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Mathematica @ 50: At the Intersection of Data Science and Social Science

In 1968, Mathematica led the nation’s first major social research experiment, helping to spur a revolution in the application of social science to public policies and programs. For more than four decades, social scientists have revised and refined those methods, but the gold standard for research remained much the same.




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40 Years of Evidence for Action at APPAM and in the Field

In a special super session at APPAM’s 40th Fall Research Conference, APPAM president-elect Matt Stagner joined a roundtable discussion with industry CEOs who are working to apply insights from our modern data revolution to social science questions and challenges that have spanned generations. Abt Associates CEO Kathleen Flanagan, Impaq International CEO Avi Benus, Mathematica CEO Paul Decker, MDRC president Gordon Berlin, and Urban Institute President Sarah Rosen Wartell shared the most important lessons from their work to advance evidence-based policy, as well as the critical challenges and emerging trends in policy analysis and program improvement.




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Understanding How HomVee Prioritizes Home Visiting Models for Review




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New Evidence of the ACA’s Effect on People with Disabilities: Health Insurance, Employment, and Benefits

The Patient Protection and Affordable Care Act (ACA) of 2010 changed several aspects of the law concerning access to health insurance that were particularly salient for people with disabilities. These changes included removing limits on preexisting conditions, extending parent’s health insurance coverage of young adults until the age of 26, expanding Medicaid to more adults with low incomes, and making it easier to obtain affordable coverage outside the traditional employer-sponsored benefit system.




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Webinar: Learning Together to Prevent Homelessness for Youth and Young Adults with Child Welfare Involvement




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Webinar: Preparing Leaders to Make a Difference for Students and Schools

Recognizing that school leaders play a critical role in school performance, states and districts are rethinking how they prepare principals. But this retooling of preparation programs raises a number of important questions: What skills do new principals need? How can we identify aspiring principals with the potential to develop those competencies? And how can we use these insights to improve the training of leaders at all levels of the system, from teacher leaders to principal supervisors?




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Serving Medicaid Beneficiaries Who Need Long-Term Services and Supports: Better Outcomes at Lower Costs

In the past two decades, many federal and state Medicaid initiatives have been designed to rebalance the long-term services and supports (LTSS) system by increasing access to home and community-based services (HCBS) in order to reduce the use of expensive institutional care.




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Understanding the Power of Long-Term Impact Evaluations

International development programs are designed to make lasting and positive improvements in the health, education, and income of disadvantaged people around the world.




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A Framework for Educational Equity and Culturally Responsive Pedagogy

This webinar defined educational inequity and discussed its implications. It included a brief introduction to culturally responsive pedagogy and what broader systemic changes may be necessary to implement equity and culturally responsive pedagogy.




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Research and Practice in Culturally Responsive Pedagogy and How to Sustain Systemic Changes

This webinar explored research on culturally responsive pedagogy and what is known about its effectiveness.




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Implementing District and School Policies and Practices to Support Culturally Responsive Pedagogy

This webinar explored how a school and district have approached the challenge of implementing culturally responsive practice. It elaborated on programs, policies, and practices that were implemented to support efforts to achieve equity and use culturally responsive pedagogy.




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Join Us and Partners for a Grantmakers for Education Webinar—Making the Case: Establishing Evidence to Support Practitioners, Strategy, and Outcomes

Interested in learning how to build more evidence into philanthropic practice? Join Mathematica, The Wallace Foundation, and the Afterschool Alliance for a Grantmakers for Education webinar.




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Sign Up for a Free Webinar on Improving Attendance in Pre-Kindergarten and Kindergarten

Chronic absenteeism is particularly high in the early grades, compared with elementary and middle school. For a young child to succeed and develop a strong foundation for learning, he or she must attend school regularly.




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Free Webinar: How States, Districts, and REL Mid-Atlantic Partner to Create New Diagnostic Measures Using Existing Data

This webinar highlights three research-to-practice partnerships between state and local policymakers and the Regional Educational Laboratory Mid-Atlantic to address this challenge, connecting educators and policymakers with researchers who provide analytic support and help education agencies build capacity to conduct their own analyses.




