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Chromatographic detection of low-molecular-mass metal complexes in the cytosol of Saccharomyces cerevisiae

Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00312F, Paper
Open Access
Trang Q. Nguyen, Joshua E. Kim, Hayley N. Brawley, Paul A. Lindahl
Labile metal pools in the cytosol of yeast, including those of iron, copper, zinc, and manganese, can be detected and characterized using size-exclusion chromatography with online ICP-MS.
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Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00015A, Paper
Norika Goto, Hirokazu Hara, Mao Kondo, Naomi Yasuda, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Copper (Cu) is an essential trace element and acts as a redox cofactor for many enzymes; however, excess Cu is toxic to cells.
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Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00064G, Paper
Diana Fontinha, Silvia Andreia Sousa, Tânia S. Morais, Miguel Prudêncio, Jorge Leitão, Yann Le Gal, Dominique Lorcy, Rafaela Silva, Mariana Velho, Dulce Belo, Manuel Almeida, Joana Guerreiro, Teresa Pinheiro, Fernanda M. Marques
The anticancer, antimicrobial and antiplasmodial activities of six gold(III) bis(dithiolene) complexes were studied. Complexes (1-6) showed relevant anticancer properties against A2780/A2780cisR ovarian cancer cells (IC50 values of 0.08-2 µM), also...
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Studies of the labile lead pool using a rhodamine-based fluorescent probe

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00056F, Communication
Jianping Zhu, Jia Hao Yeo, Amy A. Bowyer, Nicholas Proschogo, Elizabeth J. New
A rhodamine-based fluorescent lead probe reports on the labile lead pool within cells.
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Enantiomeric Copper Based Anticancer Agents Promoting Sequence-Selective Cleavage of G-Quadruplex Telomeric DNA and non-random cleavage of plasmid DNA

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00084A, Paper
Sabiha Parveen, J. A. Cowan, Zhen Yu, Farukh Arjmand
Copper-based binuclear enantiomeric complexes 1S and 1R were synthesized as anticancer chemotherapeutic agents to target G-quadruplex rich region of DNA and thoroughly characterized by various spectroscopic and single X-ray crystal...
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Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
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Chiral Ru(II) complexes act as a potential non-viral gene carrier for directional transportation to the nucleus and cytoplasm

Metallomics, 2020, 12,504-513
DOI: 10.1039/C9MT00192A, Paper
Qiong Wu, Shuang-Yan Zhang, Si-Yan Liao, Jie-Qiong Cao, Wen-Jie Zheng, Li Li, Wen-Jie Mei
A novel approach has been proposed to develop a potent gene carrier system for enantioselectivity on the self-assembly of G-quadruplex DNA promoted by chiral Ru(II) complexes, and the different assembled nanostructures of cellular uptake to the nucleus and cytoplasm.
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Heterobimetallic Ru(II)/Fe(II) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

Metallomics, 2020, 12,547-561
DOI: 10.1039/C9MT00272C, Paper
Adriana Pereira Mundim Guedes, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Maria Alice Montes de Sousa, Paula Francinete Faustino da Silva, Mariana S. de Camargo, Hendryk Gemeiner, Menegário A. Amauri, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Elisângela de Paula Silveira-Lacerda, Alzir A. Batista
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment.
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Comparative differential cuproproteomes of Rhodobacter capsulatus reveal novel copper homeostasis related proteins

Metallomics, 2020, 12,572-591
DOI: 10.1039/C9MT00314B, Paper
Nur Selamoglu, Özlem Önder, Yavuz Öztürk, Bahia Khalfaoui-Hassani, Crysten E. Blaby-Haas, Benjamin A. Garcia, Hans-Georg Koch, Fevzi Daldal
Cuproproteome of model bacterium Rhodobacter capsulatus reveals 75 Cu-responsive proteins that are strongly influenced (2–300 fold) by Cu availability.
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Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
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Ruthenium(III) complexes containing thiazole-based ligands that modulate amyloid-β aggregation

Metallomics, 2020, 12,491-503
DOI: 10.1039/D0MT00054J, Paper
Samantha E. Huffman, Gideon K. Yawson, Samuel S. Fisher, Paige J. Bothwell, David C. Platt, Marjorie A. Jones, Christopher G. Hamaker, Michael I. Webb
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder where one of the commonly observed pathological hallmarks is extracellular deposits of the peptide amyloid-β (Aβ).
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Investigation of the impact of magnesium versus titanium implants on protein composition in osteoblast by label free quantification

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00028K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
M. Omidi, N. Ahmad Agha, A. Müller, F. Feyerabend, H. Helmholz, R. Willumeit-Römer, H. Schlüter, B. J. C. Luthringer-Feyerabend
To our knowledge, this is the first report describing and comparing the effects of magnesium and titanium biomaterials on human osteoblast proteome.
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Diphenyl Diselenide Protects Caenorhabditis elegans Model for Huntington's Disease by Activation of Antioxidant Pathway and Decrease in Protein Aggregation

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00074D, Paper
Fabiane Bicca Obetine Baptista, Marina Lopes Machado, Aline da Silva Franzen, Larissa Marafiga Cordeiro, Tassia da Silveira, Leticia Arantes, Félix A. A. Soares
Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disease with a distinct phenotype. It occurs due to a mutation in huntingtin (or IT19) gene with abnormal CAG repeat, leading...
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A liver-targeting Cu(I) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00069H, Paper
Marie Monestier, AnaÏS M. Pujol, Aline Lamboux, Martine Cuillel, Isabelle Pignot-Paintrand, Doris Cassio, Peggy Charbonnier, Khémary Um, Amélie Harel, Sylvain BOHIC, Christelle GATEAU, Vincent Balter, Virginie Brun, Pascale Delangle, Elisabeth Mintz
Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of...
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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
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Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
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Maths formulae book released

Maths formulae book released




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AMACSU takes case to Governor

AMACSU takes case to Governor




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Disqualification case of 7 MLAs : Tribunal reserves judgement

Disqualification case of 7 MLAs : Tribunal reserves judgement




as

Kangpokpi asks passenger vehicles not to stop midway

Kangpokpi asks passenger vehicles not to stop midway




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[ASAP] In Vitro Identification of the Hamiltonian Cycle Using a Circular Structure Assisted DNA Computer

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00150




as

[ASAP] Development of Mischmetal–Fe–Co–B Permanent Magnet Alloys via High-Throughput Methods

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00190




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[ASAP] Ce(OTf)<sub>3</sub>-Catalyzed Multicomponent Reaction of Alkynyl Carboxylic Acids, <italic toggle="yes">tert</italic>-Butyl Isocyanide, and Azides for the Assembly of Triazole–Oxazole Derivatives

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00012




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[ASAP] Immobilized Carbodiimide Assisted Flow Combinatorial Protocol to Facilitate Amide Coupling and Lactamization

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00001




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[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00061




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[ASAP] Optimized Multimetal Sensitized Phosphor for Enhanced Red Up-Conversion Luminescence by Machine Learning

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00035




as

[ASAP] Magnetic Bead-Immobilized Mammalian Cells Are Effective Targets to Enrich Ligand-Displaying Yeast

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00036




as

[ASAP] Experimental and Theoretical Investigation on Phase Formation and Mechanical Properties in Cr–Co–Ni Alloys Processed Using a Novel Thin-Film Quenching Technique

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00170




as

NCI study finds long-term increased risk of cancer death following common treatment for hyperthyroidism

Findings from a new NCI study of patients who received radioactive iodine (RAI) treatment for hyperthyroidism show an association between the dose of treatment and long-term risk of death from solid cancers, including breast cancer.




as

The colonial fantasy : why white Australia can't solve black problems / Sarah Maddison

Maddison, Sarah, author




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Manyjilyjarra - English pictorial dictionary of landscape terms / [prepared for Kanyirninpa Jukurrpa by Clair Hill and Andrew Turk with assistance from Martu language speakers: Gladys Bidu; Jakayu Biljabu; Nancy Chapman; Mulyatingki Marney; Minyawu Miller




as

Young dark emu : a truer history / Bruce Pascoe

Pascoe, Bruce, 1947- author




as

Illustrated topical dictionary of the Western Desert language : based on the Ngaanyatjarra dialect / W.H. Douglas

Douglas, Wilfrid H. (Wilfrid Henry)




as

A stolen life : the Bruce Trevorrow case / Antonio Buti

Buti, Antonio, author




as

Song dai jian dang guan ti xi zhi yan jiu / Lei Jiasheng zhu

Lei, Jiasheng, 1970-




as

Duo chong fu za bei jing xia de Zhongguo jing ji an quan wen ti / Lei Jiasu, Lin Bao, Wang Yilin zhu bian




as

Ren kou dao gua di qu she hui guan li yan jiu = A study of public administration in areas where migrant residents outnumber permanent residents / Jin Sanlin zhu

Jin, Sanlin




as

Six dynasties civilization. Chinese

Dien, Albert E




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Chuang xin xing ren cai ji li ji zhi yan jiu : ji yu xin li qi yue de shi jiao = Study on incentive mechanism of innovative talent based on psychological contract perspective / Zhu Xiaomei zhu

Zhu, Xiaomei




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Zhongguo di fang zheng fu ji xiao guan li yan jiu : yi Shenzhen de shi jian wei li = Research on performance management of local government in China : a case of Shenzhen practice / Zhu Yanqiang zhu

Zhu, Yanqiang




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Sheng yin = The reason for success : Mao Zedong kao shen me tong yi da lu? / Wu Gengbin zhu

Wu, Gengbin




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Za rou yu hui tong : ci hui yu yi xue yu xiu ci de jiao cha yan jiu = Mingling and mastery : an interdisciplinary study of lexical semantics and rhetoric / Liu Zhuo zhu

Liu, Zhuo, author




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Tanomoshiki Nihongo / Kawasaki Bura, Yoshida Sensha

Kawasaki, Bura, 1963-




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Tondemo redīsu komikku no gyakushū / Karasawa Shun'ichi ; Sorubonnu Kko ; Sorubonnu Kko




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Yoshimoto Takaaki no 1940-nendai / Watanabe Kazuyasu

Watanabe, Kazuyasu




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Rekishi to gaikō : Yasukuni, Ajia, Tōkyō saiban / Tōgō Kazuhiko

Tōgō, Kazuhiko, 1945-




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Nihon riberarizumu no keifu : Fukuzawa Yukichi, Hasegawa Nyozekan, Maruyama Masao / Tanaka Hiroshi cho

Tanaka, Hiroshi, 1926-




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Maruyama Masao o yominaosu / Tanaka Kyūbun

Tanaka, Kyūbun, 1952-




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Yoshimoto Takaaki no sengo : 1950-nendai no kiseki / Watanabe Kazuyasu

Watanabe, Kazuyasu




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BC-kyū senpan saiban / Hayashi Hirofumi cho

Hayashi, Hirofum, 1955- author