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A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00193A, Paper
Yinsong Wu, Guanghao Shi, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Xiaobing Wu, Yongjia Shang, Xinwei He
We have developed a cascade annulation strategy triggered by rhodium(III)-catalyzed C–H activation for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines from free NH-sulfoximines with maleimides under mild conditions.
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Catalyst- and base-free visible light-enabled radical relay trihalomethylation/functional group-migration/carbonylation with CX3SO2Cl

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00292J, Paper
Jinkai Hu, Chenglei Yang, Xiaotao Qin, Hui Liu, Tongtong Ma, Ao-tong Shi, Qing-Long Lv, Xingman Liu, Jinhui Yang, Dianjun Li
A visible light-enabled photocatalyst-free radical trihalomethylation/cyano (or benzo[d]thiazol-2-yl) 1,4-migration/carbonylation reaction of 2-hydroxy-2-hex-5-enenitrile (or (benzo[d]thiazol-2-yl)-pent-4-enol) with CX3SO2Cl (X = F, Cl) is reported.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Reduction of sulfoxides catalyzed by the commercially available manganese complex MnBr(CO)5

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00204K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Daniel Leal Lourenço, Ana Cristina Fernandes
A new methodology for the reduction of a wide variety of aliphatic and aromatic sulfoxides catalyzed by the air-stable, cheap and commercially available manganese catalyst MnBr(CO)5 with excellent yields is...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
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Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00171K, Review Article
Bor-Cherng Hong, Ranadheer Reddy Indurmuddam
This review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00348A, Paper
Yong-Xiang Lü, Xinqian Wang, Ying-Ming Pan, Keyume Ablajan
A method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rolling out Public Key Pinning with HPKP Reporting




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Year-end blues for beleagued airlines

The results of IndiGo and SpiceJet hold clues to the mid-term future of the country’s airline industry




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Sustainable aviation fuels could be a game-changer

But adopting it in Indian aviation could take time




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Cabin crew with an invisible cape 

Being a cabin crew member is not a mere job, but an ineffable life experience




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Blockchain: Piloting the future of aviation

Enables effective solutions that positively impact industry players and end consumers




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5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




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Mission to Net Zero: Aviation’s focus on making sustainable connections 

Flying the cleanest, greenest, youngest fleet possible can be a way towards the goal 




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Why opening the emergency door mid-flight is not possible




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Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




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Hong Kong unveils responsible AI framework for financial sector

Hong Kong’s responsible AI framework comes amid increasing international competition and tensions affecting access to AI technology




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Apple AirPods Pro’s new hearing aid feature could help people face a problem they’d rather ignore

Millions who could benefit from hearing aids have never tried them, but the Apple AirPods could change this




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Indonesia bans sales of Google phones days after blocking Apple's iPhone 16

Indonesia said it has banned sales of smartphones made by Alphabet's Google due to rules requiring the use of locally manufactured components




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Rajasthan-based firm barred from making ‘Insulin’ homeopathic tablets

A licence for the manufacture of this product was cancelled; this follows a complaint from Kerala-based RTI activist K.V. Babu with the Prime Minister’s public grievance cell




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Trachoma eliminated as a public health problem in India; what next?

The achievement marks a significant public health victory and has profound economic implications. Trachoma’s impact, through blindness and visual impairment, results in an estimated economic loss of $2.9 to 5.3 billion annually due to reduced productivity




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For type 2 diabetes, focusing on when you eat – not what – can help control blood sugar

Time-restricted eating, also known as the 16:8 diet, became popular for weight loss around 2015. Studies have since shown it is also an effective way for people with type 2 diabetes to manage blood glucose




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Glioblastoma: why immunotherapy may offer hope for brain cancer patients

Recent trials have shown that immunotherapy can safely be delivered through injections into the cerebrospinal fluid; scientists are now exploring how to adapt these methods to penetrate the tumour more effectively




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'Once in a blue moon you get a lottery like Animal'

'It has never happened that all Top 5 songs on Spotify are from one film. On the Ormax list, the Top 9 are from Animal.''The music is good, sure. But everything has taken off with Animal the film.'




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'Nothing honorable about this killing'

'Find a name that changes the words honor killing and hopefully it includes the word murder.''If you use the words, you are trying to justify the murders.'




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'If you are brave, you're unstoppable'

'I remember that when I was about seven years old, a doctor saw me and told my family that I would only survive for six months and that the disease had no cure. But my mother never gave up. She would always say, 'My son is born to become a renowned wrestler'.'




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'I'm not blaming fathers, but...'

'I'm talking about that predator in your house, and how one should protect one's children from him.'




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The Man Behind Bollywood's Blockbuster Horror Films

'People worship Krishna. People don't worship Ved Vyas, who wrote the Mahabharata.''It's a cultural thing because we don't see the heroes behind the screen, we see the heroes who are in front of the screen.'




