The public tours of the historic residence hadn't been overhauled in decades. For two years, the first lady's office has been working to make them more interactive and educational

The pachyderm, named Kamala, was suffering from osteoarthritis when zoo staff chose to euthanize her

The Art Gallery of New South Wales is showcasing works full of the Surrealist artist's signature motifs—such as apples, pipes and bowler hats—in addition to lesser-known pieces

The farthest spacecraft in the universe went momentarily rogue, but scientists breathed a sigh of relief when it reconnected at an unexpected radio frequency

Born October 30 to parents Gloria and Otto at the Edinburgh Zoo in Scotland, the hippo is already gaining popularity, following in the footsteps of viral sensation Moo Deng

Steve Lazarides' personal collection of prints, original works, handwritten press releases and burner phones sold at auction for around $1.4 million

On its 66th flyby of the king of planets, Juno has captured spectacular views of the stormy atmosphere, processed by citizen scientists

The beloved reptile in Australia died last weekend and was thought to be up to 120 years old, though that age is only an estimate. Research on his bones might reveal a more exact number

The viral king penguin chick at Sea Life Melbourne Aquarium is beginning to lose his youthful down, a process that will give him his distinctive and waterproof adult plumage

A new study has shattered historians' long-held assumptions about some of the people who died in Mount Vesuvius' eruption in 79 C.E.

Mary, a 54-year-old Asian elephant at the Berlin Zoo, is the “queen of showering,” but her companion Anchali seems to have figured out how to exploit that habit to play pranks

The team traveled from New Zealand to Tonga along a humpback highway to collect environmental DNA and raise awareness of the plight of the marine mammals

See photographs of the beautiful natural wonders from the Smithsonian Magazine Photo Contest

See images of the American flag captured by our readers.

In a twist befitting its pages, the satirical, anti-establishment publication that delivered laughs and hijinks to generations of young readers gets the respect it always deserved with a new museum exhibition

Dominic April fell in love with forging after his career in the military came to an end in 2015. Now operating a blacksmith studio near Quebec City, he hopes to help other veterans dealing with PTSD find creativity and purpose.

The Société de transport de Montréal (STM) has established a non-urgent text line for transit users to signal security issues in the Metro network.

Genetically encoded calcium indicators (GECIs) allow for the noninvasive evaluation of neuronal activity in vivo, and imaging GECIs in Drosophila has become commonplace for understanding neural functions and connectivity in this system. GECIs can also be used as read-outs for studying sleep in this model organism. Here, we describe a methodology for tracking the activity of neurons in the fly brain using a two-photon (2p) microscopy system. This method can be adapted to perform functional studies of neural activity in Drosophila under both spontaneous and evoked conditions, as well as during spontaneous or induced sleep. We first describe a tethering and surgical procedure that allows survival under the microscopy conditions required for long-term recordings. We then outline the steps and reagents required for optogenetic activation of sleep-promoting neurons while simultaneously recording neural activity from the fly brain. We also describe the procedure for recording from two different locations—namely, the top of the head (e.g., to record mushroom body calyx activity) or the back of the head (e.g., to record central complex activity). We also provide different strategies for recording from GECIs confined to the cell body versus the entire neuron. Finally, we describe the steps required for analyzing the multidimensional data that can be acquired. In all, this protocol shows how to perform calcium imaging experiments in tethered flies, with a focus on acquiring spontaneous and induced sleep data.

In insects, oocyte resorption (oosorption) or follicular atresia is one of the key physiological processes and evolutionary strategies used to optimize reproductive fitness. Mosquitoes are ideal model organisms for studying egg maturation in arthropods, as their follicle development is initiated only following the ingestion of a blood meal, followed by a carefully orchestrated series of hormonally regulated events leading to egg maturation. A cohort of approximately 100 follicles per mosquito ovary begin developing synchronously. However, a significant fraction of follicles ultimately undergo apoptosis and oosorption, especially when available resources from the blood meal are limited. Therefore, simple, rapid, and reliable techniques to accurately evaluate follicular atresia are necessary to understand mechanisms underlying follicle development in insects. This protocol describes how to detect apoptotic follicle cells within the Aedes aegypti mosquito ovaries using a commercially available fluorescent-labeled inhibitor of caspases (FLICA). Caspases are key players in animal apoptosis. In this assay, the FLICA reagent enters the intracellular compartment of follicles in dissected mosquito ovaries and covalently binds to active caspases. The bound reagent remains within the cell and its fluorescent signal can be observed by confocal microscopy. Although this method was specifically developed for visualizing apoptotic ovarian follicles during Ae. aegypti mosquito egg development, it should be applicable to other mosquito tissues that undergo caspase-mediated program cell death in a time-dependent manner.

Former Dawson City Mayor Bill Kendrick has filed his defence against the town's encroachment violation lawsuit.

Water quality guidelines for mercury are 0.02 micrograms per litre of water. Several results show that levels at four sites are far above that threshold. During the second week of October, one value close to the mine was more than seven times the acceptable level.

