der Party on the move: On the Aam Aadmi Party, its leader By www.thehindu.com Published On :: Thu, 19 Sep 2024 00:20:00 +0530 AAP’s Arvind Kejriwal continues to surprise, also outlining his political ambitions Full Article Editorial
der First responder: On Maldives-India ties By www.thehindu.com Published On :: Fri, 11 Oct 2024 00:10:00 +0530 India and Maldives let subtle diplomacy surpass muscular posturing Full Article Editorial
der Over the borderline: On the India-China deal By www.thehindu.com Published On :: Wed, 23 Oct 2024 00:20:00 +0530 The agreement between India and China opens new opportunities Full Article Editorial
der Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
der Towards Europe: On the India visits by the leaders of Germany, Spain By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:20:00 +0530 India used visits by leaders of Germany and Spain to balance ties in Europe Full Article Editorial
der Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3433-3443DOI: 10.1039/D4MD00468J, Research ArticleMeijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing LiA synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00537F, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry LombergetA series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00608A, Research ArticleSunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo MathewA total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00494A, Research Article Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan KumarIn pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00383G, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia OueisAn AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00511B, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca SistoMonoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00450G, Review ArticleShikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan DwivediThiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00670D, Research ArticleYuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen ZhouIn the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00373J, Research ArticleYongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian ZhangThe mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00495G, Research ArticleYakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez TumerNew isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00724G, Research ArticleZhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei MaoA series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
der Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:44:09 +0530 Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago Full Article Tamil Nadu
der Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents By www.thehindu.com Published On :: Tue, 05 Nov 2024 21:04:51 +0530 Full Article Tiruchirapalli
der HR&CE plans to bring properties around the Vennaimalai Temple under tenants list By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:36:32 +0530 The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders Full Article Tiruchirapalli
der NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:53 +0530 Full Article Tiruchirapalli
der ‘State should retain primary agricultural cooperative societies under its purview’ By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:23:59 +0530 Full Article Tiruchirapalli
der 557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life By shoptalkshow.com Published On :: Mon, 20 Mar 2023 07:01:51 +0000 When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life. Full Article All Episodes AI chatgpt Conferences CSS fidgets
der 564: Render ATL, New Colors Available, Gradients, HDR, and More By shoptalkshow.com Published On :: Mon, 08 May 2023 08:45:29 +0000 Chris previews a bit of his Render ATL 2023 talk, and then we mouth blog some color ideas, thoughts, and shame you for your non-HD websites. Full Article All Episodes color gradient render ATL
der 569: Apple’s Web Apps, Meta Quest and Vision Pro, and Missing Sticky Headers By shoptalkshow.com Published On :: Mon, 12 Jun 2023 07:20:15 +0000 How do you point out things in a UI? Are Arc Boosts the end of the web? What do you think of VR and AR / Vision Pro and Meta Quest? And what do you do when the sticky header goes missing? Full Article All Episodes meta quest vision pro Web Apps
der 573: Google Reader, Sticky and Overflow, and Figma Thoughts By shoptalkshow.com Published On :: Mon, 10 Jul 2023 08:01:45 +0000 Chris breaks out his banjo, some thoughts on making music vs recording music, what happened to Google Reader and social reading, what black box properties can't Dave or Chris remember, follow up for dev teams communicating with designers, and what's Adobe going to do about Figma? Full Article All Episodes banjo figma google reader music rss
der 622: Website Rendering, Updating Software, and Edge Gets Faster By shoptalkshow.com Published On :: Mon, 01 Jul 2024 08:26:04 +0000 We're talking website rendering, server side rendering, Astro's server islands, perf hits for navigation elements, updating software because the docs aren't available for older versions, and a new Microsoft Edge was released. Full Article All Episodes microsoft edge rendering server islands
der The pros and cons of spouses teaming up as co-founders By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 20:40:00 +0530 How do married co-founders navigate the personal and professional ties at work Full Article Emerging Entrepreneurs
