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Indian cauliflower rice and coriander pesto

Cauliflower rice: 1 head cauliflower, cut into florets 2 tbsps. ghee Coriander pesto: 1 large bunch coriander 1 garlic clove 1/4 cup cashews 2 tbsps. parmesan, finely grated 1 lime, zested and juiced 3 tbsps. coconut oil




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David wins record sixth squash world title

Malaysian squash superstar Nicol David has won a record sixth women's World Open title, overtaking Australia's Sarah Fitz-Gerald.




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Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial

OBJECTIVE

To evaluate the impact of once-weekly exenatide (EQW) on microvascular and cardiovascular (CV) outcomes by baseline renal function in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL).

RESEARCH DESIGN AND METHODS

Least squares mean difference (LSMD) in estimated glomerular filtration rate (eGFR) from baseline between the EQW and placebo groups was calculated for 13,844 participants. Cox regression models were used to estimate effects by group on incident macroalbuminuria, retinopathy, and major adverse CV events (MACE). Interval-censored time-to-event models estimated effects on renal composite 1 (40% eGFR decline, renal replacement, or renal death) and renal composite 2 (composite 1 variables plus macroalbuminuria).

RESULTS

EQW did not change eGFR significantly (LSMD 0.21 mL/min/1.73 m2 [95% CI –0.27 to 0.70]). Macroalbuminuria occurred in 2.2% of patients in the EQW group and in 2.5% of those in the placebo group (hazard ratio [HR] 0.87 [95% CI 0.70–1.07]). Neither renal composite was reduced with EQW in unadjusted analyses, but renal composite 2 was reduced after adjustment (HR 0.85 [95% CI 0.74–0.98]). Retinopathy rates did not differ by treatment group or in the HbA1c-lowering or prior retinopathy subgroups. CV outcomes in those with eGFR <60 mL/min/1.73 m2 did not differ by group. Those with eGFR ≥60 mL/min/1.73 m2 had nominal risk reductions for MACE, all-cause mortality, and CV death, but interactions by renal function group were significant for only stroke (HR 0.74 [95% CI 0.58–0.93]; P for interaction = 0.035) and CV death (HR 1.08 [95% CI 0.85–1.38]; P for interaction = 0.031).

CONCLUSIONS

EQW had no impact on unadjusted retinopathy or renal outcomes. CV risk was modestly reduced only in those with eGFR ≥60 mL/min/1.73 m2 in analyses unadjusted for multiplicity.




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Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study

OBJECTIVE

Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD.

RESEARCH DESIGN AND METHODS

In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation—a cohort of 528 individuals with no previous cardiovascular event undergoing CCTA), participants were grouped into CAD (clean coronaries) and CAD+ (diffuse lumen narrowing or plaques). Plasma proteins were screened by aptamer analysis. Two-way partial least squares was used to simultaneously rank proteins by diabetes status and CAD.

RESULTS

Though CAD+ was more prevalent among participants with T2D (HbA1c 6.7 ± 1.1%) than those without diabetes (56 vs. 30%, P < 0.0001), CCTA-based atherosclerosis burden did not differ. Of the 20 top-ranking proteins, 15 were associated with both T2D and CAD, and 3 (osteomodulin, cartilage intermediate-layer protein 15, and HTRA1) were selectively associated with T2D only and 2 (epidermal growth factor receptor and contactin-1) with CAD only. Elevated renin and GDF15, and lower adiponectin, were independently associated with both T2D and CAD. In multivariate analysis adjusting for the Framingham risk panel, patients with T2D were "protected" from CAD if female (P = 0.007), younger (P = 0.021), and with lower renin levels (P = 0.02).

CONCLUSIONS

We concluded that 1) CAD severity and quality do not differ between participants with T2D and without diabetes; 2) renin, GDF15, and adiponectin are shared markers by T2D and CAD; 3) several proteins are specifically associated with T2D or CAD; and 4) in T2D, lower renin levels may protect against CAD.




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Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide

OBJECTIVE

We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the complete cohort after 2 years of follow-up.

RESEARCH DESIGN AND METHODS

A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments.

RESULTS

No infusion-related adverse events were observed. β-Cell function declined after UCB infusion. Area under the curve C-peptide was 24.3% of baseline 1 year postinfusion (P < 0.001) and 2% of baseline 2 years after infusion (P < 0.001). Flow cytometry revealed increased regulatory T cells (Tregs) (P = 0.04) and naive Tregs (P = 0.001) 6 and 9 months after infusion, respectively.

CONCLUSIONS

Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide.




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Migration &amp; Coronavirus: A Complicated Nexus Between Migration Management and Public Health

This webinar, organized by MPI and the Zolberg Institute on Migration and Mobility at The New School, discussed migration policy responses around the globe in response to the COVID-19 pandemic, and examined where migration management and enforcement tools may be useful and where they may be ill-suited to advancing public health goals. 




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The State of Sex Research Today, According to 4 Sex Scientists

What’s going on in the world of sex research today? What are some of the biggest controversies and challenges? I recently sat down with a few of my colleagues to discuss these and other interesting questions. In the video below, I chat with Drs. Zhana Vrangalova (New York University), Diana Fleischman (University of Portsmouth), and Geoffrey Miller (University of New Mexico).




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How can we control the coronavirus pandemic? | Adam Kucharski

As the threat of COVID-19 continues, infectious disease expert and TED Fellow Adam Kucharski answers five key questions about the novel coronavirus, providing necessary perspective on its transmission, how governments have responded and what might need to change about our social behavior to end the pandemic. (This video is excerpted from a 70-minute interview between Kucharski and head of TED Chris Anderson. Listen to the full interview at http://go.ted.com/adamkucharski. Recorded March 11, 2020)




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A camera that can see around corners | David Lindell

To work safely, self-driving cars must avoid obstacles -- including those just out of sight. And for this to happen, we need technology that sees better than humans can, says electrical engineer David Lindell. Buckle up for a quick, groundbreaking tech demo as Lindell explains the significant and versatile potential of a high-speed camera that can detect objects hidden around corners.




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How we must respond to the coronavirus pandemic | Bill Gates

Philanthropist and Microsoft cofounder Bill Gates offers insights into the COVID-19 pandemic, discussing why testing and self-isolation are essential, which medical advancements show promise and what it will take for the world to endure this crisis. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 24, 2020)




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The quest for the coronavirus vaccine | Seth Berkley

When will the coronavirus vaccine be ready? Epidemiologist Seth Berkley (head of Gavi, the Vaccine Alliance) takes us inside the effort to create a vaccine for COVID-19. With clarity and urgency, he explains what makes it so challenging to develop, when we can expect it to be rolled out at scale and why we'll need global collaboration to get it done. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 26, 2020)




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What the world can learn from China's response to the coronavirus | Gary Liu

From Hong Kong, South China Morning Post CEO Gary Liu tracks China's response to the coronavirus pandemic -- from the initial outbreak in Wuhan to the shutdown of Hubei province and the containment measures taken across its major cities. Sharing insights into how the culture in places like Hong Kong and South Korea contributed to fast action against the virus, Liu identifies lessons people across the world can use to stop its spread. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 25, 2020)




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How we can navigate the coronavirus pandemic with courage and hope | Rabbi Lord Jonathan Sacks

Rabbi Lord Jonathan Sacks offers thoughts on how we can navigate the coronavirus pandemic with courage, hope and empathy. With wisdom and clarity, he speaks on leadership, fear, death, hope and how we could use this moment to build a more just world. Watch for a special, impromptu prayer about halfway through the conversation. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and head of curation Helen Walters. Recorded March 30, 2020)




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A global hackathon to take on the coronavirus pandemic | Marko Russiver

Looking to put your skills to use to fight the pandemic? Consider joining The Global Hack, a virtual hackathon designed to rapidly develop solutions to the coronavirus crisis. Designer and technologist Marko Russiver shares the motivation behind a movement looking to help people build post-pandemic resilience. (This virtual conversation is part of the TED Connects series, hosted by head of curation Helen Walters. Recorded April 8, 2020)




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What coronavirus means for the global economy | Ray Dalio

"I'm a capitalist. I believe in the system. I believe you can increase the size of the pie and you could divide it well," says Ray Dalio, founder of Bridgewater Associates. He offers wide-ranging insight and advice on how we might recover from the global economic fallout of the coronavirus crisis -- and use it as an opportunity to reform the systems that help grow our economy. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and business curator Corey Hajim. Recorded April 8, 2020)




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How the coronavirus is impacting India -- and what needs to happen next | Gayathri Vasudevan

The coronavirus pandemic put India's population of 1.3 billion into an extreme and sudden lockdown. Social entrepreneur Gayathri Vasudevan explains how the situation is impacting the country's migrant workers, who are stuck far from home with limited access to food and shelter, and calls for an overhaul of India's social infrastructure in order to get people the essentials they need right now. (This virtual conversation is part of the TED Connects series, hosted by current affairs curator Whitney Pennington Rodgers. Recorded April 9, 2020)




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How the coronavirus pandemic is changing the world | Fareed Zakaria

The coronavirus pandemic is more global, dramatic and unusual than any crisis we've seen in a long time, says journalist Fareed Zakaria. Listen as he shares his perspective on how we can recover from the economic fallout, why certain countries were able to avoid major outbreaks and what this might mean for the balance of global power. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded April 9, 2020)




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How American and Chinese values shaped the coronavirus response | Huang Hung

To combat COVID-19, countries have enforced city-wide shutdowns, stay-at-home orders and mask mandates -- but the reaction (and adherence) to these rules has differed markedly in the East and West. In conversation with TED's head of curation Helen Walters, writer and publisher Huang Hung sheds light on how Chinese and American cultural values shaped their responses to the outbreak -- and provides perspective on why everyone needs to come together to end the pandemic. (Recorded April 16, 2020)




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During Coronavirus Crisis, How Can State Leaders Help Schools?

I recently talked with Carrie Conaway, Harvard lecturer and former Massachusetts state administrator, about the challenges coronavirus presents for state ed. departments.




