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Continuous flow synthesis of the URAT1 inhibitor lesinurad

React. Chem. Eng., 2020, 5,865-872
DOI: 10.1039/C9RE00483A, Paper
Mariana C. F. C. B. Damião, Henrique M. Marçon, Julio Cezar Pastre
A 5-steps continuous flow synthesis of lesinurad is provided and delivers this API in 68% overall yield.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents

React. Chem. Eng., 2020, 5,859-864
DOI: 10.1039/D0RE00067A, Communication
Paola Vitale, Francesco Lavolpe, Francesca Valerio, Mariaelena Di Biase, Filippo Maria Perna, Eugenia Messina, Gennaro Agrimi, Isabella Pisano, Vito Capriati
A chemo-enzymatic strategy for the preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles using a lactic acid bacterium as a whole-cell biocatalyst and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents is disclosed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Organic electrosynthesis: from academia to industry

React. Chem. Eng., 2020, Advance Article
DOI: 10.1039/D0RE00064G, Review Article
Matthew C. Leech, Anthony D. Garcia, Alessia Petti, Adrian P. Dobbs, Kevin Lam
The growing impetus to develop greener and more cost-efficient synthetic methods has prompted chemists to look for new ways to activate small organic molecules. In this review, we cover the most recent industrial developments in electrosynthesis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Continuous liquid-phase synthesis of nickel phosphide nanoparticles in a helically coiled tube reactor

React. Chem. Eng., 2020, Accepted Manuscript
DOI: 10.1039/D0RE00010H, Paper
Huidong Zheng, Donglin Li, Jingjing Chen, Jie Liu, Zuoyi Yan, S. Ted Oyama
The continuous liquid phase synthesis of nickel phosphide (Ni2P) nanoparticles was studied in a helically coiled tube (HCT) reactor both in single-phase and two-phases slug flow. The reactants were nickel...
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Fick Diffusion Coefficient Matrix of a Quaternary Liquid Mixture by Molecular Dynamics

The Journal of Physical Chemistry B
DOI: 10.1021/acs.jpcb.0c01625




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[ASAP] Dual Resolution Membrane Simulations Using Virtual Sites

The Journal of Physical Chemistry B
DOI: 10.1021/acs.jpcb.0c01842




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[ASAP] TLmutation: Predicting the Effects of Mutations Using Transfer Learning

The Journal of Physical Chemistry B
DOI: 10.1021/acs.jpcb.0c00197




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[ASAP] Quantitative Investigation of Ion Clusters in a Double Salt Ionic Liquid by Both Vibrational Spectroscopy and Molecular Dynamics Simulation

The Journal of Physical Chemistry B
DOI: 10.1021/acs.jpcb.0c01457




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Ayushmann Khurrana’s song tribute for all moms on Mother’s Day

Actor-singer Ayushmann Khurrana has collaborated with composer Rochak Kohli for a music track titled ‘Ma’, to be unveiled on Mother’s Day




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Coronavirus | It’s like 2nd innings of Test match, says Kumble on fight against COVID-19

Anil Kumble thanked all the health care workers and others who are going on with their work so that everyone else can stay safe at home.




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What is it about us as mothers?

As Mother's Day approaches, we look at women bearing the double burden of office and house work and now, with the COVID-19 lockdown, enduring extra familial pressure



  • Life & Style

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Long before the novel coronavirus, it was Malabar pepper and Maharashtrian ivory that connected Italy to India

The ancient Pompeii ruins house several evidences of long-standing trade ties between the two countries



  • History & Culture

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Just sip and flip

How it is possible Mr. Mathrubootham is having whisky and all at home?




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Ritviz turns the camera to his fans in new music video ‘Thandi Hawa’

Musician Ritviz’ new video ‘Thandi Hawa’ stitches together fast-cut shots of fans dancing to his song while they cook, clean and goof about




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Weather Warnings for Northern Territory. Issued by the Australian Bureau of Meteorology




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3 nurses strangled in Mexico; border mayor gets coronavirus

Two of the sisters were nurses for the Mexican Social Security Institute and the third was a hospital administrator, but there was no immediate evidence the attack was related to their work.




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U.S. tightens visa rules for Chinese journalists amid coronavirus tensions

The United States and China have been engaged in a series of retaliatory actions involving journalists in recent months.




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Coronavirus India lockdown Day 46 live updates | Testing capacity for COVID-19 scaled up to 95,000 per day: Harsh Vardhan

India's recovery rate currently stands at 29.36%, according to the Union Health Ministry.




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China continues to hide, obfuscate COVID-19 data from world: Pompeo

By Friday, more than 78,000 Americans had died and 13 lakh tested positive for the coronavirus. Globally, more than 274,000 people have died and 39 lakh have tested positive for the disease, according to Johns Hopkins University data.




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Pfizer to outsource some drug production, focus on coronavirus vaccine

If successful, Pfizer said it hopes to receive emergency use authorization from the U.S. Food and Drug Administration as early as October




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365 Kashmiri students to return home from Bhopal in 18 buses

The students are currently accommodated in a private school in Bhopal.




