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Defying all the impossibilities in politics, Revanth Reddy makes it as Telangana CM

Always willing to take the risk, he started his political career in the Legislature as an independent candidate in the Legislative Council




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Severe cyclone Michaung makes landfall in Andhra Pradesh, wreaks havoc

Heavy rain and high-velocity winds with a maximum sustained speed of 90-100 kmph lash coastal town of Bapatla, villages; three killed in rain-related accidents; power supply affected in many areas; cyclone moving towards north, say officials




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Hundreds of govt. employees mobilised for PM Modi’s Kashmir rally

It is reported that as many as 7,000 employees from 13 departments will attend the PM’s rally in Srinagar’s Bakshi Stadium




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BRS names candidates for four Lok Sabha seats, fields Koppula Eshwar from Peddapalli

Party president KCR holds meeting with leaders of Mahabubabad, Khammam LS seats




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Parliamentary Panel highlights significant delays in installation of telemetry systems in critical flood-prone areas

The Committee's report on the performance audit of schemes for flood control and forecasting underscores the need for urgent action to ensure timely and effective flood management




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Deeply concerning: Usha slams executive committee members for not felicitating Olympic medallists

India secured six medals, including two historic bronze by young shooter Manu Bhaker, but Usha said the "EC does not want to celebrate their success" and it makes her "very sad."




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Is football messing up women’s basketball in Malappuram?

For the second year in a row, Malappuram District could not field a team in the Kerala State senior basketball championship which begins here on Tuesday.




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All set for the first moves in the second edition of Global Chess League




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Denmark Open badminton: Indian challenge ends in women’s and mixed doubles

Both the Indian pairs is action — Treesa Jolly and Gayatri Gopichand (women’s doubles) and B Summeth Reddy and N Sikki Reddy (mixed doubles) — suffered heartbreak three-game defeats in their opening contests




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We have to go all the way back to Karpov and Kasparov on the top two boards to find something like India’s dominance: Peter Svidler

In this chat, Russian GM Svidler talks about India’s historic Olympiad, his experience of coaching Praggnanandhaa, his love affair with Test cricket and his assessment of the Global Chess League, not just as a chess player but also as a cricket fan who follows the IPL




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Deepika bags her fifth silver at Archery World Cup Final; Dhiraj falls early

It was Deepika's ninth appearance at the World Cup Final where she has also bagged a bronze




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I will be really, really surprised if Gukesh doesn’t win the World title: Anish Giri

Grandmaster Giri — the 15th strongest chess player of all time — previews the World championship match, clears up a misconception about his style, and talks about the Candidates cycle, the Olympiad, the Global Chess League and Nihal Sarin’s prodigious talent




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Chennai Grandmasters | Arjun rallies to post a win over Vidit on opening day




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Designated terrorist Arsh Dalla arrested by Canadian police after shooting incident, say sources

Though the police in Canada did not disclose the arrested person’s identity, sources in New Delhi claimed that he was believed to be Arsh Dalla, who ran terror modules on behalf of Hardeep Singh Nijjar.




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Israel urges fans to skip France-Israel football match in Paris

The National Security Council called on Israelis to “avoid attending sports games/cultural events involving Israelis




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Students foil Awami League rally in Dhaka

Eyewitnesses said activists of Anti-Discrimination Student Movement and several other political groups assembled at Noor Hossain Chattar, or Zero Point, near the Awami League’s central office




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After storm over allegations, Australia Today clarifies ban was by Meta platforms, not Canadian government 

The Ministry of External Affairs, which had slammed Canada over the allegations last week, has been silent over clarification




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Georgia President calls for fresh election after contested vote

Georgian President Salome Zurabishvili calls for fresh elections amid allegations of electoral fraud, sparking crisis and international concern




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Thousands rally in Georgia to question the vote and demand a new election

The protesters waved Georgian and European Union flags and gathered outside the Georgian parliament




