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PE and VC investments at $5.1 billion in 1Q2020; a 12-quarter low: IVCA-EY

At $2.2 billion, large deals declined by over 70 per cent on a year-on-year basis in the same period




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[ASAP] Direct Identification of a-Bisabolol Enantiomers in an Essential Oil Using a Combined Ion Mobility–Mass Spectrometry/Quantum Chemistry Approach

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00982




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[ASAP] Spongian Diterpenoids Derived from the Antarctic Sponge <italic toggle="yes">Dendrilla antarctica</italic> Are Potent Inhibitors of the <italic toggle="yes">Leishmania</italic> Parasite

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00025




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[ASAP] Kalparinol, a Salvialane (Isodaucane) Sesquiterpenoid Derived from Native Australian <italic toggle="yes">Dysphania</italic> Species That Suggests a Putative Biogenetic Link to Zerumbone

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01039




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[ASAP] The Oxidation of Phytocannabinoids to Cannabinoquinoids

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01284




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[ASAP] Cyperane-Type and Related (Nor)Sesquiterpenoids from the Root Bark of <italic toggle="yes">Acanthopanax gracilistylus</italic> and Their Inhibitory Effects on Nitric Oxide Production

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00913




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[ASAP] Psathyrins: Antibacterial Diterpenoids from <italic toggle="yes">Psathyrella candolleana</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00269




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[ASAP] Isolation of Taste-Active Triterpenoids from <italic toggle="yes">Quercus robur</italic>: Sensory Assessment and Identification in Wines and Spirit

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00106




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[ASAP] Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01022




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[ASAP] Review of Biology and Ecology of Pharmaceutical Marine Sponges<source>Biology and Ecology of Pharmaceutical Marine Sponges</source>. Edited by Ramasamy Santhanam, Santhanam Ramesh, and Anbu Jeba Sunilson. <publisher-name>CRC Press

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00352




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[ASAP] Cytotoxic Monoterpenoid Indole Alkaloids from <italic toggle="yes">Tabernaemontana corymbosa</italic> as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00856




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[ASAP] Cucurbitane-Type Triterpenoids from the Vines of <italic toggle="yes">Momordica charantia</italic> and Their Anti-inflammatory Activities

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00592




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[ASAP] Bromo-spiroisoxazoline Alkaloids, Including an Isoserine Peptide, from the Caribbean Marine Sponge <italic toggle="yes">Aplysina lacunosa</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01286




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[ASAP] Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00138




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How tiny dependencies can topple the JavaScript Jenga tower

#486 — May 1, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

???? I18n Ally: An All-in-One i18n Extension for VS Code — Got some internationalization work to do? I18n Ally gives you inline annotations, automated translations via Google Translate (which you can review), progress indication, etc. Supports React, Angular, Vue and other frameworks.

Anthony Fu

How a Few Lines of Code Broke Lots of Packages — Just under a week ago, people were reporting that create-react-app was broken. The culprit? A tiny change in a tiny dependency: is-promise. Luckily a fix was out very quickly and the creator of is-promise reflects on what happened here. Liran Tal also has some analysis of the situation.

Forbes Lindesay

Identify Front-End Issues Like JavaScript or Network Errors Fast — Datadog’s algorithmic alerts will proactively alert on any client-side issues such as JavaScript and network errors. Optimize the load time of your front-end resources, and detect any UI issues that affect critical user journeys. Try it free with Datadog Synthetics.

Datadog sponsor

Q: A JavaScript 'Quantum Circuit' Simulator — Bring quantum computing to your browser with this JavaScript simulation. If you were never quite sure what your JavaScript code was going to do, now you can formally explore the concept ????

Stewart Smith

Quick bytes:

???? Jobs

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

Senior Full-Stack Developer (Malmö/Sweden) — Every day is different from the next. Join our upbeat Team and work on exciting, major projects using a modern JavaScript stack.

Ortelius AB

???? Tutorials

A Guide to window.location — A breakdown that covers most of the methods and properties available on the DOM’s window.location object.

samantha ming

Implementing Dark Mode in React Apps Using styled-components

Blessing Krofegha

▶  Let's Build a Financial Dashboard App with React (Webinar On‑Demand) — Join TJ VanToll as he walks you through building a responsive Bootstrap-themed Stocks Portfolio app. Check it out today.

Progress KendoReact sponsor

Getting Started with NuxtJS — Learn how to create Vue.js-powered server-side rendered apps with NuxtJS including configuring an app and deploying it on Heroku.

Timi Omoyeni

▶  Learn Svelte: A 16-Part Course on Learning the Popular UI Framework — The course centers around building a chatbot, which is a nice change from the todos and other overused tutorial examples.

noah kaufman

10 Practical JavaScript Tricks — These kinds of lists are usually pretty run of the mill, but this one actually contains some lesser-known quick tips that you may not have seen before.

zander shirley

Moving TinyMCE to Modern JavaScript — The creators of TinyMCE (a popular WYSIWYG HTML editor) have been refactoring its rather legacy JavaScript (the first version came out 17 years ago!) to modern practices.

Joakim Lindkvist

7 JavaScript Design Patterns Every Developer Should Know — This is sort of like a (very) mini version of Addy Osmani’s 2017 book on JS design patterns (which is referenced at the end of the post).

deven rathore

▶  An Introduction to State Machines Using XStateXState is a neat way to work with state machines in JavaScript, Kyle is a neat teacher, and Egghead is a neat platform for unlocking these videos for us too.

Kyle Shevlin

Ride Down Into JavaScript Dependency Hell

AppSignal sponsor

A Collection of Challenging TypeScript Exercises“The goal: Let everyone play with many different TypeScript features and get an overview of TypeScript capabilities and principles.”

Marat Dulin

A Visual Guide to React Mental Models — Different people learn in different ways but good mental models are always valuable and can be helpful if you need to juggle all of the pieces involved in a framework like React.

Obed Parlapiano

Turning Vue Components Into Reusable npm Packages — Outlines how you can reuse Vue components across your projects by automating your process to bundle, test, document, and publish your components.

Sjoerd de voorhoede

???? Code & Tools

jExcel v4: A Vanilla JS Interactive Table / Spreadsheet Control — 4.0 adds support for tabs/workbooks, updating a remote data source with JSON, formula support in a sheet footer, and more. There are lots of demos and examples on the official homepage.

Paul Hodel

Will It CORS? — A handy online tool/wizard for establishing how your (potential) use case will (or won’t!) operate alongside CORS (Cross-Origin Resource Sharing).

HTTP Toolkit

Get Great Visual Feedback & Bug Reports, Even from Non-Technical Folk — Simply click a page element to pin visual feedback with screenshots & metadata. BugHerd = fast and easy bug tracking.

BugHerd sponsor

utfu: Replace Busted Characters From Legacy Text with UTF-8 — Useful when old content contains characters like “— in place of a single quote, and similar legacy text issues.

Daniel Sieradski

Middy 1.0: A Node Middleware Framework for AWS Lambda — Middy’s aim is to make writing serverless functions (hosted on AWS Lambda) easier by providing a familiar middleware abstraction to Node developers.

Luciano Mammino

useWorker() 3.0: A React Hook for Blocking-Free Background Tasks — Makes it easier to throw tasks off to a Web Worker in React.

Alessio Koci

webpack-blocks: Configure webpack using Functional Feature Blocks

Andy Wermke

JZZ: A MIDI Library for Node and the Browser — Send, receive and play MIDI messages from both Node and the browser on Linux, macOS and Windows.

Sema

MDX 1.6: Use JSX in Markdown Documents — This version introduces initial Vue support.

Compositor and Vercel

???? Upcoming Online Events

  • JavaScript Remote Conf 2020 (May 14-15) — Speakers lined up already include Raymond Camden, Christian Heilmann, and Aleksandra Sikora.
  • ESNEXT CONF 2020 (May 18-22) — From the Pika folks (of Snowpack fame). 12 speakers over 5 days so it's a gradual pace.
  • ForwardJS (May 26-29) — A real world event (ForwardJS Ottawa) that has now become a virtual event.
  • CascadiaJS 2020 (September 1-2) — This upcoming online conference is set to take place in September, and the CFP is open now through May 15.




ca

Medical inbound tourism poised to get a push: FAITH chairman Nakul Anand

Medical inbound tourism, already on the rise, will get a boost with addition of Tier-II and -III hospitals




ca

Decoding Budget 2020: Nirmala Sitharaman's fiscal maths gone awry

Slowdown in economic growth has taken a clear toll on revenue growth




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Podcast: T N Ninan and A K Bhattacharya dissect Budget 2020

Has Finance Minister Nirmala Sitharaman delivered a fiscally prudent and growth-oriented Budget 2020? Business Standard Chairman T N Ninan and Editorial Director A K Bhattacharya discuss




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New tax structure will leave more cash in the hands of people: Revenue Secy

He said the Budget gives an option to individuals to migrate to a new regime by foregoing their existing exemptions and deductions for a lower tax rate




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Govt very transparent in setting new fiscal deficit target: FM Sitharaman

She further said that many people have been speculating that the fiscal deficit would cross 4%




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Budget disappointing; but fiscal, taxation measures welcome: EAC member

India's GDP growth is expected to slip to a decadal low of 5 per cent this fiscal, pressured by domestic factors like drop in consumption, as well as global issues




ca

Understanding Depression and Distress Among Medical Students

Interview with Laura Weiss Roberts, MD, MA, author of Understanding Depression and Distress Among Medical Students




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What If Physicians Actually Had to Control Medical Costs?

