al Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE We sought to confirm a bidirectional association between severe hypoglycemic events (SHEs) and cardiovascular (CV) event risk and to characterize individuals at dual risk. RESEARCH DESIGN AND METHODS In a post hoc analysis of 14,752 Exenatide Study of Cardiovascular Event Lowering (EXSCEL) participants, we examined time-dependent associations between SHEs and subsequent major adverse cardiac events (CV death, nonfatal myocardial infarction [MI] or stroke), fatal/nonfatal MI, fatal/nonfatal stroke, hospitalization for acute coronary syndrome (hACS), hospitalization for heart failure (hHF), and all-cause mortality (ACM), as well as time-dependent associations between nonfatal CV events and subsequent SHEs. RESULTS SHEs were uncommon and not associated with once-weekly exenatide therapy (hazard ratio 1.13 [95% CI 0.94–1.36], P = 0.179). In fully adjusted models, SHEs were associated with an increased risk of subsequent ACM (1.83 [1.38–2.42], P < 0.001), CV death (1.60 [1.11–2.30], P = 0.012), and hHF (2.09 [1.37–3.17], P = 0.001), while nonfatal MI (2.02 [1.35–3.01], P = 0.001), nonfatal stroke (2.30 [1.25–4.23], P = 0.007), hACS (2.00 [1.39–2.90], P < 0.001), and hHF (3.24 [1.98–5.30], P < 0.001) were all associated with a subsequent increased risk of SHEs. The elevated bidirectional time-dependent hazards linking SHEs and a composite of all CV events were approximately constant over time, with those individuals at dual risk showing higher comorbidity scores compared with those without. CONCLUSIONS These findings, showing greater risk of SHEs after CV events as well as greater risk of CV events after SHEs, validate a bidirectional relationship between CV events and SHEs in patients with high comorbidity scores. Full Article
al Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate whether high glucose levels in the normoglycemic range and higher have a causal genetic effect on risk of retinopathy, neuropathy, nephropathy, chronic kidney disease (CKD), peripheral arterial disease (PAD), and myocardial infarction (MI; positive control) in the general population. RESEARCH DESIGN AND METHODS This study applied observational and one-sample Mendelian randomization (MR) analyses to individual-level data from 117,193 Danish individuals, and validation by two-sample MR analyses on summary-level data from 133,010 individuals from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), 117,165 from the CKDGen Consortium, and 452,264 from the UK Biobank. RESULTS Observationally, glucose levels in the normoglycemic range and higher were associated with high risks of retinopathy, neuropathy, diabetic nephropathy, PAD, and MI (all P for trend <0.001). In genetic causal analyses, the risk ratio for a 1 mmol/L higher glucose level was 2.01 (95% CI 1.18–3.41) for retinopathy, 2.15 (1.38–3.35) for neuropathy, 1.58 (1.04–2.40) for diabetic nephropathy, 0.97 (0.84–1.12) for estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, 1.19 (0.90–1.58) for PAD, and 1.49 (1.02–2.17) for MI. Summary-level data from the MAGIC, the CKDGen Consortium, and the UK Biobank gave a genetic risk ratio of 4.55 (95% CI 2.26–9.15) for retinopathy, 1.48 (0.83–2.66) for peripheral neuropathy, 0.98 (0.94–1.01) for eGFR <60 mL/min/1.73 m2, and 1.23 (0.57–2.67) for PAD per 1 mmol/L higher glucose level. CONCLUSIONS Glucose levels in the normoglycemic range and higher were prospectively associated with a high risk of retinopathy, neuropathy, diabetic nephropathy, eGFR <60 mL/min/1.73 m2, PAD, and MI. These associations were confirmed in genetic causal analyses for retinopathy, neuropathy, diabetic nephropathy, and MI, but they could not be confirmed for PAD and seemed to be refuted for eGFR <60 mL/min/1.73 m2. Full Article
al Get Free Local COVID-19 Alerts with Inoreader By blog.inoreader.com Published On :: Fri, 13 Mar 2020 19:16:25 +0000 Everyone is concerned as the novel Coronavirus spreads at rapid rates across all countries of the world. We believe every… Full Article Uncategorized
al How we made our Free COVID-19 Alerting System and how you can build your own for any topic By blog.inoreader.com Published On :: Mon, 23 Mar 2020 12:32:04 +0000 Ever since we launched our Free COVID-19 Alerting System, we’ve been continuously asked how we made it. In this blog… Full Article Uncategorized
