A new report from the National Academies of Sciences, Engineering, and Medicine outlines how to examine whether specific levels of nutrients or other food substances (NOFSs) can ameliorate the risk of chronic disease and recommends ways to develop dietary reference intakes (DRI) based on chronic disease outcomes.

The U.S. Department of Energy should place a higher priority on developing an accurate and actionable inventory of agency-owned or managed properties that can be leased or sold for energy development, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Our ability to observe and predict severe weather events and other disasters has improved markedly over recent decades, yet this progress does not always translate into similar advances in the systems used in such circumstances to protect lives.

Policymakers’ efforts to reduce threats from improvised explosive devices (IEDs) should include greater oversight of precursor chemicals sold at the retail level – especially over the Internet – that terrorists, violent extremists, or criminals use to make homemade explosives, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Consumer access to effective and affordable medicines is an imperative for public health, social equity, and economic development, but this need is not being served adequately by the biopharmaceutical sector, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Although NASA has made progress toward the overall space exploration science priorities recommended in a 2011 decadal survey by the National Academies of Sciences, Engineering, and Medicine, the space agency should raise the priority of scientific research that addresses the risks and unknowns of human space exploration.

NASA, the National Oceanic and Atmospheric Administration (NOAA), and the United States Geological Survey (USGS) should implement a coordinated approach for their space-based environmental observations to further advance Earth science and applications for the next decade, says a new report by the National Academies of Sciences, Engineering, and Medicine.

Despite progress in recent decades, more than 10,000 alcohol-impaired driving fatalities occur each year in the U.S. To address this persistent problem, stakeholders -- from transportation systems to alcohol retailers to law enforcement -- should work together to implement policies and systems to eliminate these preventable deaths, says a new report from the National Academies of Sciences, Engineering, and Medicine.

A comprehensive aviation safety system as envisioned by NASA would require integration of a wide range of systems and practices, including building an in-time aviation safety management system (IASMS) that could detect and mitigate high-priority safety issues as they emerge and before they become hazards, says a new report by the National Academies of Sciences, Engineering, and Medicine.

The emergence of inexpensive small unmanned aircraft systems (sUASs) that operate without a human pilot, commonly known as drones, has led to adversarial groups threatening deployed U.S. forces, especially infantry units.

The U.S. Census Bureau should develop a detailed concept and implementation plan for an Annual Business Survey System (ABSS) to replace the current suite of largely separate annual economic surveys, says a new report by the National Academies of Sciences, Engineering, and Medicine.

An emerging body of evidence suggests that integrating STEMM fields (science, technology, engineering, mathematics, and medicine) with the humanities and arts in higher education is associated with positive learning outcomes that may help students enter the workforce, live enriched lives, and become active and informed citizens, says a new report from the National Academies of Sciences, Engineering, and Medicine

Sexual harassment in science, engineering, and medicine diminishes the integrity of the U.S. research enterprise.

A systemwide change to the culture and climate in higher education is needed to prevent and effectively respond to sexual harassment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The National Academy of Medicine today announced Kenneth Wells is the recipient of the 2018 Rhoda and Bernard Sarnat International Prize in Mental Health, for his work developing quality and outcomes approaches to psychiatry and mental health, fostering a generation of clinical investigators and mental health system leaders, and championing partnered, participatory research to advance equity for under-resourced populations.

As new evidence about climate change and sea-level rise in South Florida continues to emerge, agencies responsible for the restoration of the Everglades should conduct a mid course assessment that rigorously analyzes scenarios of future change to the region’s ecosystem in its planning, says a new congressionally mandated report by the National Academies of Sciences, Engineering, and Medicine.

Given the current state of quantum computing and the significant challenges that still need to be overcome, it is highly unlikely that a quantum computer that can compromise public-key cryptography – a basis for the security of most of today’s computers and networks – will be built within the next decade, says a new report by the National Academies of Sciences, Engineering, and Medicine.

Medications to Treat Opioid Addiction Are Effective and Save Lives, But Barriers Prevent Broad Access and Use, Says New Report

The National Academies of Sciences, Engineering, and Medicine have joined with over 40 colleges, universities, and research institutions to launch an Action Collaborative on Preventing Sexual Harassment in Higher Education.

The changes in brain structure and connectivity that occur between the ages of 10 and 25 present adolescents with unique opportunities for positive, life-shaping development, and for recovering from past adversity, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The National Academy of Medicine today announced Daniel Weinberger is the recipient of the 2019 Rhoda and Bernard Sarnat International Prize in Mental Health, for his fundamental role in elucidating the biological origins and genetic expressions of schizophrenia, and for transforming how clinicians, researchers, and the public understand mental illness.

