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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
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Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00663A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin Krátký
Linking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory




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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago




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Doctor assaulted inside Tiruchi ESI Hospital




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Deputy CM releases commemorative flag of Bharat Scouts and Guides




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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Site identified for small-scale handloom park in Karur




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574: Estelle & Eric on CSS The Definitive Guide, 5th Edition

Estelle Weyl and Eric Meyer join us to talk about the 5th edition of their book, CSS: The Definitive Guide. We talk about some of CSS' biggest blunders, custom scroll bars, single line comments, shorthand in CSS, useless CSS trivia, and how to get started learning CSS in 2023.




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593: Beep & Texts, Tumblr, JavaScript & Web Components, & Cool Blog Post Ideas

Thoughts on smashing all communication messaging apps together, what's happened to Tumblr under Automattic, what the situation is with native web components and JavaScript, and looking at a list of types of blog posts.




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629: The Great Divide, Global Design + Web Components, and Job Titles

A bit of follow-up on vibe driven development and JavaScript not causing The Great Divide, writing testing automation, global design systems and web components, could PHP be used for web components, what if view transitions are going to be everywhere, and frontend engineer vs design systems engineer job titles and descriptions.




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631: Dave’s Second Brain Idea, Notion Thoughts, and Google’s LLM in Chrome

Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers.




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635: Jeff Robbins and Visibox as an Instrument for Video

Jeff Robbins stops by to talk about his software, Visibox, that was used at Frostapalooza for presenting video at the concert, what it's like building an app with Electron, how it's distributed, how files are used and managed, and how he supports hardware devices inside Electron.




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Guidelines for green urbanisation

The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports




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Typecasting eco-ideas

Important public buildings ignore the time-tested lessons of sustainability found in local architecture. By SATHYA PRAKASH VARANASHI




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How Ratan Tata pushed for evidence-led ayurveda 

Ratan Tata sought to promote research that could validate ayurveda through contemporary science




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Senior feline resident: Defib stays at his ambulance station 

Online petition halts re-homing of 16-year-old cat in London




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Trump presidency casts long shadow over climate summit 

The return of the climate denier as head of the world’s biggest greenhouse gas emitter threatens to throw net-zero negotiations into disarray once again




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HC tells jail authority to decide plea on lack of facilities for visiting lawyers




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Provide medical aid to jailed separatist leader Yasin Malik: Delhi HC to Tihar jail

In his plea before the high court, Malik claimed to be a patient of “serious cardiac and kidney ailments”, currently facing a “life and death situation”




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Demonising Constitutional institutions pastime for some: Vice-President Jagdeep Dhankhar

Addressing an event of an educational institution in New Delhi, the Vice-President said it is time to "bid adieu to this"




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One dead, one injured in two firing incidents in Delhi within 10 minutes

The two incidents of firing in northeast Delhi leave one dead and one injured; three suspects apprehended by police




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Security upped outside Canadian High Commission due to protest against temple attack

The Hindu Sikh Global Forum members are marching towards the High Commission in the Chanakyapuri area




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Cultural side to leadership

Exploring the relevance of Indian-ness in our leaders




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Pranab’s Presidential years

A matter-of-fact, yet reflective, memoir of a veteran politician




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Centre to provide 15,000 women self help groups with drones that can be rented out for agricultural purposes

The scheme will help in infusing advanced technology in agriculture for improved efficiency, enhance crop yield and reduced cost of operation for the benefit of farmers




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Open sale of hazardous pesticides continues to impact the health of farmers in Maharashtra

In 2017, reports of pesticide poisoning emerging from Maharashtra drew global criticism against India’s pesticide regulation policies, yet not much appears to have changed since then




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Research paper warns against nationwide switch to natural farming without proper studies

It can hamper national food production, say authors, who cite contrasting results from two studies




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SC notice to Centre on plea alleging overuse of pesticides on crops and food items





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Zomato’s losses widen in FY16




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Business confidence dips to 5-month low in May





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Mahindra rides on higher demand, Q4 net up 14 per cent




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How Facebook can decide the price of your house




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Indu Makkal Katchi youth wing president Omkar Balaji questioned for remarks on Nakkheeran Gopal

The Coimbatore police question IMK youth wing leader for threatening to “chop off editor’s tongue”, sparking legal action and protests