al Convert Almost Any Webpage Into RSS Feed With Inoreader’s Web Feeds By blog.inoreader.com Published On :: Wed, 08 Apr 2020 05:59:26 +0000 So, you wanted to follow this nice website for new content, but it doesn’t have an RSS feed yet? Don’t… Full Article Uncategorized
al Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide By care.diabetesjournals.org Published On :: 2011-11-21T22:32:39-08:00 OBJECTIVE We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the complete cohort after 2 years of follow-up. RESEARCH DESIGN AND METHODS A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments. RESULTS No infusion-related adverse events were observed. β-Cell function declined after UCB infusion. Area under the curve C-peptide was 24.3% of baseline 1 year postinfusion (P < 0.001) and 2% of baseline 2 years after infusion (P < 0.001). Flow cytometry revealed increased regulatory T cells (Tregs) (P = 0.04) and naive Tregs (P = 0.001) 6 and 9 months after infusion, respectively. CONCLUSIONS Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide. Full Article
al Effectively Serving Immigrant and Dual Language Learner Families through Home Visiting Programs By www.migrationpolicy.org Published On :: Thu, 29 Aug 2019 12:01:27 -0400 Marking a policy brief's release, this webinar explores the promise of home visiting services that support new parents alongside their infants and toddlers, plus strategies for improving how these programs work with immigrant and linguistically diverse families. Full Article
al The Colombian Response to the Venezuelan Migration Crisis: A Dialogue with Colombia’s Migration Czar By www.migrationpolicy.org Published On :: Mon, 30 Sep 2019 19:29:42 -0400 Felipe Muñoz, Advisor to the President of Colombia for the Colombian-Venezuelan Border, discusses how Colombia is coping with the influx of Venezuelan migrants, plans for future policy decisions surrounding this migration, and developments in regional and international cooperation. Full Article
al Legal Migration Pathways to Europe for Low- and Middle-Skilled Migrants By www.migrationpolicy.org Published On :: Thu, 24 Oct 2019 11:17:54 -0400 This event hosted by MPI Europe and the Research Unit of the Expert Council of German Foundations on Integration and Migration featured a discussion on research into legal migration pathways for work and training for low- and middle-skilled migrants. Full Article
al 16th Annual Immigration Law and Policy Conference By www.migrationpolicy.org Published On :: Mon, 04 Nov 2019 16:20:25 -0500 With immigration a central plank of the Trump administration's policy agenda, the 16th annual Immigration Law and Policy Conference, held in October 2019, featured analysis by top experts in and out of government regarding changing policies implemented at the U.S.-Mexico border, narrowing of asylum, cooperation with migrant-transit countries, and actions that could reduce legal immigration, including revisions to the public-charge rule. Full Article
al Turning the Tide: Addressing the Long-Term Challenges of EU Mobility for Sending Countries By www.migrationpolicy.org Published On :: Thu, 05 Dec 2019 15:26:24 -0500 Amid ongoing debates about the costs and benefits of free movement, this MPI webinar examines evidence from the EU-funded REMINDER project on different types of East-West mobility. Speakers examine big-picture trends of East-West migration; consider possible policy responses at regional, national, and EU levels to alleviate some of the challenges; and reflect on realistic actions that could be taken under a new European Commission. Full Article
al Seasonal Worker Programs in Europe: Lessons Learned and Ways Forward By www.migrationpolicy.org Published On :: Fri, 28 Feb 2020 13:36:08 -0500 As the European Union prepares to review the implementation of its Seasonal Workers Directive, as well as countries such as the United Kingdom continue to explore new approaches to selecting seasonal workers, this webinar features findings from a policy brief on the topic. Full Article
al Migration & Coronavirus: A Complicated Nexus Between Migration Management and Public Health By www.migrationpolicy.org Published On :: Tue, 24 Mar 2020 15:13:37 -0400 This webinar, organized by MPI and the Zolberg Institute on Migration and Mobility at The New School, discussed migration policy responses around the globe in response to the COVID-19 pandemic, and examined where migration management and enforcement tools may be useful and where they may be ill-suited to advancing public health goals. Full Article
