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Generalized Multiple Importance Sampling

Víctor Elvira, Luca Martino, David Luengo, Mónica F. Bugallo.

Source: Statistical Science, Volume 34, Number 1, 129--155.

Abstract:
Importance sampling (IS) methods are broadly used to approximate posterior distributions or their moments. In the standard IS approach, samples are drawn from a single proposal distribution and weighted adequately. However, since the performance in IS depends on the mismatch between the targeted and the proposal distributions, several proposal densities are often employed for the generation of samples. Under this multiple importance sampling (MIS) scenario, extensive literature has addressed the selection and adaptation of the proposal distributions, interpreting the sampling and weighting steps in different ways. In this paper, we establish a novel general framework with sampling and weighting procedures when more than one proposal is available. The new framework encompasses most relevant MIS schemes in the literature, and novel valid schemes appear naturally. All the MIS schemes are compared and ranked in terms of the variance of the associated estimators. Finally, we provide illustrative examples revealing that, even with a good choice of the proposal densities, a careful interpretation of the sampling and weighting procedures can make a significant difference in the performance of the method.




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Gaussian Integrals and Rice Series in Crossing Distributions—to Compute the Distribution of Maxima and Other Features of Gaussian Processes

Georg Lindgren.

Source: Statistical Science, Volume 34, Number 1, 100--128.

Abstract:
We describe and compare how methods based on the classical Rice’s formula for the expected number, and higher moments, of level crossings by a Gaussian process stand up to contemporary numerical methods to accurately deal with crossing related characteristics of the sample paths. We illustrate the relative merits in accuracy and computing time of the Rice moment methods and the exact numerical method, developed since the late 1990s, on three groups of distribution problems, the maximum over a finite interval and the waiting time to first crossing, the length of excursions over a level, and the joint period/amplitude of oscillations. We also treat the notoriously difficult problem of dependence between successive zero crossing distances. The exact solution has been known since at least 2000, but it has remained largely unnoticed outside the ocean science community. Extensive simulation studies illustrate the accuracy of the numerical methods. As a historical introduction an attempt is made to illustrate the relation between Rice’s original formulation and arguments and the exact numerical methods.




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Comment: Contributions of Model Features to BART Causal Inference Performance Using ACIC 2016 Competition Data

Nicole Bohme Carnegie.

Source: Statistical Science, Volume 34, Number 1, 90--93.

Abstract:
With a thorough exposition of the methods and results of the 2016 Atlantic Causal Inference Competition, Dorie et al. have set a new standard for reproducibility and comparability of evaluations of causal inference methods. In particular, the open-source R package aciccomp2016, which permits reproduction of all datasets used in the competition, will be an invaluable resource for evaluation of future methodological developments. Building upon results from Dorie et al., we examine whether a set of potential modifications to Bayesian Additive Regression Trees (BART)—multiple chains in model fitting, using the propensity score as a covariate, targeted maximum likelihood estimation (TMLE), and computing symmetric confidence intervals—have a stronger impact on bias, RMSE, and confidence interval coverage in combination than they do alone. We find that bias in the estimate of SATT is minimal, regardless of the BART formulation. For purposes of CI coverage, however, all proposed modifications are beneficial—alone and in combination—but use of TMLE is least beneficial for coverage and results in considerably wider confidence intervals.




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Matching Methods for Causal Inference: A Review and a Look Forward

Elizabeth A. Stuart

Source: Statist. Sci., Volume 25, Number 1, 1--21.

Abstract:
When estimating causal effects using observational data, it is desirable to replicate a randomized experiment as closely as possible by obtaining treated and control groups with similar covariate distributions. This goal can often be achieved by choosing well-matched samples of the original treated and control groups, thereby reducing bias due to the covariates. Since the 1970s, work on matching methods has examined how to best choose treated and control subjects for comparison. Matching methods are gaining popularity in fields such as economics, epidemiology, medicine and political science. However, until now the literature and related advice has been scattered across disciplines. Researchers who are interested in using matching methods—or developing methods related to matching—do not have a single place to turn to learn about past and current research. This paper provides a structure for thinking about matching methods and guidance on their use, coalescing the existing research (both old and new) and providing a summary of where the literature on matching methods is now and where it should be headed.