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Panchayat, aided schools in Tiruchi district bag awards for excellence in teaching, better enrolment

The schools are assessed based on including basic infrastructure, quality of education and teaching practices, technology-enabled teaching, development of the school, and activities done by students




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How free bus ride shapes women’s experience of public spaces

In Chennai, Bangalore, and Delhi that offer access to free transport, there is a visible change in the public space. The pink slip is not a cure-all for the deep-rooted patriarchy, but they are important steps towards reshaping urban spaces into more inclusive environments




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Absence of bund around deepened pond worries residents of Morais Garden Extension in Tiruchi

The pond at Runway Nagar, Kottapattu, which was deepened a few months ago, is now filled with water after recent rain. Residents are worried that it may overflow and the stagnant water might become a haven for snakes and insects.




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Co-encapsulation of organic polymers and inorganic superparamagnetic iron oxide colloidal crystals requires matched diffusion time scales

Soft Matter, 2024, 20,8312-8325
DOI: 10.1039/D4SM00935E, Paper
Open Access
Brian K. Wilson, Robert K. Prud’homme
Composite nanoparticles co-encapsulate organic materials with inorganic primary colloids. Producing “stoichiometric NPs”, where all NPs contain organic and inorganic species at similar ratios, requires matched diffusion-aggregation time scale.
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Aging iridium oxide catalyst inks: a formulation strategy to enhance ink processability for polymer electrolyte membrane water electrolyzers

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00987H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sunilkumar Khandavalli, Jae Hyung Park, Robin Rice, Diana Y. Zhang, Sarah A. Berlinger, Guido Bender, Deborah J. Myers, Michael Ulsh, Scott A. Mauger
Steady-shear rheology showing evolution of the microstructure of iridium oxide catalyst inks of PEM water electrolyzers with aging time.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Hydrophobic fouling-resistant electrospun nanofiber membranes from poly(vinylidene fluoride)/polyampholyte blends

Soft Matter, 2024, 20,8654-8662
DOI: 10.1039/D4SM00817K, Paper
Anuja S. Jayasekara, Luca Mazzaferro, Ryan O’Hara, Ayse Asatekin, Peggy Cebe
This study reports the fabrication of non-woven fibrous membranes from electrospinning blended solutions of PVDF with a random polyampholyte amphiphilic copolymer (r-PAC) in N,N-dimethylformamide and methanol.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Entropically and enthalpically driven self-assembly of a naphthalimide-based luminescent organic π-amphiphile in water

Soft Matter, 2024, 20,8684-8691
DOI: 10.1039/D4SM00986J, Paper
Sk Mursed Ali, Sujauddin Sk, Shuvajyoti Sarkar, Sayani Das, Nayim Sepay, Mijanur Rahaman Molla
Entropically and enthalpically favourable vesicular self-assembly of a naphthalimide based water soluble luminescent organic dipolar building block is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Shape transformations in peptide-DNA coacervates driven by enzyme-catalyzed deacetylation

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM01091D, Paper
Open Access
Merlijn van Haren, Nienke Helmers, Luuk Verploegen, Viveca Beckers, Evan Spruijt
Biomolecular condensates formed by liquid-liquid phase separation (LLPS) are important organizers of biochemistry in living cells. Condensate formation can be dynamically regulated, for example by protein binding or enzymatic processes....
The content of this RSS Feed (c) The Royal Society of Chemistry




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The influence of active agent motility on SIRS epidemiological dynamics

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00864B, Paper
Open Access
R. Kailasham, Aditya S. Khair
Motility induced phase separation of active disks with SIRS epidemiological dynamics.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Future Accessibility Guidelines—for People Who Can’t Wait to Read Them

Alan Dalton uses this, the International Day of Persons with Disabilities, to look back at where we’ve come from, to evaluate where we are, and to look forward to what’s coming next in the future of accessibility guidelines.


Happy United Nations International Day of Persons with Disabilities! The United Nations have chosen “Promoting the participation of persons with disabilities and their leadership: taking action on the 2030 Development Agenda” for this year’s observance. Let’s see how the World Wide Web Consortium (W3C)’s Web Accessibility Initiative (WAI) guidelines of accessibility past, present, and yet-to-come can help us to follow that goal, and make sure that the websites—and everything else!—that we create can include as many potential users as possible.