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Phased withdrawal of U.S. troops from Afghanistan sharpens focus on CPEC

China, Pakistan engaged in firmly pegging Afghanistan with CPEC, say analysts




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Workers who were "turned away on religious grounds" return to Gurugram factory

Half-a-dozen Muslim workers returned to work at Richa & Co. — a garments unit based in Udyog Vihar Phase-III in Gurugram — on Friday, a day after




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Coronavirus deaths reported by Delhi govt less than figures from hospitals

While the Delhi government’s statement says 68 coronavirus-related deaths have occurred in the national capital till Friday, the number of such deaths in just two hospitals in the city that The Hindu accessed was 107




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Egypt’s president expands powers, citing virus outbreak

An international rights group condemned the amendments, saying the government has used the global pandemic to expand, not reform, Egypt’s abusive Emergency Law.




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Coronavirus lockdown | 150 enter State via Muthanga

Those without domestic pass would be sent back, say authorities




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Putin marks Victory Day in virus-reduced ceremony

This year’s observance had been expected to be especially large because it is the 75th anniversary of the defeat of Nazi Germany in World War II.




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Coronavirus lockdown | HC closure of liquor shops is judicial overreach, TN tells SC

Curbs will lead to ‘grave’ revenue loss, says State govt. plea




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Coronavirus | ‘Confusion’ within central government in fight against COVID-19, says Congress

Maken also came down heavily on the Arvind Kejriwal-led government and asked it to be more transparent in reporting cases of the novel coronavirus.




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Coronavirus lockdown | Bengal arranging special trains to bring back 30,000 stranded people: Official

‘The stranded people are mostly migrant workers, patients and their attendants, students, pilgrims and tourists from West Bengal’




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Coronavirus | Global death toll nears 275,000

More than 3,946,130 cases were registered in 195 countries and territories. Of these, at least 1,293,700 are now considered recovered.




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Coronavirus | Police manual sets out guidelines to detect “fake news”

Asks officers to fact-check and refer to reliable sites to verify news reports




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Coronavirus lockdown | Evaluation for class 10, 12 board exams to be done at home by teachers

The pending board exams will be held from July 1 to 15.




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Coronavirus | Testing capacity for COVID-19 scaled up to 95,000 per day, says Harsh Vardhan

Harsh Vardhan flagged the large prevalence of non-smoking tobacco usage in some of the States and the problem of spitting in public places.




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09/16:01 WST Marine Wind Warning Summary for Western Australia




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'Mandi cess will be used for welfare of farmers'




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Distribute grants to gaushalas at the earliest: CM

Chief minister Ashok Gehlot on Friday directed the animal husbandry department to distribute Rs 275-crore grant sanctioned recently to gaushalas.




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April jobs data to show a record-shattering loss of jobs in US: Report

This would mean that nearly all the job growth in the 11 years since the Great Recession had vanished in a single month




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No valid basis for EU tariffs in Boeing-Airbus subsidy dispute: US to WTO

The WTO has found the world's two largest planemakers received billions of dollars of unfair subsidies in a pair of cases dating back to 2004




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Coronavirus task force to stay for now, new members will be added: Trump

Two of its top health officials, Dr Anthony Fauci and Dr Deborah Birx, would continue to be members of the task force, Trump told reporters




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Iraq Parliament chooses former intelligence chief Mustafa Khadimi as new PM

The incoming premier said he would make the fight against the coronavirus pandemic one of his priorities while in office




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Coronavirus update: India cases cross 52k; public transport may start soon

It's already May, and parts of the country hit 40 degrees Celsius a few days ago, making situations worse for people living in cramped quarters to stay indoors




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Covid-19 to push UK economy towards deepest recession: Bank of England

It would also be the sharpest annual contraction since 1706, according to reconstructed Bank of England data going back to the 18th Century




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South Africa parliament zoom call hacked with pornography, racial abuse

Zoom has been facing criticism internationally as a result of reports of hackers who disrupt meetings by posting offensive content




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Coronavirus impact: Now 33.5 mn seek unemployment benefits in US

The reports support many economists' belief that the economic slump could persist for a while




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Bank of England sees worst slump in 300 years as coronavirus bites

The BoE said Britain's economy might be on course to shrink by 25% in the three months to June and unemployment could more than double to 9% of the workforce




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China's exports up 3.5% in April despite coronavirus hitting demand

Economists had forecast that exports would shrink by 11% while imports would contract by 10%.




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World coronavirus dispatch: 20% of US workforce has sought jobless benefits

From WHO planning mission to find virus source in China, to Europe's richest man losing $30 billion, and the impact of coronavirus on indigenous people - read these and more in today's world dispatch




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Suspend guest worker visas, including H-1B for 60 days: Senators to Trump

The unemployment figures in the US have reached an all-time high due to the coronavirus pandemic




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India's five most affected states: Key coronavirus updates and highlights

Four states that have reported their highest single-day jump in cases are Assam, Delhi, Odisha and Tripura