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Backstory Radio Presents: The American Indian Story

In October 2010, the hosts of Backstory visited Colonial Williamsburg's Kimball Theatre to perform a live show.




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Capsaicin—the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems

Food Funct., 2020, 11,2848-2860
DOI: 10.1039/D0FO00351D, Review Article
Muwen Lu, Chengyu Chen, Yaqi Lan, Jie Xiao, Run Li, Junqing Huang, Qingrong Huang, Yong Cao, Chi-Tang Ho
The mechanisms of bio-efficacy of capsaicin and delivery systems with enhanced bioavailability were reviewed.
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Untargeted metabolomics revealed therapeutic mechanisms of icariin on low bone mineral density in older caged laying hens

Food Funct., 2020, 11,3201-3212
DOI: 10.1039/C9FO02882J, Paper
Jie Huang, Yanping Hu, Xiaofeng Tong, Lei Zhang, Zhengwang Yu, Zhongxin Zhou
Untargeted metabolomics revealed the therapeutic effects and mechanisms of icariin on low bone mineral density in older caged laying hens.
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Purification, characterization and molecular cloning of a dicaffeoylquinic acid-hydrolyzing esterase from human-derived Lactobacillus fermentum LF-12

Food Funct., 2020, 11,3235-3244
DOI: 10.1039/D0FO00029A, Paper
Yujin Liu, Minhao Xie, Peng Wan, Guijie Chen, Chunxu Chen, Dan Chen, Shijie Yu, Xiaoxiong Zeng, Yi Sun
Dicaffeoylquinic acids (DiCQAs), the main components of kudingcha made from the leaves of Ilex kudingcha, could be transformed by gut microbiota.
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Low-dose ethanol intake prevents high-fat diet-induced adverse cardiovascular events in mice

Food Funct., 2020, 11,3549-3562
DOI: 10.1039/C9FO02645B, Paper
Junhui Nie, Linel Darrel Ngokana, Jiayuan Kou, Yuchen Zhao, Jiajie Tu, Heng Ji, Peizhu Tan, Tingting Zhao, Yuwei Cao, Zhaojing Wu, Qi Wang, Shuangfeng Ren, Xiuchen Xuan, Hui Huang, Yanze Li, Huan Liang, Xu Gao, Lingyun Zhou
This study aimed to clarify whether low-dose ethanol intake could prevent high-fat diet-induced adverse effects on cardiomyocytes in mice.
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Inducing secondary structural interplays between scallop muscle proteins and soy proteins to form soluble composites

Food Funct., 2020, 11,3351-3360
DOI: 10.1039/C9FO03106E, Paper
Chao Wu, Jiamei Wang, Xiaokang Na, Zhenyu Wang, Xianbing Xu, Tao Wang
Scallop muscle proteins and soya proteins were packed into a composite with tunable internal, molecular arrangements of the secondary structures.
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Quantifying dietary vitamin K and its link to cardiovascular health: a narrative review

Food Funct., 2020, 11,2826-2837
DOI: 10.1039/C9FO02321F, Review Article
Claire R. Palmer, Lauren C. Blekkenhorst, Joshua R. Lewis, Natalie C. Ward, Carl J. Schultz, Jonathan M. Hodgson, Kevin D. Croft, Marc Sim
Potential beneficial pathways by which vitamin K may reduce the risk of cardiovascular disease mortality.
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DHA substitution overcomes high-fat diet-induced disturbance in the circadian rhythm of lipid metabolism

Food Funct., 2020, 11,3621-3631
DOI: 10.1039/C9FO02606A, Paper
Rulong Chen, Zhengyu Zuo, Qi Li, Hualin Wang, Na Li, Hongyu Zhang, Xiaoli Yu, Zhiguo Liu
DHA substitution overcomes high-fat diet-induced disturbance in the circadian rhythm of lipid metabolism via the core gene Clock/Bmal1 controlled circadian nuclear receptor pathway.
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Protocatechuic acid and quercetin glucosides in onions attenuate changes induced by high fat diet in rats

