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Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00442F, Communication
Fuxin Li, Hui Liu, Wanyu Xing, Qingju Zhang, Liming Wang
Here we report an efficient electrochemical nickel-catalyzed cross-coupling reaction for the synthesis of S-glycosides from preactivated phenols and ketones.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor

Org. Biomol. Chem., 2024, 22,3059-3067
DOI: 10.1039/D3OB02050A, Paper
Marie M. Le Roy, Sandra Claes, Nathalie Saffon-Merceron, Dominique Schols, Thibault Troadec, Raphaël Tripier
A rare example of C,C'-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Expanding the scope of the successive ring expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams

Org. Biomol. Chem., 2024, 22,2985-2991
DOI: 10.1039/D4OB00285G, Paper
Open Access
Zhongzhen Yang, Marion Arnoux, Damien Hazelard, Owen R. Hughes, Joe Nabarro, Adrian C. Whitwood, Martin A. Fascione, Christopher D. Spicer, Philippe Compain, William P. Unsworth
New Successive Ring Expansion (SuRE) protocols are described for use on unreactive lactams, as well as iminosugar derived lactams.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Identification and quantification of local antiaromaticity in polycyclic aromatic hydrocarbons (PAHs) based on the magnetic criterion

Org. Biomol. Chem., 2024, 22,3035-3044
DOI: 10.1039/D4OB00114A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Erich Kleinpeter, Andreas Koch
The ring current effect of entirely and partly (anti)aromatic PCHs are calculated and employed to visualize, qualify and quantify existing (anti)aromaticity, especially to decide unequivocally between PAHs and PAAHs.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00236A, Review Article
Goverdhan Mehta, Saumitra Sengupta, Srihari Pabbaraja
Often referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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History API: Scroll Restoration




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How long do commercial aircraft last?

What airlines can do to extend the longevity of their fleet




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‘The challenge was in getting the aircraft’s custom clearance’

Private jet operator JetSetGo’s CEO Kanika Tekriwal describes the intricacies of directly importing and leasing an aircraft




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Where an aircraft goes to rest




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Air India sale: Who will bag the Maharaja's crown?

Financial bid winner for sale of the State-owned airlines to be declared in three weeks; sources say it may take longer




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IFSC: Aircraft leasing gets a big boost

Around 80 per cent of the total commercial fleet in India is leased against 53 per cent of the same, globally




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Omicron: Airlines on a wing and prayer

Over 3,000 flights were cancelled on the eve of Christmas and cancellations are expected to double as New Year approaches




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Air crew at higher risk




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Insolvency of aircraft operator: default remedies.

India should adopt Cape Town Convention as part of the domestic legal framework.




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Electric aircraft set to transform urban mobility 

Investors are pouring in billions of dollars into eVTOL project (electric vertical take offs and landing aircraft) to ferry passengers




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Thrust reversal in aircraft

It functions by directing the thrust produced by the plane’s jet engines forward, rather than backwards




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Cabin crew with an invisible cape 

Being a cabin crew member is not a mere job, but an ineffable life experience




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Why do plane crashes happen?




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How do commercial aircraft navigate?




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Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




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Microsoft Teams to launch threaded conversations, combined chats and channels features

The app has also added other changes in the interface so users can organise their chats better




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Crypto firm Consensys to cut 20% of workforce amid macroeconomic, regulatory headwinds

The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment”




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As Bitcoin nears all-time high, WazirX investors are in pain over their locked crypto funds

Bitcoin was inching towards its March 2024 all-time-high price of $73,750.07, but those whose crypto assets are locked with the WazirX exchange after a cyberattack are anxious about missing out




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Microsoft, Meta, Apple, Amazon, and the burden of expectations knock Wall Street sharply lower

Drops for Big Tech companies including Microsoft and Facebook’s parent company Meta Platforms led Wall Street lower




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Out-of-pocket expenditure on health in Kerala is highest in country despite increased State investments

National Health Accounts figures show the per capita out-of-pocket expenditure on health in Kerala stands at ₹7,889. However, Kerala also tops the list when it comes to the per capita government spending on health, at ₹4,338




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Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained

India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy




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30,000 critical care beds, regional centres for National Institute of Virology are among plans under PM-ABHIM: V.K. Paul

Expanding healthcare infrastructure plans also include integrated public health units in 600 districts and 30 branches of the National Centre for Disease Control, Niti Aayog member Dr. Paul has said




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OpenAI’s Whisper transcription tool used in hospitals invents things no one ever said, researchers claim

Whisper is a popular transcription tool powered by artificial intelligence, but it has a major flaw




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'The Songs Have Already Become A Craze'

'When it was confirmed that I would do the song, Manishaji walked up to me and asked, "Please Vijayshree, tell me how are you planning to do the song. Give me a rough idea so that I am mentally prepared".'




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'The Appetite For Horror Has Increased'

'How to hold people's attention is challenging.'




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'Critics Wait 20 Years To Like My Films'

'Whenever people say to me that all my work looks unique, I say to them originality is the art of concealing your source.''You can't see the sources that I take from because usually, they are Indian.''But then Indians don't find my work Indian.'




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60fps scrolling using pointer-events: none

Paul Lewis did an interesting article a while back about avoiding unnecessary paints through disabling hover effects as the user scrolls, which is a great approach. The down side being managing all your hover states through a parent class. UPDATE: I’ve done a follow up article which demonstrates a more robust technique. .hover .element:hover { … Continue reading "60fps scrolling using pointer-events: none"




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A follow up to obtaining 60fps scrolling performance

60fps scrolling article got quite a few people excited but also a few smart people to point out some flaws in the approach. I was planning to just update the original article but I’ve compiled so much info about this topic that I thought it would be better to do a follow up article and … Continue reading "A follow up to obtaining 60fps scrolling performance"




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Creating a sunrise alarm with the LIFX lightbulb

If you’re unfamiliar with LIFX it’s basically a smart wifi enabled led lightbulb. Lifx recently released a Ruby gem to communicate with it and give it instructions. With winter looming in the southern hemisphere and the sun being up for what feels like 4 seconds at that time of year it’s really hard to get … Continue reading "Creating a sunrise alarm with the LIFX lightbulb"




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UITableView in JavaScript, list view with re-usable cells using flexbox

If you’re familiar with iOS development you will know that a UITableView is very efficient when displaying a list of data. A simplification of what it does is display enough cells to fill the viewport plus a few more either side. As you scroll it re-uses cells that are now out of the viewport so … Continue reading "UITableView in JavaScript, list view with re-usable cells using flexbox"




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The cross-over effect

From sensual to spiritual, the dance performances at the recent “Tribhanga – Explorations in Odissi dance” gave the connoisseurs plenty to reflect upon.




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Episode skilfully recreated

The Koodiyattam performance of ‘Sikhinisalabham,’ was a solo act with nuanced portrayals




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Creative Kathak

Kadamb’s performance at the Bani festival carried the Kumudini Lakhia stamp in its technique and style.




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Big brother is screening you




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The secret of doing great work

Find that sweet spot between loving what you do and doing what you love




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‘Before you can create, you must forget’

Unlearning is an indispensable part of innovation-led growth, says best-selling author Vijay Govindarajan




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Tobacco growers in Andhra Pradesh make hay as export demand spikes, seek higher crop cap

Global shortage of 400 million kg of tobacco spurs export demand for the crop; premium leaves fetch farmers in Prakasam and Nellore districts a record ₹210 a kg during e-auctions




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House panel tells government to ensure fertilizer availability, increase local production

Standing Committee also questions the high GST rate on components of fertilizers




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Manipur to compensate farmers hit by ethnic violence with ₹38-crore package 

Farmers are afraid to go to the fields because of sporadic firing by armed miscreants from higher grounds 




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Centre raises minimum support prices for Rabi crops, farmers unhappy

Farmers’ organisations say the MSP did not match the increase in input costs




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Cabinet approves ₹22,303 cr subsidy on P&K fertilisers for Rabi crop season

The decision was informed by Information and Broadcasting Minister Anurag Thakur after the Cabinet meeting




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India’s smaller rice crop paves way for prolonged export curbs

Production in India, the world’s largest rice exporter, is under unusually intense focus after New Delhi banned exports of non-basmati white rice in July, sending global prices surging




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PM KISAN Yojana | FM Nirmala Sitharaman says 11.8 crore farmers receive financial assistance

“The government under the leadership of Prime Minister Narendra Modi is addressing systematic inequalities, which have plagued the society,” Finance Minister Nirmala Sitharaman said.