PFAS, or perfluoroalkyl and polyfluoroalkyl substances, are ubiquitous fluorinated organic compounds found widely in manufactured products, from firefighting foam to stain-resistant carpets. These water- and oil-repellent compounds are known to degrade slowly over time, and have been found in humans, drinking water, and even in Arctic ecosystems.

It has been a little over a year since the Second International Summit on Human Genome Editing in Hong Kong, where scientist He Jiankui (pictured above) announced the birth of twins whose healthy embryonic genomes had been edited to confer resistance to HIV.

The federal government should foster collaboration and decrease obstacles that can keep foreign atomic, molecular, and optical (AMO) physicists from working in the United States, if the nation is to maintain its position as leader in these fields, says a new report from the National Academies of Sciences, Engineering, and Medicine.

For severe acute pain due to surgeries and medical conditions, there is a lack of guidance on the appropriate type, strength, and amount of opioid medication that clinicians should prescribe to patients, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine today announced $2 million in grant awards for seven new projects through its Understanding Gulf Ocean Systems (UGOS) Grants 2 competition.

The National Academy of Sciences, in partnership with The Kavli Foundation and the Alfred P. Sloan Foundation, will host a symposium to consider the future of science in the U.S. and how it can best serve society in the 21st century.

Today the National Academies of Sciences, Engineering, and Medicine released its review of the National Toxicology Program’s (NTP) draft monograph Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects.

“Reports & Events” is a monthly tip sheet for the news media that highlights selected meetings of interest and reports from the National Academies of Sciences, Engineering, and Medicine.

As the coronavirus outbreak has spread throughout the United States, social distancing measures have taken many forms — such as business and school closures, cancelled events, and everyone being urged to keep six feet apart.

Over the next five years, the U.S. Department of Defense’s Biological Threat Reduction Program (BTRP) should encourage and be among co-leaders in the federal government’s development of an enduring interagency mechanism to address an array of biological threats – including natural disease outbreaks, accidental releases, and intentional attacks -- to deployed U.S. forces and to the nation itself, says a new report from the National Academies of Sciences, Engineering, and Medicine

“Reports & Events” is a monthly tip sheet for the news media that highlights selected meetings of interest and reports from the National Academies of Sciences, Engineering, and Medicine.

National Academy of Medicine President Victor J. Dzau will provide remarks on behalf of the Global Preparedness Monitoring Board during a virtual event on May 4 to launch an online pledging effort, the Coronavirus Global Response.

The novel coronavirus has been called “the great equalizer,” when in reality, it has only exacerbated health inequities that racial and ethnic minorities have experienced for decades.

What once were orchards and citrus groves now is a dense but sprawling urban area. The city of Los Angeles is considering ways to capture stormwater near where it falls so that water can be made use of throughout the city. ; Credit: Los Angeles Department of Water and Power

With a historic drought showing no signs of letting up, the city of Los Angeles is drafting a new plan to use more local water sources by capturing storm water throughout the L.A. basin. At recent community meetings, officials from the Department of Water and Power (along with the city's Sanitation Department) have been showcasing potential ideas for the final plan, due out this summer.

This new plan would make storm water about 4 percent of the city's annual water budget. For the first time, LA is talking about making storm water a small but reliable part of the city’s water sources – 25,000 acre-feet, or somewhat over 8 billion gallons of storm water a year. For perspective, a typical one-inch rain event in Los Angeles County produces more than 10 billion gallons of storm water, most of which hits asphalt and concrete, flows into storm drains and goes to the sea.

It’s hardly a new idea. But storm water capture has taken on additional urgency because of the drought, because of the increasing price of importing water, and because of local water quality rules.

On top of that, Los Angeles Mayor Eric Garcetti issued an executive order last October, directing the LADWP to cut its purchase of imported water in half within a decade, in part by cutting water consumption at least 20 percent.

Storm water capture projects have captured the energy and attention of environmental groups who’ve demonstrated them in backyards, neighborhoods, and alleyways.

LA could invest in much-larger-scale versions of those ideas. Good places for those bigger projects tend to be in the San Fernando Valley, where the geology is hospitable to rain water capture and the city has clearest rights. 

Some examples featured in the LADWP’s presentation aren’t yet approved, but are in consideration:

• Water capture and storage at the Van Norman Complex; 
• The Canterbury Power Line Easement, running between the Tujunga Spreading Grounds and the Pacoima Wash, which would capture 1500 acre-feet of water a year; and 
• Converting Strathern Park (near the Hollywood Freeway) from a disused gravel pit/landfill to a wetlands park, in joint operation with L.A. County. 

