Pavel S. Silaichev, Andrey N. Maslivets, Michael Rubin
Generation of cyclic enolate-iminium 1,4-dipoles via thermolysis of dipyrazolodioxadiazocines in the presence of ketones allowed for efficient preparation of pyrazolo[5,1-d][1,3,5]dioxazines.
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Controlling the liberation rate of the in situ release of a chemical fuel for the operationally autonomous motions of molecular machines

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00669F, Paper
Chiara Biagini, Giorgio Capocasa, Daniele Del Giudice, Valerio Cataldi, Luigi Mandolini, Stefano Di Stefano
Aminolysis of the anhydride of 2-cyano-2-phenylpropanoic acid can be employed to conveniently regulate the liberation rate of the related acid which, in turn, can be used as a fuel for acid–base operated molecular machines.
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Gold(III)-catalyzed azide-yne cyclization/O–H insertion cascade reaction for the expeditious construction of 3-alkoxy-4-quinolinone frameworks

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00745E, Paper
Jingjing Huang, Han Su, Ming Bao, Lihua Qiu, Yuanqing Zhang, Xinfang Xu
A gold-catalyzed cascade reaction has been developed, and it provides an expeditious access to 3-alkoxy-4-quinolines and applications in alkaloid synthesis.
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Arylation of Indoles Using Cyclohexanones Dually-Catalyzed by Niobic Acid and Palladium-on-Carbons

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00702A, Paper
Kazuho Ban, Yuta Yamamoto, Hironao Sajiki, Yoshinari Sawama
3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C...
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Highly modified steroids from Inonotus obliquus

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00474J, Paper
Chun-Xin Zou, Zilin Hou, Ming Bai, Rui Guo, Bin Lin, Xiaobo Wang, Xiaoxiao Huang, Shaojiang Song
Six undescribed steroids were isolated from the fungus Inonotus obliquus. Notably, compounds 1 and 2 represented the first example of 8, 14-seco-4-methylpregnane. By spectroscopic data analyses, quantum chemical calculations and...
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Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00910E, Paper
Jacob St-Gelais, Vincent Denavit, Denis Giguère
Selective galectin inhibitors are valuable research tools and could also be used as drug candidates. In that context, TD139, a thiodigalactoside galectin-3 inhibitor, is currently being evaluated clinically for the...
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Delhi: 2 schools closed after students test positive for H1N1 virus

Two city schools have been closed for a week from Monday after a student each from the educational institution tested positive for swine flu.




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Mumbaikars usher in Ganesh amidst flu scare

Terror alerts and swine flu scare did not dampen the spirit of Mumbaikars as they welcomed the elephant headed-god.




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Six held for forceful religious conversion

The arrests came soon after tribals demanded the arrest of those involved in the activity.




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We’ll look back at 2014 as a new journey for India-Israel ties: Alon Ushpiz

India and Israel have signed a far-reaching agreement on homeland security where the two countries will collaborate on policing, forensics, counter-terrorism, etc. Israel's ambassador Alon Ushpiz spoke with Indrani Bagchi about shared concerns, PM Modi — and justice in the 2012 attack on an Israeli diplomat:




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Progress measures must include nature — think beyond GDP: Rachel Kyte

As India debates environmental health versus economic growth, Rachel Kyte, vice-president and special envoy for climate change at the World Bank Group, feels it is vital to think beyond basic GDP.




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Cos use foreign money for political funding. Isn’t that influencing polls?

A recent Intelligence Bureau (IB) report has claimed that some well-known NGOs are working to stall economic development at the behest of their foreign donors. Activists and rights groups have been up in arms ever since the report was leaked.




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There’s no power politics, customer is king, Piyush Goyal says

The responsibility of lighting up the country today rests on Piyush Goyal’s shoulders. Just a month into his new job, the minister for power, coal and renewable energy has set an electric pace to energize the sector.




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Australia-India cricket rivalry has even bettered Ashes: John Harnden

CEO of the ICC World Cup 2015 John Harnden spoke with Amin Ali about ensuring excitement in cricket's mega-tournament, clamping down on racism, managing 'minnows' matches — and how Australia is sizing up India as a rival for the trophy.




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Hate crime: Two Sikhs attacked in US, one dead

Two elderly Sikhs were shot at by unidentified assailants in Sacramento in US, leaving one dead and the other in critical condition, triggering panic in the neighbourhood having a sizeable Sikh population.




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Hindu guru convicted of molesting girls in US

An octogenarian Hindu religious leader, head of a Hindu ashram, one of the largest temples in the US, has been convicted of molesting two young girls.




