A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a first spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The device may further include a second spirally wound electrical conductor carried within the hydrocarbon processing container. The first spirally wound electrical conductor may be configured to generate magnetic fields with the hydrocarbon processing container that are parallel with an axis thereof.

An improved apparatus strips HPNA's from hydroprocessed streams in a fractionation column having a split shell configuration. Only one vapor stripping feed is required to the split shell of the fractionation column. The resulting reduction in steam requirement provides a superior fractionation in the column.

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The spirally wound electrical conductor may be configured to generate magnetic fields within the hydrocarbon processing container that are parallel with an axis thereof.

Systems and processes for improving quality and yield of one or more distillate products generated in a distillation column are disclosed. The system comprises a feed inlet distributor that reduces the amount of liquid entrained in vapor rising from the feed zone of the distillation column, a wash zone collection apparatus having an improved design for collecting slop wax falling from a liquid/vapor contacting structure provided in the wash zone, a recirculation subsystem for recirculating at least a portion of the collected slop wax to the top of the wash zone for distribution as wash oil, and a control subsystem. The feed inlet distributor ensures a horizontal fluid flow path free of transverse surfaces thereby minimizing atomization of liquid droplets entrained in vapor in the feed stream.

Split-shell fractionation columns and associated processes for separating aromatic hydrocarbons. A split-shell fractionation column includes a housing shell having a first height and a partition having a second height and disposed within the housing shell. The partition includes first and second vertically oriented baffles separated by a gap region, a seal plate connecting top ends of the baffles, a first input port formed to extend through the partition for the introduction of a gas into the gap region, and a first output port formed to extend outwardly from a bottom of the gap region and through the housing shell. The partition defines a first distillation zone and a second distillation zone within the housing shell.

Two-stage hydroprocessing uses a common dividing wall fractionator. Hydroprocessed effluents from both stages of hydroprocessing are fed to opposite sides of the dividing wall.

A system and process for the preparation of high quality gasoline through recombination of catalytic hydrocarbon includes fractionator and extractor. The upper part of the fractionator is equipped with light petrol pipeline, the lower part of the fractionator is equipped with heavy petrol pipeline, the middle part of the fractionator is equipped with medium petrol pipeline. The medium petrol pipeline is connected with a medium petrol extractor, the upper part of the medium petrol extractor is connected with the medium petrol raffinate oil hydrogenation unit through the pipeline, the lower part of the medium petrol extractor is connected with the medium petrol aromatic hydrocarbon hydrogenation unit through the pipeline. The medium petrol aromatic hydrocarbon hydrogenation unit is then connected with the light petrol pipeline in the upper part of the fractionator through the pipeline, the lower part of the heavy petrol extractor is connected with the medium petrol aromatic hydrocarbon hydrogenation unit through the pipeline, the upper part of the heavy petrol extractor is connected with the medium petrol raffinate oil hydrogenation unit through the pipeline.

A system and process for integrated desulfurizing, desalting and deasphalting of hydrocarbon feedstocks is provided. A hydrocarbon feedstock, a water soluble oxidant, and a water soluble catalyst can be introduced in a oxidation zone and retained for a period of time sufficient to achieve the desired degree of desulfurization, or introduced directly into the desalting zone along with wash water. Catalyst and dissolved salt are discharged along with the wastewater effluent from the desalting zone. A hydrocarbon stream including converted hydrocarbons and oxidation by-products is passed to a deasphalting zone. In the deasphalting zone, phase separation occurs, whereby a light phase including desulfurized hydrocarbons are produced, and a heavy phase including asphaltenes and oxidation by-products are discharged, e.g., passed to an asphalt pool.

The present invention provides a method and an apparatus for recovery of spent lubricating oil. The evaporation of hydrocarbon fractions from spent lubricating oil is carried out in three steps. The first step is at approximately 150-1030 mbar and between 70-240° C. in which is greater than 99% water, greater than 99% of ethylene glycol and greater than 50% of hydrocarbon molecules with normal boiling point up to 310° C. are evaporated from spent oil. The second step is operated at 6-30 mbar and 200-2900 C in which predominantly gasoil and light vacuum gasoil fractions are evaporated. The third step is operated at 250-320° C. and 0.5-15 mbar in which mainly heavy vacuum gasoil (boiling range of 425 to 570° C. on ASTM D-1160 test) is evaporated from spent oil.

