A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon.

Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.

The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

An insect-resistant protein exhibiting a sufficient resistance to insects; an insect-resistance gene encoding the insect-resistant protein; a recombinant vector containing the insect-resistance gene; a host cell and a plant cell having the recombinant vector transfected thereinto; a transformant transformed by the insect-resistance gene and a method for producing the same; a protein recovered thereby; and an insect-resistant agent comprising them as active ingredients. In accordance with the present invention, the insect-resistant protein is derived from a plant.

Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.

The invention relates to human medicine and to the use of epidermal growth factor (EGF) for preparing a pharmaceutical composition which is administered by infiltration into the periphery of nerve ganglia and/or trunks for the morphofunctional restoration of peripheral nerves in painful sensory-motor neuropathy as well as manifestations of ischemic neuritis. The invention also includes a composition containing EGF which can be formulated together with anesthetics or analgesics or encapsulated in microspheres and to the use thereof for the morphofunctional restoration of peripheral nerves in painful sensitive-motor-type diabetic neuropathy and the manifestations of ischemic neuritis.

Disclosed are polypeptides, nucleic acids, and related compositions that render plants resistant to bacterial pathogens. Also disclosed are transgenic plants having the nucleic acids and resistant to bacterial pathogens.

IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

A fixing structure of an optical component is composed of a device chassis; a holder holding an optical component; first and second plate parts for joint to the device chassis and a connecting part of both the plate parts are formed in the holder; a plurality of joint holes are formed in the second plate part; a U-groove into which the connecting part of the holder is fitted and a plurality of through-holes are formed in the device chassis; and an adhesive that is extended in a circular columnar shape and is made by inserting the holder into the U-groove of the device chassis, and applying a UV-curing adhesive in such a manner that the UV-curing adhesive is bonded to the first plate part of the holder and is continuous to the inside of the joint hole via the inside of the through-hole, and radiating UV light along the through-hole.

There is provided a disk drive apparatus including a first chassis unit that has a pickup base at which an optical pickup and a disk table have been disposed, and a first base chassis to which the pickup base has been attached, and a second chassis unit that has a second base chassis and at which a chucking pulley has been disposed. A first rectifying plate part is provided at the first base chassis. A second rectifying plate part is provided at the second base chassis.

A compact disc (CD) player, which comprises playback substrates, a conveying roller, CD sensors, a CD stopper, a first trigger member, frame members, cam members and moving members, wherein the CD stopper has a major axis and abutting portions disposed at both ends of the axis; the first trigger member rotates when a minor-diameter CD stops at a mounting position on a turntable; the frame members receive the movement of the first trigger member; the cam members are coupled to the frame members; the moving members receive the rotation of the CD sensor and move along the outside diameter of a CD; the moving members are provided with clamping portions and abutted portions configured to be clamped with the abutting portions; and the cam members are provided with clamped portions configured to abut against the clamping portions.

A holding portion includes at least three pressing members which are operable to press an inner peripheral of a hole formed on the medium. The pressing members are movable between first positions where the pressing members do not come in contact with the inner peripheral and second positions where the pressing members come in contact with and press the inner peripheral. Each of the pressing members is adapted to interlockingly move with each other when moving toward the first positions and to press the inner peripheral independently from the other members when positioning the second positions.

A holding mechanism is operable to hold a top medium from a plurality of plate-shaped media accommodated in a stacker in a stacked manner. A transport arm supports the holding mechanism. When the lift mechanism lifts down the transport arm, one of a first elastic pressing force and a second elastic pressing force greater than the first elastic pressing force is selectively applied from the holding mechanism to an upper surface of the top medium.

An optical disc drive (ODD) including a tray having a spindle motor, an optical pickup unit, and a transfer motor, may have first and second flat cables. The first flat cable may be connected to the transfer motor, and the second flat cable may have a first terminal part connected to the first flat cable and a second terminal part connected to a circuit board. The circuit board may be arranged at the front of the tray. The second flat cable may include a plurality of signal lines covered by an insulator. One or more exposure parts may be formed in the second flat cable to expose at least one of the plurality of signal lines. An electric actuator of a locking unit may be connected to the one or more of the plurality of signal lines through the one or more exposure parts.