Food Funct., 2020, 11,3585-3597
DOI: 10.1039/C9FO02633A, Paper
Katarzyna Grzelak-Błaszczyk, Joanna Milala, Krzysztof Kołodziejczyk, Michał Sójka, Andrzej Czarnecki, Monika Kosmala, Robert Klewicki, Bartosz Fotschki, Adam Jurgoński, Jerzy Juśkiewicz
Yellow onion waste from industrial peeling was used to obtain three pure preparations: protocatechuic acid (PA), quercetin diglycosides (QD) and quercetin monoglycosides (QM).
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Ptaquiloside from bracken (Pteridium spp.) promotes oral carcinogenesis initiated by HPV16 in transgenic mice

Food Funct., 2020, 11,3298-3305
DOI: 10.1039/D0FO00207K, Paper
Rui M. Gil da Costa, Tiago Neto, Diogo Estêvão, Magda Moutinho, Ana Félix, Rui Medeiros, Carlos Lopes, Margarida M. S. M. Bastos, Paula A. Oliveira
Bracken (Pteridium spp.) is a common weed that is consumed as food especially in Asia, and is suspected of promoting carcinogenesis induced by papillomaviruses in the digestive and urinary systems.
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Proteomic landscape of liver tissue in old male mice that are long-term treated with polysaccharides from Sargassum fusiforme

Food Funct., 2020, 11,3632-3644
DOI: 10.1039/D0FO00187B, Paper
Peichao Chen, Ya Zhang, Man Xu, Hongjun Chen, Huixi Zou, Xu Zhang, Haibin Tong, Cuiping You, Mingjiang Wu
The polysaccharides extracted from Sargassum fusiforme delays the aging process via mitochondria-associated anti-oxidation.
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The effect of culinary doses of spices in a high-saturated fat, high-carbohydrate meal on postprandial lipemia and endothelial function: a randomized, controlled, crossover pilot trial

Food Funct., 2020, 11,3191-3200
DOI: 10.1039/C9FO02438G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kristina S. Petersen, Connie J. Rogers, Sheila G. West, David N. Proctor, Penny M. Kris-Etherton
Lower doses of spices (2 and 6 g) than previously tested may attenuate postprandial lipemia and impairments in endothelial function caused by a high-saturated fat, high-carbohydrate meal.
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Addition of flavonols and polysaccharides as excipient ingredients into epicatechin rich green tea extract inhibited free radical formation and glucose uptake

Food Funct., 2020, 11,3105-3111
DOI: 10.1039/C9FO03020D, Paper
So-Hee Yoo, Yeong-Eun Lee, Jin-Oh Chung, Chan-Su Rha, Yong-Deog Hong, Mi-Young Park, Soon-Mi Shim
Results from the current study suggested that whole green tea components rich in flavonols and polysaccharides could be potential hypoglycemic excipient ingredients into green tea catechins by enhancing catechin absorption.
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Impact of functional foods and nutraceuticals on high blood pressure with a special focus on meta-analysis: review from a public health perspective

Food Funct., 2020, 11,2792-2804
DOI: 10.1039/D0FO00357C, Review Article
Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun Wang
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).
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cis 9, trans 11, but not trans 10, cis 12 CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice through activation of GPR120-[Ca2+]i and the MLCK signaling pathway

Food Funct., 2020, 11,3657-3667
DOI: 10.1039/D0FO00376J, Paper
Han Su, Weijie Zhao, Fenglin Zhang, Min Song, Fangfang Liu, Jisong Zheng, Mingfa Ling, Xiaohua Yang, Qiang Yang, Haiwen He, Lin Chen, Xumin Lai, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
In vitro and in vivo studies show that c9, t11-CLA, but not t10, c12-CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice via activation of GPR120-[Ca2+]i and the MLCK pathway.
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Study of viability of high pressure extract from pomegranate peel to improve carrot juice characteristics

Food Funct., 2020, 11,3410-3419
DOI: 10.1039/C9FO02922B, Paper
João P. Trigo, Elisabete M. C. Alexandre, Sara Silva, Eduardo Costa, Jorge A. Saraiva, Manuela Pintado
Extracts from fruit processing by-products usually present high amounts of bioactive compounds with several important activities such as antioxidant and antimicrobial capacities.
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Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells

Food Funct., 2020, 11,3741-3748
DOI: 10.1039/D0FO00030B, Paper
Wei Li, Mingbo Gao, Ting Han
Impairment of the intestinal barrier often occurs in inflammatory bowel diseases, and pro-inflammatory factors play a vital role in the pathogenesis of intestinal diseases.
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Dietary intakes of flavonoids and carotenoids and the risk of developing an unhealthy metabolic phenotype

Food Funct., 2020, 11,3451-3458
DOI: 10.1039/C9FO02852H, Paper
Nazanin Moslehi, Mahdieh Golzarand, Farhad Hosseinpanah, Parvin Mirmiran, Fereidoun Azizi
This study was designed to investigate prospective associations between dietary habitual intakes of flavonoids and carotenoids and the development of an unhealthy metabolic phenotype separately in normal-weight and excess weight individuals.
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Inflammation and cardiovascular disease: are marine phospholipids the answer?

Food Funct., 2020, 11,2861-2885
DOI: 10.1039/C9FO01742A, Review Article
Ronan Lordan, Shane Redfern, Alexandros Tsoupras, Ioannis Zabetakis
This review presents the latest research on the cardioprotective effects of n-3 fatty acids (FA) and n-3 FA bound to polar lipids (PL). Overall, n-3 PL may have enhanced bioavailability and potentially bioactivity versus free FA and ester forms of n-3 FA.
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Potential neurotoxicity of 5-hydroxymethylfurfural and its oligomers: widespread substances in carbohydrate-containing foods

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02526J, Paper
Cheng Wang, Zhenru Liu, Tian Hu, Youjia Li, Rui Liu, Junjie Zhang, Huaizhen He
5-Hydroxymethylfurfural (5-HMF) and its acid-catalyzed oligomers can inhibit nerve cell proliferation and induce neurological deficits at near or below the reported 24 h dietary intake of 5-HMF in humans.
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Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways

Food Funct., 2020, 11,3516-3526
DOI: 10.1039/C9FO02921D, Paper
Tunyu Jian, Jian Chen, Xiaoqin Ding, Han Lv, Jiawei Li, Yuexian Wu, Bingru Ren, Bei Tong, Yuanyuan Zuo, Kelei Su, Weilin Li
Total flavonoids isolated from loquat leaves inhibit inflammation and oxidative stress by regulating TRPV1 and the related pathway in cigarette smoke-induced COPD mice.
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A rapid protocol to distinguish between Citri Exocarpium Rubrum and Citri Reticulatae Pericarpium based on the characteristic fingerprint and UHPLC-Q-TOF MS methods

Food Funct., 2020, 11,3719-3729
DOI: 10.1039/D0FO00082E, Paper
Liqiang Shi, Rongjin Wang, Tianshu Liu, Jiajie Wu, Hongxu Zhang, Zhiqiang Liu, Shu Liu, Zhongying Liu
Citri Exocarpium Rubrum and Citri Reticulatae Pericarpium were successfully distinguished by the characteristic fingerprint and UHPLC-Q-TOF MS methods.
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Correction: Efficacy of proprietary Lactobacillus casei for anti-tuberculosis associated gastrointestinal adverse reactions in adult patients: a randomized, open-label, dose–response trial

Food Funct., 2020, 11,3751-3751
DOI: 10.1039/D0FO90017F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Song Lin, Shanliang Zhao, Jiahong Liu, Jianwen Zhang, Chao Zhang, Haibo Hao, Yuxia Sun, Jing Cai, Yang Yang, Yan Ma, Yuanyuan Li, Jinyu Wang, Aiguo Ma
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The purification, structural characterization and antidiabetic activity of a polysaccharide from Anoectochilus roxburghii

Food Funct., 2020, 11,3730-3740
DOI: 10.1039/C9FO00860H, Paper
Yuntao Liu, Tingting Tang, Songqi Duan, Cheng Li, Qinlu Lin, Hejun Wu, Aiping Liu, Bin Hu, Dingtao Wu, Suqing Li, Li Shen, Wenjuan Wu
Anoectochilus roxburghii, a traditional Chinese medicinal herb, has been widely used for treating numerous chronic diseases.
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Usage of supercritical fluid techniques to obtain bioactive alkaloid-rich extracts from cherimoya peel and leaves: extract profiles and their correlation with antioxidant properties and acetylcholinesterase and α-glucosidase inhibitory activities

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00342E, Paper
Oscar Galarce-Bustos, Mª Teresa Fernández-Ponce, Antonio Montes, Clara Pereyra, Lourdes Casas, Casimiro Mantell, Mario Aranda
The wastes generated by cherimoya cultivation and processing industries should be contemplated as a valuable source of bioactive alkaloids, with potential in pharmaceutical applications for the treatment or prevention of chronic diseases.
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Structural and physicochemical changes in almond milk during in vitro gastric digestion: impact on the delivery of protein and lipids

Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02465D, Paper
Xin Wang, Aiqian Ye, Harjinder Singh
The gastric digestion of almond milk in a human gastric simulator resulted in major structural and physicochemical changes. The changes had significant impact on the rate of delivery of protein and lipids to the small intestine.
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Physicochemical and antibacterial properties of fabricated ovalbumin-carvacrol gel nanoparticles

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00755B, Paper
Shengqi Rao, Guang-wei Xu, Huawei Zeng, Xiang-feng Zheng, Qin Hu, Qi-Yan Wang, Zhenquan Yang, Xin'An Jiao
The applications of carvacrol are limited due to its poor stability, water solubility, and high volatility; however, ovalbumin can be used to encapsulate hydrophobic molecules, improve their aqueous solubility, and...
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Enzyme reaction-guided identification of active components from the flowers of Sophora japonica var. violacea

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00625D, Paper
Yunci Zhang, Dongyu Gu, Shuai He, Jing Meng, Jifeng Wang, Yunxiao Wang, Yi Wang, Jing Tian, Yi Yang
The flower of S. japonica is a favorite food and used as traditional medicine.
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Unveiling the bioactivity potential of Allium triquetrum L. lipophilic fraction: chemical characterization and in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00769B, Paper
Samia Rabah, Kahina Kouachi, Patricia Ramos, Ana T. P. C. Gomes, Adelaide Almeida, Hayate Haddadi-Guemghar, Khodir Madani, Armando Silvestre, Sónia A. O. Santos
The lipophilic composition of Allium triquetrum L. bulbs, flowers and leaves was studied for the first time, by GC-MS. Sixty-two compounds were firstly identified in A. triquetrum L. Fatty acids...
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Evaluation of Tenebrio molitor protein as a source of peptides for modulating physiological processes

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00734J, Paper
Fernando Rivero Pino, Raúl Pérez Gálvez, F. Javier Espejo Carpio, Emilia M. Guadix
Tenebrio molitor hydrolysates produced with commercial proteases showed improved ACE inhibitory and antioxidant properties. This source could be employed as functional ingredient in food preparations.
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Dietary supplementation of L-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00019A, Paper
Hao Zhang, Yi Ma, Mengzhi Wang, Mabrouk Elsabagh, Juan J. Loor, Hongrong Wang
The work aimed at investigating the effects of N-carbamylglutamate (NCG) or L-arginine (Arg) supplementation on the duodenal mitophagy, inflammation, and barrier function in suckling lambs suffering from intrauterine-growth-retardation (IUGR).
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Deciphering calcium-binding behaviors of casein phosphopeptides by experimental approaches and molecular simulation