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Sri Lanka’s multi-ethnic east reflects challenges facing Anura Kumara Dissanayake

Voters in Ampara district voice hope, skepticism ahead of November 14 parliamentary polls 




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Flood victims of Vijayawada: People of all regions should come forward to support them, says Andhra Pradesh CM Chandrababu Naidu

CM Chandrababu Naidu said moral and financial support for victims of natural calamities would instill confidence among them




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Mission for pothole-free roads: Andhra Pradesh CM Chandrababu Naidu launches project at Anakapalli

Pothole repairs, jungle clearance and road maintenance works will be taken up with a Budget of ₹861 crore




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Tests to assess uranium availability: villagers of Kappatralla, Devanakonda raise voice against Centre’s permission 

The villagers fear losing their lands and livelihood and also adverse affects of uranium mining on their lives




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SAAP Chairman urges Chief Minister to re-allot land in Visakhapatnam

The land, meant for introducing water games, was used by former Chief Minister Y.S. Jagan Mohan Reddy for constructing a helipad for his palace, Ravi Naidu says




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A.P. government appoints Inquiry Authority to probe role of revenue officers in alleged land scam in Vizianagaram

Revenue Department Special Chief Secretary directs the Inquiring Authority to submit the inquiry report within a period of six weeks




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Aurobindo Pharma Foundation’s 108 ambulance service failed to save lives in Andhra Pradesh, alleges TDP MLA

Somireddy Chandra Mohan Reddy alleges corruption and inefficiency, claims the emergency service provider failed to move critically ill patients to hospitals on time, particularly during golden hour




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Quality education for all is our aim, says A.P. HRD Minister Nara Lokesh




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Hunt continues for tiger in Nallamala forest




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Understanding regression analysis [electronic resource] / Michael Patrick Allen

New York : Plenum Press, 1997




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The World War I databook : the essential facts and figures for all the combatants / John Ellis & Michael Cox

London : Aurum, 2001




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Nanocubic cobalt-containing Prussian blue analogue-derived carbon-coated CoFe alloy nanoparticles for noninvasive uric acid sensing

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00121D, Paper
Yunting Qin, Dan Xiao, Xilan Gao, Xicui Zhang, Yanxue Xu
This work describes an electrochemical sensor for the fast noninvasive detection of uric acid (UA) in saliva.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A reaction based carbazole–indolium conjugate probe for the selective detection of environmentally toxic ions

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00301B, Paper
Jayasudha Palanisamy, Mansour K. Gatasheh, Ashraf Atef Hatamleh
Carbazole–indolium based colorimetric probe was designed for detecting cyanide ions in various water samples. An outstanding response was shown by paper test strips prepared using the probe for the easy detection of cyanide in real time.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Proximity hybridization based “turn-on” DNA tweezer for accurate and enzyme-free small extracellular vesicles analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00487F, Paper
Jinlin Wu, Xi Mei, Xiaoqin Zhan, Fang Liu, Dongfang Liu
Small extracellular vesicles (sEVs) are a type of extracellular vesicles that carry many types of molecular information. The identification of sEVs is essential for the non-invasive detection and treatment of...
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Losing a friend, virtually




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​Last mile woes: On inflation data and the challenges

Inflation should not be allowed to undermine the economic momentum 




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​Allow for deliberation: On the legitimate demands of Ladakh

The lack of a legislature and regional autonomy in Ladakh has led to the current protests




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
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Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate

RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
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Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

RSC Med. Chem., 2024, 15,3371-3394
DOI: 10.1039/D4MD00384E, Review Article
Debasis Das, Lingzhi Xie, Jian Hong
Prospects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.
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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
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Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists

RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
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Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article
Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi




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Small-scale handloom park to come up at Sengunthapuram

Ministers R. Gandhi and S.S. Sivashankar inspect the 13,205 sq. ft. site belonging to the Tamil Nadu Cotton Corporation at Sengunthapuram




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Site identified for small-scale handloom park in Karur




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555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices

Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation.