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[ASAP] A Chemical Switch for Transforming a Purine Agonist for Toll-like Receptor 7 to a Clinically Relevant Antagonist

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00011




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[ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00395




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[ASAP] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00245




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[ASAP] Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00192




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[ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00601




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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00686




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[ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00669




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[ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00043




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[ASAP] Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00041




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[ASAP] Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00076




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[ASAP] Structure Optimization of Gatastatin for the Development of ?-Tubulin-Specific Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00526




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[ASAP] Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00625




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[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00063




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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00129




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[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00574




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[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00131




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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095




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[ASAP] Can Drug Repositioning Work as a Systematical Business Model?

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00122




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[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00155




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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00106




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[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00115




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[ASAP] Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00066




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[ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00025




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[ASAP] Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00092




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[ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00009




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[ASAP] Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00085




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[ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00022




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[ASAP] Synthesis and Evaluation of <sup>11</sup>C- and <sup>18</sup>F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00127




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Tanzania turns to solar power to increase electricity connectivity

As many as 60 percent of the Kenyan population now has access to electricity according to official data. But in neighbouring Tanzania, the penetration rate is less than half of that and sparsely populated rural communities are especially neglected.  

The post Tanzania turns to solar power to increase electricity connectivity appeared first on LatestSolarNews.




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Spacing elements

So let’s say we have a “bar” with some items inside. Like a header or footer. Let’s also say we want those items to be spaced evenly, meaning they have the same gap everywhere. Shouldn’t be a big problem. Let’s take a look:

1. Margin

We can’t just add margin: 2rem to the elements since there is no margin collapsing on the horizontal axis. And it also doesn’t work when using Flexbox. Leaving a double sized gap in between. Wishing there is something like margin: 2rem collapse; where you can enable/disable it optionally.

See the Pen Spacing elements (no collapsing) by simurai (@simurai) on CodePen.

2. Pseudo classes

Using margin: 2rem 0 2rem 2rem and then a pseudo class like :last-child { margin-right: 2rem } to add the extra margin works as long as you don’t need to hide that element with display: none. Maybe a rare case, but I’ve been running into this issue once in a while. Would be cool if there is something like :last-displayed that would ignore elements that have display:none.

See the Pen Spacing elements (pseudo) by simurai (@simurai) on CodePen.

3. Margin + padding (best)

The easiest way I think, is to add margins to all elements (like in the first example), but then also add the same value as padding to the parent element. Like this:

.Header {
  padding: 1rem;
}
.Header-item {
  margin: 1rem;
}

That way all elements are evenly spaced and you still can use display:none without having to worry about breaking it. A little flaw is that you have to keep the 2 values in sync, but if you’re using a preprocessor, it can just be a single variable. Or maybe you could use REM’s to control it with font-size from the :root.

See the Pen Spacing elements by simurai (@simurai) on CodePen.

Other?

There are more ways but I’m not aware of a simple one that also let’s you use display: none. Let me know otherwise.

Update

A couple more options:

Hmmm.. gotta try some. I kinda like the 3rd one. Keeps it independent from the parent and is not “too” complicated.




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The matter of photography in the Americas / Natalia Brizuela and Jodi Roberts ; with contributions by Lisa Blackmore, Amy Sara Carroll, Marianela D'Aprile, María Fernanda Domínguez, Heloisa Espada, Rachel Price, Diana Ruiz, Tatiane Santa Ro

Rotch Library - TR184.B75 2018




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Library of light: encounters with artists and designers / Jo Joelson

Rotch Library - N8219.L5 J64 2019




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The women of Atelier 17: modernist printmaking in midcentury New York / Christina Weyl

Rotch Library - NE538.N5 W49 2019




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The Pre-Raphaelites and science / John Holmes

Hayden Library - NX454.5.P7 H65 2018




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El nombre de un país / Mariana Telleria ; curadora, Florencia Battiti

Rotch Library - N6488.I8 V433 2019 A7




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New design, neoplasticism: Nieuwe beelding / Piet Mondrian ; English translation by Harry Holtzman and Martin S. James

Rotch Library - N6948.5.D42 M6613 2019




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The shrinking universe: Ireland at Venice 2019 / Eva Rothschild

Rotch Library - N6488.I8 V433 2019 I73




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Gordon Parks: the new tide, early work, 1940-1950 / Philip Brookman ; with essays by Maurice Berger, Sarah Lewis, Richard J. Powell, Deborah Willis ; series editor, Peter W. Kunhardt, Jr

Rotch Library - TR647.P37 2018




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I have forgotten the night / Joël Andrianomearisoa ; curated by Rina Ralay Ranaivo and Emmanuel Daydé

Rotch Library - N6488.I8 V433 2019 M28




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Fields of fungus and sunflowers / [edited and designed by Tammy Nguyen ; contributions by Lovely Umayam and Adriel Luis]

Rotch Library - N7433.35.U6 M37 no.6




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Panos Charalambous, Eva Stefani, Zafos Xagoraris / curated by Katerina Tselou

Rotch Library - N6488.I8 V433 2019 G8




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The shadow of dream cast upon Giardini della Biennale

Rotch Library - N6488.I8 V433 2019 U38




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Albanian pavilion 2019: maybe the cosmos is not so extraordinary: Driant Zaneli

Rotch Library - N6488.I8 V433 2019 A38




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Moon shine / Rachel Boillot

Rotch Library - TR647.B626 2019




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Performance now / RoseLee Goldberg

Rotch Library - NX460.5.P47 G65 2018




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The M.V.M. Cappellin glassworks and the young Carlo Scarpa: 1925-1931 / edited by Marino Barovier and Carla Sonego

Rotch Library - NK5205.S28 A4 2018




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Unfinished conversations on the weight of absence: Belu-Simion Făinaru, Dan Mihălțianu, Miklós Onucsán / curator, Cristian Nae

Rotch Library - N6488.I8 V433 2019 R6




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Jakob Mohr / herausgegeben von Doris Noell-Rumpeltes + Thomas Röske

Rotch Library - NC251.M64 J35 2018




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Conversation pieces: the world of Bruegel / Abdelkader Benali, Alexandra van Dongen, Katrien Lichtert, Sabine Pénot, Lucinda Timmermans ; translation, Patrick Lennon, Michael Lomax

Rotch Library - ND673.B73 B46 2018




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Photography reframed: new visions in contemporary photographic culture / edited by Ben Burbridge and Annebella Pollen

Rotch Library - TR185.P52 2018