Storing storm water in the ground means protecting some areas from industrial pollution, and means filtering and treating polluted groundwater as it’s pulled from aquifers. Last November’s $7.5 billion dollar water bond earmarked funds for storm water capture and for groundwater cleanup. DWP officials say they’re hoping to bring some of that money to Los Angeles.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Bob Moriarty of 321gold discusses gold, financial collapse and consequences of quarantining.

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The immersive Haus of Creep opens at ROW DTLA this weekend.; Credit: Courtesy of Just Fix It Productions

Read the full article at LAist

Marc Maron's new Netflix special is titled "End Times Fun."; Credit: Adam Rose / Netflix

Read the full article at KPCC

It’s good to be back in Southern California after a week in the hothouse of Tampa.  I mean that in both the weather and political senses.
Even though we were largely inside from 9 in the morning to 11 at night, every trip outside provided exposure to extreme humidity and more than 90-degree temperatures.  Couple that with a long wait through security to get back into the building and there wasn’t much incentive to go anywhere.
On the political side, I forget (or block out) how intense these party conventions can be.  It’s an alternate universe, where most everyone recognizes even minor national political figures.  It’s like walking through Beverly Hills with an editor from People magazine.
It makes me feel at a bit of a disadvantage, as a generalist who talks a lot of politics, but doesn’t devote himself to it exclusively.  When you hear some of the political reporters from around the country, there are times it sounds more like advanced math than policy.  From delegate counts to Congressional seats in play to dueling budget scenarios, it gets highly detailed very quickly.  The first couple of days of the convention, I feel like I’m trying to catch up and get my head around all the subplots.
Of course, just as I start feeling like I’m getting it down, we come home.  Regardless, I have terrific memories of the week.  Out team of producers, engineers, and reporter Frank Stoltze really enjoyed working together on your behalf.  Let’s do it again in four more years.

This content is from Southern California Public Radio. View the original story at SCPR.org.

I know these Presidential debates aren’t debates in the historical sense.  Regardless, I’m looking forward to seeing how both men do on a topic of immense complexity.  Is Mitt Romney going to be more forthcoming about what tax deductions he’d want cut to keep his tax reform plan from ballooning the deficit?  Will President Obama  give more detail about how he would improve the economy, short of a government stimulus that could never get through a GOP Congress?

I’ll be live tweeting during the debate.  Join me @AirTalk #debates.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Frank Romero with one of his French paintings, in his home in the South of France. But every year, he and his wife Sharon throw a big studio sale for Christmas, and you're invited.; Credit: John Rabe

"Live! Life's a banquet and most poor suckers are starving to death!" - Auntie Mame.

Your calendar is filling up, but here are four holiday events you'll want to make room for:

Every year, pioneering Chicano artist Frank Romero and his wife Sharon throw a big studio sale that includes works by a wide group of artists, and a lot of food and drink. It's just as much a party as a sales event, and Frank and the other artists are always there to meet and greet. And now that the couple is spending more time at their home in France, it's a chance for their old friends to catch up with them, so who knows who you'll see from L.A.'s arts community.

RELATED: See Frank's new works - French scenes with an East LA flavor

The Romero Studio annual Christmas party and sale is Saturday, Dec. 6, 6-10pm; and Sunday, Dec. 7, 1-5pm, at Plaza de la Raza, Boathouse Gallery, 3540 North Mission Rd., LA CA 90031 (in Lincoln Park across from the DMV — which BTW is a very good DMV).

Then, on Sunday, Dec. 14, at 4:30pm,  it's the Advent Procession of Lessons and Carols, at St. James Episcopal Church, which a friend describes as "one of the truly beautiful choral events of the season," and the highlight of the Choir of St. James' season. It's free and it's at St. James' Episcopal Church in Koreatown (3903 Wilshire Blvd., Los Angeles 90010).
 

"Auntie Mame," the 1958 Rosalind Russell movie with more quotable quips than a weekend getaway with Oscar Wilde, has become something of a Christmas tradition. It's screening at the American Cinematheque's Egyptian Theatre on Wednesday, Dec. 17, at 7:30. As delightful as this movie is any day of the week on your TV at home, this is a film to be seen in 35mm with a theater full of people reacting to every bon mot and heart-touching moment.

