The present invention extends to a disinfection cap for disinfecting a male luer end of an infusion therapy device. The disinfection cap can include an internal reservoir containing an antimicrobial or saline solution which is sealed with a flexible septum to prevent the solution from evaporating. The septum can include one or more slits or pierceable seams that allow a male luer end of an infusion therapy device to be inserted through the septum and into the solution. While the male luer is inserted through the septum, the solution contacts both the inner and outer surfaces of the male luer. Because the septum reduces evaporation of the solution and prevents the solution from leaking out of the cap, the solution remains in contact with the male luer for a longer duration then when typical disinfection caps are used thereby increasing the effectiveness of the disinfectant.

A micro device includes a substrate and a structure configured to bind to an object or a material, or not to bind to an object or material. The structure has a roughness based on a roughness of the object or material. For example, a microarray includes a substrate and a well positioned in the substrate and configured to bind to a type of bead. The well has a roughness based on a roughness of the type of bead to which the well is configured to bind. The roughness of the well is controlled by controlling a position and number of striations in the side of the well. In another example, a moveable component of a micro device may have a roughness different from a roughness of an adjacent component, to reduce the likelihood of the moveable component sticking to the adjacent component.

The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.

Bioprinting station (1) comprising:—a Bioprinting device (4) adapted to deposit a pattern of biological material (2) onto an area of interest (3a) of a substrate (3),—an imaging system (15) adapted to acquire an image of the substrate (3) and to reveal on the acquired image the area of interest (3a) with respect to a remaining part (3b) of the substrate (3), the acquired image of the substrate (3) being processed so as to detect the revealed area of interest (3a) on the acquired image and to determine the pattern corresponding to the area of interest (3a) detected on the acquired image.

Devices and methods are described herein that are configured for use in laboratory testing, such as, for example, during a procedure including the monitoring and detection of chemical reactions. For example, the systems and devices described herein can be used during a procedure to monitor and detect polymerase chain reactions (PCR). In some embodiments, a sample container includes a container body that defines an interior volume and has an open end in fluid communication with the interior volume. A cap is sealingly engageable with the open end of the container body. The cap defines a receptacle that is configured to extend within a portion of the interior volume of the container body when the cap is sealingly engaged thereto. The receptacle can receive therein a sensor, such as, a temperature sensor that can monitor the temperature of a sample material disposed within the container body.

The present invention provides methods and apparatus for efficiently providing accurate temperature control of a microtiter cold plate and precise alignment of the microtiter cold plate with a microtiter plate.

The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.

A method for producing methanol from a synthesis gas containing hydrogen and carbon oxides with a high content of inert components includes passing the synthesis gas through a synthesis reactor so as to catalytically convert a part of the carbon oxides to methanol. The methanol is separated from the obtained mixture from the reactor. The mixture liberated from methanol is separated into a cycle stream and a purge stream. The cycle stream is recirculated so as to form a synthesis circle and combined with a fresh gas stream including hydrogen and carbon oxides before being charged into the synthesis reactor. The purge stream is supplied to a secondary reactor so as to catalytically convert a further part of the hydrogen and carbon oxides to methanol. Further methanol is separated the obtained mixture including synthesis gas, inert components and methanol vapor.

The present invention is for extremely pure solutions of chlorine dioxide, methods for making such solutions and to compositions and methods for storing, shipping and using such solutions. Generally, the chlorine dioxide solutions of the invention are aqueous solutions containing about 2500 ppm or less of total impurities. The chlorine dioxide solution can be prepare by passing dilute highly pure chlorine gas through a bed of substantially solid sodium chlorite and contacting the resulting chlorine dioxide gas with a liquid.

The present invention includes a device comprising a lid and a vessel forming an interface that allows transfer of waste from a purification chamber to a waste chamber and method for purification of an analyte are disclosed wherein a supernatant is separated from a solid phase to which an analyte is bound by centrifugation via the lid of the device. The present invention also includes methods for use of the device.

