Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity.

Linda McMahon is running for the US Senate in Connecticut. For twenty (20) years, she ran World Wrestling Entertainment (WWE) with her husband, Vince McMahon. A few years ago, a documentary film examined the WWE's celebration of violence against women. Her campaign doesn't want Connecticut voters to see that film. Watch these excerpts from the film to see why. Continue reading →

Senator Max Baucus, Chairman of the U.S. Senate Committee on Finance, releases a staff discussion draft on international business tax reform. Continue reading →

Hillary Faces Questions About Cash Donations to Clinton Foundation. Continue reading →

"I think I'm the only candidate who's prepared to take on the billionaire class," Sanders, I-Vt., told ABC's George Stephanopoulos on "This Week." "We need a political revolution in this country involving millions of people who are prepared to stand up and say, enough is enough, and I want to help lead that effort." Continue reading →

The response of Senator Richard Blumenthal to my letter in opposition to the Trans-Pacific Partnership (TPP). Ask yourselves how American labor can compete against Vietnamese workers earning on average $0.56 per hour. Continue reading →

The Senate considered H.R. 1314, the legislative vehicle for trade promotion authority reauthorization.?It would give the president broad fast-track authority when negotiating trade agreements and require Congress to consider treaties without an amendment process. Senator Bernie Sanders speaks out against this bill before the Senate on May 12, 2015. Continue reading →

CNN Brianna Keilar interviews Senator Bernie Sanders on State of the Union May 17 2015. Senator Bernie Sanders says the American people want and deserve a serious debate on the serious issues facing our country today instead of merely the same old, endless 30 second, ad hominem, attack ads. Continue reading →

The Vermont senator and presidential candidate talks to Chris Hayes about his differences with Hillary Clinton and the prospects for his presidential candidacy. Continue reading →

Senator Bernie Sanders does not think that Hillary Clinton can stand up and fight for the middle class. Continue reading →

Read the text of Senator Bernie Sanders bill to make college tuition free for students and to be financed by a tax on Wall Street speculation. WASHINGTON, May 19 – Sen. Bernie Sanders (I-Vt.) today introduced legislation to make 4-year public colleges and universities tuition free. “We live in a highly competitive global economy. If our economy is to be strong, we need the best educated work force in the world. That will not happen if every year hundreds of thousands of bright young people cannot afford to go to college and if millions more leave school deeply in debt,” Sanders said. Under the legislation, $70 billion a year in assistance – two-thirds from the federal government and one-third from states – would replace what public colleges and universities now charge in tuition and fees. The federal share of the cost would be offset by imposing a tax on Wall Street transactions by investment houses, hedge funds and other speculators. The legislation also would overhaul student loan programs so students and their parents could reduce crushing debt loads which now exceed Americans’ credit card debt. Federal profits on loans would be eliminated, work-study programs expanded and incentives offered for colleges and universities to keep costs down. “We once led the world in the percentage of our people with a college degree, now we are in 12th place.” Sanders said. “Countries like Germany, Denmark, Sweden and many more are providing free or inexpensive higher education for their young people. They understand how important it is to be investing in their youth. We should be doing the same,” he added. Tuition at 4-year public colleges and universities rose by 50 percent in the United States during the past decade. As state governments have cut support for higher education, the burden has shifted to students and their parents. With this spring’s college commencement season underway, the class of 2015 is the most indebted class in American history, according to Mark Kantrowitz, publisher of Edvisors, a website on college costs and financial aid. Continue reading →

Presidential candidate Bernie Sanders says he wants to offer tuition free at public colleges and universities, paid for with a new tax on Wall Street. Ed Schultz and Sanders discuss the senator’s proposal. Continue reading →