GO INSIDE: The Disney Hall organ, "Hurricane Mama," turns 10

Last year, my husband and I blindly went to Disney Hall for the Holiday Organ Spectacular. We expected some music and a little fun. But it really was spectacular. It's back this year, on Friday, Dec. 19, with organist David Higgs leading the evening from the console of Hurricane Mama.

If you've never seen or heard the organ in person, this is a great evening because Higgs — a teacher as well as master organist — gives you a guided tour of every stop, and every mood the organ can produce, from cathedral-loud to country-church-quiet. At the end of the night, he breaks the audience into parts to sing "The Twelve Days of Christmas," and you may sing as loud as you like.

These are just a few curated selections, but they're just the tip of the iceberg in Southern California; please make your own holiday event recommendations in the comments below. 

This content is from Southern California Public Radio. View the original story at SCPR.org.

An aerial photograph of the San Gabriel Mountains in Southern California.; Credit: Bruce Perry, Department of Geological Sciences, CSU Long Beach; Courtesy National Park Service

A friend who has one of those cabins in the San Gabriels that you have to ride a mule into sent Off-Ramp a note about an event for fans of L.A.'s mountains ... which is pretty much everyone:

"The Sierra Madre Historical Preservation Society and First Water Design present the finest assembly of experts of our magnificent mountains and their impact on our history, culture, and way of life." It's a long list of historians, authors, and others who've spent their lives studying and writing about the mountains.

• John Robinson: "The San Gabriels," "Trails of the Angeles: 100 Hikes in the San Gabriels," "Sierra Madre’s Old Mount Wilson Trail"
• Michele Zack: "Southern California Story: Seeking the Better Life in Sierra Madre," "Altadena: Between Wilderness and City"
• Elizabeth Pomeroy: "John Muir: A Naturalist in Southern California," "San Marino: A Centennial History"
• Nat Read: "Don Benito Wilson: From Mountain Man to Mayor," "Los Angeles 1841 to 1878"
• Michael Patris:  "Mount Lowe Railway"
• Glen Owens: "The Heritage of the Big Santa Anita"
• Paul Rippens: " The Saint Francis Dam"
• Willis Osborne: "A Guide to Mt. Baldy & San Antonio Canyon"
• Christopher Nyerges: "Enter the Forest"
• Norma Rowley: "The Angeles Was Our Home"
• Chris Kasten: cartographer and former manager of Sturtevant Camp

The event takes place on Saturday, Jan. 24, from 1 p.m. to 4 p.m, at Pritchard Hall at the Sierra Madre Congregational Church, 170 West Sierra Madre Blvd., Sierra Madre, CA 91024.

And it's free! Email Jeff Lapides for more info, or call him at 626-695-8177.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Most people infected with the novel coronavirus develop antibodies in response.

But scientists don't know whether people who have been exposed to the coronavirus will be immune for life, as is usually the case for the measles, or if the disease will return again and again, like the common cold.

"This to me is one of the big unanswered questions that we have," says Jeffrey Shaman, a professor of environmental health sciences at Columbia University, "because it really says, 'What is the full exit strategy to this and how long are we going to be contending with it?' "

He's one of many scientists on a quest for answers. And the pieces are starting to fall into place.

Antibodies, which are proteins found in the blood as part of the body's immune response to infection, are a sign that people could be developing immunity. But they are by no means a guarantee they will be protected for life – or even for a year.

Shaman has been studying four other coronaviruses that cause the common cold. "They're very common and so people seem to get them quite often," Shaman says. Ninety percent of people develop antibodies to those viruses, at least in passing, but "our evidence is those antibodies are not conferring protection."

That may simply because colds are relatively mild, so the immune system doesn't mount a full-blown response, suggests Dr. Stanley Perlman, a pediatrician who studies immunology and microbiology at the University of Iowa. "That's why people get colds over and over again," he says. "It doesn't really tickle the immune response that much."

He's studied one of the most severe coronaviruses, the one that causes SARS, and he's found that the degree of immunity depended on the severity of the disease. Sicker people remained immune for much longer, in some cases many years.

For most people exposed to the novel coronavirus, "I think in the short term you're going to get some protection," Perlman says. "It's really the time of the protection that matters."

Perlman notes that for some people the symptoms of COVID-19 are no worse than a cold, while for others they are severe. "That's why it's tricky," he says, to predict the breadth of an immune response.

And it's risky to assume that experiences with other coronaviruses are directly applicable to the new one.

"Unforutunately, we cannot really generalize what kind of immunity is needed to get protection against a virus unless we really learn more about the virus," says Akiko Iwasaki, a Howard Hughes Medical Institute investigator at the Yale University School of Medicine.