der RNT: Judging a leader’s true nature By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 How Ratan Tata’s bold nature is evidenced by his enterprise moves Full Article Corporate File
der The last thing business founders need is a wasteful public spat By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 As entrepreneurship explodes in India, we need more iconic founders who not only build sustainable firms but also retain their humility Full Article Emerging Entrepreneurs
der Founders who firefight non-stop, risking their mental health By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:54:27 +0530 There is unbelievable pressure on entrepreneurs as they work hard non-stop to create bigger, better, faster businesses Full Article Emerging Entrepreneurs
der Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge By www.thehindu.com Published On :: Tue, 05 Nov 2024 13:00:21 +0530 Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed Full Article Delhi
der Delhi HC dismisses plea by Khalid Saifi against attempt to murder charge By www.thehindu.com Published On :: Wed, 06 Nov 2024 01:19:07 +0530 Full Article Delhi
der Lawyer sent to jail for 4 months from Delhi HC for ‘derogatory’ remarks against judges By www.thehindu.com Published On :: Fri, 08 Nov 2024 01:01:38 +0530 The court directed the police to take Sanjeev Kumar into custody directly from the court and sent him to jail Full Article Delhi
der Provide medical aid to jailed separatist leader Yasin Malik: Delhi HC to Tihar jail By www.thehindu.com Published On :: Sat, 09 Nov 2024 04:37:00 +0530 In his plea before the high court, Malik claimed to be a patient of “serious cardiac and kidney ailments”, currently facing a “life and death situation” Full Article Delhi
der Three juveniles held for murder in Delhi; political row erupts over city’s crime rate By www.thehindu.com Published On :: Sun, 10 Nov 2024 00:31:14 +0530 Full Article Delhi
der Dribbling past gender stereotypes in rural Odisha By www.thehindu.com Published On :: Sun, 10 Nov 2024 22:10:36 +0530 Odisha takes a lead in inspiring and training young tribal boys and girls to play mixed-gender football matches and drive social change in the State Full Article Odisha
der Delhi Assembly elections | Congress leader Mateen Ahmed joins AAP, AAP leader Harsharan Singh Balli returns to BJP By www.thehindu.com Published On :: Mon, 11 Nov 2024 01:32:23 +0530 Setback for Congress as five-time MLA Mateen Ahmed jumps ship to Aam Aadmi Party, days after his son, daughter-in-law join Kejriwal-led party; former Minister Balli quits AAP and returns to BJP Full Article Delhi
der AAP attacks Centre over ‘worsening’ law and order situation By www.thehindu.com Published On :: Mon, 11 Nov 2024 01:36:01 +0530 Full Article Delhi
der 1984 anti-Sikh riots case: Delhi HC says murder trial to continue against Congress leader Jagdish Tytler By www.thehindu.com Published On :: Mon, 11 Nov 2024 18:33:54 +0530 Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court would continue with the hearing on November 29 Full Article India
der Delhi HC says murder trial to continue against Jagdish Tytler in 1984 riots case By www.thehindu.com Published On :: Tue, 12 Nov 2024 00:54:12 +0530 Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court will continue with the hearing on November 29 Full Article Delhi
der Dream Rig Contest Underway By www.arrl.org Published On :: Fri, 25 Oct 2024 14:38:00 -0500 The 5th annual Youth "Dream Rig" Essay Contest has begun to accept submissions.The contest is sponsored by The Intrepid-DX Group, a U.S.-based 501 (c) (3) nonprofit organization that promotes amateur radio activities around the world and recognizes the importance of including youth in the amateur radio hobby.Contestants must be USA or Canadian amateur radio license holders aged 19 or younger. A... Full Article
der Cultural side to leadership By www.thehindubusinessline.com Published On :: Sun, 22 Nov 2020 21:12:47 +0530 Exploring the relevance of Indian-ness in our leaders Full Article Books
der The code to uncommon leadership By www.thehindubusinessline.com Published On :: Sun, 14 Feb 2021 21:16:02 +0530 Good coaches are key to ensuring organisation-wide unbiased, connected conversations Full Article Books
der 16 leaders, as many economic verities By www.thehindubusinessline.com Published On :: Sun, 07 Mar 2021 20:33:16 +0530 Vince Cable profiles 16 personalities who rung in deep rooted economic change in their societies Full Article Books
der The journey to leadership roles By www.thehindubusinessline.com Published On :: Sun, 23 May 2021 21:47:28 +0530 The author, citing his own experiences, delves into the qualities required to become a good leader Full Article Books
der Leadership in a WFH world By www.thehindubusinessline.com Published On :: Sun, 27 Jun 2021 21:08:32 +0530 Relationships, accountability, motivation and processes are vital for a high performance team Full Article Books
der Book Review: Demystifying Leadership: Unveiling the Mahabharata Code by Asha Kaul and Vishal Gupta By www.thehindubusinessline.com Published On :: Wed, 02 Feb 2022 17:42:46 +0530 The Mahabharata shows that leaders need to navigate moral codes that are as complex, varied, and subtle as the situations in which they find themselves Full Article Book Reviews