Provided are emissions treatment systems for an exhaust stream having an ammonia-generating component, such as a NOx storage reduction (NSR) catalyst or a lean NOx trap (LNT) catalyst, and an SCR catalyst disposed downstream of the ammonia-generating catalyst. The SCR catalyst can be a molecular sieve having the CHA crystal structure, for example SSZ-13 or SAPO-34, which can be ion-exchanged with copper. The LNT can be layered, having an undercoat washcoat layer comprising a support material, at least one precious metal, and at least one NOx sorbent selected from the group consisting of alkaline earth elements, rare earth elements, and combinations thereof and a top washcoat layer comprising a support material, at least one precious metal, and ceria in particulate form, the top washcoat layer being substantially free of alkaline earth components. The emissions treatment system is advantageously used for the treatment of exhaust streams from diesel engines and lean burn gasoline engines.

This disclosure describes an optical method of detecting the presence of pressure-sensitive labels, using the reflective properties of their edges. Labels that are removably attached to a liner are moved through a light beam that is directed across their direction of motion so the light impinges on the labels at a predetermined angle of incidence. The light remains in its plane of incidence when it reflects off all parts of the liner and labels except the labels' edges. Due to the angularity of the labels' edges, the light beam is deflected out of the plane of incidence upon reflection off the edges, thus enabling detection of the label edges by light reflected out of the plane of incidence.

A propulsion apparatus for an endoscope includes a propulsion assembly for mounting on a tip device of the endoscope, for propulsion in a body cavity. First and second wire devices are disposed to extend from the tip device in a proximal direction, having a coil winding, for rotating to drive the propulsion assembly. First and second motors are connected with proximal ends of respectively the first and second wire devices, for rotating the first and second wire devices. A timer is actuated if a speed difference between rotational speeds of the first and second motors becomes equal to or more than a reference speed value, for measuring an elapsed time. A break detector detects breakage of the first wire device if the elapsed time becomes equal to or longer than a predetermined time. A controller controls the first and second motors in response to an output of the break detector.

A noncontact optical three-dimensional measuring device that includes a projector, a first camera, and a second camera; a processor electrically coupled to the projector, the first camera and the second camera; and computer readable media which, when executed by the processor, causes the first digital signal to be collected at a first time and the second digital signal to be collected at a second time different than the first time and determines three-dimensional coordinates of a first point on the surface based at least in part on the first digital signal and the first distance and determines three-dimensional coordinates of a second point on the surface based at least in part on the second digital signal and the second distance.

The present invention pertains to systems and methods for the capture of information regarding scenes using single or multiple three-dimensional LADAR systems. Where multiple systems are included, those systems can be placed in different positions about the imaged scene such that each LADAR system provides different viewing perspectives and/or angles. In accordance with further embodiments, the single or multiple LADAR systems can include two-dimensional focal plane arrays, in addition to three-dimensional focal plane arrays, and associated light sources for obtaining three-dimensional information about a scene, including information regarding the contours of the objects within the scene. Processing of captured image information can be performed in real time, and processed scene information can include data frames that comprise three-dimensional and two-dimensional image data.

A 3D image sensor includes a depth pixel that includes; a photo detector generating photo-charge, first and second floating diffusion regions, a first transfer transistor transferring photo-charge to the first floating diffusion region during a first transfer period in response to a first transfer gate signal, a second transfer transistor transferring photo-charge to the second floating diffusion region during a second transfer period in response to a second transfer gate signal, and an overflow transistor that discharges surplus photo-charge in response to a drive gate signal. Control logic unit controlling operation of the depth pixel includes a first logic element providing the first transfer gate signal, a second logic element providing the second transfer gate signal, and another logic element providing the drive gate signal to the overflow transistor when the first transfer period overlaps, at least in part, the second transfer period.

An approach for IR-based metrology for detecting stress and/or defects around TSVs of semiconductor devices is provided. Specifically, in a typical embodiment, a beam of IR light will be emitted from an IR light source through the material around the TSV. Once the beam of IR light has passed through the material around the TSV, the beam will be analyzed using one or more algorithms to determine information about TSV stress and/or defects such as imbedded cracking, etc. In one embodiment, the beam of IR light may be split into a first portion and a second portion. The first portion will be passed through the material around the TSV while the second portion is routed around the TSV. After the first portion has passed through the material around the TSV, the two portions may then be recombined, and the resulting beam may be analyzed as indicated above.

A portable, tabletop fluid sampling device simplifies spectral analysis to produce an accurate but inexpensive chromatic fingerprint for fluid samples. In one embodiment, the sampling device uses an array of variable wavelength LED emitters and photodiode detectors to measure Rayleigh scattering of electromagnetic energy from the fluid sample contained in a cuvette. Either the fluid itself, or particles suspended in the fluid can then be identified by performing spectral pattern matching to compare results of a spectral scan against a library of known spectra. A wide range of applications include substance identification, security screening, authentication, quality control, and medical diagnostics.

A defect inspection device has: an illumination optical system which irradiates a predetermined region of an inspection target with illumination light; a detection optical system which has a detector provided with a plurality of pixels by which scattered light from the predetermined region of the inspection target due to illumination light from the illumination optical system can be detected; and a signal processing portion which is provided with a correction portion which corrects pixel displacement caused by change in a direction perpendicular to a surface of the inspection target with respect to a detection signal based on the scattered light detected by the detector of the detection optical system, and a defect determination portion which determines a defect on the surface of the inspection target based on the detection signal corrected by the correction portion.

Spectroscopy apparatuses oriented to the critical angle of the sample are described that detecting the spectral characteristics of a sample wherein the apparatus consists of an electromagnetic radiation source adapted to excite a sample with electromagnetic radiation introduced to the sample at a location at an angle of incidence at or near a critical angle of the sample; a transmitting crystal in communication with the electromagnetic radiation source and the sample, the transmitting crystal having a high refractive index adapted to reflect the electromagnetic radiation internally; a reflector adapted to introduce the electromagnetic radiation to the sample at or near an angle of incidence near the critical angle between the transmitting crystal and sample; and a detector for detecting the electromagnetic radiation from the sample. Also, provided herein are methods, systems, and kits incorporating the peri-critical reflection spectroscopy apparatus.

A transmissive diffraction grating includes a polarization conversion layer, a first diffractive layer disposed on one surface side of the polarization conversion layer, and a second diffractive layer disposed on the other surface side of the polarization conversion layer. Both the first diffractive layer and the second diffractive layer include refractive index modulation structures arranged with a period P in a first direction, and diffraction efficiency for a TE polarized light component is higher than a diffraction efficiency for a TM polarized light component.

The present disclosure relates to an improved device and methods for adapting to a laser diffraction apparatus used for measuring particle size distribution and density of the plume of a powder composition emitted from a dry powder inhaler.

A method of optically determining the presence of volcanic ash within a cloud comprises emitting a circularly polarized illuminating beam within a cloud and analyzing backscatter light to identify the presence of volcanic ash within the cloud. The method further includes determining the degree to which the cloud has altered the polarization state of the emitted beam. The index of refraction of the backscatter light and the opacity of the backscatter light are also analyzed.

An estimation device is configured to estimate a feature value of a specific component contained in a sample and includes: a spectral estimation parameter storage module; a calibration parameter storage module; a multiband image acquirer; an optical spectrum operator configured to compute an optical spectrum from a multiband image using a spectral estimation parameter; and a calibration processor configured to compute the feature value from the optical spectrum using a calibration parameter.

A system and method for detecting analytes using a conformal filter. A conformal filter, which may comprise a tunable filter, is configured to filter interacted photons conforming to a spectral shape correlated with an analyte of interest. Conformal filter configurations may be selected by consulting a modified look-up table associated with an analyte. An iterative methodology may be used to calibrate a conformal design for an analyte of interest, refine a previous conformal filter design for an analyte of interest, and/or generate a new conformal filter design for an analyte of interest.

A system for characterizing crude oil fractions includes a maltenes sample reservoir, a first solvent reservoir, a second solvent reservoir, and a third solvent reservoir. The system further includes a valve in fluid communication with the first solvent reservoir, the second solvent reservoir, and the third solvent reservoir and a pump in fluid communication with the valve. The system further includes a packed bed in fluid communication with the maltenes sample reservoir and the pump, a flowthrough cell in fluid communication with the packed bed, a spectrometer operably associated with the flowthrough cell, and a computer operably associated with the spectrometer. A method for characterizing crude oil fractions includes providing a maltene sample, eluting saturates, aromatics, and resins of the maltene sample, determining an optical density of each, and determining a concentration of each of the saturates, aromatics, and resins based upon optical densities over time for each.

A dispersion managed interferometric fiber optic gyroscope comprising: a coupler coupled to the broadband light source via a first input fiber; an IOC comprising: a beamsplitter that directs the input signal to a first output and a second output; a combiner configured to combine a first return signal from the first output and a second return signal from the second output into a combined return signal; an integrated optical circuit input coupled to the coupler via a second input fiber; a fiber optic gyroscope sensing coil coupled to a first pigtail fiber and second pigtail fiber, the sensing coil comprising sensing fibers, wherein at least one dispersion slope of at least one of the first input fiber, second input fiber, first pigtail fiber, second pigtail fiber, and the sensing fibers is selected such that the signals at the IOC input has a second order coherence substantially equal to two.

Techniques and devices for measuring polarization crosstalk in birefringence optical media including polarization maintaining fiber.

According to one embodiment, a three-dimensional shape measuring apparatus includes at least an aperture plate that is provided with a plurality of confocal apertures which are two-dimensionally arranged to have a predetermined arrangement period, and an aperture plate displacement portion that displaces the aperture plate at a constant speed in a predetermined direction perpendicular to the optical axis direction. Further, the aperture plate is provided with a cover member which is moved integrally with the aperture plate and which includes a transparent body allowing the light beams from the light source to pass therethrough and to be irradiated to the plurality of confocal apertures, and protects the plurality of confocal apertures from dust. Further, an imaging optical system, by which each of reflected light beams is guided to a photo-detector, is designed in consideration of optical properties of the whole optical system including the transparent body of the cover member.

An optical system for occupancy sensing according to the invention includes a plurality of optical line sensors, each consisting of a linear array of light sensing elements; and an optical light integrating device that integrates light from rays with incidence angles subject to geometric constraints to be sensed by a light sensing element.

A projection exposure tool for microlithography for imaging mask structures of an image-providing substrate onto a substrate to be structured includes a measuring apparatus configured to determine a relative position of measurement structures disposed on a surface of one of the substrates in relation to one another in at least one lateral direction with respect to the substrate surface and to thereby simultaneously measure a number of measurement structures disposed laterally offset in relation to one another.

A system and method of high-speed microscopy using a two-photon microscope with spectral resolution. The microscope is operable to provide two- to five-dimensional fluorescence images of samples, including two or three spatial dimensions, a spectral dimension (for fluorescence emission), and a temporal dimension (on a scale of less than approximately one second). Two-dimensional (spatial) images with a complete wavelength spectrum are generated from a single scan of a sample. The microscope may include one of a multi-beam point scanning microscope, a single beam line scanning microscope, and a multi-beam line scanning microscope. The line scans may be formed using one or more of curved mirrors and lenses. The multiple beams may be formed using one of a grating, an array of lenses, and a beam splitter.

Within machine vision, object movement is often estimated by applying image evaluation techniques to visible light images, utilizing techniques such as perspective and parallax. However, the precision of such techniques may be limited due to visual distortions in the images, such as glare and shadows. Instead, lidar data may be available (e.g., for object avoidance in automated navigation), and may serve as a high-precision data source for such determinations. Respective lidar points of a lidar point cloud may be mapped to voxels of a three-dimensional voxel space, and voxel clusters may be identified as objects. The movement of the lidar points may be classified over time, and the respective objects may be classified as moving or stationary based on the classification of the lidar points associated with the object. This classification may yield precise results, because voxels in three-dimensional voxel space present clearly differentiable statuses when evaluated over time.

A reflection type optical sensor that detect a surface condition of a moving body and that is used for an image generation apparatus which forms images on a recording media includes a light-emitting device which has a plurality of light emitter systems including at least two light-emitting members and a light-emitting optical system having a plurality of light-emitting lenses corresponding to a plurality of the light emitter systems and guiding light emitted from the light emitter systems to the moving body and a light-receiving device which has a light receiver system including at least two light-receiving members and a light-receiving optical system having light-receiving lenses corresponding to the at least two light-receiving members and guiding light reflected by the moving body to the light receiver system. The image generation apparatus has further a surface condition judging device in addition to the reflection type optical sensor.

There is disclosed a polarization-modulating element for modulating a polarization state of incident light into a predetermined polarization state, the polarization-modulating element being made of an optical material with optical activity and having a circumferentially varying thickness profile.

An adaptive optics scanning system using a beam projection module with four or more axes of motion that can project and control the position and angle of a beam of light to or from an adaptive optics element. The adaptive optics scanning system is compact in size, overcoming the challenges of a traditional lens and mirror based pupil relay design. The adaptive optics scanning system has little to no dispersion, chromatic aberration, and off-axis aberration for improved optical performance. The system and methods for calibrating and optimizing the system are described. A modular adaptive optics unit that scans and interfaces an adaptive optics element is described.

A ring binder has an elongate body and rings. Each ring includes ring members moveable between open and closed positions. The body and rings are made of one or more moldable polymeric materials. The binder suitably includes a retaining system operable to hold the ring members in the closed position. The retaining system has interlocking formations adjacent ends of the ring members that are moveable between a retaining position in which the retaining system holds the first and second ring members in the closed position and a non-retaining position. The ring members and body can suitably be formed together as one piece from a moldable polymeric material.

A contact organizing system has a ring device and a hole punching device. The ring device is shaped for holding the business cards. The hole punching device for adapted punching holes in the business cards. The hole punching device includes a hanging aperture through the hole punching device for hanging the hole punching device on the ring device.

A switching circuit (400) comprising an inductive component (406) including at least one winding; and a switch (404) is configured to transfer power from a voltage source (402) to the inductive component (406) in accordance with a switch control signal (412). The switching circuit (400) also comprises a controller (408) configured to integrate the voltage across the inductive component (406) in order to generate a signal representative of magnetic flux in the inductive component (406); and use the signal representative of the magnetic flux in the inductive component to account for a peak magnetization current value in order to control the switch (404).

In certain embodiments, the present invention provides a compound power converter in which the majority of power passes from input to output through only a single stage of power conversion. At least one embodiment includes a main converter with an auxiliary output. The auxiliary output energizes a reservoir that provides input power for a supplemental converter capable supplying the main output. The supplemental converter improves regulation and can provide holdover power for Power Factor Correction (PFC) or Uninterruptible Power Supply (UPS) operation.

A power conversion system with adjustable frequency includes an electric transformer, a pulse width modulation driving controller, a switching transistor, a first and second voltage division resistors connected in series, an output diode and an output capacitor. The electric transformer receives the input power and generates the sensing current and induced current. The sensing current flows through the first and second voltage division resistors to generate the feedback signal. The induced current flows through the output diode and output capacitor to generate the output voltage to supply the load. The pulse width modulation driving controller determine whether the loading state of the load based on the feedback signal, and change the switching frequency according to the loading state and the input power, thereby increasing the whole efficiency of the power conversion system and achieving the aim of dynamically adjusting the optimal frequency.

A power converter includes an active front end (AFE) that is coupled by a dc link stage to a plurality of H-bridge inverters. One or more multi-phase electro-magnetic energy conversion devices, such as transformers or electric machines, with open windings that are connected to only the AFE or only the H-bridge inverters or to both the AFE and H-bridge inverters, provide a regenerative or partial regenerative power converter.

A system, method, and apparatus for providing three level inverter modulation is disclosed. In one embodiment, control signals can be provided to control a three level inverter in a power converter based on at least one feedback signal.

An additional electric power receiving method replacing conventional grounding with a negative voltage source includes the step of transmitting electromagnetic wave or current from a power supply source to a rectifier, wherein a grounding end of the rectifier is in electrical communication with the negative voltage source, and the negative voltage source is selected from a negative potential intrinsic of an organism. A device applicable to the electric power receiving method includes a rectifier having an input end and two output ends, wherein the input end is in electrical communication with a power supply source, and rectified direct current is transmitted from the output ends. With the method and device, not only an increase in additional electric power obtained is achieved, but conversion efficiency and stability of current and electromagnetic wave is enhanced.

Methods and apparatus are presented for detecting phase loss and/or excessive ripple in a power converter, in which bandpass filters are used to obtain harmonic voltage amplitudes associated with the power converter DC bus, and phase loss is detected if a ratio of the second harmonic to the sixth harmonic and/or a ratio of the fourth harmonic to the sixth harmonic exceed predetermined threshold values.

Provided is a configuration in which it is possible to mount an applied voltage suppression circuit configured to prevent voltage breakdown of a semiconductor switching element, and a set voltage thereof can be inspected without damaging an IC or the like of a peripheral circuit. In a power converter having a semiconductor switching element, an applied voltage suppression circuit configured to suppress a voltage applied to the semiconductor switching element and at least one component of constituent components of a driving circuit which causes the semiconductor switching element to be turned off if the component is absent are transferred to and disposed on a slave substrate (separate unit) which is divided from and electrically connected to a master substrate including the semiconductor switching element, the driving circuit, a control circuit, and the like mounted thereon.

A power supply can provide brown-out protection and overheat protection. The power supply includes a rectifier, a transformer, and a power management device. The rectifier is used for receiving an alternating current voltage. The alternating current voltage has a voltage cycle. The transformer coupled to the rectifier has an inductor coupled to a switch for supplying an output voltage. The power management device is used for controlling the switch to make the inductor save power or release power. The power management device has a multi-functional pin coupled to the rectifier for receiving a detection voltage corresponding to a positive half cycle of the alternating current voltage. The multi-functional pin is also coupled to a thermistor for receiving an overheat protection signal.

An alternating-current/direct-current converter includes a rectifier, a reactor, a capacitor, and a switching rectifier. The rectifier is configured to rectify alternating-current voltage output from an alternating-current power source, thereby converting the alternating-current voltage into direct-current voltage, and to output the direct-current voltage. The capacitor includes terminals. The switching rectifier is coupled to the AC power source and switchable to output the direct-current voltage to the capacitor.

A semiconductor device of a three-level inverter circuit with a reduced number of power supplies for driving IGBTs. The semiconductor device includes a series-connected circuit of IGBTs between P and N of a DC power supply and an AC switch element that is connected between a series connection point of the series-connected circuit and a neutral point of the DC power supply. The series-connected circuit and the AC switch element are integrated into one module. The AC switch element is formed by connecting a collector of a first IGBT to which a diode is connected in reverse parallel and a collector of a second IGBT to which a diode is connected in reverse parallel, and an intermediate terminal is provided at a connection point between the collectors.

A system for controlling photovoltaic electricity production equipment having photovoltaic modules each equipped with a DC/DC microconverter connected to a DC bus, a DC bus manager, and an inverter for converting the direct current from the photovoltaic panels into alternative current intended for an electrical distribution network. Power is injected into the DC bus when the voltage of the DC bus is less than a minimum voltage until the minimum voltage is reached. Each of the microconverters injects a maximum power from the photovoltaic modules into the DC bus when the voltage of the DC bus is between a first voltage and a second voltage. The injecting of power from the photovoltaic modules into the DC bus is stopped when the voltage of the DC bus is less than a low threshold voltage or greater than a high threshold voltage.