mar

Elementary Teacher Defeats West Virginia's State Senate President in Primary

After a couple years of clashes with teachers in the state, West Virginia Senate President Mitch Carmichael was ousted in Tuesday's Republican primary election by a teacher.




mar

Alexis Markowski named to Wooden Award Watch List

Nebraska women’s basketball star Alexis Markowski was named to the Preseason Women’s Top 50 Watch List for the John R. Wooden Award. This news was confirmed on Thursday per a release from the athletic department. The award is given annually to that season's mos




mar

Former Marquette women's basketball coach Carolyn Kieger accused of misconduct by ex-players

Onward State published a story this week that contained on-the-record comments from former Marquette players about Carolyn Kieger's coaching style.




mar

Texas women's basketball preview, prediction: How to watch Longhorns' game against Lamar

On Wednesday at Moody Center, a Lamar team that went 24-7 last season should provide a tougher test for the Longhorns than in their season opener.




mar

Louisville women's basketball: Cards use size advantage to maintain streak vs UT Martin

It was Louisville women's basketball vs UT Martin at the Kathleen and Tom Elam Center. See score updates and highlights from the road clash.




mar

Markowski, Potts lead No. 21 Nebraska women to 84-56 win over road warriors Southern

Alexis Markowski scored 22 points, Natalie Potts had a double-double and No. 21 Nebraska cruised to an 84-58 win over Southern on Tuesday night. Potts had 17 points and 12 rebounds, eight on the offensive end, for the Cornhuskers (3-0). Alberte Rimdal added 12 points.




mar

Landmark exhibition in new photography gallery

Monday 30 October 2023
The State Library of NSW is staging its biggest and most significant photography exhibition to date in its new underground Photography Gallery.




mar

Library’s landmark photography exhibition now online

Tuesday 30 January 2024
Virtual door open on the Library's biggest and most significant photography exhibition to date.




mar

Landmark photography exhibition now online

The virtual doors are now open on the Library’s biggest and most significant photography exhibition.




mar

Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System

Xinying Guo
Oct 23, 2024; 44:e0727242024-e0727242024
Cellular




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Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System

Perivascular mural cells including vascular smooth cells (VSMCs) and pericytes are integral components of the vascular system. In the central nervous system (CNS), pericytes are also indispensable for the blood–brain barrier (BBB), blood–spinal cord barrier, and blood–retinal barrier and play key roles in maintaining cerebrovascular and neuronal functions. However, the functional specifications of pericytes between CNS and peripheral organs have not been resolved at the genetic and molecular levels. Hence, the generation of reliable CNS pericyte-specific models and genetic tools remains very challenging. Here, we report a new CNS pericyte marker in mice. This putative cation-transporting ATPase 13A5 (Atp13a5) marker was identified through single-cell transcriptomics, based on its specificity to brain pericytes. We further generated a knock-in model with both tdTomato reporter and Cre recombinase. Using this model to trace the distribution of Atp13a5-positive pericytes in mice, we found that the tdTomato reporter reliably labels the CNS pericytes, including the ones in spinal cord and retina but not peripheral organs. Interestingly, brain pericytes are likely shaped by the developing neural environment, as Atp13a5-positive pericytes start to appear around murine embryonic day 15 (E15) and expand along the cerebrovasculature. Thus, Atp13a5 is a specific marker of CNS pericyte lineage, and this Atp13a5-based model is a reliable tool to explore the heterogeneity of pericytes and BBB functions in health and diseases.




mar

A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State FMRI

Estimating the direction of functional connectivity (FC) can help further elucidate complex brain function. However, the estimation of directed FC at the voxel level in fMRI data, and evaluating its performance, has yet to be done. We therefore developed a novel directed seed-based connectivity analysis (SCA) method based on normalized pairwise Granger causality that provides greater detail and accuracy over ROI-based methods. We evaluated its performance against 145 cortical retrograde tracer injections in male and female marmosets that were used as ground truth cellular connectivity on a voxel-by-voxel basis. The receiver operating characteristic (ROC) curve was calculated for each injection, and we achieved area under the ROC curve of 0.95 for undirected and 0.942 for directed SCA in the case of high cell count threshold. This indicates that SCA can reliably estimate the strong cellular connections between voxels in fMRI data. We then used our directed SCA method to analyze the human default mode network (DMN) and found that dlPFC (dorsolateral prefrontal cortex) and temporal lobe were separated from other DMN regions, forming part of the language-network that works together with the core DMN regions. We also found that the cerebellum (Crus I-II) was strongly targeted by the posterior parietal cortices and dlPFC, but reciprocal connections were not observed. Thus, the cerebellum may not be a part of, but instead a target of, the DMN and language-network. Summarily, our novel directed SCA method, visualized with a new functional flat mapping technique, opens a new paradigm for whole-brain functional analysis.