Guidelines of Accessibility Past

The W3C published the Web Content Accessibility Guidelines (WCAG) 1.0 on 5th May 1999, when most of us were playing Snake on our Nokia 3210s’ 1.5” monochrome screens…a very long time ago in technology terms. From the start, those guidelines proved enlightening for designers and developers who wanted to avoid excluding users from their websites. For example, we learned how to provide alternatives to audio and images, how to structure information, and how to help users to find the information they needed. However, those guidelines were specific to the web technologies of the time, resulting in limitations such as requiring developers to “use W3C technologies when they are available […]”. Also, those guidelines became outdated; I doubt that you, gentle reader, consult their technical documentation about “directly accessible applets” or “Writing for browsers that do not support FRAME” in your day-to-day work.

Guidelines of Accessibility Present

The W3C published the Web Content Accessibility Guidelines (WCAG) 2.0 on 11th December 2008, when most of us were admiring the iPhone 3G’s innovative “iPhone OS 2.0” software…a long time ago in technology terms. Unlike WCAG 1, these guidelines also applied to non-W3C technologies, such as PDF and Flash. These guidelines used legalese and future-proofed language, with terms such as “time-based media” and “programmatically determined”, and testable success criteria. This made these guidelines more difficult for designers and developers to grasp, but also enabled the guidelines to make their way into international standards (see EN 301 549 — Accessibility requirements suitable for public procurement of ICT products and services in Europe and ISO/IEC 40500:2012 Information technology — W3C Web Content Accessibility Guidelines (WCAG) 2.0) and even international law (see EU Directive 2016/2102 … on the accessibility of the websites and mobile applications of public sector bodies).

More importantly, these guidelines enabled designers and developers to create inclusive websites, at scale. For example, in the past 18 months:

The updated Web Content Accessibility Guidelines (WCAG) 2.1 arrived on 5th June last year—almost a 10-year wait for a “.1” update!—and added 17 new success criteria to help bring the guidelines up to date. Those new criteria focused on people using mobile devices and touchscreens, people with low vision, and people with cognitive and learning disabilities.

(If you need to get up to speed with these guidelines, take 36 minutes to read “Web Content Accessibility Guidelines—for People Who Haven’t Read Them” and Web Content Accessibility Guidelines 2.1—for People Who Haven’t Read the Update.)

Guidelines of Accessibility Yet to Come

So, what’s next? Well, the W3C hope to release another minor update (WCAG 2.2) in November 2020. However, they also have a Task Force working on produce major new guidelines with wider scope (more people, more technologies) and fewer limitations (easier to understand, easier to use) in November 2022. These next guidelines will have a different name, because they will cover more than “Web” and “Content”. Andrew Kirkpatrick (Adobe’s Head of Accessibility) named the Task Force “Silver” (because the initials of “Accessibility Guidelines” form the symbol of the silver element).

The Silver Task Force want the next major accessibility guidelines to:

  • take account of more disabilities;
  • apply to more technologies than just the web, including virtual reality, augmented reality, voice assistants, and more;
  • consider all the technologies that people use, including authoring tools, browsers, media players, assistive technologies (including screen readers and screen magnifiers), application software, and operating systems.

That’s quite a challenge, and so the more people who can help, the better. The Silver Task Force wanted an alternative to W3C’s Working Groups, which are made up of employees of organisations who are members of the W3C, and invited experts. So, they created a Silver Community Group to allow everyone to contribute towards this crucial work. If you want to join right now, for free, just create a W3C account.

Like all good designers, the Silver Task Force and Silver Community Group began by researching. They examined the problems that people have had when using, conforming to, and maintaining the existing accessibility guidelines, and then summarised that research. From there, the Silver Community Group drafted ambitious design principles and requirements. You can read about what the Silver Community Group are currently working on, and decide whether you would like to get involved now, or at a later stage.

Emphasise expertise over empathy

Remember that today’s theme is “Promoting the participation of persons with disabilities and their leadership: taking action on the 2030 Development Agenda”. (The United Nations’ 2030 Development Agenda is outside the scope of this article, but if you’re looking to be inspired, read Alessia Aquaro’s article on Public Digital’s blog about how digital government can contribute to the UN’s Sustainable Development Goals.) In line with this theme, if you don’t have a disability and you want to contribute to the Silver Community Group, resist the temptation to try to empathise with people with disabilities. Instead, take 21 minutes during this festive season to enjoy the brilliant Liz Jackson explaining how empathy reifies disability stigmas, and follow her advice.

Choose the right route

I think we can expect the next Accessibility Guidelines to make their way into international standards and international law, just like their predecessors. We can also expect successful companies to apply them at scale. If you contribute to developing those guidelines, you can help to make sure that as many people as possible will be able to access digital information and services, in an era when that access will be crucial to every aspect of people’s lives. As Cennydd Bowles explained in “Building Better Worlds”, “There is no such thing as the future. There are instead a near-infinity of potential futures. The road as-yet-untravelled stretches before us in abundant directions. We get to choose the route. There is no fate but what we make.”


About the author

Alan Dalton worked for Ireland’s National Disability Authority for 9½ years, mostly as Accessibility Development Advisor. That involved working closely with public sector bodies to make websites, services, and information more accessible to all users, including users with disabilities. Before that, he was a consultant and trainer for Software Paths Ltd. in Dublin. In his spare time, he maintains StrongPasswordGenerator.com to help people stay safe online, tweets, and takes photos.

More articles by Alan




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Gift Giving to the World (Wide Web)

Frances Berriman asks us to give the gift of consideration to those who are using the web on constricted devices such as low-end smart phones or feature phones. Christmas is a time of good will to all, and as Bugsy Malone reminds us, you give a little love and it all comes back to you.


If I was given the job of Father Christmas with all my human limitations, apparently it would take me something like 6 months at non-stop full speed to deliver gifts to every kid on the planet. The real Father Christmas has the luxury of magic when it comes to delivering millions of gifts in just one night, but the only magical platform at my disposal is the world wide web, so I propose switching to digital gift cards and saving the reindeer feed.

300 million people are set to come online for the very first time in 2020, and a majority of those will be doing so via mobile phones (smart- and feature-phones). If we want those new users to have a great time online, spending those gift cards, we need to start thinking about their needs and limitations.

Suit up

We might not be hopping on the sleigh for these deliveries, but let’s suit up for the journey and get the tools we need to start testing and checking how our online gift-receivers will be enjoying their online shopping experience.

Of course, the variety of phones and OSs out there is huge and varied, but we have a few options out there to get a sense for the median. Here’s a few suggestions on where to start:

  • Never has there been a better time to advocate at your workplace for a device testing suite or lab.
  • You can also just pick up a low-end phone for a few bucks and spend some real time using it and getting a sense for how it feels to live with it every day. May I suggest the Nokia 2 or the Moto E6 - both very representative devices of the sort our new visitors will be on.
  • You’ve also got WebPageTest.org at your disposal, where you can emulate various phones and see your sites rendered in real-time to get a sense of what an experience may look like for your users.
  • You’ll also want to set yourself some goals. A performance budget, for example, is a good way to know if the code you’re shipping hits the mark in a more programmatic way.

Gift wrap

Many of us began our internet lives on desktop machines, and thanks to Moore’s law, these machines have been getting ever more powerful every year with more CPUs and memory at our disposal. The mobile phone landscape somewhat resets us on what hardware capacity is available on the client-side of our code, so it’s time to lighten the load.

What we see in the landscape of phones today is a huge spread of capabilities and CPU speeds, storage capacity and memory. And the gap between the haves and the have-nots is widening, so we have a huge task to deal with in meeting the needs of such a varied audience.

As far as possible, we should try to:

  • Keep processing off the client - do anything you can server-side. Consider a server-side render (hold the <script>, thanks) for anything relatively static (including cached frequent queries and results) to keep client-side JavaScript to the minimum. This way you’re spending your CPU, not the user’s.
  • Avoid sending everything you have to to the end user. Mobile-first access also means data-plan-first access for many, which means they may be literally paying in cold-hard cash for everything you send over the wire – or may be experiencing your site over a degraded “4G” connection towards the end of the month.
  • Aggressively cache assets to prevent re-downloading anything you’ve sent before. Don’t make the user pay twice if they don’t have to.
  • Progressively load additional assets and information as the user requests them, rather than a big upfront payload, that way you’re giving the end user a little more choice about whether they want or need that extra data set.

This is all to say that as web developers, we have a lot more control over how and when we deliver the meat of our products - unlike native apps that generally send the whole experience down as one multi-megabyte download that our 4G and data-strapped users can’t afford.