Provided are apparatuses for grounding the objective lens driving unit of an optical pickup device. An optical pickup device includes an objective lens driving unit and a base that supports the objective lens driving unit, and wherein the objective lens driving unit includes a moving structure including an objective lens and a plurality of drive coils; a static structure comprising magnets corresponding to the plurality of drive coils, a yoke that supports the magnets, and a wire holder that has a plurality of wiring layers including a ground wiring layer; a plurality of suspension wires that connect the plurality of drive coils to the plurality of wiring layers; a supporting portion connected to the yoke and fixed to the wire holder; a projection extending from the supporting portion and disposed adjacent to the ground wiring layer; and conductive bonding material connects the ground wiring layer with the projection.

A medium processing device may include a head which reads or writes data to a recording medium; and a flexible cable which is connected with the head. The flexible cable may be formed in a multilayer structure including a data signal layer formed with a data signal pattern and disconnection detecting signal layers which cover a front face and a rear face of the data signal layer and are formed with a disconnection detecting signal pattern. The flexible cable may also include a terminal connecting part formed with a through hole into which a signal terminal of the head is inserted and a terminal covering part folded to cover the terminal connecting part and fixed to the terminal connecting part.

A machine which provides for both leaf stripping and grading can be used to process plants, such as burley tobacco plants, by continuously moving the plants in a first direction while simultaneously varying the position of the plants in a second direction relative to a defoliating apparatus. The plants may be moved horizontally through a machine by a transporter engaging the plant stalks while the vertical distance between the transporter (and thus the plants) is varied relative to the defoliating apparatus. The transporter and defoliating apparatus may be positioned at an angle to one another. Due to the changing amount of vertical distance, leaves from different sections of the plants, such as leaves at different stalk heights, can be contacted and removed at different corresponding horizontal locations in the machine. Accordingly, leaves can be graded based on the location(s) from which they are retrieved after removal.

The airflow through a harvesting machine is adjusted by calculating a G-factor at a first point on an upper chaffer to determine if it is greater than 1+n, where n represents a desired factor. A blower is adjusted to reduce an airstream if the G-factor is greater than 1+n. A MOG factor is calculated if the G-factor is less than 1+n. The blower is adjusted to increase the airstream if the MOG-factor is less than 1+x, where x represents a desired factor. A MOG-factor is calculated at a second point if the MOG-factor at the point is greater than 1+x and the blower is adjusted to reduce the airstream if the MOG-factor at the second point is greater than 1+y, where y represents a desired factor or adjusted to increase the airstream if the MOG-factor at the second point is less than 1+y.

A cob conveying and cleaning system for use with a corn harvester, incorporating air induction in cooperation with an air flow from the harvester, for cleaning and separating lighter crop residue to be returned to the field from a mixed flow of the residue and cobs, such that the cleaned cobs can be collected, and the lighter residue optionally spread on the field. The air flow and induction are combined to cooperatively lift or draw the lighter residue from the mixed flow, and to optionally spread the removed lighter residue over a field. The induction apparatus can be located on the harvester, and used as a residue spreader when cobs are not collected.

A grain conveyor for a combine harvester capable of increasing capacity and reducing component wear is disclosed. The grain conveyor includes a grain elevator, a transition chamber and an auger assembly. The grain elevator has an inlet for receiving a flow of grain. The transition chamber includes an inlet and an outlet in fluid communication with the transition chamber inlet and the grain elevator inlet. The transition chamber outlet has an asymmetric non-circular opening larger than the non-cylindrical opening of the transition chamber inlet. The auger assembly is operatively connected to the transition chamber and includes an inlet for receiving a flow of grain and an outlet in fluid communication with the transition chamber inlet.

A harvesting system includes a self-propelled harvesting machine and a drivable collecting container equipped with a drive unit, which can be positioned relative to the harvesting machine and moved in parallel therewith. Crop is fed directly or indirectly to the collecting container during harvesting operation from the harvesting machine using a feed pipe equipped with an outlet chute. The collecting container is equipped with a device for loading it with crop in a uniform manner. The collecting container is moved in a constant position relative to the harvesting machine by way of a control device while the crop is being conveyed. The collecting container is preferably a filling device, by way of which uniform distribution of the crop in the collecting container (8) can be attained.

