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Recent Advances of Versatile Fluorophores for Multifunctional Biomedical Imaging in the NIR-II Region

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01957A, Review Article
Kaiming Ma, Qunying Jiang, Yang Yang, Fan Zhang
Fluorescence imaging in the second near-infrared region (NIR-II, 1,000-1,700 nm) enables high-resolution visualization of deep-tissue biological architecture and physiopathological events, due to the reduced light absorption, scattering and tissue autofluorescence....
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Recent Advances of Two-Dimensional Materials for biomedical Application

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01787K, Review Article
Ranran Zhang, Zichao Yan, Ming Gao, Bingxin Zheng, Bin Yue, Meng Qiu
Two-dimensional (2D) materials exhibit significant potential in biomedical applications, particularly as drug carriers. 2D materials, including graphene, black phosphorus, transition metal dichalcogenides, transition metal carbides/nitrides, and hexagonal boron nitride, have...
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Evaluation of Alkyl Chain Length and Photocatalytic Antibacterial Performance of Cation g-C3N4

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01118J, Paper
Junling Leng, Xuanwei Liu, Yin Xu, shien zhu, Yuefei Zhang, Zhongbing Tan, Xiaofei Yang, Jia-En Jin, YuFeng Shi, Fan Hongying, Yi Yang, Hang Yao, Yu Zhang, Hui Chong, Chengyin Wang
Several cation graphite carbon nitrides (g-C3N4-(CH2)n-ImI+) were synthesized by chemically attaching imidazolium appended alkane chains with different lengths (n = 2, 4, 8, 12 and 16) to g-C3N4. Introduction of...
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Nanocrystalline alloy-mediated delivery of mosaic epitope peptides for universal influenza vaccine

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB00742E, Paper
Hongyu Wang, Han Fu, Liyan Zhai, Jiaqing Le, Bohan Guo, Yuyang Zhou, Chenlin Ji, Dapeng Li, Yue Zhang
Mosaic influenza antimicrobial peptide-like epitopes (Ampitopes) co-crystalize with poly(I:C), a TLR3 agonist, into nanocrystalline vaccine, which boosts immunogenicity via multivalent toll like receptor 3 (TLR3) binding and immune activation.
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A bilayer hydrogel mimicking the periosteum-bone structure for innervated bone regeneration

J. Mater. Chem. B, 2024, 12,11187-11201
DOI: 10.1039/D4TB01923G, Paper
Wenhui Lyu, Yuyue Zhang, Shaopei Ding, Xiang Li, Tong Sun, Jun Luo, Jian Wang, Jianshu Li, Lei Li
The bilayer hydrogel GS@Mg/GP@Mg in this study is a promising material to promote innervated bone regeneration for functional and structural repair of bone defects.
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A simple hydrogen peroxide-activatable Bodipy for tumor imaging and type I/II photodynamic therapy

J. Mater. Chem. B, 2024, 12,11165-11171
DOI: 10.1039/D4TB01650E, Paper
Fangqing Ge, Yujie Sun, Yu Wang, Dan Yu, Zhijia Wang, Fabiao Yu, Bingran Yu, Hongbing Fu
A H2O2-activatable Bodipy with simultaneous type I and type II photosensitization was designed for tumor imaging and therapy.
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Advances in osteoimmunomodulation of biomaterials after intrabone implantation: focus on surface hydrophilicity

J. Mater. Chem. B, 2024, 12,11089-11104
DOI: 10.1039/D4TB01907E, Review Article
Xinpeng Wei, Linshan Lei, Ling Luo, Ying Zhou, Zheng Zheng, Wenchuan Chen
Hydrophilicity of implantable biomaterials can facilitate osteoimmunomodulation through influencing proteins adsorption, blood clotting, neutrophils activation, macrophages polarization, angiogenesis and osteogenesis to enhance osseointegration.
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Chitosan-functionalized nanobubbles for precision oncology: advances in targeted cancer therapeutics

J. Mater. Chem. B, 2024, 12,11076-11088
DOI: 10.1039/D4TB01930J, Review Article
Vivek Pandey, Tejasvi Pandey
The convergence of nanotechnology and cancer therapeutics has opened new frontiers in the development of advanced drug delivery systems.
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A single-injection vaccine providing protection against two HPV types