A biocompatible surgical silk mesh prosthetic device employs a knit pattern that substantially prevents unraveling and preserves the stability of the mesh device, especially when the mesh device is cut. An example prosthetic device employs a knitted mesh including at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes. The at least two yarns include a first yarn and a second yarn extending between and forming loops about two nodes. The second yarn has a higher tension at the two nodes than the first yarn. the second yarn substantially prevents the first yarn from moving at the two nodes and substantially prevents the knitted mesh from unraveling at the nodes.

Auxetic fabric structures, of the sort which can be useful in conjunction with composite materials, and related methods of fabrication.

A compression bandage with a tubular, flexible flat material for surrounding a bodily member and with a number of elastic compression threads, whereby this flat material constitutes a main body that can be stretched in the circumferential direction. A number of elastic compression threads run in the plane of the flat material in the direction of the circumference, and create the compressive effect when the compression bandage is applied. At least parts of at least some of the compression threads protrude outside the flat material, allowing the compressive effect to be adjusted by varying the length of each of the protruding external portions.

Provided is a glove which has good adhesiveness to a rubber or resin coating material and excellent durability and further fits a hand well enabling good work efficiency. The glove is knitted from a covered yarn obtained by winding a sheath yarn around a core yarn and at least a part of the surface thereof is coated with a rubber or resin coating material, wherein the sheath yarn is a crimped yarn made of a high strength fiber having, as a property of a raw yarn, a tensile strength of 1.75 N/tex or more as measured according to JIS L 1013 8.5, and the crimped yarn simultaneously satisfies the following (1) to (3): (1) a degree of bulkiness of 40 cm3/g or more as measured according to JIS L 1013 8.16 A method after hot water treatment at 90° C. for 20 minutes, (2) a bulk compression modulus of 80% or more as measured according to the same method, and (3) a shrinkage/elongation ratio of 20% or more as measured according to JIS L 1013 8.11 A method.

A reversible garment with a warming side and a cooling side is comprised of a double knit fabric including a first face and a second face. The garment is reversible such that either face may be worn on the exterior of the garment. When the first side of the garment is worn against the body, the garment provides a heating effect by trapping air and body heat while wicking moisture to the outside of the fabric. When the second side of the garment is worn against the body, the garment provides a cooling garment by accelerating moisture movement across the fabric. Indicia are provided on the garment to indicate whether heating or cooling effects will be provided in the first-side-out configuration and the second-side-out configuration.

A light-based medical diagnostic system includes a plurality of semiconductor diodes with pump beams and a multiplexer capable of combining the pump beams and generating at least a multiplexed pump beam comprising one or more wavelengths. A first waveguide structure is configured to receive at least a portion of the one or more wavelengths and outputs a first optical beam. A second waveguide structure is configured to receive at least a portion of the first optical beam and to communicate at least the portion of the first optical beam to an output end of the second waveguide structure to form an output beam. A lens system is configured to receive at least a portion of the output beam and to communicate at least the portion of the output beam onto a part of a patient's body, such as a patient's blood.

A knitting head of a knitting machine for manufacturing flexible hoses (1) with a knitted reinforcement layer, which comprises a guide body (14) with a central tubular conduit (15) for the passage of the bearing layer (2) and having a outlet end portion (16) with a first outer peripheral surface (17) having a first predetermined radius (r1), a plurality of knitting needles (18) arranged along the periphery of said end portion (16) of said conduit (15) and having first longitudinal end sections (18') arranged along the circumference of said outer peripheral surface (17) and second longitudinal end sections (18″) arranged over a second cylindrical surface (19) having a second radius (r2) greater than said first radius (r1), at least one disk-shaped cam element (22), which is adapted to rotate at a first rotation speed and has a third predetermined radius (r3). The third radius (r3) is greater than said second radius (r2), connection means (23) being provided for connecting said disk-shaped element (22) to said second end sections (18″) of said needles (18), said connection means (23) having at least one longitudinal portion (24) with a radial dimension decreasing from said third radius (r3) to said second radius (r2).

A knit fabric having a modified knit structure, having a front layer of knit fabric and a back layer of knit fabric, wherein the front layer and back layer are joined together by rows of tuck stitches formed from a yarn having no more than 3% elongation and wherein the knit fabric is puncture resistant, and optionally cut and/or abrasion resistant, and a protective garment made therefrom.