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Heteromodal Cortical Areas Encode Sensory-Motor Features of Word Meaning

The capacity to process information in conceptual form is a fundamental aspect of human cognition, yet little is known about how this type of information is encoded in the brain. Although the role of sensory and motor cortical areas has been a focus of recent debate, neuroimaging studies of concept representation consistently implicate a network of heteromodal areas that seem to support concept retrieval in general rather than knowledge related to any particular sensory-motor content. We used predictive machine learning on fMRI data to investigate the hypothesis that cortical areas in this "general semantic network" (GSN) encode multimodal information derived from basic sensory-motor processes, possibly functioning as convergence–divergence zones for distributed concept representation. An encoding model based on five conceptual attributes directly related to sensory-motor experience (sound, color, shape, manipulability, and visual motion) was used to predict brain activation patterns associated with individual lexical concepts in a semantic decision task. When the analysis was restricted to voxels in the GSN, the model was able to identify the activation patterns corresponding to individual concrete concepts significantly above chance. In contrast, a model based on five perceptual attributes of the word form performed at chance level. This pattern was reversed when the analysis was restricted to areas involved in the perceptual analysis of written word forms. These results indicate that heteromodal areas involved in semantic processing encode information about the relative importance of different sensory-motor attributes of concepts, possibly by storing particular combinations of sensory and motor features.

SIGNIFICANCE STATEMENT The present study used a predictive encoding model of word semantics to decode conceptual information from neural activity in heteromodal cortical areas. The model is based on five sensory-motor attributes of word meaning (color, shape, sound, visual motion, and manipulability) and encodes the relative importance of each attribute to the meaning of a word. This is the first demonstration that heteromodal areas involved in semantic processing can discriminate between different concepts based on sensory-motor information alone. This finding indicates that the brain represents concepts as multimodal combinations of sensory and motor representations.




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Angel over the city.

1990.




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We thank you for not smoking / design : Biman Mullick.

London (33 Stillness Rd, London, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]




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'Smoking is slow-motion suicide' / Biman Mullick.

London (33 Stillness Rd, London, SE23 ING) : Cleanair, Campaign for a Smoke-free Environment, [198-?]




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Smoking affects us all. / Biman Mullick.

London (33 Stillness Rd, London, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]




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Passive smoking kills / Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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No smoking no hate / Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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No smoking zone / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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Smoking is anti-social / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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No smoking is the norm / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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We thank you for not smoking / design : Biman Mullick.

London (33 Stillness Rd, London, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]




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No smoking zone / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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We thank you for not smoking / Biman Mullick.

London : Cleanair, [1988?]




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We thank you for not smoking / design : Biman Mullick.

London (33 Stillness Rd, London, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]




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No smoking is the norm / design : Biman Mullick.

London : Cleanair, Smoke-free Environment (33 Stillness Rd, London, SE23 1NG), [198-?]




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Smoking is bad for your image / design : Biman Mullick.

[London?], [199-?]




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Each year in Britain 9,300 babies are killed by their smoking mums. / Biman Mullick.

[London?], [6th June 1990]




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[Silhouette of a pregant woman smoking with death skull inside womb, 29 January 1994] / design: Biman Mullick.

London, [29 January 1994]




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Danny Smith from No Human Being Is Illegal (in all our glory). Collaged photograph by Deborah Kelly and collaborators, 2014-2018.

[London], 2019.




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The Joyful Reduction of Uncertainty: Music Perception as a Window to Predictive Neuronal Processing




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The 2019 Victoria’s Secret Fashion Show Is Canceled After Facing Backlash for Lack of Body Diversity

The reaction on social media has been fierce.