J. Mater. Chem. B, 2024, 12,11237-11250
DOI: 10.1039/D4TB00606B, Paper
Jianchen Zhang, Yu Liu, Ying Guan, Yongjun Zhang
A bivalent single-injection HPV vaccine was designed using a new pulsatile release drug carrier.
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A guanidiniocarbonyl-pyrrole functionalized cucurbit[7]uril derivative as a cytomembrane disruptor for synergistic antibacterial therapy

J. Mater. Chem. B, 2024, 12,11105-11109
DOI: 10.1039/D4TB01840K, Communication
Ruixue Han, Kehan Du, Shengke Li, Minzan Zuo, Ponmani Jeyakkumar, Hao Jiang, Leyong Wang, Xiao-Yu Hu
A guanidiniocarbonyl-pyrrole functionalized cucurbit[7]uril derivative as a cytomembrane disruptor has been successfully constructed for synergistic antibacterial therapy.
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An innovative electrohydrodynamics-driven SERS platform for molecular stratification and treatment monitoring of lung cancer

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01434K, Highlight
Tuotuo Zhang, Biao Dong, Huiling Wang, Shuai Zhang
A schematic electrohydrodynamics-driven SERS platform to profile four proteins on sEVs to generate a unique molecular signature for lung cancer stratification.
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Nanobiopolymers in cancer therapeutics: advancing targeted drug delivery through sustainable and controlled release mechanisms

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB00599F, Review Article
Shikha Gulati, Nabeela Ansari, Yamini Moriya, Kumud Joshi, Disha Prasad, Gargi Sajwan, Shefali Shukla, Sanjay Kumar, Rajender S. Varma
Nanobiopolymers in cancer therapeutics offer sustainable and targeted drug delivery with controlled release, enhancing treatment efficacy while ensuring sustainability and biodegradability for improved patient care.
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Biomaterials Enhancing Localized Cancer Therapy Activated Anti-Tumor Immunity: A Review

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01995D, Review Article
Jipeng Yao, Zhencun Cui, Feifei Zhang, Haidong Li, Longlong Tian
Localized cancer therapy such as radiotherapy, phototherapy, and chemotherapy are precise cancer treatment strategy, aiming to minimize systemic side effect. However, cancer metastasis remains the primary cause of cancer patients’...
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Extracellular matrix mimetic supramolecular hydrogels reinforced with covalent crosslinked mesoporous silica nanoparticles

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB00499J, Paper
Open Access
Aygül Zengin, Shahzad Hafeez, Pamela Habibovic, Matthew Baker, Sabine van Rijt
Here we present a promising strategy to create hybrid, biomimetic supramolecular injectable hydrogels reinforced covalent crosslinked mesoporous silica nanoparticles for tissue engineering applications.
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H2O2-activated mitochondria-targeting photosensitizer for fluorescence imaging-guided combination photodynamic and radiotherapy

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01653J, Paper
Qiufen Tian, Zifan Zhu, Yun Feng, Shirui Zhao, Hui Lin, Wen Zhang, Zhiai Xu
Radiotherapy is a primary modality in cancer treatment but accompanied by severe side effects to healthy tissues and radiation resistance to some extent. To overcome these limitations, we developed a...
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Quantum DFT analysis and molecular docking investigation of various potential breast cancer drugs

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01803F, Paper
Ashraf Ayub, Ankit Raj Tyagi, Sunil Kumar Srivastava, Pranveer Singh
Breast cancer is the most often diagnosed and deadliest type of cancer in the world. These days, the world is facing the threat of breast cancer. It is essential to...
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Fluorescence sensing techniques for quality evaluation of traditional Chinese medicines: a review

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01886A, Review Article
Yanyu Xiao, Hui Wang, Chenxia Gao, Xinyi Ye, Yuting Lai, Meiling Chen, Xiaoliang Ren
We summarized the advantages and advanced applications of fluorescence sensing technology compared with other analytical techniques, as well as the challenges and prospects of current application in the field of TCM quality evaluation.
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Advancing cancer therapy with a heptamethine carbocyanine dye-conjugated radionuclide drug

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01798F, Paper
Mingxing Huang, Weichen Wang, Yingwei Wang, Rang Wang, Lili Pan, Xin Li, Bo Li, Jingsong Zhang, Ruoxiang Wang, Yi Zhang, Rong Tian
Malignant tumors pose substantial treatment challenges due to their heterogeneity, metastatic potential, and therapeutic resistance, underscoring the urgent need for more effective treatment options.
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Illuminating cisplatin-induced ferroptosis in non-small-cell lung cancer with biothiol-activatable fluorescent/photoacoustic bimodal probes