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Learning Remotely in the Age of COVID-19: Lessons from Evidence and Concerns for Equity

The spread of COVID-19 has caused schools and districts across the country to shutter their doors. States, districts, and schools must suddenly and unexpectedly grapple with the new reality of providing a quality education to every student remotely.




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Supporting Pre-K to Grade 3 Children and Their Learning Partners at Home

This webinar will review the research on the home and parenting characteristics that support young children’s learning.




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Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD)

Chem. Commun., 2020, 56,4922-4925
DOI: 10.1039/D0CC00513D, Communication
Zhongyan Wang, Chuanrui Ma, Yuna Shang, Lijun Yang, Jing Zhang, Cuihong Yang, Chunhua Ren, Jinjian Liu, Guanwei Fan, Jianfeng Liu
An ingenious co-assembled nanosystem based on fenofibrate and ketoprofen peptide for the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses.
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Photochemical α-carboxyalkylation of tryptophols and tryptamines via C–H functionalization

Chem. Commun., 2020, 56,4930-4933
DOI: 10.1039/D0CC00847H, Communication
Zhiqiang Pan, Yuchang Liu, Fengchi Hu, Qinglong Liu, Wenbin Shang, Chengfeng Xia
A process for the α-carboxyalkylation of tryptophols and tryptamines by the functionalization of C–H bonds under visible light irradiation has been developed.
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Noncovalent structural locking of thermoresponsive polyion complex micelles, nanowires, and vesicles via polymerization-induced electrostatic self-assembly using an arginine-like monomer

Chem. Commun., 2020, 56,4954-4957
DOI: 10.1039/D0CC00427H, Communication
Qingqing Zhao, Qizhou Liu, Chao Li, Lei Cao, Lei Ma, Xiyu Wang, Yuanli Cai
The noncovalent locking of nanostructured thermoresponsive polyion complexes can be achieved via polymerization-induced electrostatic self-assembly (PIESA) using an arginine-like cationic monomer.
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Synthesis of chiral α-substituted α-amino acid and amine derivatives through Ni-catalyzed asymmetric hydrogenation

Chem. Commun., 2020, 56,4934-4937
DOI: 10.1039/D0CC01220C, Communication
Gongyi Liu, Xianghe Zhang, Heng Wang, Hengjiang Cong, Xumu Zhang, Xiu-Qin Dong
Efficient Ni-catalyzed asymmetric hydrogenation of cyclic N-sulfonyl ketimino esters and ketimines was successfully developed to prepare a series of chiral α-monosubstituted α-amino acid derivatives and amine derivatives with excellent results.
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Nonlinear organic–inorganic halide hybrids containing unprecedented linear [MIX2]− coordination units and quasi-two-dimensional lone pairs

Chem. Commun., 2020, 56,4894-4897
DOI: 10.1039/D0CC01532F, Communication
Qi Wu, Xian Liu, Yeshuang Du, Chunlin Teng, Fei Liang
A first example of monovalent-metal-based hybrid halides [N(CH3)4]MCl2 (M = Ga+, In+) with zero-dimensional configuration containing unprecedented linear [GaCl2]/[InCl2] units have been designed and synthesized.
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A heteroleptic diradical Cr(III) complex with extended spin delocalization and large intramolecular magnetic exchange

Chem. Commun., 2020, 56,4906-4909
DOI: 10.1039/D0CC00548G, Communication
Xiaozhou Ma, Elizaveta A. Suturina, Mathieu Rouzières, Fabrice Wilhelm, Andrei Rogalev, Rodolphe Clérac, Pierre Dechambenoit
Ligand-based successive reductions in a heteroleptic Cr(III) complex give rise to intended extremely strong metal–radical magnetic interactions.
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Oxyanion transport across lipid bilayers: direct measurements in large and giant unilamellar vesicles

Chem. Commun., 2020, 56,4910-4913
DOI: 10.1039/C9CC09888G, Communication
Krzysztof M. Bąk, Bartjan van Kolck, Krystyna Maslowska-Jarzyna, Panagiota Papadopoulou, Alexander Kros, Michał J. Chmielewski
A simple, carbazole-based dithioamide receptor transports a variety of biologically relevant anions through lipid bilayers, as shown by direct fluorescent assays in LUVs and GUVs.
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The design of hypercrosslinked polymers from benzyl ether self-condensing compounds and external crosslinkers