An apparatus is disclosed for placement on a support surface between the support surface and a living being, wherein the living being has a bony prominence. The apparatus includes a first zone having a first coefficient of friction, the first zone being configured for positioning proximate the bony prominence. A second zone is adjacent the first zone, the second zone having a second coefficient of friction higher than the first coefficient of friction. The second zone is configured for positioning remote from the bony prominence. A method of preventing or healing decubitus ulcers includes positioning the bony prominence over the first zone and positioning an area remote from the bony prominence over the second zone.

A knit sock includes a foot portion having an upper instep area and a lower sole area integrally knit of a body yarn in circumferential courses and axial wales. The lower sole area defines inner and outer arch regions. The inner arch region incorporates a targeted compression zone adapted to reside generally adjacent an inner arch of a wearer's foot. The compression zone includes axially extending compression ridges of variable length spaced apart from a top of the compression zone to a bottom of the compression zone. When the sock is worn, a compression force applied by the foot portion within the targeted compression zone is greater than the compression force in directly adjacent areas of said foot portion.

A cut resistant sweater is provided including a chest portion, sleeves, collar, and closure extending from the top edge of the collar through at least part of the chest portion. The closure includes an opening extending from the top of the collar through at least part of the chest portion, and a strip having a first part of a hook and loop fastener thereon. A second part of the hook and loop fastener is disposed on the sweater in at least two pieces, a piece adjacent to a first side of the opening and a piece adjacent to a second side of the opening. The closure is stiff relative to the collar to support the collar. A method for manufacturing the sweater includes providing a cut resistant yarn, and knitting it into a sweater in the order of cuff of first sleeve, first sleeve, body and collar, second sleeve, and cuff of the second sleeve.

The present disclosure is directed to a flexible filament that includes a length of material configured to be used in forming at least a portion of a textile product to have at least a portion of a visual pattern that is visible on at least one of a first side or a second side of the textile product. The material includes a plurality of stitch indicators formed on the material to separate the material into a plurality of segmented regions, at least one of the stitch indicators or the segmented regions forming at least the portion of the visual pattern visible on the at least one of the first side or the second side of the textile product.

There is described herein a knitting technique for creating a garment having one or more 3D textile electrodes integrated therein. The knitting technique involves knitting the item with integrated electrodes and transmission channels in one single step. The electrode is knit using conducting thread while a base fabric is knit using non-conducting thread. The electrode is knit on a first needle bed and the base fabric is knit on a second needle bed opposite to and facing the first needle bed, the two needle beds being separated by a few millimeters. During the knitting process, the surface knit on the first needle bed and the surface knit on the second needle bed may be linked using an isolating thread network that is simply deposited, without forming a mesh, on the fabric, in order to provide the three-dimensional effect.

A preservation system for storage and logistic transport of nutritional substances. The preservation system obtains information about the nutritional substance to be preserved, senses and measures the external environment to the preservation system, senses and measures the internal environment to the preservation system, senses and measures the state of the nutritional substance, and stores such information throughout the period of preservation. Using this accumulated information, the preservation system can measure, or estimate, changes in nutritional content (usually degradation) during the period of preservation. Additionally, the preservation system can use this information to dynamically modify the preservation system to minimize detrimental changes to the nutritional content of the nutritional substance, and in some cases actually improve the nutritional substance attributes.

An apparatus for preparing a melon juice concentrate, such as watermelon juice concentrate, includes a finisher with brushes for separating melon flesh from melon rind including leaving at least 1/16 inch flesh on the rind and screens for separating juice from flesh. The apparatus also includes a steamer to reduce bacteria count on whole melon, a chopper for chopping melons into pieces less than about 16 inches square, an extractor for extracting juice from the flesh, and an evaporator for concentrating melon juice to form melon juice concentrate. The steamer includes a cylinder frame, steam jets directing steam through apertures in the cylinder frame at whole melon therein, and a motivator to move the whole melon along the cylinder frame. The apparatus can also process cantaloupe, honeydew melon, and other melon.

The present invention is a froth wand for an espresso machine that can generate a high velocity stream of steam to foam a beverage at the beverage brewing apparatus. The wand includes an adapter for attaching to the beverage brewing machine at a steam supply outlet, and a conduit for communicating the steam to a steam tube. The steam tube has a cylindrical body with an annular recessed exit, and is surrounded by a cylindrical sheath. The sheath includes a cylindrical plug with a small longitudinal aperture that fits into the outlet of the steam tube. The mating of the sheath's plug and the steam tube forces the steam through the aperture, accelerating the steam at the exit.