J. Mater. Chem. B, 2024, Advance Article
DOI: 10.1039/D4TB01656D, Paper
Li Xu, Hongwen Liu, Yi Kong, Lingyun Li, Jia Li, Kang Li, Shuzhi Liang, Bolin Chen
Using activatable NIR fluorescent/PA bimodal probes, we successfully monitored real-time biothiol changes during ferroptosis in NSCLC cells and tumors, revealing enhanced ferroptosis with the combined use of erastin and cisplatin.
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Recent Advances in Polymer-based Thin-film Electrode for ECoG Applications

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB02090A, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhengchen Xiang, Liangtao Yang, Bin Yu, Qi Zeng, Tao Huang, Shuo Shi, Hao Yu, Yi Zhang, Jinglong Wu, Meifang Zhu
Electrocorticography (ECoG) has garnered widespread attention due to its superior signal resolution compared to conventional electroencephalogram (EEG). While ECoG signal acquisition entails invasiveness, the invasive rigid electrode inevitably inflicts damage...
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Bioinspired programmable coacervate droplets and self-assembled fibers through pH regulation of monomers

J. Mater. Chem. B, 2024, Accepted Manuscript
DOI: 10.1039/D4TB01550A, Paper
Satyajit Patra, Sushmitha Chandrabhas, Subi J. George
Phase separation or phase transitions pervade the biological domain, where proteins and RNA engage in liquid-liquid phase separation (LLPS), forming liquid-like membraneless organelles. The misregulation or dysfunction of these proteins...
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Is Varun Going To Be A Daddy?

Though Archana Gautam was evicted from Bigg Boss for physically hurting Shiv Thakare, the actress-turned-politician was brought back in the game over the weekend.




va

Bigg Boss 16: Sreejita De's SPICY New Avatar

Television actress Sreejita De is back on Bigg Boss 16 as a wild card contestant.




va

TV Actors Vaibhavi Upadhyaya, Nitish Pandey No More

Vaibhavi rose to fame with Sarabhai vs Sarabhai while Nitish starred in Anupama.




va

Making Shiva's Love Story Look Divine

Colors TV's new show Shiv Shakti: Tap Tyag Tandav tells the story of love between Lord Shiva and Parvati/ Shakti.




va

Bigg Boss OTT: Who Is Shivani Kumari?

Let's take a closer look at her through her Instagram feed.




va

Bharat Biotech releases Covaxin Phase-3 trial data, claims 77.8% efficacy

Vaccine also offers 65% protection against Delta variant, according to firm




va

At K Sureshkumar’s pedagogical laboratory in Thiruvananthapuram students understand basic concepts of Physics by doing experiments on their own

National award-winning science teacher K Sureshkumar’s pedagogical laboratory in Thiruvananthapuram enables students of high school to conduct experiments in Physics and learn the concepts themselves



  • Life & Style

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Imperilled Immunity — India’s ailing Vaccine PSUs

At one time the primary producers of the country’s vaccine requirements, the units are in terminal decline. Can they be revived?




va

Monsoon in the Aravallis

As birds perform acrobatic aerial displays, insects and beetles helicopter under green canopies, and buffaloes wallow in muddy ponds, the venerable mountain range teems with life during the rainy season




va

Making all at work feel wanted and valued

When every member of the support function in a company is recognised and respected, it becomes a visible indicator of the culture and happiness quotient of an organisation





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Golden Globes: Meet The Red Carpet Divas

The 80th Annual Golden Globe awards saw Hollywood's A-set at their glamorous best.




va

Captain America Chris Evans Weds

The wedding was attended by several of the couple's friends including Chris Hemsworth (who plays Thor in the Marvel Cinematic Universe) and his wife Elsa Pataky, Robert Downey Jr (Iron Man in the MCU) and Susan Downey, Jeremy Renner (Hawkeye in the MCU), John Krasinski and his wife Emily Blunt.




va

The Voice of Darth Vader Dies

Legendary actor James Earl Jones, who voiced Darth Vader in Star Wars, passed away at his home in Dutchess County, New York. He was 93.