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UITableView in JavaScript, list view with re-usable cells using flexbox

If you’re familiar with iOS development you will know that a UITableView is very efficient when displaying a list of data. A simplification of what it does is display enough cells to fill the viewport plus a few more either side. As you scroll it re-uses cells that are now out of the viewport so … Continue reading "UITableView in JavaScript, list view with re-usable cells using flexbox"




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How can AI, ML skills help sharpen problem-solving abilities in children?

As the world is rapidly moving towards the evolving digital space, skills like problem-solving have become more important than ever. The entire market size of AI is projected to grow from USD 214.6 billion in 2024 to 1,339.1 billion in 2030 with a CAGR of 35.7%. In Today's scenario, skills like problem-solving are not just limited to professionals, it becomes crucial to teach kids how to think critically and creatively to steer through the complexities of modern life. This not only sharpens their abilities but also boosts innovation and helps develop young minds to use tools needed to solve real-world problems.




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Dubai siblings Jainam and Jivika who own JioHotstar domain, have THIS offer for Mukesh Ambani's Reliance

Dubai-based siblings have seemingly decided to offer the domain to Reliance free of charge, according to their website.




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How entrepreneurial innovation is helping HR solve complex problems

Players like Mynoticeperiod, Hackerearth, e-poise and Merajob are expected to play a role in changing the HR start-up ecosystem




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Stumbling at the last mile

In e-commerce, the quality of last mile connectivity determines who wins and who loses




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#BLChat : Of bell curves and appraisals

Missed BusinessLine's Twitter Chat on performance reviews? Read the Storify here!




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'Withholding' a problem in relationship building




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Goyal asks FCI officers to turn whistleblowers to curb corruption

The Food Minister says the role of FCI is not only to deliver ration, but also to instill confidence in farmers and beneficiaries by bringing in transparency, efficiency and accountability




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India may earmark $48 bln for next year's food, fertiliser subsidies

Food and fertiliser subsidies are expected to be increased in the Union Budget 2024, sources say




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Cheaper blueberries, cranberries, turkeys headed to India




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G-33 nations urge WTO members to find a permanent solution to public stockholding issue

A group of developing and least developed countries want WTO to find a solution to the issue of public stockholding of rice and wheat




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Will work faster to double income of farmers, says Agriculture Minister Shivraj Singh Chouhan

Shivraj Singh Chouhan has also been allocated the Rural Development Ministry in Prime Minister Narendra Modi's new Cabinet




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India needs to hike domestic fertiliser output to offset unstable market: Economist

Dr. Sitko warns that the West Asia and Ukraine situation will continue to impact fertiliser and oil prices. He urged reducing dependence on imported fertilisers and boosting domestic production




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‘The borderless Republic’: Sheffield celebrates migration

Britain’s largest festival about refugees and sanctuary is more relevant than ever, writes Lydia Noon.




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Smashing Conf: How to Use AI to Build Accessible Products

In her How to Use AI to Build Accessible Products presentation at Smashing Conf New York, Carie Fisher discussed using AI coding tools to test and suggest fixes for accessibility issues in Web pages. Here's my notes on her talk.

  • AI is everywhere. You can use it to write content, code, create images, and more. It impacts how everyone will work.
  • But ultimately, AI is just a tool but it might not always be the right one. We need to find the tasks where it has the potential to add value.
  • Over 1 billion people on the planet identify as having a disability. Accessible code allows them to access digital experiences and helps companies be complaint with emerging laws requiring accessible Web pages and apps. Businesses also get SEO, brand, and more benefits from accessible code.
  • AI tools like Github Copilot can find accessibility issues in seconds consistently, especially compared to the manual checks currently being done by humans. AI can also spot patterns across a codebase and suggest solutions.
  • Existing AI coding tools like Github Copilot are already better than Linters for finding accessibility issues.
  • AI can suggest and implement code fixes for accessibility issues. It can also be added to CI/CD pipelines to check for accessibility issues at the point of each commit. AI can also serve as an accessibility mentor for developers by providing real-time suggestions.
  • More complex accessibility issues especially those that need user context may go unfound when just using AI. Sometimes AI output can be incomplete or hallucinate solutions that are not correct. As a result, we can't over rely on just AI to solve all accessibility problems. We still need human review today.
  • To improve AI accessibility, provide expanded prompts that reference or include specifications. Code reviews can double check accessibility suggestions from AI-based systems. Regularly test and refine your AI-based solutions to improve outcomes.
  • Combing AI and human processes and values can help build a culture of accessibility.




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India: More trouble on the cards



  • M R Subramani

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Blown away, or not?

Dyson’s new soundless hairdryer has raked up a lot of noise, but is it worth the price tag?




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A bibliophile’s delight

A walk through the University of Leuven in Belgium throws up insights, brews and delicious food




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Pink goes royal blue

To live like a king — or a queen — take a trip to Jaipur, now being called the City of Palaces




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The Montblanc Summit 2 is ahead of its time

Montblanc Summit 2 comes with a range of features — and oozes style




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The Bloomsbury handbook of Hip Hop pedagogy [electronic resource] / edited by Lauren Leigh Kelly and Daren Graves

London : Bloomsbury Academic, [2024]