Make a wish

Finally, it’s time for your gift recipients to go out onto the web and find whatever their greatest wish is. For many, that’s going to begin when they first turn on their phone and see all those enticing icons on their home screen. Opening a browser may not be their first port of call.

They’ll be primed to look for sites and information through the icon-heavy menu that most mobile OSs use today, and they will be encouraged to find new experiences through the provided app store interface.

The good news is that web experience can be found in many modern app-stores today.

For example, if you build an app using Trusted Web Activities, the Google Play Store will list your web site right alongside native apps and allow users to install them on their phones. Samsung and Microsoft have similar options without the extra step of creating a TWA - they’ll list any Progressive Web App in their stores. Tools like Microsoft’s PWA Builder and Llama Pack are making this easier than ever.

If your users are primed to search for new experiences via a search engine instead, then they’ll benefit from the work you’ve put in to list them in app stores regardless, as PWAs are first and foremost about making websites mobile-friendly, regardless of point of sale. A PWA will provide them with offline support, service works, notifications and much more.

We do have a grinch in this story, however.

Apple’s iOS explicitly does not allow your website to be listed in their app store, so sadly you’ll have a harder time reaching those users. But it is possible! Fortunately, iOS isn’t as all-dominating world wide as it is in the tech community, selling only around 10-15% of smartphones out in the world.

The best present

The WWW is a wonderful gift that we received over 30 years ago and, as web developers, we get to steward and share this truly global, open, platform with millions of people every day. Let’s take care of it by building and sharing experiences that truly meet the needs of everyone.


About the author

Frances Berriman is a San Francisco-based British-born designer and web developer who blogs at fberriman.com. She’s done all sorts of things, but has a special soft spot for public sector projects, and has worked for the Government Digital Service, building GOV.UK, Code for America, Nature Publishing and the BBC and is currently Head of UX and Product Design at Netlify.

More articles by Frances




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The Accidental Side Project

Drew McLellan puts the chairs up on the tables, sweeps the floor, and closes off our season, and indeed the entire 24 ways project with a look back at what it’s meant to run this site as a site project, and what impact side projects can have on the work we do. Will the last one out turn off Christmas the lights?


Brought to you by The CSS Layout Workshop. Does developing layouts with CSS seem like hard work? How much time could you save without all the trial and error? Are you ready to really learn CSS layout?


Fifteen years ago, on a bit of a whim, I decided it would be fun to have a Web Standards version of something like the Perl Advent calendar. A simple website with a new tip or trick each day leading the readers through December up until Christmas.

I emailed a bunch of friends that kept web design and development themed blogs (remember those?) suggesting the idea and asking if they’d like to contribute. My vision had been that each post would be a couple of paragraphs of information. A small nugget of an idea, or a tip, or a suggestion. What happened was something really amazing. I began to receive really insightful blog posts containing some of the most valuable writing I’d seen online all year.

Look at this piece from Ethan Marcotte on Centered Tabs with CSS, or this detailed piece on scripting block quotes from Jeremy Keith. I was blown away, and the scene was set.

Part of the original design. Photo by Bert Heymans.

Collaboration

What I hadn’t anticipated in 2005 was that this little side project would turn into a fixture of the industry calendar, would introduce me to a raft of field experts, and would have me working with an eclectic team of collaborators for fifteen long seasons.

And that last point is crucial. I’ve by no means produced this alone. Rachel Andrew has been a constant supporter in helping each year to see the light of day and producing our ebooks. After a couple of years, Brian Suda stepped in to help me plan and select authors. In 2008, I managed to persuade Tim Van Damme to replace my very basic site design with something altogether more fitting. In 2010, Anna Debenham came on board initially to help with the production of articles, but rapidly became a co-producer working with me on all aspects of the content. Owen Gregory joined up that same year to help with the proofing and editing of articles, and for many years did a fantastic job writing the home page article teasers, which are now but a shadow of their former selves.

Tim Van Damme’s 2008 redesign.

Also in 2010, we produced a book in collaboration with Five Simple Steps and raising funds in the memory of Remy and Julie’s daughter, Tia Sharp.

The Five Simple Steps 24 ways book. Photo by Patrick Haney.