Paraglider Ben Lewis remembers spinning around wildly as he got pulled up higher and higher into the violent storm. That was when he realized, about 6,700 metres up in the sky and still rising, that he was not likely to see his family again.

A Whitehorse homeowner has been charged in connection with an explosion last year that destroyed his home and killed a man in a neighbouring house. 

The 1898 Wilmington massacre left dozens of Black North Carolinians dead. Conspirators also forced the city's multiracial government to resign at gunpoint

Send your best snaps and video from across the province to cbcnb@cbc.ca

Emergency officials said the fire at the Herring Pub and Restaurant on Water Street broke out around 4 p.m. and appears to have started in an air conditioning unit.   

New Brunswick’s Court of Appeal has reserved judgment in the case of a man found guilty of criminal negligence in the death of Fredericton teenager in 2018.

Inflation, an increase to the debt limit, and a series of mega-projects have been focuses of the municipal election in Regina.

Even as they fundraise for other community organizations, some legions across Canada are having trouble keeping their own lights on amid rising inflation and maintenance costs.

Hospice Northwest Services is inviting people to visit its third annual photography exhibit, "A Personal Lens on Grief." Here's what the project in Thunder Bay, Ont., entails, and why staff say it's important to find creative ways to express loss.

At 2,700 square kilometres, CFB Suffield is the largest military training area in Canada. It has been the site of military training in southern Alberta since 1972.

The Town of Kensington, P.E.I., has committed to implementing a new campaign to end gender-based violence.

The mayor of the eastern P.E.I. town of Three Rivers says comments on social media have become so 'aggressive' that council has decided to hold Tuesday night’s meeting virtually instead of in-person out of concerns for their own safety.

There is a sign of progress in the effort toward four-laning the final section of Highway 69 that links northern Ontario to the southern part of the province, and improving the safety of the heavily-travelled route.

A retired lawyer from Sault Ste. Marie has written a book that celebrates the working-class neighbourhood in which he grew up. The West End: A Magical Place Created by Giants is by Frank Sarlo, whose grandfather emigrated to Chicago from Italy, but ended up in Sault Ste. Marie with the promise of work on the railroad.

A missing 26-year-old Sagkeeng First Nation man has been found dead in the community of Fort Alexander, about 100 kilometres northeast of Winnipeg, Powerview RCMP say. Christian Letander's body was found Monday near the Winnipeg River.

Team Reid Carruthers has started the search for a new second after Derek Samagalski's decision to step back from the Winnipeg-based rink.

The City of Winnipeg wants security guards at the Millennium Library to receive a living wage, but councillors recently rejected a motion that would have made a living wage mandatory for all city staff and contractors.

Workers in Ontario are owed tens of millions of dollars in unpaid wages that the provincial government has yet to collect from employers, according to internal government records obtained by CBC Toronto.

Canada head coach Jesse Marsch has summoned 19 players, including York United FC teenager Shola Jimoh, to a camp in Toronto ahead of the full men's team gathering for the two-legged CONCACAF Nations League quarterfinal later this month against Suriname.

After nearly six complete seasons, the Canadian Premier League finds itself at an inflection point. Ahead of Saturday’s championship match, it appears there’s some stability — and, consequently, an opportunity to further establish the league’s place within the rapidly growing soccer landscape.

Cavalry FC defender Daan Klomp who considered quitting soccer in the Netherlands in 2020, will go after the Canadian Premier League title Saturday against defending champion Forge FC. And his trophy case may grow a little fuller Thursday at the CPL awards show.

Calgary's Cavalry FC could win its first Canadian Premier League championship on Saturday when it takes on Hamilton's Forge FC in front of a home crowd at ATCO field.

CPL commissioner Mark Noonan says the league is in discussions with groups in Edmonton, Laval, Que., Kelowna, B.C., Kitchener, Waterloo and Windsor, Ont., Quebec City, Saskatoon and the Toronto area.

Calgary’s Cavalry FC can finally call itself Canadian Premier League champions. Playing in front of its hometown crowd, Cavalry FC dethroned the four-time champions Forge FC from Hamilton 2-1 Saturday in Calgary.

Across Canada, there’s a growing number of political leaders proposing to force people into treatment for drug addiction, despite inconclusive evidence about its effectiveness.

A recent study out of the University of Calgary estimates that more than 10 million Canadians are being exposed to high levels of radon, an odourless, tasteless radioactive gas that is the second leading cause of lung cancer in the country.

A Saskatoon woman is accused of damaging multiple vehicles and assaulting a man with a baseball bat on Nov. 11.

Windsor Light Music Theatre's production of A Christmas Story: The Musical will feature sign language interpreters at the Nov. 22 show to make the entertainment accessible to those who are deaf or hard of hearing.

Wade Cudmore told the jury at his first-degree murder trial that he was not present when brothers Carlo and Erick Fryer were killed during a drug deal in May 2021.