An unload auger assembly for a combine harvester includes a drive coupler configured between adjacent first and second auger segments. The coupler includes a driver component and associated driver cog coupled to the first auger segment. A driven component and associated driven cog is coupled to the second auger segment. The driven cog is rotationally engaged by the driver cog to transmit rotational drive from the first auger segment to the second auger segment. A friction clutch is configured in-line between the driver component and driven component and rotationally couples the driver component to the driven up to a release torque value wherein the friction clutch disengages the driver component from the driven component.

A support assembly for supporting a moveable member of an agricultural combine is provided. The support assembly includes a moveable member, such as a foldable chaff pan assembly for spreading chaff and other crop residue from the rear of an agricultural combine, a support member and a resilient member connected to the support member for supporting the moveable member. The resilient member can be configured as an arched shaped or cylindrically shaped member.

A flow distribution system for use with a combine spreader having an inlet opening at the top thereof for receiving crop residue, a pair of counter-rotating spreader paddles disposed generally side by side and forward of a back plate of the spreader, and a discharge opening below the spreader paddles. A flow guide element has an apex portion and a pair of opposed arm portions pivotally connected to the apex portion, the arm portions laterally extending to free end portions. An adjusting mechanism is operably connected to the arm portions to effect rotational movement of the arm portions about the apex portion, ends of spreader paddle members defining the outer swept diameters of the pair of spreader paddles and the crop residue flow surfaces of at least the arm portions defining clearance regions therebetween to controllably distribute crop residue in a desired pattern over a field.

The invention concerns a harvested crop residue chopper and distribution arrangement for a combine (10) with a straw chopper (60) with a rotor (74) that can be brought into rotation about a horizontal axis (98) with chopper blades (76) fastened thereto that define an outer envelope (96), and with at least one impeller blower (82) arranged downstream of the straw chopper (60) with impeller blades (84) that can rotate about an axis of rotation (88) that extends vertically, in which the impeller blades (84) are provided with outer edges (94) that conform to the envelope (96) of the chopper knives (76) and follow it very closely and are not in contact with it.

The present disclosure is a handheld harvester apparatus including a threshing drum configured to rotate. The harvester may further include a plurality of teeth connected to the threshing drum and configured to strip seeds from a head of a plant. The harvester also includes a screening assembly coupled to the threshing drum. The screening assembly is configured to receive seeds and plant material from the threshing drum and to eject the plant material from the harvester and direct the seeds downward. The harvester further includes a first screen configured to receive the seeds from the screening assembly and to allow seeds sized below a predetermined threshold to pass through the first screen and to prevent plant material exceeding the predetermined threshold to pass through the first screen. The harvester may further include a collection chamber coupled to the first screen and configured to receive the seeds.

An agricultural combine having an adjustable spreader assembly is provided that includes a spreader with one or a pair of regulators. The spreader includes a discharge opening about its lateral side. The regulator is pivotably connected to the lateral side of the spreader such that the regulator is in fluid communication with the discharge opening. The regulator can be configured to move from a retracted position to an extended position or to vary the direction of discharge of crop residue. The spreader can be a vertical spreader, a horizontal spreader, or a spread board.

A forage harvester has an engine which is drivingly connected to a chopper cylinder via first drive belt, and to a first end of a drive shaft of a discharge accelerator. A second end of the drive shaft of the discharge accelerator is drivingly connected to a kernel processor via a second drive belt, is arranged, in the direction of harvested material flow, between the chopper cylinder and the discharge accelerator. The discharge accelerator comprises support disks which extend radially, and paddles. The support disks are attached to a hollow shaft enclosing the drive shaft, and, a sensor is arranged between the drive shaft and the discharge accelerator for the determination of the force transmitted by the drive shaft to the discharge accelerator.

A sensor for monitoring a plant population in front of a harvester and a transfer process of the crop from the harvester to a transport vehicle is arranged on an unmanned aircraft. The aircraft moves in the vicinity of the harvester in the harvesting mode and communicates in a wireless fashion with a control unit that controls an actuator for influencing an operating parameter of the harvester and/or the transport vehicle (in real time based on signals of the sensor in the harvesting mode.

