k Talk Evidence - Z drugs, subclinical hypothyroidism and Drazen's dozen By feeds.bmj.com Published On :: Tue, 25 Jun 2019 16:58:44 +0000 This week on the podcast, (2.02) a listener asks, when we suggest something to stop, should we suggest an alternative instead? (8.24) Helen tells us to stop putting people on treatment for subclinical hypothyroidism, but what does that mean for people who are already receiving thyroxine? (20.55) Carl has a black box warning about z drugs, and... Full Article
k Talk evidence - smoking, gloves and transparency By feeds.bmj.com Published On :: Wed, 10 Jul 2019 11:11:50 +0000 This month we have some more feedback from our listeners (2.20) Carl says it's time to start smoking cessation (or stop the reduction in funding for smoking reduction) (11.40) and marvels at how pretty Richard Doll's seminal smoking paper is. It's gloves off for infection control (22.20) Andrew George, a non-executive director of the Health... Full Article
k Burnout - Don't try to make the canary in the coal mine more resilient By feeds.bmj.com Published On :: Thu, 08 Aug 2019 16:59:04 +0000 Burnout is a problem in healthcare - it’s a problem for individuals, those who experience it and decide to leave a career they formerly loved, but it’s also a problem for our healthcare system. Burnout is associated with an increase in medical errors, and poor quality of care. Fundamentally it’s a patient safety issue. But, unlike other patient... Full Article
k Talk Evidence - Tramadol, medical harm, and alexa By feeds.bmj.com Published On :: Wed, 21 Aug 2019 10:49:28 +0000 Welcome back to Talk Evidence - where Helen Macdonald and Carl Heneghan take you through what's happening in the world of Evidence. This month we'll be discussing tramadol being prescripted postoperatively, and a new EBM verdict says that should change(1.36). How much preventable harm does healthcare causes (11.20. A canadian project to help... Full Article
k Tackling burnout in The Netherlands By feeds.bmj.com Published On :: Fri, 30 Aug 2019 16:35:45 +0000 We heard a few podcasts ago about burnout - what it is, and why it should be thought of as a systems issue. Now a project in the Netherlands is trying to investigate who it is that is particularly at risk of burnout, and hopes to test whether individually tailored coaching and counselling can help those who are experiencing the symptoms change the... Full Article
k The government is lacking detail over Brexit planning By feeds.bmj.com Published On :: Wed, 04 Sep 2019 17:43:31 +0000 Brexit. Who knows what’s going to happen in the next few weeks, months, years - the uncertainty is high. In the face of that, you’d hope that the government was doing all it could to plan for any eventuality - let alone for a massive, country altering one like suddenly crashing out without a deal - but Martin McKee, professor of public health at... Full Article
k Extending the UK's sugar tax to snacks By feeds.bmj.com Published On :: Fri, 06 Sep 2019 11:54:58 +0000 In the UK, for just over a year, we've been paying the "Soft Drinks Industry Levy" - a tax on sugary beverages intended to reduce our consumption of free sugars. That was based on taxes that had happened in other countries, however, in the UK high sugar snacks, such as confectionery, cakes, and biscuits make a greater contribution to intakes of... Full Article
k Vaping deaths - does this change what we think about public health messages By feeds.bmj.com Published On :: Thu, 12 Sep 2019 16:58:18 +0000 This week the Trump administration has banned the sale of flavoured vapes in the USA. The reason for that is the sudden rash of cases of pulmonary disease, including deaths, linked to vaping. The mechanism by which vaping may be causing damage to the lungs is as yet unclear, and our understanding is hampered by the heterogeneous nature of the... Full Article
k Cancer drug trials used for regulatory approval are at risk of bias By feeds.bmj.com Published On :: Thu, 19 Sep 2019 14:09:14 +0000 Around half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, in a new study. Huseyin Naci,assistant professor of health policy a the London School of Economics joins us to talk about why potential bias may mean potential exaggeration of treatment effects, and could be... Full Article
k Talk Evidence - Recurrent VTE, CRP testing for COPD, CMO report, and a consultation By feeds.bmj.com Published On :: Mon, 23 Sep 2019 10:21:58 +0000 Helen talks about new research on prevention of recurrent VTE - and Carl things the evidence goes further, and we can extend prophylaxis for a year. 13.00 - CRP testing for antibiotic prescription in COPD exacerbations, should we start doing it in primary care settings - and what will that mean. We also hear from Chris Butler, one of the... Full Article
k Climate change will make universal health coverage precarious By feeds.bmj.com Published On :: Tue, 24 Sep 2019 14:26:52 +0000 The BMJ in partnership with The Harvard Global Health Institute has launched a collection of articles exploring how to achieve effective universal health coverage (UHC). The collection highlights the importance of quality in UHC, potential finance models, how best to incentivise stakeholders, and some of the barriers to true UHC. One of those... Full Article
k Talk Evidence - eating less, drinking less, drug approval data By feeds.bmj.com Published On :: Fri, 04 Oct 2019 16:41:57 +0000 Talk Evidence is back, with your monthly take on the world of EBM with Duncan Jarvies and GPs Carl Heneghan (also director for the Centre of Evidence Based Medicine at the University of Oxford) and Helen Macdonald (also The BMJ's UK research Editor). This month Carl talks about evidence that restricting your diet might improve health at a... Full Article
k A new way to look at behaviour change in UK GPs By feeds.bmj.com Published On :: Tue, 08 Oct 2019 14:52:42 +0000 In quality improvement, measurement is seen as a key driver of change - how well do you know you’re doing, if you can’t actually measure it. So, when something changes in the NHS (say a new guideline) how can you tell how quickly that’s filtering down to the front line. Ben goldacre, from the Nuffield Department of Primary Care Health Sciences... Full Article
k How Blockchain could improve clinical trial transparency By feeds.bmj.com Published On :: Sat, 12 Oct 2019 13:06:50 +0000 Blockchain is the digital technology that underpins cryptocurrencies such as bitcoin, and has been proposed as the digital panacea of our times. But Leeza Osipenko, from the London School of Economics, has thought about how it could actually be used in clinical trials, and what else would need to change in our regulatory environment to make that... Full Article
k Ancestry DNA tests can over or under estimate genetic disease risk By feeds.bmj.com Published On :: Thu, 17 Oct 2019 14:36:18 +0000 Direct-to-consumer genetic tests are sold online and in shops as a way to “find out what your DNA says". They insights into ancestry or disease risks; others claim to provide information on personality, athletic ability, and child talent. However, interpretation of genetic data is complex and context dependent, and DTC genetic tests may produce... Full Article
k Testing for TB is only skin deep By feeds.bmj.com Published On :: Fri, 25 Oct 2019 18:36:01 +0000 A TB infection can take two forms, active and latent. Active disease is transmissible, and causes the damage to the lungs which makes TB one of the biggest killers in the world. In the latent form, the bacteria Mycobacterium tuberculosis is quiescent and can stay that way for years until it becomes active and causes those clinical signs. Testing... Full Article
k Creating a speak out culture By feeds.bmj.com Published On :: Thu, 07 Nov 2019 17:00:38 +0000 Giving staff the confidence to speak out is important in healthcare - It's a key aspect of the WHO patient safety checklist, decreasing incidence of medical error, but it's also important to stop incidents of harassment and abuse which undermine staff and increase burnout. Creating that culture is a difficult task, but two hospitals in the... Full Article
k Talk Evidence - aggravating acronyms, a time to prescribe, and screening (again) By feeds.bmj.com Published On :: Mon, 11 Nov 2019 11:51:44 +0000 Talk Evidence is back, with your monthly take on the world of EBM with Duncan Jarvies and GPs Carl Heneghan (also director for the Centre of Evidence Based Medicine at the University of Oxford) and Helen Macdonald (also The BMJ's UK research Editor). This month Helen talks about the messy business of colon cancer screening - which modality is... Full Article
k Talk Evidence - Talking about harms By feeds.bmj.com Published On :: Fri, 13 Dec 2019 18:18:10 +0000 In this special edition of talk evidence, Helen Macdonald and Carl Henneghan talk about creating an evidence base from harms. We hear from a member of the pubic who experienced harm from a drug, and now advises the FDA. A former regulator who explains why reporting harms is so important. And finally, an investigative journalist who explains what... Full Article
k Talk Evidence - digital clubbing, osteoarthritis & sustainable EBM By feeds.bmj.com Published On :: Mon, 16 Dec 2019 19:36:54 +0000 We’re back for the December Talk Evidence, and this month we’re being very digital Firstly,(1.20) Helen tells us about arthritic fingers - should we be using prednisolone for treatment when people have painful osteoarthritis of the hand Then (13.30) Carl gets us all to check our fingers for clubbing, and we find out how useful it is as a test... Full Article
k Talking up your research - Sex makes a difference By feeds.bmj.com Published On :: Fri, 20 Dec 2019 15:50:09 +0000 As editors, we feel like we’re spending a lot of time taking the superlatives out from articles - amazing, novel, important… But new research on BMJ.com suggests that we might not be doing that great a job, and that for some reason, papers authored by men tend to have more of them - because men put more in, or maybe a bias against woman writing in... Full Article
k Talk Xmas Evidence By feeds.bmj.com Published On :: Tue, 31 Dec 2019 14:52:53 +0000 Welcome to the festive talk evidence, giving you a little EBM to take you into the new year. As always Duncan Jarvies is joined by Helen Macdonald (resting GP and editor at The BMJ) and Carl Heneghan (active GP, director of Oxford University’s CEBM and editor of BMJ Evidence) This month: (2.00) Helen look back at a Christmas article, which... Full Article
k Editors pick of education in 2019 By feeds.bmj.com Published On :: Fri, 03 Jan 2020 14:58:44 +0000 If you’re lucky enough to not be back at work, you might be feeling like you need to quickly refresh your medical knowledge - and this podcast the BMJ’s education editors take you on a whistlestop tour through the BMJ’s education articles of 2019. Tom Nolan (GP in London) is joined by Navjoyt Ladher (GP in London), Anita Jain (GP in India) and... Full Article
k Talk Evidence - Sepsis, talc and blindsided by blinding By feeds.bmj.com Published On :: Wed, 22 Jan 2020 17:40:40 +0000 Welcome to the festive talk evidence, giving you a little EBM to take you into the new year. As always Duncan Jarvies is joined by Helen Macdonald (resting GP and editor at The BMJ) and Carl Heneghan (active GP, director of Oxford University’s CEBM and editor of BMJ Evidence)* This month: (1.20) Carl tells us about new research on treating... Full Article
k Talk Evidence - Building an evidence base for covid-19 By feeds.bmj.com Published On :: Mon, 17 Feb 2020 15:22:17 +0000 We're taking a break from the usual Talk Evidence to focus on the new corona virus that has emerged in China. With a brand new disease, we have to build our evidence base from scratch - basic virology, epidemiology, pathogenicity, transmissibility, and ultimately treatment are all unknowns. In this episode of Talk Evidence, we're trying to get... Full Article
k Cycling - Does the health benefit outweigh the accident risk (in the UK) By feeds.bmj.com Published On :: Thu, 12 Mar 2020 16:22:11 +0000 We all know we should be doing more exercise, and one way to do that is by active commuting - journeying to work on foot or by bike. One thing preventing people from taking up cycling is the fear of being involved in road traffic accidents, and that the risk isn't worth the benefit of the extra exercise. It’s even more confusing when air... Full Article
k Talk Evidence - testing under the microscope and opioid prescription By feeds.bmj.com Published On :: Fri, 20 Mar 2020 20:08:10 +0000 This edition of talk evidence was recorded before the big increase in covid-19 infections in the UK, and then delayed by some self isolation. We'll be back with more evidence on the pandemic very soon. As always Duncan Jarvies is joined by Helen Macdonald (resting GP and editor at The BMJ) and Carl Heneghan (active GP, director of Oxford... Full Article
k Organisational kindness during covid-19 By feeds.bmj.com Published On :: Thu, 26 Mar 2020 11:52:48 +0000 Reports from Italy, and more recently from the U.S. show the strain the healthcare system is under during this pandemic. We know that staff will step up in an emergency, but this isn’t a fire or a bombing, this is going to last for months. So how can organisations be proactive in supporting staff, and how can leaders try to mitigate the... Full Article
k Talk Evidence Covid-19 update - Confused symptoms, fatality rate uncertainty, Iceland's testing By feeds.bmj.com Published On :: Fri, 27 Mar 2020 16:14:17 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
k Look after yourself during covid-19 By feeds.bmj.com Published On :: Tue, 07 Apr 2020 14:44:42 +0000 Continuing our series on wellbeing during the pandemic, in this podcast we speak to Occupational Psychologist Roxane Gervais about how doctors can look after themselves during the covid-19 pandemic. We discuss the importance of reaching out to friends and family during this difficult time, how to deal with the loss of control, as well how to... Full Article
k Wellbeing - Some advice on working in PPE By feeds.bmj.com Published On :: Wed, 08 Apr 2020 17:38:56 +0000 Wellbeing might not seem the obvious place to talk about PPE - but lack of appropriate PPE is causing healthcare staff a great deal of stress now. Mary Brindle is a pediatric surgeon and the director of The EQuIS (Efficiency Quality Innovation and Safety) Research platform at Alberta Children’s hospital. In this podcast she reflects on the use... Full Article
k Talk Evidence covid-19 update - pneumonia, guidelines, preprints and testing By feeds.bmj.com Published On :: Thu, 09 Apr 2020 09:53:16 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
k Talk Evidence covid-19 update - hydroxy/chloroquinine, prognostic models and facemaskss By feeds.bmj.com Published On :: Mon, 13 Apr 2020 20:39:17 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
k Talk Evidence - Remdesivir, care homes, and death data By feeds.bmj.com Published On :: Fri, 17 Apr 2020 15:00:49 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
k Talk Evidence - covid ethics, waste and a minimum RCT size By feeds.bmj.com Published On :: Fri, 24 Apr 2020 16:19:18 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
k Frontline stories - working as a GP during covid By feeds.bmj.com Published On :: Mon, 27 Apr 2020 16:56:13 +0000 As the pandemic plays out - the way in which doctors in the UK practice is changing, hospitals are reconfigured to increase critical care capacity, GPs are working from home and doing their day to day work remotely. Some of the changes have come at the detriment of staff and patient wellbeing but covid-19 has also helped cut through some of the... Full Article
k Talk Evidence covid-19 update - lack of testing transparency, how to give good debate By feeds.bmj.com Published On :: Mon, 04 May 2020 16:25:18 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give you... Full Article
k Talk evidence covid-19 update: natural history of covid, include patients in guidelines By feeds.bmj.com Published On :: Sat, 09 May 2020 09:13:00 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give you... Full Article
k Fuel selection in human skeletal muscle in insulin resistance: a reexamination By diabetes.diabetesjournals.org Published On :: 2000-05-01 DE KelleyMay 1, 2000; 49:677-683Articles Full Article
k C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study By diabetes.diabetesjournals.org Published On :: 2002-05-01 Dilys J. FreemanMay 1, 2002; 51:1596-1600Complications Full Article
k 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle By diabetes.diabetesjournals.org Published On :: 1999-08-01 EJ Kurth-KraczekAug 1, 1999; 48:1667-1671Articles Full Article
k Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles By diabetes.diabetesjournals.org Published On :: 1997-11-01 Shane ReaNov 1, 1997; 46:1667-1677Perspectives in Diabetes Full Article
k Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of {beta}-Cell Death By diabetes.diabetesjournals.org Published On :: 2001-01-01 Christophe BonnyJan 1, 2001; 50:77-82Islet Studies Full Article
k Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study By diabetes.diabetesjournals.org Published On :: 2003-03-01 Joachim SprangerMar 1, 2003; 52:812-817Pathophysiology Full Article
k A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm By diabetes.diabetesjournals.org Published On :: 1996-02-01 Franz M MatschinskyFeb 1, 1996; 45:223-241Banting Lecture 1995 Full Article
k Tumor Necrosis Factor {alpha}: A Key Component of the Obesity-Diabetes Link By diabetes.diabetesjournals.org Published On :: 1994-11-01 Gökhan S HotamisligilNov 1, 1994; 43:1271-1278Perspectives in Diabetes Full Article
k Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships By diabetes.diabetesjournals.org Published On :: 2000-12-01 D DabeleaDec 1, 2000; 49:2208-2211Articles Full Article
k Evidence for 5'AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport By diabetes.diabetesjournals.org Published On :: 1998-08-01 Tatsuya HayashiAug 1, 1998; 47:1369-1373Rapid Publications Full Article
k High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells By diabetes.diabetesjournals.org Published On :: 2000-11-01 T InoguchiNov 1, 2000; 49:1939-1945Articles Full Article
k Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance By diabetes.diabetesjournals.org Published On :: 1992-03-01 Eve Van CauterMar 1, 1992; 41:368-377Original Article Full Article