Chem. Commun., 2020, 56,4938-4941
DOI: 10.1039/D0CC01002B, Communication
Robert T. Woodward
Hypercrosslinked polymers were produced via the self-condensation of benzyl ether compounds, providing a one-component route to highly porous networks and significant reductions in catalyst waste compared to conventional routes.
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A convenient reagent for the conversion of aldoximes into nitriles and isonitriles

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC00188K, Communication
Wei Zhang, Jin-Hong Lin, Pengfei Zhang, Ji-Chang Xiao
Described herein is the convenient transformation of aldoximes into nitriles or isonitriles by slightly modifying reaction conditions.
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Host-guest interaction based supramolecular photodynamic therapy system: a promising candidate in the battle against cancer

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02001J, Feature Article
Kui Yang, Zhihua Zhang, Jie Du, Wei Li, Zhichao Pei
Owing to its spatiotemporal selectivity and noninvasive nature, photodynamic therapy (PDT) has become a promising approach for the treatment of cancer. However, the non-targeting capability and the accompanying side effects...
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Fluorescent Molecular Logic Gates based on Photoinduced Electron Transfer (PET) Driven by a Combination of Atomic and Biomolecular Inputs

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC00478B, Communication
Open Access
Glenn Wright, Chaoyi Yao, Tom Moody, A. P. De Silva
Molecular AND logic gates 1, 3, 5 and 7, which are designed according to principles of photoinduced electron transfer (PET) switching, respond to co-existing Candida antarctica lipase B and H+...
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Deep imaging for visualizing nitric oxide in lipid droplets: discovering the relationship between nitric oxide and resistance to cancer chemotherapy drugs

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01856B, Communication
Miantai Ye, Wei Hu, Meng He, Chenchen Li, Shuyang Zhai, Zhihong Liu, Yanying Wang, Huijuan Zhang, Chunya Li
A near-infrared two-photon fluorescent probe for selective detection and deep-depth imaging of NO helps to discover the relationship between NO and resistance to antitumor drugs.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Smart azobenzene-containing tubular polymersomes: fabrication and multiple morphological tuning

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01934H, Communication
Lishan Li, Songbo Cui, An Hu, Wei Zhang, Yiwen Li, Nianchen Zhou, Zhengbiao Zhang, Xiulin Zhu
Several kinds of novel azobenzene-containing tubular polymersomes were fabricated via self-assembly, and their shape could be tuned precisely by changing the chemical structure, self-assembly condition and external stimuli.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A highly active and robust iron quinquepyridine complex for photocatalytic CO2 reduction in aqueous acetonitrile solution

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01930E, Communication
Yanfei Qin, Lingjing Chen, Gui Chen, Zhenguo Guo, Lei Wang, Hongbo Fan, Marc Robert, Tai-Chu Lau
[Fe(qnpy)(H2O)2]2+ is a highly efficient and robust catalyst for visible-light-driven reduction of CO2 to CO, with a TON for CO of up to 14 095 and selectivity of 98% using Ru(phen)3Cl2 as photosensitizer and BIH as sacrificial reductant.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A radical-mediated 1,3,4-trifunctionalization cascade of 1,3-enynes with sulfinates and tert-butyl nitrite: facile access to sulfonyl isoxazoles

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01659D, Communication
Xin Yue, Ming Hu, Xingyi He, Shuang Wu, Jin-Heng Li
An unprecedented indium-promoted three-component 1,3,4-trifunctionalization cascade of 1,3-enynes with sulfinates and tert-butyl nitrite for producing 5-sulfonylisoxazoles via [3+2] annulation is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Catalytic cycle of carbohydrate dehydration by Lewis acids: structures and rates from synergism of conventional and DNP NMR

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01756F, Communication
Pernille Rose Jensen, Sebastian Meier
Structures and rates in the catalytic cycle of carbohydrate dehydration by Lewis acidic salt are determined through the systematic use of complementary NMR approaches.
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Generic high-capacity protein capture and release by pH control

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01250E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
G. Ferrand-Drake del Castillo, R. L. N. Hailes, Z. Adali-Kaya, T. Robson, Andreas Dahlin
A new and generic method for protein capture-release by polyelectrolyte brushes and pH control.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Three component hydroxyletherification and hydroxylazidation of (trifluoromethyl)alkenes: access to α-trifluoromethyl β-heteroatom substituted tertiary alcohols