THE AMERICAN PEOPLE IN THIS PARTICULAR MOMENT IN OUR HISTORY MUST MAKE A VERY FUNDAMENTAL DECISION, AND THAT DECISION IS DO WE CONTINUE THE STATUS QUO WHICH INCLUDES A 40-YEAR DECLINE OF OUR MIDDLE CLASS AND A HUGE AND GROWING GAP BETWEEN THE VERY, VERY RICH AND EVERYONE ELSE, OR DO WE FIGHT FOR A BOLD AND MEANINGFUL ECONOMIC AGENDA THAT CREATES JOBS, RAISES WAGES, PROTECTS OUR ENVIRONMENT AND PROVIDES HEALTH CARE FOR EVERY AMERICAN Continue reading →

SANDERS: ... there is more coverage about the political gossip of a campaign, about raising money, about polling, about somebody saying something dumb, or some kid works for a campaign sends out something stupid on Facebook, right? We can expect that to be a major story. But what your job is, what the media's job is, is to say, look, these are the major issues facing the country. We're a democracy. People have different points of view. Let's argue it. Continue reading →

Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading →

“Thank you all very much for being here and for all the support that you have given me over the years: as the mayor of this great city, as Vermont’s only congressman and now as a U.S. senator. Thanks also … Continue reading →

Pulitzer Prize-winning reporter James Grimaldi of The Wall Street Journal, who has covered the Clinton Foundation for years, looks at the relationship between the Clinton Foundation and the State Department during Hillary Clinton’s time as secretary of state, and what it would be if she became president. Newly released State Department emails include exchanges between top members of the Clinton Foundation and Clinton’s top State Department advisers, including Huma Abedin and Cheryl Mills. The FBI reportedly wanted to investigate the Clinton Foundation earlier this year, but U.S. Attorney General Loretta Lynch pushed back. Continue reading →

"And you know, we have to stop looking beyond this election cycle and see that this corporate driven ideology, you know, this commodification of the culture, this constant extracting of blood from us as citizens to pay what in essence were private debts of the banks which engaged in casino capitalism, has political consequences. History has taught us that. And Hillary Clinton is only going to further that process." Continue reading →

Questions surrounding Hillary Clinton and the Clinton Foundation continue to grow. On Sunday, Democratic National Committee interim chairperson Donna Brazile defended Clinton’s meetings as secretary of state with Clinton Foundation donors, saying, "When Republicans meet with their donors, with their supporters, their activists, they call it a meeting. When Democrats do that, they call it a conflict." Donna Brazile’s comments come in response to an Associated Press investigation revealing that while Hillary Clinton served as secretary of state, more than half of the private citizens she met with during the reporting period had donated to the Clinton Foundation. The AP investigation comes after a three-year battle to gain access to State Department calendars. The analysis shows that at least 85 of 154 people Hillary Clinton had scheduled phone or in-person meetings with were foundation donors. We speak to Pulitzer Prize-winning journalist Glenn Greenwald of The Intercept. His most recent piece is headlined "Why Did the Saudi Regime and Other Gulf Tyrannies Donate Millions to the Clinton Foundation?" Continue reading →

The Democratic National Committee is controlled by its big corporate donors. Tom Perez was recruited to defeat progressive Keith Ellison to keep the Democratic Party in the coffers of its corporate donors. Ellison's defeat as head of the DNC was a hit job by the corporate machine within the DNC. Continue reading →

NEWS 8 IS YOUR LOCAL ELECTION HEADQUARTERS…. AND TONIGHT…VOODOO ECONOMICS! CHIEF POLITICAL CORRESPONDENT MARK DAVIS TELLING US HOW REPEALING THE STATE INCOME TAX IS THE LATEST HEATED TOPIC BETWEEN THE CANIDATES FOR GOVERNOR.   DEMOCRAT NED LAMONT IS OPENING A … Continue reading →

"Leaves Of Yesteryear", новый альбом группы GREEN CARNATION, доступен для прослушивания ниже. Эта работа вышла 8 мая на Season Of Mist.

