Bone marrow transplantation, now often known as haematopoietic stem cell transplantation (HSCT), is a complex choreographed procedure used to treat both acquired and inherited disorders of the bone marrow. It has proven invaluable as therapy for haematological and immunological disorders, and more recently in the treatment of metabolic and enzyme disorders. As the number of performed transplants grows annually, and with patients enjoying improved survival, a knowledge of both early and late complications of HSCT is essential for respiratory trainees and physicians in practice. This article highlights the spectrum of respiratory complications, both infectious and non-infectious, the timeline of their likely occurrence, and the approaches used for diagnosis and treatment, keeping in mind that more than one entity may occur simultaneously. As respiratory issues are often a leading cause of short- and long-term morbidity, consideration of a combined haematology/respiratory clinic may prove useful in this patient population.

The two robots, working alone and far apart from one another, are struggling on their respective treks along the Red Planet's rough terrain.

HBO's Casey Bloys was asked about the Game of Thrones author's spicy take on House of the Dragon season two.

It will likely release in 2026 and feature Apple Intelligence, according to a reliable analyst.

Secretary of State Rex Tillerson speaks at the Center for Strategic and International Studies on Wednesday.

WASHINGTON — Secretary of State Rex Tillerson is condemning reported atrocities committed against Rohingya Muslims in Myanmar, and he says those responsible — perhaps the country’s military — will be held accountable.

Tillerson says accounts of the suffering of the Rohingya are “heartbreaking” — and that if those reports are true, then “someone is going to be held to account for that.”

Tillerson — who’s set to visit South Asia next week — is urging the Myanmar government to improve humanitarian access to the population in western Rakhine state.

Amnesty International has accused Myanmar’s security forces of killing hundreds of men, women and children during a systematic campaign to expel the Rohingya. More than 580,000 refugees have fled to neighboring Bangladesh since late August.

“We really hold the military leadership accountable for what’s happening,” Tillerson said at the Center for Strategic and International Studies, a Washington think tank. “What’s most important to us is that the world can’t just stand idly by and be witness to the atrocities that are being reported in that area.”

He also called Wednesday for the U.S. and India to expand strategic ties. He pointedly criticized China, which he accused of challenging international norms needed for global stability.

He said the world needed the U.S. and India to have a strong partnership. The two nations share goals of security, free navigation, free trade and fighting terrorism in the Indo-Pacific, and serve as “the eastern and western beacons” for an international rules-based order which is increasingly under strain, he said.

Both India and China had benefited from that order, but Tillerson said India had done so while respecting rules and norms, while China had “at times” undermined them. To make his point, he alluded to China’s island building and expansive territorial claims in seas where Beijing has long-running disputes with Southeast Asian neighbors.

“China’s provocative actions in the South China Sea directly challenge the international law and norms that the United States and India both stand for,” Tillerson said in an address at the Center for Strategic and International Studies, a Washington think tank.

He added that the U.S. seeks constructive relations with China but “won’t shrink” from the challenges it poses when it “subverts the sovereignty of neighboring countries, and disadvantages the U.S. and our friends.”

U.S.-India relations have generally prospered in the past decade, in part because of their shared concerns about the rise of China. While President Donald Trump has looked to deepen cooperation with China on addressing the nuclear threat from North Korea, he’s also sought a closer relationship with India, which shares U.S. worries on Islamic extremism.

“In this period of uncertainty and angst, India needs a reliable partner on the world stage. I want to make clear: with our shared values and vision for global stability, peace and prosperity, the United States is that partner,” Tillerson said.

Tillerson said the U.S. wants to help improve India’s military capabilities, and also improve security cooperation among the region’s major democracies, which included Japan and Australia.

Tillerson said the U.S. and India were leading regional efforts on counterterrorism. He called for India’s archrival Pakistan “to take decisive action against terrorist groups based within their own borders that threaten its own people and the broader region.”

The post Tillerson: ‘Heartbreaking’ reports of suffering in Myanmar appeared first on PBS NewsHour.

As Chris and Anna Marie work out where the Romulan Neutral Zone is in their bed, Kelley steps in to host the show. There's also marbles. Time to go date some dog owners.

The post RPG Cast – Episode 553: “Greasing the Marbles” appeared first on RPGamer.

The cast regulars (Anna Marie, Chris and Kelley) are joined by Robert and newcomer Corey to discuss this week's news. A heated debate about free-to-play mechanics breaks out as the crew is split on Genshin Impact and other mobile titles while Chris eats chocolate covered almonds. Three weeks to go until Extra Life!

The post RPG Cast – Episode 560: “Kmart Breath of the Wild” appeared first on RPGamer.

This week we discuss the bacon that broke Anna's back, Kelley shows us the power of the nip-nado, Pascal meets the Bok Choys, Josh is sponsored by revengecrabs.com, and Robert speedruns the produce department.

The post RPG Cast – Episode 567: “Supermarket Cloth Map” appeared first on RPGamer.