The invention relates to a method for determining the residual time until a cooking process of a foodstuff (12) has been finished. At first a set temperature value for a core (14) of the foodstuff (12) is defined. Next the actual temperatures in the core (14) of the foodstuff (12) at predetermined times are measured and the time dependence of the measured temperature in the core (14) of the foodstuff (12) is determined. At last the time dependence of the measured temperature is compared with the set temperature value and “the residual time of the cooking process is estimated. The invention relates further to a corresponding apparatus for determining the residual time until a cooking process of a foodstuff (12) has been finished.

A system and method for brewing beverages utilizing inertial separation and an adjustable-volume brewing chamber to selectively retain or release particulate matter, oils, and/or other components of the brewed beverage, whereby mechanical filtration may be avoided and smaller particulates may be separated from the beverage. Thus, less material is needed to achieve similar levels of infusion and brewing time may be reduced.

A method and apparatus for forming a beverage. Movement of a brew chamber may automatically enable the provision of beverage precursor liquid into a reservoir in a brewer, which is then used (heated or not) to form a beverage. For example, closing of the brew chamber may cause a lid for a water reservoir to be fully opened or otherwise permit movement of the lid to allow access to the reservoir, allowing a user to provide water into the reservoir. The reservoir lid may open with an abrupt action, causing attention to be drawn to the reservoir lid. In another arrangement, closure of the brew chamber may cause actuation of a baffle, pump, valve or other device to provide a suitable amount of water to a reservoir for beverage formation. In another arrangement, opening of the brew chamber may cause the reservoir lid to be automatically and simultaneously opened with the brew chamber.

The invention relates to a domestic cooking pot (1) comprising means of controlling (7) at least part of its operation, wherein said control means (7) have a mobile mounting between a plurality of positions, wherein said pot (1) is characterized in that it is further fitted with an information window (8) and at least an indicator (10) that is representative of one of the positions of the control means (7), and in that the window (8), the indicator (10) and the control means (7) work together so that said indicator (10) appears in the window (8) when the control means (7) are in the corresponding position.

In a method for controlling a cooking process of a cooking item contained in a cooking container, the sound of the cooking process is detected by means of at least one acoustic sensor and the course of the sound is directly analyzed for determining of a temperature and in particular the boiling point of the cooking item.

A coffee machine comprises a frothing device, wherein an internal milk channel leading to a frothing chamber is provided into which opens a bypass air inlet for operable air supply to the frothing device. A flexible milk suction line connects the frothing device with a milk supply container. Means are provided for cleaning the frothing device and the milk suction line with rinsing water from a continuous-flow water heater of the coffee machine. A controlled valve arrangement is provided which feeds rinsing water from the continuous-flow water heater to the bypass air inlet of the frothing device. A milk suction end of the milk suction line is directly or indirectly, fluid-conductively connectable with a residual water pan of the coffee machine prior to feeding rinsing water to the bypass air inlet.

The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.

A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.

The disclosure provides methods and compositions for suppressing retroviruses, including novel methods for treating a retroviral infection in a human in need of such treatment, comprising delivering a functional meiosis arrest female protein 1 (MARF1) to cells containing a retroviral provirus, together with novel expression constructs comprising a coding sequence encoding a functional MARF1 operatively linked to a promoter, vectors comprising such constructs, and packaging cell lines for use in making such vectors.

The present disclosure provides antibodies, and antigen-binding fragments thereof that bind to EBOV glycoprotein. The present disclosure further provides hybridoma cell lines and methods for making and using the compositions provided herein.

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.

The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

Cysteine engineered antibodies useful for the site-specific conjugation to a variety of agents are provided. Methods for the design, preparation, screening, selection and use of such antibodies are also provided.

Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

Provided herein are methods of treatment to regenerate, restore or rejuvenate a tissue. Methods include making adult somatic and germ cells pluripotent for administration to a patient. Alternatively, created pluripotent cells may be differentiated to the desired tissue type and administered to a patient to repair or enhance the target tissue.

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have Acute Rejection (AR), Hepatitis C Virus Recurrence (HCV-R), both AR/HCV-R, or Acute Dysfunction No Rejection (ADNR). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

This disclosure relates to methods, computer products, computer-implemented methods, and systems for predicting the probability or risk of prostate cancer recurrence and tumor aggressiveness in a patient. The method is based, in part, on the patient's risk profile that includes the presence/degree of specific copy number variations and predictive clinical factors. The methods and systems can be used to aid in treatment selection.