An intake feeder system having a stone separator mounted between a crop elevator and the mouth of a threshing mechanism disposed longitudinally in a combine harvester. The stone separator includes a rotary feed beater and a sump disposed beneath the feed beater. The feed beater serves to advance crop raised by the elevator along a crop flow path towards the mouth of the threshing mechanism and to propel stones in the crop into the sump. A duct is provided in parallel with the crop flow path for connecting a space above the rotary feed beater to the mouth of the threshing mechanism.

A biomass conveying and distributing system for separating and distributing lighter biomass residue from heavier or denser biomass, utilizing available air flow from the cleaning system of the harvester. The harvester will discharge a flow of heavier or denser biomass with an airborne flow of lighter biomass residue. The system includes a conveyor for receiving and conveying the heavier or denser biomass, and residue distributing apparatus disposed above the conveyor in a path of at least a portion of the airborne flow of lighter residue, including at least one deflector configured and operable for redirecting the airborne flow sidewardly away from the conveyor, above a passage through which the conveyor passes carrying the heavier biomass away from the harvester.

Example embodiments relate to a combine harvester including a straw chopper having an inlet for unchopped straw, an outlet for chopped straw in an essentially horizontal direction, and a spreader fan, connected downstream of the outlet of the straw chopper and having an essentially horizontal plane of rotation, for spreading the chopped straw over a ground surface. The combine harvester further includes a guide member, which is arranged to deflect at least a part of the stream of chopped straw material to an axial intake of the spreader fan such that a part of chopped straw material meets the blades of the spreader fan in the direction of transport of the chopped straw material through the spreader fan at an acute angle (α) relative to the plane of rotation of the spreader fan.

A grain bin located atop a harvester includes upstanding walls having a substantially continuous upper edge defining an opening. A grain bin extension is deployable between extended and retracted positions to expand the capacity of the grain bin. The extension includes extension panels and a cap overlaying the opening. The cap is supported by a cap frame that is also deployable between extended and retracted positions. An extension deployment apparatus raises and lowers the extension panels. Extension deployment mechanisms located at opposing corners of the grain bin control the deployment of adjacent extension panels. Each extension deployment mechanism has a first rack and a trunnion to drive extension panels in a vertical direction and pivot the panels in an outward direction and a second rack mounted to the trunnion to drive the cap frame in a vertical direction, and a drive gear between the first and second racks.

A system for removing plant material from harvested crops includes a pinch roller conveyor including pairs of rotatable pinch rollers whose longitudinal axes are aligned with a length of the conveyor, the pinch rollers forming nips in which plant material can be caught and pulled down through the conveyor as the pinch rollers rotate, wherein first ends of the pinch rollers are laterally displaceable so that the pinch rollers can laterally separate from each other to facilitate passage of plant material.

An agricultural harvesting machine has a measurement device for investigating a crop flow conveyed through the harvesting machine. The measurement device includes at least one optical detection unit disposed at the crop flow for detecting light reflected by the crop and an evaluation unit for evaluating the spectrum of the detected light in order to derive properties of the crop. The evaluation unit is disposed at a position of the harvesting machine that is decoupled from mechanical loading by the crop flow to the greatest extent possible and is connected to the detection unit by way of at least one optical waveguide.

A system and method for controlling spreader output from a harvester includes a distribution chamber for receiving an agricultural material removed from a field. The harvester includes a spreader system configured to distribute the agricultural material onto the field, and an opening configured to receive the agricultural material from the distribution chamber. Moreover, the distribution chamber includes a first panel rotatably coupled to a first side of the distribution chamber, and a second panel rotatably coupled to a second side of the distribution chamber. The first and second panels are configured to direct the agricultural material toward the opening of the spreader system. An angle of the first panel is independently adjustable to control a first amount of agricultural material directed toward a first inlet portion. An angle of the second panel is independently adjustable to control a second amount of agricultural material directed toward a second inlet portion.