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC02550J, Communication
Hao Zeng, Chuanle Zhu, Chi Liu, Yingying Cai, Fulin Chen, Huanfeng Jiang
The three component hydroxyletherification and hydroxylazidation reactions of (trifluoromethyl)alkenes are reported, providing various useful α-trifluoromethyl β-heteroatom substituted tertiary alcohols in high yields.
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A Caveat to Common Hemicyanine Dye Components and Its Resolution

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC01833C, Communication
Hyeon Jin Park, Chang Wook Song, Sourav Sarkar, Yong Woong Jun, Ye Jin Reo, Mingchong Dai, Kyo Han Ahn
Near-infrared-emitting hemicyanine dyes are widely used in activatable fluorescent probes for various biological analytes, which fact, on the contrary, poses a chemical stability issue along with photoinstability as shown here...
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Investigation of the cathodic interfacial stability of a nitrile electrolyte and its performance with a high-voltage LiCoO2 cathode

Chem. Commun., 2020, 56,4998-5001
DOI: 10.1039/D0CC00049C, Communication
Fang Xian, Jiedong Li, Zhenglin Hu, Qian Zhou, Chen Wang, Chenglong Lu, Zhongyi Zhang, Shanmu Dong, Chunbo Mou, Guanglei Cui
We adopted a SN based deep eutectic electrolyte with the SN as the only solvent and found that the high-state Co ion could be reduced by the SN solvent on the interface of the LiCoO2 electrode, causing a reverse phase change of the LiCoO2.
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para-Selective arylation and alkenylation of monosubstituted arenes using thianthrene S-oxide as a transient mediator

Chem. Commun., 2020, 56,5058-5061
DOI: 10.1039/D0CC00641F, Communication
Xiao-Yue Chen, Xiao-Xue Nie, Yichen Wu, Peng Wang
Using thianthrene S-oxide (TTSO) as a transient mediator, para-arylation and alkenylation of mono-substituted arenes have been demonstrated via a para-selective thianthrenation/Pd-catalyzed thio-Suzuki–Miyaura coupling sequence under mild conditions.
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Synthetic method, growth mechanism and electrochemical properties of PbSnS2 nanosheets for supercapacitors

Chem. Commun., 2020, 56,5062-5065
DOI: 10.1039/D0CC01011A, Communication
Yuhan Zeng, Hehe Huang, Shenhu Huang, Tongtong Jiang, Zekai Fang, Lin Li, Yuming Dai
Facile hydrothermally synthesized PbSnS2 nanosheets with various morphologies were developed to obtain high performance electrode materials for supercapacitors.
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Live cell fluorescent stain of bacterial curli and biofilm through supramolecular recognition between bromophenol blue and CsgA

Chem. Commun., 2020, 56,5014-5017
DOI: 10.1039/D0CC01643H, Communication
Lixia Zhang, Zhenhua Li, Zhijun Chen
A curli fluorescent light-up probe called bromophenol blue, which binds to curli via recognizing CsgA.
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The synergy between the CsPbBr3 nanoparticle surface and the organic ligand becomes manifest in a demanding carbon–carbon coupling reaction

Chem. Commun., 2020, 56,5026-5029
DOI: 10.1039/D0CC01339K, Communication
Ignacio Rosa-Pardo, Carla Casadevall, Luciana Schmidt, Miguel Claros, Raquel E. Galian, Julio Lloret-Fillol, Julia Pérez-Prieto
The cooperative action between the CsPbBr3 surface and capping makes the photoredox homo-/cross-coupling of benzyl bromides under mild conditions possible.
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Modulation of an intermediate layer between NiCoP and Ni foam substrate in a microwire array electrode for enhancing the hydrogen-evolution reaction

Chem. Commun., 2020, 56,4990-4993
DOI: 10.1039/D0CC01488E, Communication
Dan Guo, Huayu Chen, Hanmin Tian, Shuxin Ouyang, Jianbo Wang, Jun Lv
A strategy involving modulating the intermediate layer of an electrode was developed to promote the electrocatalysis kinetics of the electrode and therefore enhance its performance.
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Ring-opening iodination and bromination of unstrained cycloalkanols through β-scission of alkoxy radicals