al Expert Podcast: Meeting Seasonal Labor Needs in the Age of COVID-19 By www.migrationpolicy.org Published On :: Tue, 31 Mar 2020 09:35:25 -0400 Governments are facing urgent pandemic-related questions. One of the more pressing ones: Who is going to harvest crops in countries that rely heavily on seasonal foreign workers? In this podcast, MPI experts examine ways in which countries could address labor shortages in agriculture, including recruiting native-born workers and letting already present seasonal workers stay longer. Catch an interesting discussion as border closures have halted the movement of seasonal workers even as crops are approaching harvest in some places. Full Article
al COVID-19 in Latin America: Tackling Health Care & Other Impacts for Vulnerable Migrant Populations By www.migrationpolicy.org Published On :: Mon, 06 Apr 2020 12:44:50 -0400 This MPI webinar brought together public health and migration experts to analyze the impact that COVID-19 preventative measures will have on vulnerable immigrants and refugees in Colombia and Latin America. Speakers also discussed how policymakers and international organizations can include migrant populations in their emergency response plans. Full Article
al Mental Health Risks and Resilience among Somali and Bhutanese Refugee Parents By www.migrationpolicy.org Published On :: Wed, 26 Oct 2016 10:00:06 -0400 Somali and Bhutanese refugees are two of the largest groups recently resettled in the United States and Canada. This report examines factors that might promote or undermine the mental health and overall well-being of children of these refugees, with regard to factors such as past exposure to trauma, parental mental health, educational attainment, social support, and discrimination. Full Article
al The Nutritional Health of Young Refugee Children Resettling in Washington State By www.migrationpolicy.org Published On :: Tue, 01 Nov 2016 12:08:38 -0400 Refugee children are vulnerable to health and nutrition risks that can have long-term consequences for their development and well-being. This report examines the prevalence of malnutrition—from stunting and wasting to overweight and obesity—among refugee children from birth to age 10, using data from an overseas medical screening exam before they were resettled in Washington State between 2012 and 2014. Full Article
al Chilling Effects: The Expected Public Charge Rule and Its Impact on Legal Immigrant Families’ Public Benefits Use By www.migrationpolicy.org Published On :: Fri, 08 Jun 2018 14:09:59 -0400 According to leaked drafts, the Trump administration is considering a rule that could have sweeping effects on both legal immigration to the United States and the use of public benefits by legal immigrants and their families. This report examines the potential scale of the expected rule’s impact, including at national and state levels and among children, as well as Hispanic and Asian American/Pacific Islander immigrants. Full Article
al Millions Will Feel Chilling Effects of U.S. Public-Charge Rule That Is Also Likely to Reshape Legal Immigration By www.migrationpolicy.org Published On :: Thu, 08 Aug 2019 12:09:29 -0400 The public-charge rule issued by the Trump administration in August 2019 will have profound effects on future immigration and on use of public benefits by millions of legal noncitizens and their U.S.-citizen family members. Complex standards for determining when an immigrant is likely to become a public charge could cause a significant share of the nearly 23 million noncitizens and U.S. citizens in benefits-using immigrant families to disenroll, as this commentary explains. Full Article
al Leveraging the Potential of Home Visiting Programs to Serve Immigrant and Dual Language Learner Families By www.migrationpolicy.org Published On :: Thu, 22 Aug 2019 10:48:18 -0400 Home visiting programs for young families are growing in popularity across the United States, and have demonstrated their effectiveness in supporting maternal health and child well-being. At the same time, more infants and toddlers are growing up in immigrant families and households where a language other than English is spoken. Why then are these children under-represented in these programs? This brief explores common barriers, ways to address them, and why it is important to do so. Full Article
al Health Insurance Test for Green-Card Applicants Could Sharply Cut Future U.S. Legal Immigration By www.migrationpolicy.org Published On :: Thu, 10 Oct 2019 11:55:01 -0400 A new Trump administration action requiring intending immigrants to prove they can purchase eligible health insurance within 30 days of arrival has the potential to block fully 65 percent of those who apply for a green card from abroad, MPI estimates. Full Article
al Health Insurance Coverage of Immigrants and Latinos in the Kansas City Metro Area By www.migrationpolicy.org Published On :: Tue, 19 Nov 2019 10:26:37 -0500 Latinos and immigrants are at least twice as likely to lack health insurance coverage as the overall population in the Kansas City metropolitan area. This gap that has significant implications for the region, as Latinos and immigrants will form an ever-growing share of the area’s labor force and tax base amid anticipated declines in the native-born, non-Latino population. Full Article
al The Public-Charge Rule: Broad Impacts, But Few Will Be Denied Green Cards Based on Actual Benefits Use By www.migrationpolicy.org Published On :: Tue, 03 Mar 2020 17:57:09 -0500 While the Trump administration public-charge rule is likely to vastly reshape legal immigration based on its test to assess if a person might ever use public benefits in the future, the universe of noncitizens who could be denied a green card based on current benefits use is quite small. That's because very few benefit programs are open to noncitizens who do not hold a green card. This commentary offers estimates of who might be affected. Full Article
al As U.S. Health-Care System Buckles under Pandemic, Immigrant & Refugee Professionals Could Represent a Critical Resource By www.migrationpolicy.org Published On :: Mon, 06 Apr 2020 11:32:00 -0400 In a time of critical shortages of U.S. health-care workers during the COVID-19 pandemic, retired doctors are being called back to work and medical students are graduating on a fast track. There is another important pool that could be tapped: Immigrants and refugees who have college degrees in health fields but are working in low-skilled jobs or out of work. MPI estimates 263,000 immigrants are experiencing skill underutilization and could be a valuable resource. Full Article
al Barriers to COVID-19 Testing and Treatment: Immigrants without Health Coverage in the United States By www.migrationpolicy.org Published On :: Tue, 05 May 2020 15:58:10 -0400 As millions of U.S. workers lose jobs and the health insurance associated with them, Medicaid and similar programs are increasingly important for people seeking COVID-19 testing and treatment. Yet many low-income uninsured noncitizens, including green-card holders, are excluded from such programs because of their immigration status, as this fact sheet explores. Full Article
al The Digital Transformation Playbook: Rethink Your Business for the Digital Age By brandleadership.wordpress.com Published On :: Wed, 17 Feb 2016 16:24:52 +0000 Every business begun before the Internet now faces the same challenge: How to transform to compete in a digital economy? This is the leadership challenge examined by BRITE founder and Columbia Business School faculty member David Rogers in his newest book, The Digital Transformation Playbook (April 5, 2016; Columbia Business School Publishing). In the book, […] Full Article Uncategorized
al Algorhythms for Marketing Transformation By brandleadership.wordpress.com Published On :: Fri, 24 Jun 2016 17:24:16 +0000 We all understand that digital media, data, and analytics are driving transformations in society and business. Most marketers are now armed with case studies of what can be done differently, but many are still challenged with how to truly develop new ideas and execute new strategies to grow their business. Mitch Joel, President of Mirum […] Full Article Uncategorized
al Musculoskeletal Complications of Diabetes Mellitus By clinical.diabetesjournals.org Published On :: 2001-07-01 Rachel Peterson KimJul 1, 2001; 19:Practical Pointers Full Article
al Evaluating the Effect of U-500 Insulin Therapy on Glycemic Control in Veterans With Type 2 Diabetes By clinical.diabetesjournals.org Published On :: 2015-01-01 Joseph A. GranataJan 1, 2015; 33:14-19Feature Articles Full Article
al Gestational Diabetes in High-Risk Populations By clinical.diabetesjournals.org Published On :: 2013-04-01 Wilfred FujimotoApr 1, 2013; 31:90-94Diabetes Advocacy Full Article
al Case Study: Potential Pitfalls of Using Hemoglobin A1c as the Sole Measure of Glycemic Control By clinical.diabetesjournals.org Published On :: 2004-07-01 Huy A. TranJul 1, 2004; 22:141-143Case Studies Full Article
al Diabetes and Periodontal Infection: Making the Connection By clinical.diabetesjournals.org Published On :: 2005-10-01 Janet H. SoutherlandOct 1, 2005; 23:171-178Feature Articles Full Article
al Medical Nutrition Therapy: A Key to Diabetes Management and Prevention By clinical.diabetesjournals.org Published On :: 2010-12-01 Sara F. MorrisDec 1, 2010; 28:12-18Feature Articles Full Article
al Integration of Clinical Psychology in the Comprehensive Diabetes Care Team By clinical.diabetesjournals.org Published On :: 2004-07-01 Steven B. LeichterJul 1, 2004; 22:129-131The Business of Diabetes Full Article
al The Death of the "1800-Calorie ADA Diet" By clinical.diabetesjournals.org Published On :: 2002-04-01 Irl B. HirschApr 1, 2002; 20:Editorials Full Article
al The Potential of Group Visits in Diabetes Care By clinical.diabetesjournals.org Published On :: 2008-04-01 Andrew M. DavisApr 1, 2008; 26:58-62Feature Articles Full Article
al Gestational Diabetes Mellitus By clinical.diabetesjournals.org Published On :: 2005-01-01 Tracy L. SetjiJan 1, 2005; 23:17-24Feature Articles Full Article
al Therapeutic Inertia is a Problem for All of Us By clinical.diabetesjournals.org Published On :: 2019-04-01 Stephen BruntonApr 1, 2019; 37:105-106Editorials Full Article
al Diapression: An Integrated Model for Understanding the Experience of Individuals With Co-Occurring Diabetes and Depression By clinical.diabetesjournals.org Published On :: 2011-04-01 Paul CiechanowskiApr 1, 2011; 29:43-49Feature Articles Full Article
al PROactive: A Sad Tale of Inappropriate Analysis and Unjustified Interpretation By clinical.diabetesjournals.org Published On :: 2006-04-01 Jay S. SkylerApr 1, 2006; 24:63-65Commentary Full Article
al Interdisciplinary Team Care for Diabetic Patients by Primary Care Physicians, Advanced Practice Nurses, and Clinical Pharmacists By clinical.diabetesjournals.org Published On :: 2011-04-01 David WillensApr 1, 2011; 29:60-68Feature Articles Full Article
al Opportunities and Challenges for Biosimilars: What's on the Horizon in the Global Insulin Market? By clinical.diabetesjournals.org Published On :: 2012-10-01 Lisa S. RotensteinOct 1, 2012; 30:138-150Features Full Article
al Health Care Transition in Adolescents and Young Adults With Diabetes By clinical.diabetesjournals.org Published On :: 2010-06-01 Michael E. BowenJun 1, 2010; 28:99-106Feature Articles Full Article
al Management of Diabetic Peripheral Neuropathy By clinical.diabetesjournals.org Published On :: 2005-01-01 Andrew J.M. BoultonJan 1, 2005; 23:9-15Feature Articles Full Article
al Helping Patients Make and Sustain Healthy Changes: A Brief Introduction to Motivational Interviewing in Clinical Diabetes Care By clinical.diabetesjournals.org Published On :: 2008-10-01 Michele HeislerOct 1, 2008; 26:161-165Practical Pointers Full Article
al Hospital Management of Hyperglycemia By clinical.diabetesjournals.org Published On :: 2004-04-01 Kristen B. CampbellApr 1, 2004; 22:81-88Practical Pointers Full Article
al Diabetes Self-Management in a Community Health Center: Improving Health Behaviors and Clinical Outcomes for Underserved Patients By clinical.diabetesjournals.org Published On :: 2008-01-01 Daren AndersonJan 1, 2008; 26:22-27Bridges to Excellence Full Article
al Cardiac Manifestations of Congenital Generalized Lipodystrophy By clinical.diabetesjournals.org Published On :: 2016-10-01 Vani P. SanonOct 1, 2016; 34:181-186Feature Articles Full Article
al Standards of Medical Care in Diabetes--2019 Abridged for Primary Care Providers By clinical.diabetesjournals.org Published On :: 2019-01-01 American Diabetes AssociationJan 1, 2019; 37:11-34Position Statements Full Article
al Perspectives in Gestational Diabetes Mellitus: A Review of Screening, Diagnosis, and Treatment By clinical.diabetesjournals.org Published On :: 2007-04-01 Jennifer M. PerkinsApr 1, 2007; 25:57-62Feature Articles Full Article