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Viral contamination in biologic manufacture and implications for emerging therapies




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Convalescent serum lines up as first-choice treatment for coronavirus




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African-American men with low-risk prostate cancer treated with radical prostatectomy in an equal-access health care system: implications for active surveillance




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Telomere-based risk models for the early diagnosis of clinically significant prostate cancer




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Clinical utility of the exosome based ExoDx Prostate(<i>IntelliScore</i>) EPI test in men presenting for initial Biopsy with a PSA 2–10 ng/mL




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MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility

npj Microgravity, Published online: 16 March 2020; doi:10.1038/s41526-020-0099-7

MHD surrogate model for convection in electromagnetically levitated molten metal droplets processed using the ISS-EML facility




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How does spaceflight affect the acquired immune system?

npj Microgravity, Published online: 07 May 2020; doi:10.1038/s41526-020-0104-1

How does spaceflight affect the acquired immune system?




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Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity




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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy




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Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i>




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CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians




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Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome




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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




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NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




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QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




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NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Nanomolar-scale, high throughput chemical synthesis of drug-like molecules

A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds.




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Sortilin 1 (SORT1)

Mouse studies suggest inhibiting SORT1 in macrophages and T cells could help treat atherosclerosis.




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Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




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Neutralizing the negatives of RNAi

The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside the liver and expand their use to a host of new diseases.




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LIS1 cracks open dynein




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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Machine intelligence lights up imaging




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Microbiota and colorectal cancer: colibactin makes its mark




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Ironing out mucosal healing




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Universal screening for hepatitis C virus infection should be linked to universal treatment access




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Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Obesity and impaired metabolic health in patients with COVID-19




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New insights into K<sub>ATP</sub> channel gene mutations and neonatal diabetes mellitus




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Listening to the sound of a bacterium




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




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SIN List criticism based on misunderstandings




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Supporting sexual adjustment from the perspective of men living with spinal cord injury




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




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Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human