Chris launches a new MLM. Alex plays Shooty Souls. And Kelley reveals a new screenshot from her upcoming game. Now if you don't mind, we all have resolutions to go break.

The post RPG Cast – Episode 569: “Mario’s Essential Oils” appeared first on RPGamer.

Chris does an Xbox 180 while Josh steals Anna Marie's needle. Robert gets the snotty kleenex award because he can't figure out how to stream Suikoden. And Kelley is too busy fawning over Revali to notice.

The post RPG Cast – Episode 570: “Kmart Cowboy Bebop” appeared first on RPGamer.

It's just the core trio this week, as Chris tosses a coin to his hunting horn partner Kelley, and Anna Marie rolls her eyes as Chris cracks terrible jokes about what the Vita really means. We all consider MiHoYo's bottom line, as well as whether we're classified as normies.

The post RPG Cast – Episode 580: “Marshmallow Is Canon” appeared first on RPGamer.

Chris is on the dice web. Kelley's cat will break her foot with a metal d20. Johnathan fights his "bad me" supervillain self.

The post RPG Cast – Episode 658: “Space Marines Were in the Bible” appeared first on RPGamer.

Chris is a nub on the internet. Kelley enslaves dogs to find silver ore. Ryan goes 8-bit.

The post RPG Cast – Episode 663: “Min-Maxing Anna Marie” appeared first on RPGamer.

Chris builds a house with a tiger in it. Ryan remembers that bush. And Robert has to fend off the fan boys trying to take his Nikke girls. One week till Extra Life, please help us heal kids and identify bicycles.

The post RPG Cast – Episode 697: “Paper Marliano” appeared first on RPGamer.

Phil goes for the water bottle. Sam releases her Thirst-Sona. Matt talks about cantaloupes in panties. Kelley regrets visiting a kitty strip club. All of this and Extra Life to boot! Donate! Now!

The post RPG Cast – Episode 698: “Marry, Thwack, Puff Puff” appeared first on RPGamer.

Super Mario Party Jamboree (NS) has remained in first place on the retail charts in Japan with sales of 57,522 units, according to Famitsu for the week ending October 27, 2024. 

Farmagia (NS) debuted in eighth place with sales of 4,296 units.

Romancing SaGa 2: Revenge of the Seven (NS) remained in second place with sales of 14,646 units. The PS5 version fell from third to seventh place with sales of 5,097 units.

Call of Duty: Black Ops 6 (PS5) is up one spot to third place with sales of 8,620 units and Mario Kart 8 Deluxe (NS) re-entered the top 10 in fourth place with sales of 5,782 units.

Professional Baseball Spirits 2024-2025 (PS5) is up two spots to fifth with sales of 5,729, and The Legend of Zelda: Echoes of Wisdom (NS) is up two spots to sixth place with sales of 5,492 units.

The Nintendo Switch was the best-selling platform with 60,096 units sold. The PlayStation 5 sold 13,965 units, the Xbox Series X|S sold 2,610 units, and the PlayStation 4 sold 53 units.

Here are the best-selling games in Japan:

1. [NSW] Super Mario Party Jamboree (Nintendo, 10/17/24) – 57,522 (364,484)
2. [NSW] Romancing SaGa 2: Revenge of the Seven (Square Enix, 10/24/24) – 14,646 (85,013)
3. [PS5] Call of Duty: Black Ops 6 (Activision, 10/25/24) – 8,620 (35,567)
4. [NSW] Mario Kart 8 Deluxe (Nintendo, 04/28/17) – 5,782 (6,044,039)
5. [PS5] Professional Baseball Spirits 2024-2025 (Konami, 10/17/24) – 5,729 (84,989)
6. [NSW] The Legend of Zelda: Echoes of Wisdom (Nintendo, 09/26/24) – 5,492 (294,371)
7. [PS5] Romancing SaGa 2: Revenge of the Seven (Square Enix, 10/24/24) – 5,097 (37,254)
8. [NSW] Farmagia (Marvelous, 11/01/24) – 4,296 (New)
9. [NSW] Animal Crossing: New Horizons (Nintendo, 03/20/20) – 4,253 (7,943,533)
10. [NSW] Minecraft (Microsoft, 06/21/18) – 4,242 (3,666,338)

Here is the hardware breakdown (followed by lifetime sales):

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463007/super-mario-party-jamboree-tops-the-japanese-charts/

Publisher Xbox Game Studios and developer The Coalition have announced John DiMaggio, the voice actor for Marcus Fenix, and Carlos Ferro, the voice actor for Dom Santiago, will reprise their roles for the prequel Gears of War: E-Day.

"On today's 18th anniversary of Gears of War, we're proud to share that John DiMaggio and Carlos Ferro are reprising their roles as the iconic voices of Marcus Fenix and Dominic Santiago in Gears of War: E-Day," announced the developer.

Gears of War: E-Day is in development for the Xbox Series X|S, PC, and Xbox Game Pass.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463012/marcus-and-dom-voice-actors-to-return-for-gears-of-war-e-day/

Life simulation game Inzoi will launch on PC via Steam early access on 28th March 2025, publishers Krafton have announced. Billed as a potential Sims 4 usurper, and equipped with syrupy Unreal Engine 5 visuals, it was originally slated for launch this year.

Read more

"Where’s my Neo-Volkite pistol, Warhammer 40,000: Space Marine 2?" was my perhaps slightly ungrateful reaction upon booting the action game up after the previous patch. "I didn’t even know what a Neo-Volkite pistol was until five minutes ago, but now this whole game is trash until I get one!." As promised in the roadmap, the last big update added a whole new Operations map, complete with a gargantuan new pseudo-boss in the form of a hierophant bio-titan. It did not, however, give me my beloved pistol. It’s fine. It’s in now, along with a few, less Neo-Volkite updates to other weapons.

Read more

October marked the "biggest" sales month for supermarkets in the UK so far despite food price hikes.

Martin Lewis has warned Tesco customers of a piece of small print that could see £18m worth of Clubcard points wasted.

If we want to terraform the Red Planet to make it better able to host microbial life, tiny rods of iron and aluminium may be the answer

Researchers recently found a possible reservoir of liquid water more than 11 kilometres below Mars's surface – the latest in a long series of potential water discoveries on the Red Planet, hinting at its temperate past

Mars rocks that were blasted off the surface of the Red Planet millions of years ago have been traced back to craters where they originated, which could transform our understanding of Mars’s volcanism and evolution

If you were standing on Mars as it was hit by charged particles from the sun, you might be able to see an aurora just like on Earth

Using images captured by the European Space Agency’s Mars Express spacecraft, researchers have created a cloud atlas of Mars, to better understand the climate of the Red Planet

The largest and most ambitious Martian drone yet could carry kilograms of scientific equipment over great distances and set itself down on the Red Planet unassisted

Asteroids that regularly fly between Earth, Venus and Mars could provide radiation shielding for human missions to explore neighbouring planets

Data collected by the Zhurong rover and orbiting satellites suggests the existence of an ancient shoreline in the Utopia Planitia region of Mars

Dangerous radiation reaches Mars at levels we aren't exposed to on Earth, which makes the Red Planet a particularly dangerous place to be during pregnancy

You might have heard about plans to establish a self‑sustaining city on Mars. Here’s what life would really be like on the Red Planet

A newly identified smartphone vulnerability can reveal the floor plans of where you are and what you are doing - and it is possible that companies or intelligence agencies are already making use of it

Information on faces recognised, voice commands and internet searches can be extracted from an Amazon Echo smart assistant without help from the user or manufacturer

NASA’s Valkyrie is undergoing tests to understand what it would take to get a humanoid robot onto offshore facilities or into space. New Scientist's James Woodford took the controls to see what it is capable of

A powerful new AI called o1 is the most dangerous that OpenAI has ever released, the firm claims – but who are these warnings for, asks Chris Stokel-Walker

An artificial intelligence model that can identify the calls of eight whale species is helping researchers track the elusive whale behind a perplexing sound in the Pacific

Smart TVs from Samsung and LG monitor what you are watching even when you are using the screens to display a feed from a connected laptop or video game console

Smartphones have indeed created an "anxious generation", but it isn't young people, it is their parents, argues neuroscientist Dean Burnett

Motion sensors in smartphones can be turned into makeshift microphones to eavesdrop on conversations, outsmarting security features designed to stop such attacks

A new supercapacitor design that uses only water, clay and graphene could source material on Mars and be more sustainable and accessible than traditional batteries

Joe Marler discussed his recent comments about the Haka, which sparked backlash.

Most people work just hard enough not to get fired and get paid just enough money not to quit. -George Carlin Every four years, presidential opinion polling reliably causes regime media to misplace...

People keep predicting that each wave of new technology will mean humans can put their feet up. It hasn't happened yet. Some economists and anthropologists who study the subject say even with the arrival of artificial intelligence, humans will remain integral to making the world go round.

The Tablelands in Gros Morne National Park, a UNESCO World Heritage Site, is one of the most unique landscapes in the world — and its orange peridotite rocks could hold the secret to finding life on Mars.

Apple recently announced its new lineup of Macs and rolled out Apple Intelligence, its latest artificial intelligence-powered feature for its products.

The Massimo Modular E9 is a sleek, smart and comfy tiny home in 409 square feet. Tech expert Kurt “CyberGuy" Knutsson takes a closer look at what the future of housing might look like.

The Adison Vein Locator gives medical professionals Superman-like X-ray vision for finding patients' veins for easy insertion of needles.

The Portuguese midfielder is settling into life in east London well after his loan move.

Liverpool already have one song synonymous with the club but they did attempt to officially do likewise with another. The Reds tried to trademark 'Allez Allez Allez'..