Chem. Commun., 2020, 56,5002-5005
DOI: 10.1039/D0CC01720E, Communication
Jiang-Ling Shi, Yuankai Wang, Zixuan Wang, Bowen Dou, Jianbo Wang
Ring-opening iodination or bromination of unstrained cycloalkanols with NaI or NaBr and PhI(OAc)2 under visible light irradiation is developed.
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On-demand acid-gated fluorescence switch-on in photo-generated nanospheres

Chem. Commun., 2020, 56,4986-4989
DOI: 10.1039/D0CC01557A, Communication
Jordan P. Hooker, Florian Feist, Laura Delafresnaye, Federica Cavalli, Leonie Barner, Christopher Barner-Kowollik
Polymer particles are synthesized using a photo-active ortho-methyl benzaldehyde with a terminal alkyne for cross-linking. The reactive 1,4-dihydronaphthalene at every cross-linking point undergoes aromatisation to a fluorescent naphthalene upon exposure to acid.
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Halogen bonding for molecular recognition: new developments in materials and biological sciences

Chem. Commun., 2020, 56,4970-4981
DOI: 10.1039/D0CC00841A, Highlight
Gilles Berger, Pierre Frangville, Franck Meyer
This review highlights recent developments of halogen bonding in materials and biological sciences with a short discussion on the nature of the interaction.
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Improving the structural and cyclic stabilities of P2-type Na0.67MnO2 cathode material via Cu and Ti co-substitution for sodium ion batteries

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01442G, Communication
Xueping Zhang, Feilong Qiu, Kezhu Jiang, Ping He, Min Han, Shaohua Guo, Haoshen Zhou
An air-stable Na0.67Mn0.7Cu0.15Ti0.15O2 (NMCT) has been synthesized using a solid-state method. And it showed the excellent performance as a cathode material for sodium ion batteries.
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Facile construction of double network cross-linked luminescent supramolecular elastomer from hydrosilylation and pillar[5]arene host–guest recognition

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02214D, Communication
Rong Fu, Junying Zhang, Shaojie Liu, Xing-Dong XU, Shengyu Feng
Reticulated copolymer hosts pillar[5]arene crosslinked with poly(dimethylsiloxane) (PDMS) were synthesized for the facile construction of double network crosslinked elastomer upon noncovalently cross-linking with tetraphenyethylene (TPE)-based tetratopic guests through host-guest interactions....
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A combined viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02943B, Communication
Le Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung Kim
We report a novel fluorescent molecular conjugate V-M1 enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, well within the near-infrared therapeutic window. Tumor...
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Efficient generation of sulfate radicals in Fe (II)/S (IV) system induced by WS2 nanosheets and examined by its intrinsic chemiluminescence

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC01999B, Communication
Tong Sun, Yingying Su, Houjing Liu, Hongjie Song, Yi Lv
In this study, more 〖SO〗_4^( ∙-) and strong intrinsic chemiluminescence (CL) can be achieved through activating sulphite (〖SO〗_3^( 2-)) with ferrous ions (Fe2+) on the WS2 nanosheets with the thickness...
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Superstructural diversity in salt-cocrystals: higher-order hydrogen-bonded assemblies formed using U-shaped dications and with assistance of π(-)−π stacking

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02671A, Communication
Shweta P. Yelgaonkar, Daniyal Kiani, Jonas Baltrusaitis, Len R MacGillivray
Salt cocrystals with components that assemble by hydrogen bonds and aromatic anion-molecule stacks (π(−)−π stacks) are reported. U-shaped bipyridines and an isocoumarin carboxylic acid self-assemble to form 5-, 6-, and...
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Engineering of Decameric D-fructose-6-phosphate Aldolase A by Combinatorial Modulation of Inter- and Intra-subunit Interactions

Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02437F, Communication
Xiaohong Yang, Lian Wu, Aipeng Li, Lidan Ye, Jiahai Zhou, Hongwei Yu
Combinatorial modulation of inter- and intra-subunit interactions on decameric D-fructose-6-phosphate aldolase A (FSAA) generated a triple-site variant I31T/Q59T/I195Q FSAA with 27 to 278-fold activity improvement towards target heteroaromatic aldehydes. X-ray...
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