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PIX: What is Neeraj Chopra celebrating?

He also conveyed his wishes on the occasion of Haryana Day.




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Champions League PIX: Inter down Arsenal; Barca win

IMAGES from the Champions League matches played on Wednesday.




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PIX: Man United log first Europa League win

The win leaves United in 15th place in the Europa League standings on six points from four games.




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Bundesliga PIX: Bayern win; champions Leverkusen held

Bayern Munich earned a nervous 1-0 win at St Pauli thanks to a sensational 28-metre drive from Jamal Musiala to stay unbeaten.




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EPL PIX: Liverpool stay on top; City lose again

IMAGES from the EPL matches played on Saturday.




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PIX: Vinicius 'tricks' in Real win; PSG maintain lead

Real Madrid forward Vinicius Jr scored a hat-trick to help the LaLiga champions snap a two-game winless run in all competitions.




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PIX: Messi's Miami stunned by Atlanta in MLS play-offs

Miami were overwhelming favourites to win it all after producing a league record 74 points in the regular season but could not keep the momentum after Matias Rojas' close-range goal in the 17th minute and Messi's score in the 65th minute.




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EPL PIX: United thrash Leicester; Ipswich stun Spurs

IMAGES from the English Premier League matches played on Sunday.




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PIX: Barcelona suffer shock defeat; Napoli hold Inter

Barcelona suffered a shock 1-0 LaLiga defeat at Real Sociedad on Sunday that ended their seven-match winning streak in all competitions.




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‘AI tooling is helping us do more for less,’ Cognizant CEO

The CEO said that the company’s AI strategy was utilised to increase speed, reduce costs and improve the predictability of clients’ data modernisation journeys




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India among fastest-growing markets for Microsoft Copilot

Microsoft’s refreshed Copilot, launched last month, gives users the ability to talk with Copilots real-time, moving human-computer interaction to a completely new paradigm




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In a win for Elon Musk, Scindia rejects spectrum auction pitch from Ambani, Mittal

Musk’s Starlink has applied for a licence to start operations in the country




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Dropping a bombshell

What pushed one of the world’s greatest football legends over the edge? Did he hope to right a wrong?




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Exploring the self-assembly dynamics of novel steroid–coumarin conjugates: a comprehensive spectroscopic and solid-state investigation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00192C, Paper
Open Access
Claudia M. Ramírez-Lozano, Ma. Eugenia Ochoa, Pablo Labra-Vázquez, Arturo Jiménez-Sánchez, Norberto Farfán, Rosa Santillan
The design, synthesis, and characterization of seven novel steroid–coumarin conjugates with diverse steroidal nuclei as lipophilic fluorescent materials for bioimaging applications are presented.
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00256C, Paper
Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
A total of 27 novel spirooxindoles were synthesized through a water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds. Several compounds showed excellent antifungal activity against Physalospora piricola.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00358F, Paper
Open Access
Yuma Matsuura, Shinichiro Fuse
Various 2,5-disubstituted furans were synthesized via 5-substituted 2-halomethylfurans using microflow technology.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00404C, Paper
Tatiana P. Gerasimova, Almaz A. Zagidullin, Anastasiia N. Nikolaeva, Robert R. Fayzullin, Aliya M. Saitova, Vasili A. Miluykov, Stefan Grimme, Sergey A. Katsyuba
Keto-enol transformations of 6-R-3-hydroxy-2-pyrazinecarboxamides in solutions are accompanied by deprotonation of enol tautomers and the formation of corresponding anionic species. The key factors determining these processes have been identified.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Stereoselective Synthesis of gem-Dihalopiperidines via Halo-Aza-Prins Cyclization Reaction: Access to Piperidin-4-ones and Pyridines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00338A, Paper
Anil Kumar Saikia, Surjya Kumar Bora, Subhamoy Biswas, Bipin Kumar Behera
An efficient methodology for the synthesis of 4,4-dihalopiperidine derivatives has been developed from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide and aldehyde catalyzed by In(OTf)3 in excellent yields. The reaction involves an initial formation of six...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent advances in spirocyclization of maleimides via transition-metal catalyzed C–H activation

Org. Biomol. Chem., 2024, 22,2916-2947
DOI: 10.1039/D3OB01904G, Review Article
Swadhin Swaraj Acharya, Sagarika Patra, Rojalini Maharana, Manaswini Dash, Liza Mama Barad, Bibhuti Bhusan Parida
In recent years, the maleimide scaffold has received a great deal of attention in C–H activation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00274A, Communication
Gaurav Jaiswal, Subhas Chandra Pan
BBr3 mediated dearomative spirocyclization of biaryl ynones has been reported for the direct synthesis of spiro[5.5]dienones with a tri-substituted double bond.
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Photoproperties of Favipiravir and their 6-Substituted Analogues: Fluorescence Controlled through Halogen Substitution and Tautomerism

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00397G, Paper
Angel H Romero, Marcos Couto, Ivan E Romero, German Fuentes, Matías N. Möller
Herein, we showed the photophysical properties of the favipiravir and their 6-substituted analogues. Also, we interpreted the origin of the fluorescence of the favipiravir and their 6-substituted analogues as function...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00610K, Communication
Chandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali Nair
We hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Getting Started with CSS Shapes: Wrapping content around custom paths

Using CSS Shapes we can create experiences that we have never been able to create on the web before.




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Rolling out Public Key Pinning with HPKP Reporting




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History API: Scroll Restoration




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Updates to the service worker cache API




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Piloting through the pandemic

How AirAsia India innovated with a distance-learning training programme for its cockpit crew




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As the price of aviation turbine fuel soars, airlines’ finances spin out of control




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Pick the rear seats to fly safe

Passengers who pick a seat near the tail of an aeroplane are more likely to survive a crash




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Deep tech is helping airlines sustain operations during Covid

Integrated biometric-enabled frameworks for real-time test results, travel details and vaccine status are key to making air travel safe




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Profits offer hope of soft landing to Spicejet

Apart from swift settlement with former owners, the airline urgently needs an immediate infusion of cash




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Do pilots really need to be good at maths?

Being accurate with calculations can never go wrong




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UDAN flies high despite the odds

The scheme has made short commutes via flight accessible to over 92 lakh people




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Mishandled baggage rates spike

Transfer bags continue to account for most mishandled bags




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Yoke vs. sidestick: Jury still out on what works best for pilots

Why do Airbus commercial aircraft have sidesticks and Boeing have yokes as control units?




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Blockchain: Piloting the future of aviation

Enables effective solutions that positively impact industry players and end consumers




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Global shipping lines look skywards

Container carriers launch freighters to offer integrated services and expand their transport offerings




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Why has private capital not been taken to Indian aviation 

With banks becoming increasingly cautious and credit flows tightening, private capital must be explored and enticed




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Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




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GitHub unveils multi-model Copilot, Spark for AI developers

Anthropic’s Claude 3.5 Sonnet will be available via GitHub Copilot starting today and Google’s Gemini 1.5 Pro will be available in the coming weeks




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Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




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Out-of-pocket expenditure on health in Kerala is highest in country despite increased State investments

National Health Accounts figures show the per capita out-of-pocket expenditure on health in Kerala stands at ₹7,889. However, Kerala also tops the list when it comes to the per capita government spending on health, at ₹4,338




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Rapid assessment of pulse polio campaign shows high vaccine coverage, highlights gaps in Chennai

Chennai accounted for nearly 21% of the non-vaccinated children, highlighting the gaps in an urban area and the need for targeted community outreach




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Centre eyes ‘presumed consent’ for cornea retrieval in hospital deaths

THOTA may be amended to facilitate retrieval of cornea from all Indians who die in hospitals, without family consent. 




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OpenAI’s Whisper transcription tool used in hospitals invents things no one ever said, researchers claim

Whisper is a popular transcription tool powered by artificial intelligence, but it has a major flaw




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Air passenger with suspected mpox symptoms isolated at Tiruchi govt. hospital

When contacted, a senior hospital official told The Hindu that the patient’s blood sample has been sent for further testing




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National Task Force files interim report on safety measures for hospital staff

NTF report has suggested short term, medium, and long term measures to protect doctors and medical staff in their workplaces.




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WATCH Seepi Sing Sabki Baaratein Aayi 2!

'There was this music director who approached me for a song. He called me to his house for practice.''I took my mother with me and I felt he did not like that.''It took me a while to gauge his intentions.''That really scarred me.'




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'I Don't Preach About Keeping Two Wives'

'My primary reason to participate was -- and I told my wives as well -- that the three of us would live happily together on the show and create history. We would make sure that people remember us for the longest time.'