An immunobiologist, she is part of a rapidly expanding effort to figure this out. She and her colleagues are already studying the immune response in more than 100 patients in the medical school hospital. She's encouraged that most people who recover from the coronavirus have developed antibodies that neutralize the coronavirus in a petri dish.

"Whether that's happening inside the body we don't really know," she cautions.

Research like hers will answer that question, eventually.

But not all antibodies are protective. Iwasaki says some can actually contribute to the disease process and make the illness worse. These antibodies can contribute to inflammation and lead the body to overreact. That overreaction can even be deadly.

"Which types of antibodies protect the host versus those that enhance the disease? We really need to figure that out," she says.

The studies at Yale will follow patients for at least a year, to find out how slowly or quickly immunity might fade. "I wish there was a shortcut," Iwasaki says, "but we may not need to wait a year to understand what type of antibodies are protective."

That's because she and other immunologists are looking for patterns in the immune response that will identify people who have long-term immunity.

Researchers long ago figured out what biological features in the blood (called biomarkers) correlate with immunity to other diseases, says Dr. Kari Nadeau, a pediatrician and immunologist at the Stanford University School of Medicine. She expects researchers will be able to do the same for the new coronavirus.

Nadeau is working on several studies, including one that seeks to recruit 1,000 people who were previously exposed to the coronavirus. One goal is to identify people who produce especially strong, protective antibody responses. She says the antibody-producing cells from those people can potentially be turned into vaccines.

Another critical question she's zeroing in on is whether people who become immune are still capable of spreading the virus.

"Because you might be immune, you might have protected yourself against the virus," she says, "but it still might be in your body and you're giving it to others."

That would have huge public health implications if it turns out people can still spread the disease after they've recovered. Studies from China and South Korea seemed to suggest this was possible, though further studies have cast doubt on that as a significant feature of the disease.

Nadeau is also trying to figure out what can be said about the antibody blood-tests that are now starting to flood the market. There are two issues with these tests. First, a positive test may be a false-positive result, so it may be necessary to run a confirmatory test to get a credible answer. Second, it's not clear that a true positive test result really indicates a person is immune, and if so for how long.

Companies would like to be able to use these tests to identify people who can return to work without fear of spreading the coronavirus.

"I see a lot of business people wanting to do the best for their employees, and for good reason," Nadeau says. "And we can never say you're fully protected until we get enough [information]. But right now we're working hard to get the numbers we need to be able to see what constitutes protection and what does not."

It could be a matter of life or death to get this right. Answers to these questions are likely to come with the accumulation of information from many different labs. Fortunately, scientists around the world are working simultaneously to find answers.

You can contact NPR Science Correspondent Richard Harris at rharris@npr.org.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Patt Morrison and Stephen Hawking at Cal-Tech. ; Credit: Dave Coelho/KPCC

The renowned physicist, cosmologist and lover of Indian food is at Caltech for his annual dinner and lecture visit. I broke naan across from him Thursday at dinner, which was cooked by a class of adept Caltech students.

I had a short interview with him, and with the student-chefs, which will be airing on “Off-Ramp” soon. As we took the photograph, I had just made a little joke, which accounts for his smile [producer Dave Coelho didn’t get a smile, but maybe he’s not as funny nor as glamorous as I am].  

This content is from Southern California Public Radio. View the original story at SCPR.org.

COVID-19 Research and Development Sean's pick this week is COVID-19 Research and Development by MathWorks. We were recently introduced to this page which highlights uses of... read more >>

Before he Picks this Week's featured File Exchange submission, Brett would like to give a nod of appreciation to the developers of the Image Processing Toolbox. Back in September of 2018, I wrote... read more >>

KJ Apa and Britt Robertson in "I Still Believe" ; Credit: Lionsgate/I Still Believe (2020)

Larry Mantle and KPCC film critics Amy Nicholson and Wade Major review this weekend’s new movie releases.

• "I Still Believe" on VOD

• "Banana Split" on VOD 

• "Vivarium" on VOD

• "Resistance" on VOD

• "Vitalina Varela" on GrasshopperFilm.com

• "Uncorked" on Netflix

• "Dosed" on film's website

• "The Occupant" on Netflix

• "Tape" on VOD

• "There's Something In The Water" on Netflix

Guests:

Amy Nicholson, film critic for KPCC, film writer for The Guardian and host of the podcasts ‘Unspooled’ and the podcast miniseries “Zoom”; she tweets @TheAmyNicholson

Wade Major, film critic for KPCC and CineGods.com

This content is from Southern California Public Radio. View the original story at SCPR.org.