Трек-лист:

"Leaves Of Yesteryear"
"Sentinels"
"My Dark Reflections Of Life And Death"
"Hounds"
"Solitude" #Green_Carnation #GreenCarnation #ProgressiveRock #Progressive_Rock #AcousticRock #Acoustic_Rock #ProgressiveMetal #Progressive_Metal

An updated Disaster Resilience Scorecard to help cities and local government agencies improve their preparedness and reduce risks from disasters was launched today at the Global Platform for Disaster Risk Reduction. Developed for the UN Office for Disaster Risk Reduction by AECOM, IBM with support from USAID and the European Commission, the Scorecard gives better access to information, knowledge resources, and tools to effectively reduce risks from the impacts of natural hazards and climate change.

DC made a good choice in moving away from Diamond.

The post The Coronavirus Journal: Alternative Distribution Will Help Us Survive appeared first on The Beat.

IBM today announced the first clients to tap into its IBM Q™ early-access commercial quantum computing systems to explore practical applications important to business and science. They include: JPMorgan Chase, Daimler AG, Samsung, JSR Corporation, Barclays, Hitachi Metals, Honda, Nagase, Keio University, Oak Ridge National Lab, Oxford University and University of Melbourne.

Today IBM and Eurobank announced the first cloud-based digital platform for online international commercial trading. Using IBM's industry-leading Digital Experience software, with advanced cloud capabilities and social offerings, Eurobank is uniting exporters and importers from around the globe to enhance international trade operations and increase transactions.

IBM today announced a new IBM Cloud Private software platform to help companies unlock billions of dollars in technology investment in core data and applications and extend cloud-native tools across public and private clouds.

[Image: Der Wanderer über dem Nebelmeer by Caspar David Friedrich (c. 1818).] It would be interesting to look at locations of the American popular imagination, as seen in movies and TV, mapped against regional tax breaks for the film industry. There was a brief span of time, for example, when rural Pennsylvania stood in for … Continue reading "Tax Incentives and the Human Imagination"

IBM today announced a new agreement with Walgreens, one of the country’s largest drugstore chains, to deploy IBM retail analytics at more than 8,100 locations nationwide to help improve the efficiency of field service support for these locations.

IBM y organizaciones aliadas lanzaron la iniciativa global 'Call for Code', el esfuerzo más grande y ambicioso para reunir a desarrolladores del sector académico y empresarial, para resolver uno de los problemas más acuciantes de la sociedad de nuestro tiempo: prevenir, responder y recuperarse de desastres naturales.

IBM today announced that as part of its Celebration of Service, designed to allow employees, retirees, clients and business partners to donate their time and expertise during the company's Centennial year, 300,000 IBMers around the world -- close to three quarters of its global workforce -- are volunteering in more than 5,000 projects in 120 countries, meeting civic and societal challenges and serving millions in need.

IBM has implemented a cloud-based enterprise mobility management and security solution at Arrow International.

Rakon has selected the IBM Storwize V7000 SAN as part of a strategic storage upgrade to meet the needs of its rapidly expanding international quartz crystal manufacturing business.

Australia’s largest 100% family-owned meat processor, Thomas Foods International, and largest independent grocery retailer, Drakes Supermarket have signed on as members to the blockchain-based food ecosystem solution, IBM Food Trust™. The successful pilot can trace the entire lifecycle of a food product, from region to plate, and update the record in real-time.

IBM (NYSE: IBM) today announced the IBM National Cyber Security Centre in Canberra (NCSC). The NCSC aims to foster greater collaboration with government and business aligned to Australia’s new national Cyber Security Strategy. IBM has appointed Kevin Zuccato, one of Australia’s most experienced cyber security experts to lead the NCSC, where he will oversee a team of cyber security specialists. The team will work within Australia’s cyber security eco-system to ensure a strategic and proactive approach to cyber resilience.

IBM (NYSE: IBM) today announced it has been awarded a $23.6M dollar contract with the National E-Health Transition Authority (NEHTA) to design and build Australia’s National Authentication Service for Health (NASH) project.