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Rapid quantification of disaccharide isomers by derivatization in combination with ion mobility spectrometry in beer and milk

Analyst, 2024, 149,5298-5305
DOI: 10.1039/D4AN00995A, Paper
Keqi Ye, Jiacheng Ye, Yinghua Yan, Chuan-Fan Ding
This work introduces rapid quantification of disaccharide isomers by derivatization in combination with ion mobility spectrometry in beer and milk.
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Hyperpolarised [2-13C]-pyruvate by 13C SABRE in an acetone/water mixture

Analyst, 2024, Advance Article
DOI: 10.1039/D4AN01005A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Oksana A. Bondar, Gamal A. I. Moustafa, Thomas B. R. Robertson
The NMR hyperpolarisation technique SABRE has been used to hyperpolarise 13C labelled pyruvate in a predominantly aqueous solution which has then been measured by benchtop NMR.
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Phenoxy-1,2-dioxetane-Based Activatable Chemiluminescent Probes: Tuning of Photophysical Properties for Tracing Enzymatic Activities in Living Cells

Analyst, 2024, Accepted Manuscript
DOI: 10.1039/D4AN01082E, Critical Review
Open Access
Jagpreet Singh Sidhu, Gurjot Kaur, Atharva Rajesh Chavan, Mandeep Chahal, Rajeev Taliyan
The use of chemiluminophores for tracing enzymatic activities in live-cell imaging has gained significant attention, making them valuable tools for diagnostic applications. Among various chemiluminophores, the phenoxy-1,2-dioxetane scaffold exhibits significant...
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Advancing triage of acute lymphoblastic leukaemia subtypes diagnosis: label-free Raman spectroscopy for precise single-cell phenotyping and subtype classification

Analyst, 2024, 149,5443-5454
DOI: 10.1039/D4AN00956H, Paper
Patrycja Leszczenko, Anna M. Nowakowska, Patrycja Dawiec, Karolina Czuja, Justyna Jakubowska, Marta Zabczynska, Agata Pastorczak, Kinga Ostrowska, Szymon Tott, Wojciech Mlynarski, Malgorzata Baranska, Katarzyna Majzner
Acute lymphoblastic leukaemia (ALL) is a complex disease in pediatric oncology, necessitating accurate diagnostic strategies for effective treatment planning.
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Advancing cerumen analysis: exploring innovative vibrational spectroscopy techniques with respect to their potential as new point-of-care diagnostic tools

Analyst, 2024, 149,5381-5393
DOI: 10.1039/D4AN00868E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Edoardo Farnesi, Matteo Calvarese, Chen Liu, Carl Messerschmidt, MohammadSadegh Vafaeinezhad, Tobias Meyer-Zedler, Dana Cialla-May, Christoph Krafft, Jonas Ballmaier, Orlando Guntinas-Lichius, Michael Schmitt, Jürgen Popp
The study demonstrates the potential of advanced vibrational spectroscopy to reveal the complex molecular composition of cerumen, suggesting its promising application as a non-invasive diagnostic tool for identifying disease-related biomarkers.
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Electrochemical and imaging evaluations of electrochemically activated screen-printed gold electrodes

Analyst, 2024, 149,5401-5410
DOI: 10.1039/D4AN00990H, Paper
Nor Dyana Zakaria, Ibrahim Luqman Salih, Hairul Hisham Hamzah, Turgut Sönmez, Muhamad Huzaifah Omar, Noorhashimah Mohamad Nor, Khairunisak Abdul Razak, Venugopal Balakrishnan
The graphic abstract displays the integration of the SPGE measurement system with an electrochemical cell-based 3D printing to evaluate the electrochemical behaviors and 3D images of both unactivated and activated SPGEs.
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Evaluating protocols for reproducible targeted metabolomics by NMR

Analyst, 2024, 149,5423-5432
DOI: 10.1039/D4AN01015A, Paper
Darcy Cochran, Panteleimon G. Takis, James L. Alexander, Benjamin H. Mullish, Nick Powell, Julian R. Marchesi, Robert Powers
Evaluating how sample preparation methods and data analysis platforms impact measured metabolite concentrations underscores the need for a universal consensus in the followed approaches for metabolomics data analysis.
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Liquid saliva-based Raman spectroscopy device with on-board machine learning detects COVID-19 infection in real-time

Analyst, 2024, 149,5535-5545
DOI: 10.1039/D4AN00729H, Paper
Open Access
Katherine J. I. Ember, Nassim Ksantini, Frédérick Dallaire, Guillaume Sheehy, Trang Tran, Mathieu Dehaes, Madeleine Durand, Dominique Trudel, Frédéric Leblond
Raman spectroscopy and machine learning is used in combination to detect COVID-19 positive saliva in liquid form.
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