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00844C, Paper
Minna Luo, Jie Xiao, Shengwei Sun, Fengchao Cui, Wei Li, Guo Liu, Yunqi Li, Yong Cao
Although specific groups in casein phosphopeptides (CPPs) have been identified to be essential for the calcium-binding capacity, how calcium binds with CPPs remains unclear. In the present study, experimental methods...
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Polysaccharides from Enteromorpha prolifera protect against carbon tetrachloride-induced acute liver injury in mice via activation of Nrf2/HO-1 signaling, and suppression of oxidative stress, inflammation and apoptosis

Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00575D, Paper
Fuchuan Guo, Xinyun Zhuang, Mengyuan Han, Wenting Lin
EPP protected against hepatic injury induced by CCl4-derived reactive intermediates through the suppression of hepatic oxidative stress, inflammation, and apoptosis.
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Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00711K, Paper
J. Q. Ma, Yun-Zhi Sun, Qing-Lei Ming, Zhi-Kai Tian, Yu-Jia Zhang, Chan-Min Liu
Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential renoprotective properties. Here we examined the protective effects of GAS against carbon tetrachloride (CCl4)-induced kidney inflammation and...
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Need cash? Medical personal loans can help tide over coronavirus crisis

Your existing bank will give this loan, and rates may be better




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Need cash? Loan against fixed deposits is cheaper than a personal loan

Here is how the rares of loan against fixed offered by various banks stack up




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Using telemedicine to get critical medical advice in times of the lockdown

All you need is a smart phone to start consulting health specialists over video call, phone call, whatsapp, and other applications. And it does not burn a hole in your pocket




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Quick approval, grace period: Medical insurance process eased amid Covid-19

Use instalments to increase cover; benefit from quick approvals




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You can claim 100% tax deduction on donation towards PM CARES Fund

The government has provided tax relief and extensions in deadlines for statutory compliances




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OS X El Capitan Available as Free Update Tomorrow

OS X El Capitan, the latest major release of the world’s most advanced desktop operating system, will be available Wednesday, September 30, as a free update for Mac users. El Capitan builds on the groundbreaking features and beautiful design of OS X Yosemite. “People love using their Macs, and one of the biggest reasons is the power and ease of use of OS X,” said Craig Federighi, Apple’s senior vice president of Software Engineering. “El Capitan refines the Mac experience and improves performance in a lot of little ways that make a very big difference. Feedback from our OS X beta program has been incredibly positive and we think customers are going to love their Macs even more with El Capitan.”




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Apple Advances Health Apps with CareKit

Apple today announced CareKit, a new software framework designed to help developers enable people to actively manage their own medical conditions. iPhone apps using CareKit make it easier for individuals to keep track of care plans and monitor symptoms and medication, providing insights that help people better understand their own health. “We believe that giving individuals the tools to understand what is happening with their health is incredibly powerful, and apps designed using CareKit make this a reality by empowering people to take a more active role in their care,” said Jeff Williams, Apple’s chief operating officer.




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Can Bollywood make a film as smart as this one?

Sreehari Nair reviews Ayyappanum Koshiyum.




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BJP is turning into a party of capitalists: Babulal Marandi

Interview with Jharkhand Vikas Morcha president




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Why can't we just be friends, says Husain Haqqani

Interview with former Pakistan ambassador to the US




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Cost of pendency of cases could be as high as 1.5% of GDP: Harish Narasappa

Interview with Co-founder, DAKSH & Samvad Partners




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I will eradicate drug menace in 4 weeks: Amarinder Singh

Interview with Punjab Congress President




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We can sense the soul of the country: Ramdev

Interview with Yoga guru and Patanjali founder




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A visit from Modi to Israel will be important: Daniel Carmon

Interview with ambassador of Israel to India