IBM (NYSE: IBM) today announced it will establish a Natural Resources Solution Centre (NRSC) in Perth to help mining, LNG and petroleum companies accelerate the development and adoption of innovative technologies and business strategies.

dollypopinspiration:

nanushka

Open space with natural light in the Lousiana Museum of Modern Art ✨ via

@mariavannguyen

This Thursday (4/9), eighteen authors (including yours truly!) will be doing live readings to celebrate International Unicorn Day!!! At 10:30am ET, I'll be on Facebook Live on my author page here: https://www.facebook.com/sarahbethdurst

And I may be wearing a unicorn onesie... 

There was a time – before I sank my teeth into the board game hobby and before I took on the demands of being a stepmom to three children - that I planned frequent trips for my friends circle. Each month would see us jet setting off to a different part of the United States (or a different part of the world) in search of adventure and great cuisine. I would pour myself into the research project that proper trip planning requires and create a custom itinerary for our group, working to ensure we caught all the highlights of our destination. This post is about the one I worked up for our last trip to some of the great Western National Parks in the United States.  I share it here with the hope that you might find the itinerary useful in planning your trip out west.

--> Full Photo Gallery – Come and Explore 

On March 31, the volunteer computing part of SETI@home will stop distributing work and will go into hibernation.

We're doing this for two reasons:

1) Scientifically, we're at the point of diminishing returns; basically, we've analyzed all the data we need for now.

2) It's a lot of work for us to manage the distributed processing of data. We need to focus on completing the back-end analysis of the results we already have, and writing this up in a scientific journal paper.

However, SETI@home is not disappearing. The web site and the message boards will continue to operate. We hope that other UC Berkeley astronomers will find uses for the huge computing capabilities of SETI@home for SETI or related areas like cosmology and pulsar research. If this happens, SETI@home will start distributing work again. We'll keep you posted about this.

If you're currently running SETI@home on your computer, we encourage you to attach to other BOINC-based projects as well. Or use Science United and sign up to do astronomy. You can stay attached to SETI@home, of course, but you won't get any jobs until we find new applications.

We're extremely grateful to all of our volunteers for supporting us in many ways during the past 20 years. Without you there would be no SETI@home. We're excited to finish up our original science project, and we look forward to what comes next.

CEOs of the major Wall Street banks have been summoned to the White House to discuss the coronavirus...

To the women from all over the world I'm privileged to know, and everybody who loves international women.

I have been saving up some articles for the occasion: here are two marvellous bios of trans lesbian elders.

Jan Morris. [Content note: the article is in the Guardian which takes a somewhat transphobic editorial stance, though this article is very positive towards trans women. However it does deadname Morris and includes a picture of her from back when she was presenting as male.]

Sandy Stone, a couple of years old from Vice but it came to my attention recently.

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So, I ordered a bunch of native plants on Etsy, and they were WAY cheaper than they are in stores around here. They came as chunks of root, essentially. It only occurred to me after I ordered to worry about why they were so cheap — is it possible they’re being illegally harvested from woodlands? … Continue reading "Native Plants From Etsy"

This is the Call for Nominations for the 2019 Theszie Awards (the rec.sport.pro-wrestling Awards). To nominate candidates for all categories, you may use this form. Nominations are due by January 5, 2019. Finally, to see previous years’ results, click here for 2018, click here for 2017, here for 2016, here for 2015, here for 2014, […]

1. ICMR partners with Bharat Biotech International Limited for developing indigenous coronavirus COVID-19 vacc...  Zee News
2. Bharat Biotech to lead monoclonal antibodies project for Covid-19 therapy  The Financial Express
3. Bharat Biotech to lead project on monoclonal antibodies therapy for COVID-19  The New Indian Express
4. ICMR teams up with Bharat Biotech to develop Covid-19 vaccine  Times of India
5. CSIR approves project to develop human monoclonal antibodies that can neutralize COVID-19 in patients  Times Now
6. View Full coverage on Google News

A new play by Nick Dear, based on the novel by Mary Shelley. Watch Danny Boyle’s monster hit Frankenstein with Benedict Cumberbatch as the creature and Jonny Lee Miller as Victor Frankenstein. Frankenstein with Benedict Cumberbatch as the creature is streaming for free from 7pm UK time on Thursday 30 April. Available on demand until […]