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Hindu guru gets 14 years prison for sexual molestation in US

Absconding Indian godman Prakashanand Saraswati, also known as Shree Swamiji, has been sentenced to 14 years in prison and fined USD 10,000.




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Indian girl raped, murdered and stuffed inside suitcase in Australia

24-year-old Tosha Thakkar was last seen alive on March 9 in Sydney. Her alleged attacker, Daniel Stani-Reginald, has been denied bail.




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Indian-origin model accuses Aus modelling agency of racism

According to a report in the local daily, Kema Rajandran was told by a Parth-based modelling agency that her work chances were "limited" in the country because she was not Caucasian.




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Australia's Victoria police inducts first turban wearing Sikh

Police in Australia's Victoria state today inducted its first officer from Sikh community who will wear a newly designed police turban, a media report said today.




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US housing society to pay $110,000 for keeping Indians out

A Seattle-based housing society will pay over $110,000 to settle a lawsuit that alleged the society discriminated against Indians and African-Americans seeking to rent apartments in the complex.




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Coming to UP? You can use your own vehicle

More than 1.48 lakh people registered on the government's Jan Sunwai portal on Thursday, requesting to be brought back to UP from other states that they have been stuck in since the lockdown was imposed.




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E-tokens fail to take off; liquor shops see rush

Booze lovers continued to throng liquor shops in the city, even as the e-token system introduced by the Delhi government could not fully take off due to heavy traffic on the designated website.




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Delhi construction workers told to use Aarogya app

Amid the debate over privacy concerns, Delhi government has issued orders to make Aarogya Setu mobile application popular among factory and construction workers returning to work after six weeks of lockdown.




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Confusion prevails over Delhi's Covid-19 toll

According to the bulletin, AIIMS (Delhi and Jhajjar) reported two deaths, Safdarjung Hospital reported four, RML 26 and Lady Hardinge Medical College had none till Friday.




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Coronavirus: Citing privacy concerns, New York City bans schools from using Zoom amid lockdown

The ban comes right after the video conferencing service company started receiving a lot of criticism for poor security policies and privacy practices from it users.




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Coronavirus Pandemic: WhatsApp limits forwarding to one chat at a time to curb fake news

WhatsApp is also working directly with NGOs and governments, including the WHO and over 20 national health ministries, to help connect people with accurate information.




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Indian researchers start working on genome sequencing of novel coronavirus

In the next 3-4 weeks researchers would be able to get at least 200-300 isolates and this information would help them to make some further conclusion about the behaviour of this virus.




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USGS releases first comprehensive geological map of moon using Apollo data

The new map explains the 4.5-billion-year-old history of our neighbour in space.




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Elon Musk's SpaceX, Jeff Bezos' Blue Origin selected by NASA to build lunar landing systems

Boeing Co, the aerospace company also submitted its concept for a lunar lander last year but it was not selected.




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YouTube sensation PewDiePie signs exclusive live-streaming deal with the video-sharing platform

In the month of Jan, he announced a break from YouTube but continued posting his regular videos after his break.




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WhatsApp may soon allow you to use it on multiple devices simultaneously

The feature been under testing for some time.




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Konkona: 15 years ago, I didn't take acting seriously

'I have changed and matured.''There is still a certain kind of detachment but I have far more appreciation and gratitude.'




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Why Ayushmann is not interested in Rs 200 crores

'I can do slice-of-life kind of films anytime; But playing a cop is different. It's difficult to maintain that intensity on screen. That's where the real acting comes in place.'




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The Manoj Bajpayee interview you MUST READ!

'Mumbai is very different from the rest of India. It can be ruthless if you don't have work or friends. The struggle time and times of disappointment are horrific and can break you.'




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'It's because of Bigg Boss that I am here'

'So many things opened up for me after I did the show.'





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'All of us need counselling at some point'

'People will be entertained by the Singhams and the Simmbas but they will still not respect cops. Batla House is an opportunity for us to show the true side of policemen and their sacrifices.'




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'I don't do films that just want to make money'

Nithya Menen's fiery interview.





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'I am so nervous, I want to lock myself in a room!'

'I did not have a quintessential debut even though my father is a well known actor in the industry. That's why I never felt like an industry kid.'




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'I was worried if people would accept Ayushmann'

'When a person is poor, no one asks him anything, fearing that he might ask for a loan. But when he gets rich, everyone comes. So that changeover is happening and it is nice that it is happening.'