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The impact of 2018 ASCO-CAP HER2 testing guidelines on breast cancer HER2 results. An audit of 2132 consecutive cases evaluated by immunohistochemistry and in situ hybridization




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<i>KRAS</i> amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy




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An analysis of the effect of mu-opioid receptor gene (<i>OPRM1</i>) promoter region DNA methylation on the response of naltrexone treatment of alcohol dependence




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Cost-effectiveness of <i>CYP2C19-</i>guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data




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Identification of gene modules associated with survival of diffuse large B-cell lymphoma treated with CHOP-based chemotherapy




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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment




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10 years of biosimilars: lessons and trends




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Publisher Correction: ASPI: a public–private partnership to develop treatments for autism




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TRAIL blockade improves heart function




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Targeting CDK12 to treat DM1




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Watching North Korea

Illicit nuclear detonations are anything but secret




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50, 100 & 150 Years Ago

Innovation and discovery as chronicled in Scientific American




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The Health-Wealth Gap

The growing gulf between rich and poor inflicts biological damage on bodies and brains




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Team Players

Microbial partnerships turn out to be more common and influential than scientists could have ever imagined




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Sleep Learning Gets Real

Experimental techniques demonstrate how to strengthen memories when our brains are off-line




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Why Oral Cancer Threatens Men

Researchers wrestle with the rising rates of virus-related tumors




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Measure for Measure

Officials will vote to overhaul the standard system of scientific measurements




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Time for Women Leaders

The gender gap in leadership narrows when groups spend more time together




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Lifelong Learning

Creating artificial intelligence that continues to adapt




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When Will We Learn?




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Coronavirus diaries: creature comforts




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Screams on a Zoom call: the theory of homeworking with kids meets reality




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Daily briefing: How desperate measures might shorten the coronavirus vaccine timeline — and at what risk




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COVID-19 mental-health responses neglect social realities




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Urban sprawl overspreads Earth at an unprecedented speed




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Daily briefing: Convalescent serum — the antibody-laden blood of survivors — lines up as first-choice treatment for coronavirus




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Going viral: how to boost the spread of coronavirus science on social media




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Daily briefing: More than 1 billion people face unbearable temperatures within 50 years




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Coronavirus in charts: historical funding for coronavirus research has been tiny




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The sustained undermining of science by the EPA’s leaders is a travesty




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Worm brain, ocean giant and soothing Jupiter — April’s best science images




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China is promoting coronavirus treatments based on unproven traditional medicines




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Coronavirus drug, water warning and virus-research funding




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Identification of type 2 diabetes loci in 433,540 East Asian individuals




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Statin drugs might boost healthy gut microbes




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A better way to ‘squeeze the vacuum’ could speed the search for gravitational waves




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How do children spread the coronavirus? The science still isn’t clear




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Coronavirus research updates: A strong antibody response is common in people who’ve recovered




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Ignoring coronavirus outbreaks in homeless shelters is proving perilous




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Ancient Andean cities boasted cosmopolitan residents




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How swamped preprint servers are blocking bad coronavirus research




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Coronapod: The overlooked outbreaks that could derail the coronavirus response




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Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma




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Breaking through the glioblastoma micro-environment via extracellular vesicles




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HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1α




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Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide




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The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications’ door




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Blood pressure control and complex health conditions in older adults: impact of recent hypertension management guidelines




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Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk




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Blood pressure load per body surface area is higher in women than in men