mar

Family farmers' market being held in FAO headquarters Atrium

Family farming is inextricably linked to national and global food security. Both in developing and developed countries, family farming is the leading form of agriculture in food production. Family farmers [...]




mar

Ministers meet at FAO to discuss role of commodity markets

Rome - Governments ought to review the [...]




mar

EL PAÍS, Maria Helena Semedo: “Agriculture should be integrated in climate change policies”

MANUEL PLANELLES, EL PAÍS, Paris- “Agriculture is seen as a threat in the fight against climate change,” Maria Helena Semedo warns. The Deputy Director-General of the Food and Agriculture Organization [...]




mar

FAO uses unearmarked funding strategically

The FMM is a funding mechanism for partners willing to contribute unearmarked funds or slightly earmarked funds. Created in 2010, the FMM is currently supported by the Kingdoms of Belgium, [...]




mar

The State of Agricultural Commodity Markets (SOCO) 2018

The report will be released during a presentation on Monday, 17 September, at 11:30 CEST, in FAO-HQ, Sheikh Zayed Center.

This new edition of the report focuses on the complex [...]




mar

The global fertilizer market: taking stock of a tightening market situation

International fertilizer benchmark prices have risen throughout 2021.




mar

FAO Director-General addresses G7 Agriculture Ministers on Global Food Markets and Prices

Click here to access the presentation by QU Dongyu.

 




mar

The importance of Ukraine and the Russian Federation for global agricultural markets and the risks associated with the current conflict

Information Note.




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First Session of COAG's Sub-Committee on Livestock 16-18 March 2022

It all started in 2016 and after many productive deliberations, in October 2020 at the 27th session of the Committee on Agriculture (COAG) the



mar

Latest issue: The State of Agricultural Commodity Markets (SOCO) 2022

This edition of The State of Agricultural Commodity Markets (SOCO) discusses how trade policies, based on both multilateral and regional approaches, can address today’s challenges for sustainable development. 




mar

The State of Agricultural Commodity Markets (SOCO) 2022

This edition of The State of Agricultural Commodity Markets (SOCO) discusses how trade policies, based on both multilateral and regional approaches, can address today’s challenges for sustainable development. Trade policies [...]




mar

FAO Brief - 8 March 2024

In this episode, the FAO Food Price Index eased in February, driven mostly by lower cereal prices; FAO calls for restoration of humanitarian space to eliminate the risk of famine [...]




mar

Shooting Stars: Jos Antonio Martnez

Selected by Mary Ellen Mark for our special issue, this up-and-coming photographer discusses his work




mar

SmartNews: Apps for Apes

Zookeepers at the National Zoo keep orangutans mentally stimulated with an innovative use of iPads




mar

SmartNews: 3D Printers in Space

If you need something while up in space, soon all you'll have to do is print it.




mar

Jose Gomez-Marquez Wants to Turn Every Doctor and Nurse into a Maker

Kennedy Center president Deborah Rutter interviews the co-founder of MIT’s Little Devices Lab about democratizing health technology




mar

SmartNews: Why Are These Mice Unafraid of Cats?

Scientists are researching how the rodent can become less susceptible to its feline foe.




mar

SmartNews: Maya Beheadings

Dismembered war captives from the 17th century uneartherd




mar

One Smart Crow

A crow named Icarus uses a short tool to extract a long tool, which he then uses to fish out a piece of meat.




mar

John Lewis' Journey to the March on Washington

At age 23, the former chairman of SNCC stepped up to the podium to deliver a powerful speech to thousands on the steps of the Lincoln Memorial.




mar

SmartNews: Making Gasoline from Bacteria

Researchers from South Korea have discovered a unconventional way to produce gasoline.




mar

March on Washington - Eleanor Holmes Norton




mar

Remembering the March on Washington

An oral history of the March on Washington: http://j.mp/1feuQK3 John Lewis, Eleanor Holmes Norton and others relive the pivotal moment of the Civil Rights Movement.




mar

U.S. Marine Corps Archival Footage: 28th Marines on Iwo Jima

Recently digitized footage shows the Marine assault on Iwo Jima during World War II, including prepping equipment, arriving on the island and raising the flag. (U.S. Marine Corps History Division and Moving Image Research Collections, University of South Carolina)




mar

March on Washington - Critical Past 1




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U.S. Marine Corps Footage: Marines in the Field at Iwo Jima

Recently digitized footage shows Marine in dugouts in the field, working on building a hospital and assisting the wounded on the front lines. (U.S. Marine Corps History Division and Moving Image Research Collections, University of South Carolina)




mar

March on Washington - John Lewis




mar

SmartNews: Fight Crime with Water?