In 2013, Paul Robert Lloyd stepped up to the plate to provide us with the design you see today, which not only subtly shifts colours between each day, but across the years as well. Compare the reds of 2005 to the purples of 2019, and the warm tones of a Day 1 to its correspondingly cool Day 24. It’s a terrific piece of work.

Paul Robert Lloyd’s design plays subtly with colour shifts.

In 2014 we won a Net Award for Best Collaborative Project at a fancy ceremony in London. Many past authors were there, and as it was an aware for our collaborative efforts, we all posed with the glassware for photos.

We all went to a right fancy do.

Looking back, looking forward

But even I, Sea Captain Belly Button am not enough of a navel gazer to just be writing an article just about this website. As we draw our fifteenth and final year to a close, it’s important to reflect on what can be learned. Not from the articles (so much!) or from the folly of committing to a nightly publishing schedule for a month every year for fifteen years (don’t do it!) but from the value in starting something not because you have to, but just because you want to. From scratching an itch. From working with a friend just because you love spending time with them. Or for doing something because you see the opportunity for good.

As web designers and developers, we have the opportunity to turn the skills we use in our profession to so many different purposes. In doing so you never know what good might come from it.

Seeing the good

This week I asked around to find out what good others have seen from their side projects. Long time 24 ways contributor Simon Willison had this to say:

Simon went onto explain how it was a website side project that got him his first job in tech. After that, his personal blog lead him to getting a job at Lawrence Journal-World where he created Django. On his honeymoon, Simon and his new wife (and 24 ways contributor) Natalie Downe created Lanyrd, and Simon’s more recent Datasette project landed him a JSK Fellowship at Stanford. That’s an impressive record of side projects, for sure.

Others had similar stories. My good friend Meri Williams is currently CTO of challenger bank Monzo, as well as being a trustee at Stonewall and Chair of The Lead Developer conference.

Again, an impressive list of achievements, and I’m sure both Simon and Meri would have eventally found other routes to their individual success, but the reality is they did it through side projects. Through being present and active, contributing a little to their communities, and receiving so much more back in return.

Of course, not all projects have to be directly related to the web or software to be fulfilling. Of course they don’t. Mark Small and Jack Shoulder embraced their love of a good rear end and created MuseumBums, informally cataloging perfect posteriors for your perusing pleasure. On its success, Mark says:

Jack adds:

I had so many heartwarming responses to my request for stories, I really recommend you go over to the thread on Twitter and read it. It’s been one of my favourite set of replies in a long time.

Focussing on what’s important

As the years progressed, more and more publications sprang up both at Christmas and throughout the year with how-to articles explaining techniques. As a natural response, 24 ways started mixing up solution-based articles with bigger picture takes on a wider range of topics, but always with a practical takeaway to impress your friends.

After the embarrassment of white dudes that dominated the early years, we actively sought to open the opportunity to write to a wider and more diverse range of experts. While I don’t think we ever got as much racial diversity in our lineup as I would have liked to have achieved, I’m very proud that each season has been closely gender-balanced since 2012. This is something that was never forced or remotely hard to achieve, all it took was an awareness of the potential for bias.

Calling time

With all the benefits that side projects can bring, it’s also important to be mindful of downsides. Not every project will take flight, and those that do can also start to consume valuable time. That’s fine while it’s fun and you’re seeing the benefits, but it’s neither fun or healthy long-term to have no time away from something that might otherwise be your job.

Spending time with family, friends, and loved ones is equally important especially at this time of year. Just as anyone who does a lot of sport or fitness will tell you about the value of rest days between your activities to let the body recover, time away from ‘work’ is important to do the same for your brain.

Having run this site every Christmas for 15 seasons, it’s time to take a breather and give it a rest. Who knows if we might return in the future, but no promises. It’s been a good run, and an absolute privilege to provide this small tradition to the community I love.

So from me and the whole 24 ways family, Happy Christmas to all, and to all a good night.

Anna and Drew at the 2014 Net Awards dinner.

About the author

Drew McLellan is a developer and content management consultant from Bristol, England. He’s the lead developer for the popular Perch and Perch Runway content management systems, and public speaking portfolio site Notist. Drew was formerly Group Lead at the Web Standards Project, and a Search Innovation engineer at Yahoo!. When not publishing 24 ways, he keeps a personal site about web development, takes photos, tweets a lot and tries to stay upright on his bicycle.

More articles by Drew