A feed system for a biomass collection device uses a conveyor for dropping a flow comprising a mixture of denser or heavier biomass to be collected such as cobs, and less dense or lighter biomass residue such as leaf trash, through a space, and rotary feed apparatus below for receiving the flow, operable for propelling the received flow into a collection device, in combination with a fan configured and operable for directing a flow of air along a second path intersecting the first path in a manner to divert at least a substantial portion of the less dense or lighter biomass residue away from the feed apparatus, while allowing substantially all of the denser or heavier biomass to continue along the first path to the feed apparatus for feeding into the collection device. Distribution apparatus along the second path can then be used to spread the diverted biomass.

A method and device for harvesting threshed crops including a threshing assembly (3) arranged downstream of a cutting assembly (2) of a combine harvester (1) for separating the grain-chaff mixture (12) from the straw. A chaffing device (4) is arranged downstream of the threshing assembly (3) for separating the total straw fraction into a first and a second straw fraction (5.1, 5.2). A comminution device (8) is arranged downstream of the chaffing device (5) for comminuting the second straw fraction (5.2). A blower (10) having a suction pipe (9) draws in and mixes the grain-chaff mixture (12) and the second straw fraction (5.2) to form a mixture (18) of grain, chaff, and second straw fraction and conveys the mixture (18) into a silo (14).

An agricultural combine has a threshing assembly for threshing a crop to produce chaff and grain, a cleaning assembly for removing the chaff from the grain, and a control system. The threshing assembly and the cleaning assembly operate at threshing and cleaning settings, respectively, for tending to produce a balance between a threshing load applied across the threshing assembly and a cleaning load applied across the cleaning assembly that tends to have a favorable influence on grain loss. The control system is for sensing an imbalance between the threshing load and the cleaning load tending to have an unfavorable influence on grain loss, and for concurrently adjusting the threshing and cleaning settings of the threshing and cleaning assemblies, respectively, for tending to convert the imbalance between the threshing and cleaning loads to a balance between the threshing and cleaning loads tending to have a favorable influence on grain loss.

A combine harvester comprises a separating apparatus arranged to receive a threshed crop stream and convey rearwardly. The separating apparatus comprises a grate for allowing grain and chaff to fall onto an underlying separator pan, the separator pan being driven in an oscillating manner to convey a grain/chaff stream forwardly for delivery to a cleaning unit. The separator pan comprises a first portion and a second portion disposed forwardly of the first portion. A rear edge of the second portion is releasably attached to a front edge of the first portion, the second portion being pivotable around a forward mounting around a transverse axis between an operating position in which the second portion is attached to the first portion forming a continuous pan surface, and a lowered position in which the second portion is detached from the first portion giving maintenance access to the underside of the separating apparatus.

A helical auger flight has an inner edge, an outer edge, an inner face, an outer face, and a leading extremity that includes a prominence and a leading edge that extends from the outer edge to the prominence. The prominence extends outward from the leading edge of the leading extremity to an outer end having an upturned jut. A wear plate is releasably connected to the inner face of the helical auger flight. The wear plate extends from the outer edge of the helical auger flight to the prominence. A front extremity of the wear plate extends forwardly of the leading edge of the helical auger flight so as to be in a shielding relationship with respect to the leading edge of the helical auger flight, and a nose of the front extremity of the wear plated is seated in direct contact against a contact surface of the jut.

A harvester grain bin monitoring system is disclosed. The system includes a sensor that monitors the perimeter of the bin proximate to the top rim to provide a warning to an operator when the grain level reaches approaches the bin rim. The sensor may be optical or mechanical.

A cleaning system for a combine harvester that includes a cleaning shoe having a sieve, a cleaning fan, an air plenum and a pair of air diverters is provided. The cleaning fan is rotatably driven for generating a flow of air and positioned within the air plenum. The air plenum extends across the entire length of the cleaning fan and includes an inlet for the intake of air, an outlet downstream the inlet for directing the flow of air in a first direction, lateral walls forming a portion of the outlet, and a bottom wall extending between the lateral walls. The pair of air diverters extends inwardly from the lateral walls. Each air diverter is configured substantially as a pyramid having a rounded corner that extends inwardly from the lateral wall and upwardly from the bottom wall.