A new law enforcement tool is marking alleged criminals without their knowledge




mar

How the Osage Changed Martin Scorsese’s Mind About "Killers of the Flower Moon"

A true-life saga involving organized crime, racial prejudice, and evolving American identity, David Grann’s 2017 nonfiction book Killers of the Flower Moon: The Osage Murders and the Birth of the F.B.I. seemed at first glance like a perfect fit for Martin Scorsese, the beloved filmmaker whose dozens of critically adored movies include Taxi Driver, GoodFellas, and The Departed. But when Jim Gray, a former chief of the Osage Nation, and other Osage leaders invited the filmmaker to Oklahoma to hear their concerns about his new project, Scorsese came. Scorsese listened. And then he rewrote and reconfigured Killers of the Flower Moon from soup to nuts, with a result that has earned a rapturous response from Native viewers like Gray and journalist Sandra Hale Schulman, and from the broader critical community, too. The movie opens in theatres tomorrow and will appear on the Apple+ streaming service before the end of the year. In this episode, Schulman walks me through a brief history of how Native Americans have been depicted in a century’s worth of movies. Then, Chief Gray tells me about his personal connection to Killers of the Flower Moon, the pattern of Native American erasure from national discourse, and how he and his colleagues persuaded Scorsese to rethink the new movie. A transcript of this episode can be found here (https://www.smithsonianmag.com/smithsonianmag/how-the-osage-changed-martin-scorseses-mind-180983094smithsonianmag.com/smithsonianmag/how-the-osage-changed-martin-scorseses-mind-180983094) . Sandra’s Smithsonian story about Native representation in cinema is here (https://www.smithsonianmag.com/history/a-brief-history-of-native-representation-in-film-180983043/) . You can learn more about Sandra and her work at her site (http://www.sandraschulman.com/) . Dennis McAuliffe Jr.’s The Deaths of Sybil Bolton: An American History, which Chief Gray cites as formative in this episode, is here (https://www.amazon.com/Deaths-Sybil-Bolton-American-History/dp/081292150X) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.




mar

Michael Craig-Martin Drawings

Timelapse of a British artist creating a site-specific piece for the Ulster Museum




mar

U.S. Marine Corps Archival Footage: 5th Div. Cemetery Dedication on Iwo Jima

Recently digitized footage shows the 5th Div. cemetery dedication on Iwo Jima with band, gun salute and officers speaking. In the final scene, tow Marines kneel over the temporary resting place of 3/13 PFC Ernest T. Langbeen. (U.S. Marine Corps History Division and Moving Image Research Collections, University of South Carolina)




mar

The Lincoln Assassination: Was Mary Surratt a Conspirator?

The southern widow's Maryland house was a crucial stop on the escape route for assassin John Wilkes Booth the night he shot the president. Read more about Abraham Lincoln at http://www.smithsonianmag.com/history-archaeology/life-of-lincoln.html




mar

SmartNews: Animal Spies

The CIA used birds, cats and even dolphins to help them on covert operations.




mar

March on Washington - Julian Bond




mar

The Only Footage of Mark Twain in Existence

Silent film footage taken in 1909 by Thomas Edison at Mark Twain's estate




mar

SmartNews: Fly the Friendly Skies With a Jetpack

Tired of waiting to catch your flight? Then strap on your very own jetpack and off you go!




mar

You Can Test Out Life on Mars in This State

Soaring over Utah, it's easy to imagine that you've left Earth and have stepped onto another planet.




mar

U.S. Marine Corps Archival Footage: 27th and 28th Marines Embarkation at Iwo Jima

Recently digitized footage showing Marines loading onto LST with supplies on equipment and waiting on the beach, among other things. (U.S. Marine Corps History Division and Moving Image Research Collections, University of South Carolina)