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Blake Lively's Favorite Affordable Jeans Brand Is Having a Major Sale Right Now

Here's everything you need to know about Old Navy's Black Friday and Cyber Monday plans.




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Taylor Swift, Hailey Bieber, and Tons of Other Celebs’ Favorite Leggings Are on Sale Ahead of Black Friday

Here’s where you can snag their Alo Yoga Moto leggings for less.




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Gabrielle Union's Mesmerizing Tie Dye Activewear Set Is On Sale for Black Friday

The rainbow sports bra and leggings set from Splits59 is a must-have for anyone craving a pop of color in their workout wardrobe.




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Kourtney Kardashian's Favorite Leggings Are So Good, Everyone Should Own A Pair

And they're on sale for Black Friday. 




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Jennifer Lopez Is Wearing the Hell Out of These $60 Sneakers—and You Can Buy Them at Zappos

The chic sneaks are part of Zappos' massive Cyber Monday sale.




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These Nordstrom Cyber Monday Deals Are Giving Black Friday a Run for Its Money

This is not a drill: You can get up to 50% off at Nordstrom right now.




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Forget Black Booties, Amal Clooney and J.Lo Are Wearing This Weather-Resistant Boot Trend Instead

And it’s on sale at Nordstrom.




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This is the Only Jacket I’ll Be Living in This Winter

Canada Goose has long been a leader in the outdoor gear space.




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Jennifer Lopez Just Stepped Out in These Glittery Leggings (Again)—and We Found Them on Sale

They’re already going out of stock.




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Amazon Just Launched an Exclusive Clothing Collection Full of Warm and Comfy Basics Under $45

The womenswear line is new, and there’s already a variety of items to shop.




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Shoppers Swear These $30 Colorfulkoala Leggings Are the Ultimate Lululemon Dupes

And they’re available in 19 fun prints.




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Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Jasper Akerboom
Oct 3, 2012; 32:13819-13840
Cellular




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Metacognitive Mechanisms Underlying Lucid Dreaming

Elisa Filevich
Jan 21, 2015; 35:1082-1088
BehavioralSystemsCognitive




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Sleep Deprivation Biases the Neural Mechanisms Underlying Economic Preferences

Vinod Venkatraman
Mar 9, 2011; 31:3712-3718
BehavioralSystemsCognitive




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Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control

William W. Seeley
Feb 28, 2007; 27:2349-2356
BehavioralSystemsCognitive




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Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry

Brian Zingg
Apr 15, 2020; 40:3250-3267
Systems/Circuits




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Nurture versus Nature: Long-Term Impact of Forced Right-Handedness on Structure of Pericentral Cortex and Basal Ganglia

Stefan Klöppel
Mar 3, 2010; 30:3271-3275
BRIEF COMMUNICATION




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The Representation of Semantic Information Across Human Cerebral Cortex During Listening Versus Reading Is Invariant to Stimulus Modality

Fatma Deniz
Sep 25, 2019; 39:7722-7736
BehavioralSystemsCognitive




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Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease

Sibylle Béchet
Apr 8, 2020; 40:3104-3118
Neurobiology of Disease




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Significant Neuroanatomical Variation Among Domestic Dog Breeds

Erin E. Hecht
Sep 25, 2019; 39:7748-7758
BehavioralSystemsCognitive




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Physiological Basis of Noise-Induced Hearing Loss in a Tympanal Ear

Ben Warren
Apr 8, 2020; 40:3130-3140
Neurobiology of Disease




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White Matter Microstructure in Transsexuals and Controls Investigated by Diffusion Tensor Imaging

Georg S. Kranz
Nov 12, 2014; 34:15466-15475
Systems/Circuits




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A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

John D. Cahoy
Jan 2, 2008; 28:264-278
Cellular




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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Ye Zhang
Sep 3, 2014; 34:11929-11947
Cellular




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The Encoding of Sound Source Elevation in the Human Auditory Cortex

Régis Trapeau
Mar 28, 2018; 38:3252-3264
BehavioralSystemsCognitive