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Coronavirus Squeezes Supply of Chromebooks, iPads, and Other Digital Learning Devices

School districts are competing against each other for purchases of digital devices as remote learning expands to schools across the country.




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Coronavirus Upends After-School World

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.




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West Virginia Teachers Scored a Victory But Will Remain on Strike

Lawmakers effectively killed the controversial education bill that had prompted the second statewide strike in two years.




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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Coronavirus Is Pushing Teacher Hiring Online. Here's What That Means

Districts that can screen, interview, and select candidates virtually will have less disruption to their hiring, despite how coronavirus is upending every aspect of school operations.




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WATCH: What It's Really Like for Homeschooling During Coronavirus

Coronavirus has shut down schools across the country, forcing millions of students to learn at home. In this video, families from Seattle to Maine describe how they are adjusting to this new reality.




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States Ordering Schools to Close in Response to Coronavirus

"We have a responsibility to save lives," Ohio Gov. Mike DeWine said on Twitter. "We could have waited to close schools, but based on advice from health experts, this is the time to do it."




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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Coronavirus Upends After-School World

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.




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Wyoming Schools Chief on the Coronavirus Challenge

"In communities most devastated by COVID-19, academic achievement is pretty far down on the priority list—this is the reality," says Wyoming state chief Jillian Balow.




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Measuring the Impact of Common-Core Test Disruptions in Three States

A Smarter Balanced testing vendor has released completion rates in three states that had serious challenges giving the common-core aligned exam.




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North Dakota Bill Targets Common Core in Both Substance and Name

North Dakota lawmakers fended off an effort to ensure that the state's new standards, and any tests that might be used with them, won't mirror the common core.




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School Board Member's Use of Student Records Stirs Dust-Up

A little story out of Lexington, Ky., raises some big questions for K-12 districts to consider on how to handle ongoing murkiness over student privacy, open-records laws, and how candidates for school boards should best communicate with their constituents.




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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How Coronavirus Is Jeopardizing Teacher Pay Raises

The momentum to raise teacher salaries in several states has ground to a halt amid fears of coronavirus’ massive economic blow.




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Coronavirus concerns may delay school shooting trial




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Iconic Teacher Leader on Coronavirus Response

"Educators are completely redesigning instructional delivery while constantly being thrown new rules. It's like 'flying the plane as you build it,'" says Maddie Fennell.




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Alabama Will Keep Its Common Core Standards--For Now

Board members didn't act on a resolution to revoke Alabama's version of the Common Core State Standards.




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School Closures May Go Into the Fall If Coronavirus Resurges, State Chiefs Warn

Schools may have to continue closures in the fall if the coronavirus resurges, state schools chiefs in Maryland and Washington said. The warnings came the same week thata key federal official predicted schools would be able to reopen for the 2020-21 school year.




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New York Set to Revise Common-Core Reading and Math Standards

New York state is considering adopting a new set of K-12 reading and math standards that differ somewhat from the Common Core State Standards, which have had rocky reception in the state since they went into place in 2010.




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New York Takes Final Step to Separate State Test Scores From Teacher Evaluations

The New York state legislature passed a bill that would make the use of state test scores in these evaluations optional, leaving the decision up to districts and making it subject to collective bargaining.




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School Closures for Coronavirus Could Extend to the End of School Year, Some Say

More than half of all states have ordered schools closed for multiple weeks to help slow the pandemic.




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Colorado Shooting Underscores Challenges of Keeping Students Safe (Video)

The STEM School shooting underscores the huge challenges educators face in keeping students safe, even as fatal and injurious gunfire inside K-12 schools remains statistically rare.




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Coronavirus Upends After-School World

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.




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How Schools Will Overcome the 'Coronavirus Slide:' Ideas From 5 Superintendents

With many school buildings closed for the rest of the academic year—and more to follow—district leaders turn their attention to making up for what may be deep learning losses.




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How Districts Are Helping Teachers Get Better at Tech Under Coronavirus

Educators are struggling to learn how to use new tech tools—devices, apps, software, and online textbooks—in greater volume than ever before.




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Hacked and Cut Off From the Public: This Is School Board Business in the Coronavirus Crisis

Social distancing is forcing school business to be conducted virtually, putting school boards in the difficult spot of making crucial decisions on spending and other issues without the same level of public input.




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Teach New Content or Review Familiar Material? A Tough Call During Coronavirus Closures

Schools must make the critical decision whether to reinforce the learning that students have already done this year or introduce new content.




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Rhode Island PARCC Scores Lower on Computer-Based Exams

A state-by-state breakdown shows that Colorado, Rhode Island and Illinois found some evidence that students' familiarity with technology impacted scores on 2014-15 PARCC exams. An analysis in Maryland is pending.




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Coronavirus Upends After-School World

With schools shut down, social distancing in place, and parents at home, after-school programs are laying off staff and switching gears to meet families' needs.




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How Districts Are Helping Teachers Get Better at Tech Under Coronavirus

Educators are struggling to learn how to use new tech tools—devices, apps, software, and online textbooks—in greater volume than ever before.