is

A systematic review and meta-analysis of bone loss in space travelers

npj Microgravity, Published online: 05 May 2020; doi:10.1038/s41526-020-0103-2

A systematic review and meta-analysis of bone loss in space travelers




is

Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity




is

CRISPR off-target detection with DISCOVER-seq




is

Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system




is

CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians




is

npj Aging and Mechanisms of Disease




is

COVID-19 outcomes in patients with hematologic disease




is

High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




is

Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody




is

Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells




is

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors




is

QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




is

WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




is

NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




is

Cell Death & Disease




is

Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




is

Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




is

Nanomolar-scale, high throughput chemical synthesis of drug-like molecules

A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds.




is

Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




is

Topoisomerase II binding protein 1 (TOPBP1)

Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer.




is

Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




is

LIS1 cracks open dynein




is

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




is

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




is

Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis




is

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




is

MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




is

TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




is

High-purity orbital angular momentum states from a visible metasurface laser




is

The rise of integrated quantum photonics




is

Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




is

Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




is

Head-to-head trials in inflammatory bowel disease: past, present and future




is

Universal screening for hepatitis C virus infection should be linked to universal treatment access




is

Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys




is

Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




is

Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial




is

Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




is

Listening to the sound of a bacterium




is

Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




is

Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




is

SIN List criticism based on misunderstandings




is

Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why?




is

Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




is

Associations of interruptions to leisure-time sedentary behaviour with symptoms of depression and anxiety




is

Rodent models of post-traumatic stress disorder: behavioral assessment




is

Functional neural correlates of psychopathy: a meta-analysis of MRI data




is

Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders




is

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis




is

The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro