end Democrats already have a popular, progressive agenda. They just need to amplify it. By www.washingtonpost.com Published On :: Thu, 21 Nov 2019 23:06:52 +0000 How best for the party to get its message across to voters. Full Article
end Trump’s anti-immigrant agenda isn’t about rule of law or economics at all By www.washingtonpost.com Published On :: Fri, 31 Jan 2020 00:44:15 +0000 The latest immigration rule is based on obvious lies. Full Article
end Wanna spend $2 trillion? Here’s the agonizing choice you face. By www.washingtonpost.com Published On :: Mon, 23 Mar 2020 12:58:14 +0000 Money needs to get spent fast. Money needs to get spent well. To some extent, those objectives are in tension. Full Article
end Ending the TOC Conference, But Still Pushing Tools of Change for Publishing By feedproxy.google.com Published On :: Thu, 02 May 2013 20:17:51 +0000 O’Reilly has been publishing books since 1986, but I’ve often said that we consider ourselves more of a technology transfer company than a typical publisher. Twenty years after our first book, Unix in a Nutshell, we realized that the insights … Full Article Uncategorized
end oscon: Only 48 hours left to get discounted tickets to #OSCON. Early registration prices end tomorrow at midnight http://t.co/E0JKpcj1Rp By twitter.com Published On :: Wed, 05 Jun 2013 15:05:42 +0000 oscon: Only 48 hours left to get discounted tickets to #OSCON. Early registration prices end tomorrow at midnight http://t.co/E0JKpcj1Rp Full Article
end oscon: RT @mark_grover: Attending #oscon at end of July in Portland? Come hear my talk on Apache Bigtop http://t.co/kkSdOyyY5a By twitter.com Published On :: Fri, 07 Jun 2013 18:52:00 +0000 oscon: RT @mark_grover: Attending #oscon at end of July in Portland? Come hear my talk on Apache Bigtop http://t.co/kkSdOyyY5a Full Article
end oscon: @edd @bkerensa Sure, anyone can attend evening BoFs By twitter.com Published On :: Tue, 11 Jun 2013 16:35:25 +0000 oscon: @edd @bkerensa Sure, anyone can attend evening BoFs Full Article
end oscon: Easily Invoke Common Protocols with Twisted - Spin up Python-friendly services with 0 lines of code http://t.co/29oTkk0isW By twitter.com Published On :: Tue, 11 Jun 2013 16:40:44 +0000 oscon: Easily Invoke Common Protocols with Twisted - Spin up Python-friendly services with 0 lines of code http://t.co/29oTkk0isW Full Article
end strataconf: Can data rescue the forest elephant? Yes, with your help. http://t.co/DZBXKRdUcA Read about Elephant Listening Project & send us your ideas By twitter.com Published On :: Sat, 08 Jun 2013 17:32:07 +0000 strataconf: Can data rescue the forest elephant? Yes, with your help. http://t.co/DZBXKRdUcA Read about Elephant Listening Project & send us your ideas Full Article
end strataconf: A detailed agenda for #StrataRx 2013 is now posted: workshops, sessions, speakers + more http://t.co/RtaRpQroaN #healthdata By twitter.com Published On :: Mon, 10 Jun 2013 20:57:23 +0000 strataconf: A detailed agenda for #StrataRx 2013 is now posted: workshops, sessions, speakers + more http://t.co/RtaRpQroaN #healthdata Full Article
end Realtors® Applaud Administration’s Calls to End Conservatorship By feedproxy.google.com Published On :: Wed, 17 Oct 2018 16:59:27 +0000 Realtors® Applaud Administration’s Calls to End... Earlier this week, during an address to the Mortgage Bankers Association 2018 Annual Conference in Washington, D.C, Treasury Department Secretary... By: Wesley Shaw Full Article
end NAR commends Senators Cotton, Duckworth for Work on Behalf of the RLI By feedproxy.google.com Published On :: Thu, 21 Mar 2019 20:16:28 +0000 NAR commends Senators Cotton, Duckworth for Work on... Today, the National Association of Realtors(R), along with REALTORS(R) Land Institute President Jeramy Stephens, commended Senators Tom Cotton and... By: Wesley Shaw Full Article
end Advertisers signal glimmers of optimism, start spending again By feeds.searchengineland.com Published On :: Tue, 05 May 2020 13:08:05 +0000 Despite numerous unknowns and continued challenges, many agencies and advertisers say they have shifted gears for the next phase. Please visit Search Engine Land for the full article. Full Article
end Attend SMX June 23-24… for free! By feeds.searchengineland.com Published On :: Wed, 06 May 2020 10:00:00 +0000 Join us online for SMX Next, a free virtual event designed to equip you with actionable SEO and SEM tactics that can drive more traffic, leads, and sales. Please visit Search Engine Land for the full article. Full Article
end velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform By feedproxy.google.com Published On :: Tue, 21 May 2013 15:01:58 +0000 velocityconf: Free webcast from our friends at @citrix 5/29 http://t.co/IOeY4U0wUP Learn to consolidate 40 load balancers and ADCs into single platform Full Article
end velocityconf: New #velocityconf CA program preview is up: http://t.co/rKjf91RXdD @ariyahidayat on End-to-End JS Quality Analysis. By feedproxy.google.com Published On :: Thu, 23 May 2013 17:01:13 +0000 velocityconf: New #velocityconf CA program preview is up: http://t.co/rKjf91RXdD @ariyahidayat on End-to-End JS Quality Analysis. Full Article
end velocityconf: @da3mon Sorry! We were just doing some followup with past Velocity attendees. Sorry to intrude. No harm intended. :-( By feedproxy.google.com Published On :: Thu, 23 May 2013 20:03:49 +0000 velocityconf: @da3mon Sorry! We were just doing some followup with past Velocity attendees. Sorry to intrude. No harm intended. :-( Full Article
end Channel24.co.za | A wildlife safari, comedy show, and 3 other virtual events to keep you entertained this weekend By www.channel24.co.za Published On :: Fri, 24 Apr 2020 16:39:33 +0200 We may not be able to go out during the national lockdown, but that does not mean that we can't attend events. Full Article
end Channel24.co.za | Rock 'n' roll legend Little Richard, 87, dies By www.channel24.co.za Published On :: Sat, 09 May 2020 16:55:54 +0200 Little Richard, whose outrageous showmanship and lightning-fast rhythms intoxicated crowds in the 1950s with hits like 'Tutti Frutti' and 'Long Tall Sally', has died. Full Article
end 2019 Must-Know Trends for Online Business – Live Panel Wrap-up By feedproxy.google.com Published On :: Thu, 21 Feb 2019 00:00:00 +0000 We recently hosted an engaging live discussion with industry experts from G2Crowd, Instapage and Subscription Insider, covering trends and growth tips for online businesses. Check out what these leaders had to say about what they learned last year in the software industry, where people are missing opportunities and what’s coming next. Full Article
end AT#193 - Independent Travel to Beijing, China By amateurtraveler.com Published On :: Sat, 01 Aug 2009 14:00:00 +0000 The Amateur Traveler talks to Lee from Atlanta who is currently living in Qing Dao, China about traveling independently in Beijing, China. Lee describes getting around by bus, subway and taxi, eating street food, and biking through the Hutongs of Beijing. He guides us to lesser known sites like Beijing’s underground city and the site of the old Summer Palace. He leads us to the great wall at Badaling, Mutianyu, and Simatai. Lee also talks about side trips to see the Buddhas in the Yungang Caves near Datong and the nearby hanging monasteries and to see the Qing royal villas and replica of the Lhasa temple in Chungde. We talk about where to find a guide (and why you may not need one), Chinese history and what Lee suggested his parents should bring to China. Full Article
end AT#227 - Three Weekend Trips From Shanghai, China By traffic.libsyn.com Published On :: Sat, 10 Apr 2010 14:00:00 +0000 The Amateur Traveler talks to Lee from Atlanta about side trips that you can take when you travel to Shanghai this year for Expo 2010. Lee is currently living in China and talks about 3 different weekend trips to destinations that are located near Shanghai. Lee starts us the in history-rich city of Nanjing the site of “China’s Holocaust” in WW 2. Nanjing has been the capital for 6 different Chinese governments and still retains its ancient walls in addition to modern shopping and the tomb of Sun Yat-sen. It was also the location of the world’s worst civil war, the Taiping Rebellion. After Nanjing we explore the many gardens and the canals of Suzhou. Finally Lee takes us to Hangzhou with its beautiful West Lake which the Chinese compare to heaven.NewsSpirit Air to experiment with carry-on bag feesAirlines losing 3000 bags – every hour of every dayWomen try to smuggle dead relative onto flightPaying to use the plane potty?Ky. Judge Rules in Favor of Online Travel SitesShow NotesExpo 2010 Shanghai ChinaTravel to Shanghai, China – Episode 26NanjingNanjing, ChinaNanking MassacreJohn Rabe – a German businessman and Nazi party member who is best known for his efforts to stop the atrocities of the Japanese army during the Nanking OccupationSun Yat-sen – “Father of the Chinese Nation”Ming DynastyCheongsam or Qipao – traditional Chinese dressTaiping Rebellion – largest civil war in history started by Hong Xiuquan who declared himself the brother of Jesus.RestaurantsSkyway Bakery and DeliLes 5 SensTairyo TeppanyakiSuzhouGardens – Master of the Nets, Lion’s Forest, Humble AdministratorMingtown Suzhou International Youth HostelHangzhouTea MuseumA History of Chinese in CaliforniaBraised Pork Belly – Hangzhou Dongpo PorkSweet and Sour Pork RecipeWushanyi International Youth HostelShanghaiCaptain Youth Hostelelong.com, ctrip.com – for accompodationsCommunityEgypt Photo TourAmateur Traveler NewsletterDoes Amateur Traveler work for you at work? Full Article
end AT#453 - Travel to Guanajuato and San Miguel de Allende, Mexico By mexico.amateurtraveler.com Published On :: Sat, 24 Jan 2015 16:30:00 +0000 Hear about travel to the state of Guanajuato Mexico (including San Miguel de Allende) as the Amateur Traveler talks to Tim Leffel of perceptivetravel.com about his adopted home. Full Article
end AT#479 - Hike Japan's Nakasendo Trail By asia.amateurtraveler.com Published On :: Sat, 15 Aug 2015 16:02:44 +0000 Hear about hiking Japan's Nakasendo Trail as the Amateur Traveler talks to Dave Grenewetzki about his experiences on this trip into the Japanese countryside between Kyoto and Tokyo. Full Article
end Florida Fishermen Nab 6-Foot Bull Shark During First Weekend of Reopened Beaches By www.westernjournal.com Published On :: Sat, 09 May 2020 14:52:59 +0000 Everybody wanted to get to the shore last weekend when the state of Florida reopened its beaches. But one of the beachgoers who came in for some extra attention was a six-foot-long bull shark caught near Navarre Beach, according to WKRG-TV. Video shot by Shelley Goudy of Fort Walton showed several men gathered around the… The post Florida Fishermen Nab 6-Foot Bull Shark During First Weekend of Reopened Beaches appeared first on The Western Journal. Full Article News Animals Coronavirus Florida nature US News Wildlife
end For Some Refugees, Safe Haven Now Depends on a DNA Test By feedproxy.google.com Published On :: Mon, 19 Oct 2015 15:43:58 EST Changes to a program designed to reunite refugees with family in the U.S. have slowed -- and in some cases outright denied -- legitimate entries into the country. Full Article
end Send love to faraway friends and family with this video montage app By feedproxy.google.com Published On :: Sat, 09 May 2020 09:00:00 +0000 TL;DR: Give a meaningful gift during these difficult times with a Tribute Video Montage for $64.99, a 34% saving as of May 9. A Zoom happy hour only goes so far. If you're looking for a way to celebrate and send affection to your loved ones, regardless of the reason, check out Tribute Video Montage as an alternative to those wonky (and sometimes awkward) video calls. Sending a Tribute might just be one of the best morale-boosting presents you can send during these trying times. It's a way for friends and family to share their love and appreciation for someone they want to celebrate, whether for a major milestone, like a 50th anniversary or 30th birthday or just because. The platform is super easy to use and breaks a 10-hour process down to just 10 minutes. Read more...More about Apps And Software, Mashable Shopping, Tech, and Consumer Tech Full Article Apps And Software Mashable Shopping Tech Consumer Tech
end Radar trends to watch: March 2020 By feedproxy.google.com Published On :: Thu, 05 Mar 2020 12:00:00 +0000 AI in practice In his book TinyML, Pete Warden talks about smart stickers that can do limited AI, communicate via radio, and contain sensors so they can easily be put onto machinery or other objects. That technology is here, with disposable bluetooth stickers powered by ambient RF. A year ago, Foster Provost said that causality […] Full Article Radar Trends Signals
end 6 trends framing the state of AI and ML By feedproxy.google.com Published On :: Thu, 19 Mar 2020 10:00:00 +0000 O’Reilly online learning is a trove of information about the trends, topics, and issues tech leaders need to know about to do their jobs. We use it as a data source for our annual platform analysis, and we’re using it as the basis for this report, where we take a close look at the most-used […] Full Article AI & ML Research
end Radar trends to watch: April 2020 By feedproxy.google.com Published On :: Mon, 13 Apr 2020 19:39:00 +0000 Since early in March, technology news has been all Coronavirus, all the time. That’s a trend we expect to continue through April and probably beyond. So let’s start with Coronavirus news, and hope that we have something different for next month. Coronavirus The Coronavirus pandemic is forcing reconsideration of how private data is used. Maciej […] Full Article Radar Trends Signals
end Radar trends to watch: May 2020 By feedproxy.google.com Published On :: Thu, 07 May 2020 12:22:02 +0000 After last month’s “all coronavirus, all the time” report, I was concerned that this month would be more of the same. And there is, indeed, a lot of coronavirus. But there are many other trends and interesting items to look at–possibly a sign that people are working effectively from home. Coronavirus Coronavirus prompts serious discussion […] Full Article Radar Trends Signals
end Legendary East Village corner store, Gem Spa, closes its doors By feedproxy.google.com Published On :: Fri, 08 May 2020 10:14:17 PDT The Gothamist is reporting the sad news that Gem Spa, the iconic NY corner store that has been a fixture at St. Marks Place and Second Avenue for around 100 years is being forced to shutter its doors and windows for the last time. The Spa has been struggling to keep up with increasing rent prices and COVID-19 has apparently proven to be the final nail in its coffin. "It’s where Robert Mapplethorpe bought Patti Smith an egg cream on the day they met. It’s on the back cover of the New York Dolls’ 1973 debut (and where, according to lore, Johnny Thunders and others went for post-heroin sugar fixes between sets at CBGB). Before that, it was where Abbie Hoffman gathered Yippies to rain money on the New York Stock Exchange. It’s where Allen Ginsberg, Ted Berrigan, and other neighborhood poets went to pick up the Sunday New York Times on Saturday nights (and which was inevitably commemorated in their poems)." Read the rest. Image: Alex Lozupone, CC BY-SA 4.0 Read the rest Full Article Post loss new york city sad endings
end Puppy training doesn’t have to descend your house into chaos thanks to these online classes By feedproxy.google.com Published On :: Fri, 08 May 2020 19:00:49 PDT One positive upside of the past two months is how sheltering at home has all but emptied area animal shelters. It’s tough to get solid numbers nationally, but shelters in cities and regions all across America are reporting massive surges in animal adoptions. Even the steep increase in Google searches for “adopt a pet,” up a whopping 335 percent in April, proves what we probably all knew anyway — that in times of stress, having a furry friend is a huge comfort for millions. Unfortunately, one of the downsides of the past two months is there are no trainers available to help whip some of these new family pets, particularly puppies, into shape. From barking and jumping to house training and scratching, The Complete Guide to Puppy and Dog Training Bundle is a full plan for getting the newest member of your family integrated into the house safely and sanely all by yourself. The collection includes eight courses all geared toward getting a new dog or puppy behaving the right way. And if you’ve ever had any thoughts about starting a dog training business of your own, this coursework is a perfect starting spot. Puppies: A-Z Guide to Puppy & Dog Training kicks off the learning, explaining the best way to train, teach and socialize your puppy so they grow into a joyful, well balanced, and well-behaved dog. Of course, most puppies each have their particular issues, so a handful of courses look more closely at some of the tactics for helping your puppy overcome certain challenging behaviors. Read the rest Full Article Post shop
end March 2020 Pending Home Sales By feedproxy.google.com Published On :: Thu, 30 Apr 2020 16:34:04 +0000 March 2020 Pending Home Sales March’s pending home sales pace dropped 20.8% last month and fell 16.3% from a year ago. By: Michael Hyman Full Article
end Five of the Best B2B Content Marketing Trends That Are Proven Effective To Gain New Clients By feedproxy.google.com Published On :: Wed, 06 May 2020 16:30:12 +0000 Digital marketing is fast-paced with trends and new updates to existing systems continuously popping out. That’s why it is important to stay up-to-date with the latest strategies that can be beneficial in reaching new audiences. Keeping up to date with the marketing trends will also help a business stay ahead of their competition. The best […] The post Five of the Best B2B Content Marketing Trends That Are Proven Effective To Gain New Clients appeared first on Dumb Little Man. Full Article Business Entrepreneur
end Newsroom: Coronavirus Hits China Ad Spending By www.emarketer.com Published On :: Wed, 18 Mar 2020 04:01:00 GMT eMarketer cuts forecast for total media ad spending by 6.2%   March 17, 2020 (New York, NY) – Just months after the first case was reported, it is already clear […] Full Article
end Donald Trump Jr. Offers To Walk Bride-to-Be Down The Aisle After Liberal Parents Refuse To Attend Her Wedding Because Fiance Is A Conservative By 100percentfedup.com Published On :: Wed, 06 May 2020 02:26:06 +0000 The following article, Donald Trump Jr. Offers To Walk Bride-to-Be Down The Aisle After Liberal Parents Refuse To Attend Her Wedding Because Fiance Is A Conservative, was first published on 100PercentFedUp.com. TDS or Trump Derangement Syndrome brings out the worst in a lot of people. One young Texan girl’s story of her intolerant parents who refuse to attend her wedding because she’s marrying a conservative, however, is a new low. Lawyer and conservative civil rights activist, Rogan O’Handley tweeted a Tik Tok video of a Texan […] Continue reading: Donald Trump Jr. Offers To Walk Bride-to-Be Down The Aisle After Liberal Parents Refuse To Attend Her Wedding Because Fiance Is A Conservative ... Full Article Featured Political Correctness Politics
end Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters By 100percentfedup.com Published On :: Wed, 06 May 2020 22:43:02 +0000 The following article, Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters, was first published on 100PercentFedUp.com. The media and even some governors are trying to paint the Americans who are protesting to open businesses up as racists and even Nazis. The Governor of Michigan recently made a derogatory statement about the protesters implying they are racists. Painting a negative picture of the people who want their freedom and businesses demonizes our […] Continue reading: Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters ... Full Article Featured Left News Political Correctness Politics
end BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her By 100percentfedup.com Published On :: Thu, 07 May 2020 22:53:35 +0000 The following article, BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her, was first published on 100PercentFedUp.com. Michigan was the first state to see protests against draconian lockdown measures by an overreaching governor. On April 15, the Michigan Conservative Coalition organized an in-vehicle protest in Lansing, MI that drew an estimated 15,000 vehicles. Since that time, several protests by Michigan workers who are being devastated by the one-size-fits-all shut down of the […] Continue reading: BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her ... Full Article Featured Politics
end BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO] By 100percentfedup.com Published On :: Fri, 08 May 2020 17:34:35 +0000 The following article, BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO], was first published on 100PercentFedUp.com. This morning during a nearly one hour interview with Fox & Friends, President Trump addressed the decision by the DOJ to drop the case against the innocent General Michael Flynn. Trump ripped into the “dirty politicians and dirty cops” who went after General Michael Flynn. President Trump called the players involved in the horrible plot […] Continue reading: BREAKING: President Trump’s Fiery Interview On Fox & Friends…”These are dirty politicians and dirty cops…They put our nation in danger with other nations, including Russia” [VIDEO] ... Full Article Featured Politics
end Webinar: Will COVID-19 Mark the Endgame for Iraq's Muhasasa Ta'ifia? By feedproxy.google.com Published On :: Mon, 27 Apr 2020 13:50:01 +0000 Research Event 30 April 2020 - 2:00pm to 3:00pm Event participants Ahmed Tabaqchali, Chief Investment Officer, Asia Frontier Capital Iraq Fund; Adjunct Assistant Professor, American University of Iraq SulaimaniModerator: Renad Mansour, Senior Research Fellow, Middle East and North Africa Programme, Chatham House Control of oil rents underpins Iraq’s post-2003 political order. This political order, known as Muhasasa Ta’ifia (ethno-sectarian apportionment), features an elite bargain inclusive of all major ethnic and sect-based political groups. It has enabled the state's continuity and apparent stability through multiple crises, including the 2008 financial crisis, the 2014 oil crisis, and the war with ISIS.In a recent article, Ahmed Tabaqchali examines how the crash in oil rents, brought about by COVID-19’s disruption of the world economy, exposes the structural inconsistencies and inherent contradictions of the Muhasasa Tai’fia system. The article argues that the current Iraqi political elite is ill-equipped to resolve the multi-faceted challenge facing the country because of its increasing fragmentation and the erosion of its legitimacy, advanced institutional decay and fundamentally different oil dynamics.In this webinar, part of the Chatham House project on the future of the state in the Middle East and North Africa, the article’s author will discuss the deficiencies of the Muhasasa Ta’ifia system and will offer his insight into the future of this governance model in the context of a worsening economic crisis resulting from the COVID-19 pandemic and existing demographic pressures. You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page. Department/project Middle East and North Africa Programme, The Future of the State in the Middle East Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
end Progress in tackling illegal logging slows as new trends offset effective reforms By feedproxy.google.com Published On :: Tue, 14 Jul 2015 13:32:40 +0000 15 July 2015 20150715IllegalLogging.jpg Photo: iStock Lire en français >阅读中国 >Efforts to address illegal logging and reduce the trade in illegal timber have borne fruit and prompted some positive reforms in producer countries, a new report from Chatham House has found. However, changes in the sector mean overall trade in illegal timber has not fallen in the last decade. EU and US policies designed to reduce demand for illegal timber have helped cut illegal imports to those markets. These reforms and the EU’s partnership agreements with producer countries have prompted improvements in forest governance and a fall in large-scale illegal timber production.But growth of demand in emerging markets means that the progressive policies of so-called ‘sensitive markets’ are now less influential. China is now the world’s largest importer and consumer of wood-based products, as well as a key processing hub. India, South Korea, and Vietnam are also growing markets. The increasing role of small-scale producers, whose activities often fall outside legal frameworks, and a rapid increase in illegal forest conversion, also present new challenges. Alison Hoare: 'The EU and US have spearheaded some progressive and effective reforms. However, the changing scale and nature of the problem demands more coordinated international action. To stop further deforestation and associated carbon emissions, and to help achieve global objectives for sustainable development, the EU and US need to maintain their leadership while other countries - especially China, Japan, India and South Korea - need to step up their efforts to tackle illegal logging.'The Chatham House report, which is based on the studies of 19 countries, which include key producers, consumers, or processors of timber, and is an update of a 2010 study found: Timber productionMore than 80 million m3 of timber was illegally produced in 2013 in the nine producer countries assessed, accounting for about one-third of their combined total production.An estimated 60% of this illegal timber is destined for these countries’ domestic markets.Small-scale producers are increasingly important – for example, in Cameroon, the DRC and Ghana, they account for an estimated 50, 90 and 70% respectively of annual timber production. The majority of this is illegal.For the nine producer countries, the area of forest under voluntary legality verification or sustainability certification schemes increased by nearly 80% between 2000 and 2013. Imports of illegal wood-based products In most of the consumer and producer countries assessed, the volume of illegal imports of wood-based products fell during the period 2000–13. The exceptions were China, and India and Vietnam where the volume of illegal imports more than doubled. As a proportion of the whole, illegal imports declined for nearly all countries. However, at the global level, the proportion of illegal timber imports remained steady at 10% - a result of the growth of the Chinese market. The EU and US The volumes of illegal imports into the UK, France and the Netherlands nearly halved over the period 2000-13, from just under 4 million m3 to 2 million m3. The volume of illegal imports into the US increased between 2000 and 2006, from around 5 to 9 million m3, and then declined to just under 6 million m3 in 2013. In 2013, more than 60% of illegal imports of wood-based products to the UK and US came from China.ChinaThe volume of illegal imports into China doubled between 2000 and 2013 from 17 to 33 million m3; but as a proportion of the whole illegal imports fell, from 26 to 17%. The volume of exports of wood-based products (legal and illegal) from the nine producer countries to China nearly tripled, from 12 million m3 in 2000 to 34 million m3 in 2013.The Chatham House report makes the following recommendations:The EU and US need to maintain and reinforce current efforts Other countries need to take stronger action – China in particular, but also India, Japan and South KoreaStrong international cooperation is needed to maintain & reinforce current efforts – the G20 could provide a forum to galvanise international actionProducer countries need to focus on strengthening efforts to tackle corruption, improving legality within the small-scale sector, and reforming land-use governance Alison Hoare: 'Developing countries are losing significant amounts of potential revenue from illegal logging, which is also causing the loss and degradation of forests, depleting livelihoods, and contributing to social conflict and corruption. Tackling illegal logging and strengthening forest governance are essential for achieving critical climate and development goals. Having seen the progress that can be made, it’s imperative that governments agree to work together to rise to new challenges and promote a more sustainable forest sector for the benefit of all.' Read the report >> Editor's notes For more information or to arrange interviews please contact: Alison Hoare, report author, Chatham House, +44 (0) 2073143651Amy Barry, Di:ga Communications, +44 (0) 7980 664397The report and associated infographics will be available to download from the project website and the Chatham House website from 15 July 2015. These findings are part of Chatham House’s Indicators of Illegal Logging and Related Trade project, which looks at consumer, producer and processing countries. Follow us on Twitter: @CH_logging External expert spokespeople available for comment: Téodyl Nkuintchua, Programmes Coordinator, Centre pour l’Environnement et le Développement, Cameroon, (+237) 674 37 96 43, Skype: teodyl Rod Taylor, Director, Forests, WWF International via Huma Khan, +1 202-203-8432 Approved quote: 'The report shows the progress made in keeping illegally-sourced wood out of Western markets, but also highlights the urgent need to focus more on emerging countries and informal markets. It also highlights the global problem of illegal forest clearing, and the need for new policy measures to help sound forest stewardship compete with the conversion of forests to other land-uses.' Ben Cashore, Professor of Environmental Governance and Political Science, Yale University, +1 203 432-3009 Mauricio Volvodic, Executive Director, Imaflora, Brazil, +55 19 3429 0810, +55 19 98157 2129 Chris Davies MP, Chair of the All Party Parliamentary Group on Forestry and Conservative MP for Brecon and Radnorshire, via Simon Francis, 020 7061 6252 Approved quote: 'While it is encouraging that illegal timber imports to the UK have halved, it is vital that we remove the market for illegally logged timber in the UK altogether. One way is to ensure we have a sustainable forestry and wood processing sector that can supply more of our timber needs. Government can aid this by enabling the sector to plant more trees now and in the future.' Full Article
end Transatlantic Trends 2014 By feedproxy.google.com Published On :: Thu, 11 Sep 2014 13:30:01 +0000 Research Event 15 September 2014 - 2:00pm to 3:15pm Chatham House, London Event participants Dr Constanze Stelzenmüller, Senior Transatlantic Fellow, German Marshall FundChair: Xenia Wickett, Project Director, US; Acting Dean, The Academy, Chatham House During this event, Dr Constanze Stelzenmüller will discuss the findings of the Transatlantic Trends 2014 Survey. Transatlantic Trends is a comprehensive annual survey measuring public opinion in the United States, Turkey, Russia, and 10 European Union member states. This year’s survey examines key issues facing the transatlantic community, such as European and US responses to the crisis in Ukraine, the state of the transatlantic relationship in the wake of the NSA scandal, the future of European integration, Russian foreign policy preferences, and views on major foreign policy issues like NATO’s future and Iran’s nuclear ambitions. Department/project US and the Americas Programme Rory Kinane +44 (0) 20 7314 3650 Email Full Article
end Institutionalization, path dependence and the persistence of the Anglo- American special relationship By feedproxy.google.com Published On :: Fri, 26 Aug 2016 10:57:44 +0000 1 September 2016 , Volume 92, Number 5 Ruike Xu Full Article
end The End of the Transatlantic Era? By feedproxy.google.com Published On :: Wed, 06 Sep 2017 15:00:00 +0000 Corporate Members Event 5 October 2017 - 2:30pm to 7:00pm Chicago Council on Global Affairs, Chicago, US Event participants Ivo H. Daalder, President, Chicago Council on Global AffairsBryon G. Ehrhart, Global Head of Strategic Growth & Development, AonLaura Haim, Political Journalist; Former Spokesperson for the Presidential Campaign of Emmanuel MacronJoão Vale de Almeida, Ambassador of the European Union to the United Nations; Former Ambassador of the European Union to the United StatesThomas Raines, Research Fellow and Programme Manager, Europe Programme, Chatham HouseCharles A. Kupchan, Senior Fellow, Council on Foreign RelationsThomas Wright, Director, Center on the United States and Europe, The Brookings InstitutionShawn Donnan, World Trade Editor, Financial TimesIgnacio Garcia Bercero, Director, Directorate General for Trade, European CommissionLaura Lane, President of Global Public Affairs, UPSFurther speakers TBC The US and the EU face many of the same challenges today: they must maintain economic growth in the face of global competition, harness and manage rapid technological change and respond to diverse security threats. Yet a transatlantic alliance that has endured since the end of the Second World War now appears increasingly divided over how to respond. The 2016 Brexit referendum and the US presidential election resulted in victories for populist campaigns that questioned the core values and institutions of this alliance. More recent elections in Europe have bolstered centrist candidates, and helped to rejuvenate the EU. But on questions of trade, security, climate change and relations with Russia, Europe’s leaders have frequently been at odds with the Trump administration. On these and other critical issues, an opportunity and impetus has arisen for the EU to assume a global leadership role that many feel the US is abandoning.Are the EU and the US on divergent paths? How are changing geopolitical and economic realities transforming the transatlantic alliance? And how committed is this alliance to defending the global institutions and rules it created? Chatham House and the Chicago Council on Global Affairs will convene policy experts, journalists and practitioners for a half-day event to chart these trends and consider their implications.Please note, this event will take place in Chicago between 2.30pm and 7pm Greenwich Mean Time (GMT). Chatham House members will be able to follow a livestream of the event here on the day.This event is being co-hosted with the Chicago Council on Global Affairs. David Pagliaro Email Full Article
end The mRNA levels of heat shock factor 1 are regulated by thermogenic signals via the cAMP-dependent transcription factor ATF3 [Metabolism] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Heat shock factor 1 (HSF1) regulates cellular adaptation to challenges such as heat shock and oxidative and proteotoxic stresses. We have recently reported a previously unappreciated role for HSF1 in the regulation of energy metabolism in fat tissues; however, whether HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues remain unclear. Here, we show that HSF1 levels are higher in brown and subcutaneous fat tissues than in those in the visceral depot and that HSF1 is more abundant in differentiated, thermogenic adipocytes. Gene expression experiments indicated that HSF1 is transcriptionally regulated in fat by agents that modulate cAMP levels, by cold exposure, and by pharmacological stimulation of β-adrenergic signaling. An in silico promoter analysis helped identify a putative response element for activating transcription factor 3 (ATF3) at −258 to −250 base pairs from the HSF1 transcriptional start site, and electrophoretic mobility shift and ChIP assays confirmed ATF3 binding to this sequence. Furthermore, functional assays disclosed that ATF3 is necessary and sufficient for HSF1 regulation. Detailed gene expression analysis revealed that ATF3 is one of the most highly induced ATFs in thermogenic tissues of mice exposed to cold temperatures or treated with the β-adrenergic receptor agonist CL316,243 and that its expression is induced by modulators of cAMP levels in isolated adipocytes. To the best of our knowledge, our results show for the first time that HSF1 is transcriptionally controlled by ATF3 in response to classic stimuli that promote heat generation in thermogenic tissues. Full Article
end Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells [Signal Transduction] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells. A recent study has reported that IL-23 is also secreted by lung adenoma cells and generates an inflammatory and immune-suppressed stroma. Here, we observed that proinflammatory tumor necrosis factor (TNF)/NF-κB and mitogen-activated protein kinase (MAPK) signaling strongly induce IL23A expression in intestinal epithelial cells. Moreover, we identified a strong crosstalk between the NF-κB and MAPK/ERK kinase (MEK) pathways, involving the formation of a transcriptional enhancer complex consisting of proto-oncogene c-Jun (c-Jun), RELA proto-oncogene NF-κB subunit (RelA), RUNX family transcription factor 1 (RUNX1), and RUNX3. Collectively, these proteins induced IL23A secretion, confirmed by immunoprecipitation of endogenous IL23A from activated human colorectal cancer (CRC) cell culture supernatants. Interestingly, IL23A was likely secreted in a noncanonical form, as it was not detected by an ELISA specific for heterodimeric IL-23 likely because IL12B expression is absent in CRC cells. Given recent evidence that IL23A promotes tumor formation, we evaluated the efficacy of MAPK/NF-κB inhibitors in attenuating IL23A expression and found that the MEK inhibitor trametinib and BAY 11–7082 (an IKKα/IκB inhibitor) effectively inhibited IL23A in a subset of human CRC lines with mutant KRAS or BRAFV600E mutations. Together, these results indicate that proinflammatory and mitogenic signals dynamically regulate IL23A in epithelial cells. They further reveal its secretion in a noncanonical form independent of IL12B and that small-molecule inhibitors can attenuate IL23A secretion. Full Article
end Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues By feedproxy.google.com Published On :: 2015-05-01 Roland BrudererMay 1, 2015; 14:1400-1410Research Full Article
end Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis By feedproxy.google.com Published On :: 2012-06-01 Ludovic C. GilletJun 1, 2012; 11:O111.016717-O111.016717Research Full Article
end The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 We previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases lung cancer cell proliferation by activating RAS signaling and that CYP24A1 knockdown inhibits tumor growth. However, the mechanism of CYP24A1-mediated cancer cell proliferation remains unclear. Here, we conducted cell synchronization and biochemical experiments in lung adenocarcinoma cells, revealing a link between CYP24A1 and anaphase-promoting complex (APC), a key cell cycle regulator. We demonstrate that CYP24A1 expression is cell cycle–dependent; it was higher in the G2-M phase and diminished upon G1 entry. CYP24A1 has a functional destruction box (D-box) motif that allows binding with two APC adaptors, CDC20-homologue 1 (CDH1) and cell division cycle 20 (CDC20). Unlike other APC substrates, however, CYP24A1 acted as a pseudo-substrate, inhibiting CDH1 activity and promoting mitotic progression. Conversely, overexpression of a CYP24A1 D-box mutant compromised CDH1 binding, allowing CDH1 hyperactivation, thereby hastening degradation of its substrates cyclin B1 and CDC20, and accumulation of the CDC20 substrate p21, prolonging mitotic exit. These activities also occurred with a CYP24A1 isoform 2 lacking the catalytic cysteine (Cys-462), suggesting that CYP24A1's oncogenic potential is independent of its catalytic activity. CYP24A1 degradation reduced clonogenic survival of mutant KRAS-driven lung cancer cells, and calcitriol treatment increased CYP24A1 levels and tumor burden in Lsl-KRASG12D mice. These results disclose a catalytic activity-independent growth-promoting role of CYP24A1 in mutant KRAS-driven lung cancer. This suggests that CYP24A1 could be therapeutically targeted in lung cancers in which its expression is high. Full Article