Interview with Robert H. Brook, MD, ScD, author of What If Physicians Actually Had to Control Medical Costs?




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Putting the Public Back in Public Reporting of Health Care Quality

Interview with Tara Lagu, MD, MPH, author of Putting the Public Back in Public Reporting of Health Care Quality




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Discussing Radiation Risks Associated With CT Scans With Patients

Interview with Mark Otto Baerlocher, MD, author of Discussing Radiation Risks Associated With CT Scans With Patients




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Active Surveillance for Prostate Cancer

Interview with Ian M. Thompson, MD, author of Active Surveillance for Prostate Cancer




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Damage Prevention and Control for Financial Incapacity

Interview with Charles Sabatino, JD, author of Damage Prevention and Control for Financial Incapacity




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Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries

Interview with Lawrence O. Gostin, JD, author of Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries




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Physician Communication in the 21st Century

Interview with Allan S. Detsky, MD, PhD, author of Physician Communication in the 21st Century




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How to Enroll Participants in Research Ethically

Interview with David Wendler, PhD, author of How to Enroll Participants in Research Ethically




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Patient-Physican Communication: It's About Time

Interview with Wendy Levinson, MD, author of Patient-Physican Communication: It's About Time




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From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep

Interview with Benjamin Djulbegovic, MD, PhD, author of From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep




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Application of Electronic Health Records to the Joint Commission's 2011 National Patient Safety Goals

Interview with Ryan Radecki, MD, author of Application of Electronic Health Records to the Joint Commission's 2011 National Patient Safety Goals




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Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage

Interview with J. Michael McWilliams, MD, Phd, author of Implementation of Medicare Part D and Nondrug Medical Spending for Elderly Adults With Limited Prior Drug Coverage




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Use of Radioactive Iodine for Thyroid Cancer

Interview with Megan R. Haymart, MD, author of Use of Radioactive Iodine for Thyroid Cancer




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Implementing Accountable Care Organizations: Ten Potential Mistakes and How to Learn From Them

Interview with Stephen M. Shortell, PhD, MPH, MBA, author of Implementing Accountable Care Organizations: Ten Potential Mistakes and How to Learn From Them




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Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents

Interview with Colin P. West, MD, PhD, author of Quality of Life, Burnout, Educational Debt, and Medical Knowledge Among Internal Medicine Residents




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Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students

Interview with Julie A. Freischlag, MD, author of Association of Unconscious Race and Social Class Bias With Vignette-Based Clinical Assessments by Medical Students




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Prediction of Erectile Function Following Treatment for Prostate Cancer

Interview with Martin G. Sanda, MD, author of Prediction of Erectile Function Following Treatment for Prostate Cancer




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Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures

Interview with Lauren Hersch Nicholas, PhD, MPP, author of Regional Variation in the Association Between Advance Directives and End-of-Life Medicare Expenditures




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Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT

Interview with Eric A. Klein, MD, author of Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)




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National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008

Interview with Jersey Chen, MD, MPH, author of National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries, 1998-2008




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Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans

Interview with Pim A. de Jong, MD, PhD, author of Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans




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Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk

Interview with Wendy Y. Chen, MD, MPH, author of Moderate Alcohol Consumption During Adult Life, Drinking Patterns, and Breast Cancer Risk




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Association Between Physician Billing and Cardiac Stress Testing Patterns Following Coronary Revascularization

Interview with Bimal R. Shah, MD, MB, author of Association Between Physician Billing and Cardiac Stress Testing Patterns Following Coronary Revascularization




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Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial

Interview with Jay H. Traverse, MD, author of Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial




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Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events

Interview with Martin J. O'Donnell, MB, PhD, author of Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events




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Association Between Valvular Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Heart

Interview with Andrew Wang, MD, author of Association Between Valvular Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Heart Failure




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What Patients Really Want From Health Care

Interview with Allan S. Detsky, MD, PhD, author of What Patients Really Want From Health Care




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Causes of Death Among Stillbirths

Interview with Robert M. Silver, MD, author of Causes of Death Among Stillbirths